Navigation Links
University of Pennsylvania researchers develop formula to gauge risk of disease clusters
Date:8/16/2007

Researchers at the University of Pennsylvania have developed a mathematical formula to assess whether concentrated disease outbreaks can be ascribed to random-chance events or, instead, suggest a contagious or environmental effect that requires epidemiological investigation.

A feature of the formula is that, given the relevant data, the required probability calculations can be done in less than five seconds on a personal computer.

In statistical terms, the formula gives an exact expression for the probability distribution of the maximum of a number of multinomially distributed random variables. Mathematically, the formula depends on generating function technology developed by Herbert Wilf, professor of mathematics in the School of Arts and Science at Penn. Warren Ewens of Penns Department of Biology joined Wilf in developing the formula. Until now, only potentially unreliable, approximate formulae have been available.

The formula was used to investigate two disease cluster cases.

The first was the classic case of a clustering of eight cases of leukemia in Niles, Ill., in 1956-1960, which was reasonably assessed as a chance, random event. On the other hand, 12 cases of acute lymphocytic leukemia in Churchill County, Nev., in 1999-2001 was assessed not to be a chance event but due to a common, possibly environmental cause.

Multiple cases of non-communicable disease, like leukemia, have clustered in small geographic areas quickly, resulting in costly epidemiological study. The authors note that a purely mathematical calculation cannot answer serious public-health questions, but that they can nevertheless point to cases that appear to require further public health study.


'/>"/>
Contact: Jordan Reese
jreese@pobox.upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1

Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. New protein discovered by Hebrew University researchers
3. Next Generation Body Scanner Launched By The University Of Manchester
4. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
5. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Carnegie Mellon University research reveals how cells process large genes
8. University of Delaware researchers develop cancer nanobomb
9. University of Arizona plant scientists to unravel maize genome
10. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
11. University of Utah to help build bionic arm
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... Non-biting blow fly Chrysomya megacephala is commonly ... investigations to determine the time of death, referred to ... derived form of C. megacephala from Tamil ... morphological features and molecular characterization through generation of DNA ... in the open access Biodiversity Data Journal . ...
(Date:7/23/2014)... the world by 2050, according to one of the ... (IPCC), may be advantageous to the physiology and the ... forage plants such as Stylosanthes capitata Vogel , ... such as Brazil., The conclusion is from a study ... at the Ribeiro Preto Faculty of Philosophy, Sciences and ...
(Date:7/23/2014)... publish the International Journal of Fuzzy Systems ... Fuzzy Systems Association (TFSA). The cooperation will allow the ... of fuzzy research., The International Journal of Fuzzy ... deal with the theory, design and application of fuzzy ... systems ranging from hardware to software. Launched in 1999, ...
Breaking Biology News(10 mins):Dead body feeding larvae useful in forensic investigations 2An increase in temperature by 2050 may be advantageous to the growth of forage plants 2An increase in temperature by 2050 may be advantageous to the growth of forage plants 3An increase in temperature by 2050 may be advantageous to the growth of forage plants 4
... journal Acta Biomaterialia , researchers from the University of ... in the grafting of stem cells onto the eye, mimicking ... designed to treat damage to the cornea, the transparent layer ... the major causes of blindness in the world. Using ...
... PRUSSIA, Pa., Dec. 4, 2012 /PRNewswire-iReach/ -- Greenphire CEO ... Spend Bootcamp on the implications of the Physician Sunshine ... on advances in technology which streamlines financial reporting required ... discussion focused on how pharmaceutical, biotech, and medical device ...
... a professor of entomology at the University ... California Citrus Quality Council ,s prestigious Albert G. ... in the field of entomology which has contributed vitally ... three decades, Morse has provided timely research results and ...
Cached Biology News:New technique to deliver stem cell therapy may help damaged eyes regain their sight 2Greenphire CEO Sam Whitaker speaks on Sunshine Act and Clinical Trial Payments 2UC Riverside entomologist recognized for research in citrus entomology 2
(Date:7/23/2014)... , July 24, 2014 Lyfebulb, ... Pharmaceuticals Inc. (OTCQX and NASDAQ OMX First North ... or "the Company"), announced a collaboration to increase ... last night at an event attended by more ... parties. Lyfebulb is a health and wellness company ...
(Date:7/23/2014)... made great strides in saving China,s endangered national treasure, ... 65 giant panda reserves that have been established and ... 1596 pandas remain in the wild. , Breeding ... the panda by improving genetic diversity, avoid inbreeding and ... are these high-profile programs doing so far? , In ...
(Date:7/23/2014)... , July 23, 2014 /PRNewswire-iReach/ -- Think Drinks ... performance for the long term. They are the first ... of sustained energy as an alternative to the temporary ... Drinks on Indiegogo on July 29, 2014, with hopes ... campaign. Photo - http://photos.prnewswire.com/prnh/20140723/129697 ...
(Date:7/23/2014)... Last year, Formedix celebrated ... global provider of data management solutions for clinical trials. ... system for electronic data capture (EDC) and clinical data ... study execution tools added TrialMaster to its Transform for ... of Transform for TrialMaster, is being released this week, ...
Breaking Biology Technology:Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 4Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 5truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3
... Hikma Pharmaceuticals today,announced strong revenue growth and stable ... business. The weakness in the US was offset by ... Branded,businesses. CEO, Said Darwazah, said "The US operations, in ... we had a loss there so in spite of,this ...
... of Helsinki, Finland, has succeeded in producing nano-sized metallic ... to a nano-scale (one nanometre being one billionth of ... changes. Unlike in bulk materials, in nanoparticles the number ... of atoms inside the material, which, among other things, ...
... SOUTHAMPTON, Pa., March 16 Environmental Tectonics Corporation ... "Company") today announced that their BioMedical Division will ... Conference. The American Professional Wound Care Association (APWCA) ... - 4 in Philadelphia, at the Sheraton, Philadelphia, ...
Cached Biology Technology:Paper electrified by copper particles 2Environmental Tectonics Corporation Announces Participation at APWCA National Conference 2Environmental Tectonics Corporation Announces Participation at APWCA National Conference 3
... novel disposable spin filtration device especially designed ... in plasmid purification procedures. , ,The ... filtration device especially designed to aid the ... procedures. The neutralized lysate is centrifuged at ...
Comp Dim: chamber L W D 45 45 0.8 mm chamber maximum volume 1500 μL...
HybriWell seals securely to a microscope slide surface in seconds to enclose single or multiple specimens in a small reagent volume and eliminate evaporation....
... Reusable, press-to-seal gasket and cover slip enclosures ... for hybridizing and imaging thick or free ... to a 13 mm diameter. Build up ... handling, eliminate evaporation and leaking even when ...
Biology Products: