Navigation Links
University of Arizona scientist shares in discovery of microbe filaments' power
Date:4/18/2008

Researchers from The University of Arizona and Columbia University have discovered that tiny filaments on bacteria can bundle together and pull with forces far stronger than experts had previously thought possible.

The team of researchers, including Magdalene Maggie So, a member of the BIO5 Institute and the department of immunobiology in the UA College of Medicine, studied Type IV pili or filaments on the surface of Neisseria gonorrhoeae, the bacterium that causes the infectious disease gonorrhea. The research results help them understand the role that Type IV pili play in initiating a variety of infectious diseases including tuberculosis and how retracting pili allow bacteria to crawl and to exchange genes with each other.

When a bundle of Type IV pili retracts, it pulls with a force in the nanoNewton range, which is 10 times the force of a single retracting filament. The study demonstrates the power and cooperative nature of the nanomotors that cause Type IV pili to retract.

The motor that causes these filaments to pull is one of the strongest nanomotors known in biology, So said.

In previous studies, the same group of investigators measured single filament retraction forces in the 50 to 100 picoNewton range. This force allows the bacterium to move an object 10,000 times its own body weight. Retraction forces from a bundle are roughly 10 times higher, allowing the bacterium to move objects 100,000 times its body weight.

Pilus retraction forces are an important factor in how N. gonorrhoeae starts an infection. So, who has studied these microbes for more than 20 years, says N. gonorrhoeae communicates with a human cell by pulling on it. These pulling forces perturb the normal circuitry of the cell. As a result, the infected cell is fooled into lowering its defenses against the infecting microbe.

So said that the team of investigators came up with a new method to measure the tremendous forces applied by
'/>"/>

Contact: Deborah Daun
ddaun@email.arizona.edu
520-626-2059
University of Arizona
Source:Eurekalert

Page: 1 2

Related biology news :

1. Flowers fragrance diminished by air pollution, University of Virginia study indicates
2. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
3. Yale Universitys Strobel recognized for work on RNA
4. Womens health-related scientific findings presented by University of Pittsburgh researchers
5. Researchers at Stockholm University awarded the Descartes prize
6. Policing cells demand ID to tell friend from foe, say University of Pennsylvania cell engineers
7. Antarcticas coldest, darkest season draws Montana State University researchers
8. University of Colorado at Boulder awarded $1 million for biofuels research
9. Viruses evolve to play by host rules, according to University of Pennsylvania researchers
10. New whitepaper offers options for university implementation of NIH policy
11. Electronic structure of DNA revealed for 1st time by Hebrew University and collaborating researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... organisms, including humans, have parasitic DNA fragments called "jumping ... instructions in the process. And that phenomenon can result ... the University of Rochester now report that the "jumping ... when a multi-function protein stops keeping them in check ... In a study published today in Nature Communications ...
(Date:9/22/2014)... Chicago have shown that after a long stay in ... pathogenic microbe species remain behind in patients, intestines. The ... can become deadly when provoked by conditions that mimic ... published in mBio , the online open-access journal ... better monitoring and treatment of ICU patients who can ...
(Date:9/22/2014)... September 23, 2014 A new American Cancer ... Nutrition Assistance Program (SNAP), previously known as the ... compared with income eligible non-participants. The authors say ... aimed at enhancing the dietary quality of SNAP ... low-income individuals and households with the resources to ...
Breaking Biology News(10 mins):A multi-function protein is key to stopping genomic parasites from 'jumping' 2Critically ill ICU patients lose almost all of their gut microbesand the ones left aren't good 2Critically ill ICU patients lose almost all of their gut microbesand the ones left aren't good 3Federal food program puts food on the table, but dietary quality could be improved 2
... Santa Barbara have developed new methods for studying how environmental ... spatial and temporal scales. The scientists merged data collected ... canopies taken by the Landsat 5 Thematic Mapper. The findings ... issue of Marine Ecology Progress Series. In ...
... of State Foresters released the first phase of the Southern ... areas forest managers will focus on to maintain southern forests ... urbanization, bioenergy use, weather patterns, land ownership changes and invasive ... 2010 and 2060. About 23 million acres of forest ...
... is available in Spanish . The ... Ikerbasque, is participating in the AWIN -Animal Welfare Indicators project. ... international experts in animal welfare from 11 centres. The group ... University of Edinburgh on the 10 and 11 of May, ...
Cached Biology News:UCSB scientists track environmental influences on giant kelp with help from satellite data 2UCSB scientists track environmental influences on giant kelp with help from satellite data 3Forest Service unveils first comprehensive forecast on southern forests 2Forest Service unveils first comprehensive forecast on southern forests 3Neiker-Tecnalia participates in a European project for improving the welfare of farm animals 2Neiker-Tecnalia participates in a European project for improving the welfare of farm animals 3
(Date:9/23/2014)... September 23, 2014 Texas Fertility Center ... in South Austin, expanding a Central Texas footprint that ... Antonio. The satellite office for the region’s most established ... to the South Austin, Buda, Kyle and San Marcos ... affordable fertility treatment directly to individuals and couples living ...
(Date:9/23/2014)... September 23, 2014 Marktech Optoelectronics has ... ultra violet emitters in the 280 nm wavelength range. ... emitters which range from 280nm to 405nm. These new ... sanitation as well as curing. Mark Campito, Marktech’s CEO ... special interest to manufacturers is that we offer it ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 Dr. Williams ... third book on healthcare offers a three phase process ... century healthcare delivery system that would go far beyond ... responsibility regarding the delivery of healthcare.” , “Every effort ... has failed to provide discernable progress throughout that system ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 ... the globe will convene at the Society ... to be held October 26-28 in Houston, ... research and practice in individualized integrative cancer ... researchers, nurses, psychologists, nutritionists, naturopaths, acupuncturists, and ...
Breaking Biology Technology:Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 3Marktech Introduces its New Line of Deep UV Emitters 2Dr. Ira Williams Offers the Healthcare Solution Necessary for Patient Safety Improvement 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 3
... to grow over 23% per year due to new cellulite ... Millennium Research Group, WALTHAM, Mass., April 9, 2008 ... Devices 2008 report,the cellulite reduction device market was worth almost ... next five years, rising to over,$215 million by 2012. Growth ...
... Cytopia Limited,(ASX: CYT) today announced that it ... American Association for Cancer Research Annual Meeting being ... 17,000,participants from around the world to discuss new ... titled "A Novel JAK2 inhibitor for the treatment ...
... 2008 Dendreon Corporation,(Nasdaq: DNDN ) today ... direct offering of 8.0 million shares of its ... million shares of its common,stock. Net proceeds received ... LLC served as sole placement agent for the ...
Cached Biology Technology:Say Good-Bye to Cellulite 2Dendreon Announces Closing of Registered Direct Offering 2
... PS603. Immunogen: Synthetic phosphopeptide ... the phosphorylated Ser603 residue of ... Specific for synapsin I when ... Reactivity: Rat (positive control: ...
CMRL Medium-1066 (1X) liquid...
... 11(R)-HETE is biosynthesized by the ... purpuratus, and the fresh water hydra, ... 11(R)-HETE relates to oocyte maturation and ... species.11(R)-HETE is also produced when aspirin-treated ...
... PhosphatidylEthanolamine-Binding Protein (PEBP) does not share ... inhibitors. PEBP is expressed in ... ovary, muscle, and stomach. One ... is exerting inhibitory activity against several ...
Biology Products: