Navigation Links
University of Cincinnati to study impact of blood 'microparticles' in inflammation, injury
Date:3/24/2014

CINCINNATIA University of Cincinnati (UC) trauma and critical care researcher has received a National Institutes of Health grant to better understand how "microparticles" in stored blood can contribute to inflammation and injury after resuscitation from traumatic injury.

Timothy Pritts, MD, PhD, UC associate professor of surgery and UC Health trauma surgeon, received a five-year, $1.5 million R01 research award to investigate the nature of microparticles, or small vesicles, that bud off of damaged or active blood cells during storage.

UC researchers have been studying resuscitation with blood products for several years as part of their work with UC's Institute for Military Medicine.

"Hemorrhagic shock is the most common cause of potentially preventable death after traumatic injury," says Pritts. "With recent studies showing the benefits of giving traumatically injured patients blood products instead of the previously standard saline solution, many trauma centers are now using stored red blood cells and plasma for resuscitation. But there's some data to indicate stored blood products may have unforeseen effects on severe injury."

During storage, packed red blood cells (pRBC) undergo biochemical changes known as the "RBC storage lesion." Transfusion with aged pRBC units is associated with worsened outcomes in patients receiving these units, including increased risk of multisystem organ failure, pneumonia, renal failure, sepsis and death.

Originally thought to be harmless cellular debris, microparticles have now been shown to actively contribute to the RBC storage legion.

But Pritts says researchers know little about when and how microparticles form in stored pRBC, as well as how they may lead to cellular inflammation and worsening injury.

"Our preliminary data also show that the number of microparticles increases rapidly during storage and then plateaus, suggesting microparticles may continually f
'/>"/>

Contact: Katy Cosse
kathryn.cosse@uc.edu
513-558-0207
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wheat stem sawfly devastations lead to another international conference at Montana State University
2. University of Nevada, Reno joins with NevadaNano for flying robot sensor project
3. Queens University included in chemical engineering roll of honor
4. Israel Prize in Medicine awarded to Hebrew University developer of Alzheimers drug
5. Western University primatologist teams with international group to save lemurs
6. Discovery by Baylor University researchers sheds new light on the habitat of early apes
7. University of Illinois study of 2011 flood will lead to better preparedness
8. Iowa State Universitys Wintersteen talks partnerships at national science meeting
9. University of Guelph study assesses environmental impact of Ontario corn production
10. 2013 AAAS Mentor Award goes to Paul B. Tchounwou of Jackson State University
11. 2013 AAAS Lifetime Mentor Award goes to Andrew Tsin of the University of Texas at San Antonio
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2015)... , August 26, 2015 The ... and Five Factor), Application (Travel & Immigration, Government, Banking, ... Global Forecast to 2020", published by MarketsandMarkets, Multi-Factor Authentication ... 2020, growing at a CAGR of 17.7% between 2015 ... 82 F igures spread through 169 ...
(Date:8/20/2015)... , Aug. 20, 2015   Sensory, ... on improving the user experience and security of ... technologies, today announced that its TrulySecure™ ... authentication software to be FIDO Certified™. ... for compliance with the FIDO UAF (Universal Authentication ...
(Date:8/17/2015)... , Aug. 17, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market and ... sales campaign for Q4 2015. The new marketing campaign ... consisting of Amplitude Marketing Group ( http://amplitudemarketing.com/ ) and ... is a leader in retail driven marketing and brand ...
Breaking Biology News(10 mins):Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... Boston, MA Using 120 years of feathers ... University researchers have been able to track increases in ... nigripes ), an endangered seabird that forages extensively throughout ... the observed increase in methylmercury levels, most likely from ...
... University of the Negev software engineering students have developed ... computer without using a keyboard or mouse only ... to develop devices to read brainwaves and operate specific ... a laboratory setting. The BGU ...
... April 18, 2011 Mention vitamin D-fortified foods and ... with the sunshine vitamin since the 1930s. A new ... Challenges/Chemistry Solutions" podcast series says that vitamin D-fortified bread ... essential nutrient that is difficult to get naturally in ...
Cached Biology News:Mercury on the rise in endangered Pacific seabirds 2
(Date:8/31/2015)... Tampa, FL (PRWEB) , ... August 31, 2015 ... ... will bring together the world's most successful food and beverage processors, equipment manufacturers ... its competencies in product inspection and industrial weighing and formulation for manufacturers of ...
(Date:8/28/2015)... , August 28, 2015 According ... (Media, Sera, Cryogenic Storage Systems, Thawing Equipment, Alarms), by ... Medicine, Clinical Trials), End User - Global Forecast to ... expected to reach USD 3,731.03 Million by 2020 from ... of 11.65% between 2015 and 2020. ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... Since the initial launch of FireflySci Inc. ... quirky humor and excellent customer service. Images such as the Fonz in a lab ... add some flavor to the humdrum spectroscopy field. , FireflySci is proud to ...
(Date:8/27/2015)... Aug. 27, 2015 The National Necrotizing ... eyes—and life—were saved by doctors at Vanderbilt University Hospital ... NNFF, NovaBay Pharmaceuticals and Dr. John Crew , ... at Seton Medical Center in Daly City, ... a breakthrough approach, pioneered by Dr. Crew, that had ...
Breaking Biology Technology:METTLER TOLEDO Hosts Food Safety Educational Center at 2015 PROCESS EXPO 2Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3
... Pa., Dec. 24 Wyeth,Pharmaceuticals, a division of ... will,pursue a patent infringement claim for lost profits ... from Teva,s launch of a,pantoprazole tablet -- a ... not disputed that its product infringes the United ...
... presents a new marvel of just how much memory can ... nanolasers being developed in Sakhrat Khizroevs lab at the University ... smaller. , As reported in the latest issue of ... tiny that they point to a future where a 10-terabit ...
... WALTHAM, Mass., Dec. 21 Inverness Medical,Innovations, Inc. ... marketer of rapid,diagnostic products for the consumer and ... upcoming JP Morgan Healthcare Conference,being held January 7 ... Hotel in,San Francisco. Ron Zwanziger, Chief Executive Officer, ...
Cached Biology Technology:Wyeth Will Pursue Claim for Damages Resulting From Teva Pharmaceuticals' Launch of Generic Pantoprazole in Violation of PROTONIX Patent 2Wyeth Will Pursue Claim for Damages Resulting From Teva Pharmaceuticals' Launch of Generic Pantoprazole in Violation of PROTONIX Patent 3Wyeth Will Pursue Claim for Damages Resulting From Teva Pharmaceuticals' Launch of Generic Pantoprazole in Violation of PROTONIX Patent 4The Library of Congress in your wrist watch? 2Inverness Medical Innovations to Participate at JP Morgan Healthcare Conference on January 8, 2008 2
solute carrier family 25, member 13 (citrin)...
poliovirus receptor-related 2 (herpesvirus entry mediator B), mRNA...
CREB-2 (H-290)...
Anti-Dynamin Monoclonal Antibody Description: 100 g Research Focus: neuroscience Storage: -20C Shipping Temperature: 4C...
Biology Products: