Navigation Links
University of Alberta's designer compounds inhibit prion infection
Date:7/23/2012

(Edmonton) A team of University of Alberta researchers has identified a new class of compounds that inhibit the spread of prions, misfolded proteins in the brain that trigger lethal neurodegenerative diseases in humans and animals.

U of A chemistry researcher Frederick West and his team have developed compounds that clear prions from infected cells derived from the brain.

"When these designer molecules were put into infected cells in our lab experiments, the numbers of misfolded proteins diminishedand in some cases we couldn't detect any remaining misfolded prions," said West.

West and his collaborators at the U of A's Centre for Prions and Protein Folding Diseases say this research is not yet a cure, but does open a doorway for developing treatments.

"We're not ready to inject these compounds in prion-infected cattle," said David Westaway, director of the prion centre. "These initial compounds weren't created for that end-run scenario but they have passed initial tests in a most promising manner."

West notes that the most promising experimental compounds at this stage are simply too big to be used therapeutically in humans or animals.

Human exposure to prion-triggered brain disorder is limited to rare cases of Creutzfeldt-Jakob or mad cow disease. The researchers say the human form of mad cow disease shows up in one in a million people in industrialized nations, but investigating the disease is nonetheless well worth the time and expense.

"There is a strong likelihood that prion diseases operate in a similar way to neurodegenerative diseases such as Alzheimer's, which are distressingly common around the world," said West.
'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. University of Tennessee Space Institute researchers develop laser technology to fight cancer
2. University of Tennessee professor wins worlds top prize for ecology, environmental science
3. Carnegie Mellon Universitys Biometrics Center Selected To House New Pedo-Biometrics Research and Identity Automation Lab
4. Wayne State University researchers program targets safer river fishing, anglers health
5. Winemaking goes high-tech at the University of British Columbia
6. University of Miami-led study finds winds played important role in keeping oil away from S. Fla.
7. New York University scientists discover possible treatment to reduce scarring
8. Royal Astronomical Society and Oxford University Press partnership announced
9. Mainz University coordinates new EU project on the origins of human settlement
10. University of Tennessee professor receives funding for clean coal research
11. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... 23, 2015   Valencell, a leader ... of a recent study that illustrates its PerformTek ... during activity. In a study conducted at Valencell,s ... with the Apple Watch against a chest strap ... during activity. The study demonstrated that Valencell,s biometric ...
(Date:6/18/2015)... , June 18, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market announces that ... featured segment on "Money on the Mark", scheduled to air ... June 20 th . The ... be from 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO ...
(Date:6/17/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... that Xiaomi, one of the world,s largest mobile ... ® family of capacitive touchscreen solutions and ... for its latest smartphones, the Xiaomi Mi Note ... in-cell display solutions and DDICs in discrete display ...
Breaking Biology News(10 mins):Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3
... will use a $120,000 grant from the Foundation for AIDS ... cells it attacks have evolved together over time. The goal ... When HIV infiltrates cells, the virus hijacks its host,s ... has been recently found that the retrovirus hijacks about 1,000 ...
... by researchers at the Montreal Neurological Institute (MNI), ... provides vital insights into the neurological basis of ... some instances develop various addictions when undergoing medical ... 25) issue of the scientific journal Neuron ...
... new statistical model could be used to predict an ... the Children,s Hospital Informatics Program (CHIP). Using genetic information ... predictive model could estimate an individual,s overall risk of ... -- with 86 percent accuracy. The findings are reported ...
Cached Biology News:Evolutionary biologist will study HIV with grant from AIDS research foundation 2Addiction: Insights from Parkinson's disease 2Predicting risk of stroke from one's genetic blueprint 2
(Date:7/7/2015)... 2015  SME,s Advanced Manufacturing Media is proud to ... issue, celebrating young men and women who have demonstrated ... issue of Manufacturing Engineering magazine ... their accomplishments. Among the standouts: Christopher Tyler , ... optimizing the topology of flapping wing vehicles; Kathryn ...
(Date:7/7/2015)... ... July 07, 2015 , ... uBiome, the leading microbial genomics company, ... microbiome sampling kits and full 16S laboratory analysis. The goal is to fast-track a ... also have access to their own dashboard, enabling them to view and compare the ...
(Date:7/7/2015)... ... , ... Since its inception in 2004 PhUSE has become ... conference for European Statistical Programmers, has evolved in the past eleven years to ... Data Managers and Biostatisticians all over the world, share, contribute and advance at ...
(Date:7/7/2015)... Pensacola, FL (PRWEB) , ... July 07, 2015 ... ... trials, ActiGraph’s CentrePoint Study Admin system was developed to solve many ... collection and analysis, particularly within studies that involve multiple clinical sites and/or remote ...
Breaking Biology Technology:SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 2SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 3SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 4SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 5uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 2uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 3PhUSE Delighted to Welcome Member Number 5.000 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 3
... Cardium Therapeutics (Amex:,CXM) announced today that Richard A. ... is an early pioneer of coronary stent,technology and is ... stent, the Palmaz-Schatz stent. Dr. Schatz is Research Director ... at,Scripps Clinic in La Jolla, California. He is also ...
... ... in Rockville, MD, ... NVAX ), the State of Maryland and Montgomery County ... the company,s headquarters in Rockville, Maryland. The 5,000,square-foot, $5 million ...
... "Anatomy of a Deal - BioMS Medical and Eli ... - BioMS Medical Corp (TSX: MS),a leading developer in ... Kevin Giese, President and CEO, BioMS Medical and Buu ... will take part in a speciality panel session at ...
Cached Biology Technology:Richard A. Schatz, M.D. Joins Cardium's Scientific Advisory Board 2Richard A. Schatz, M.D. Joins Cardium's Scientific Advisory Board 3Richard A. Schatz, M.D. Joins Cardium's Scientific Advisory Board 4Novavax Opens Its First U.S. Vaccine Plant 2Novavax Opens Its First U.S. Vaccine Plant 3Novavax Opens Its First U.S. Vaccine Plant 4BioMS Medical to Participate in Speciality Panel Session at BioFinance 2008 2BioMS Medical to Participate in Speciality Panel Session at BioFinance 2008 3
... Pyrophosphate Detection Kit,provides a fast, convenient ... inorganic pyrophosphate (PPi ) produced,by a ... DNA and,RNA polymerizations, cyclic AMP formation ... enzymatic activation of fatty acids to,form ...
... Terminal deoxynucleotidyl transferase (TdT) is an intracellular ... cortical thymocytes and minor subpopulation of bone ... and increased numbers of TdT cells are ... leukaemias and lymphomas. Presence of TdT thus ...
... matrix proteins (NMPs) make up the internal structural ... such functions as DNA replication, RNA synthesis, and ... been shown to be highly insoluble in ... death releases soluble nuclear matrix proteins that can ...
Recombinant Cat Interferon Alpha Activity: 2.7 x 10 7 u/mg...
Biology Products: