Navigation Links
University of Alberta's designer compounds inhibit prion infection
Date:7/23/2012

(Edmonton) A team of University of Alberta researchers has identified a new class of compounds that inhibit the spread of prions, misfolded proteins in the brain that trigger lethal neurodegenerative diseases in humans and animals.

U of A chemistry researcher Frederick West and his team have developed compounds that clear prions from infected cells derived from the brain.

"When these designer molecules were put into infected cells in our lab experiments, the numbers of misfolded proteins diminishedand in some cases we couldn't detect any remaining misfolded prions," said West.

West and his collaborators at the U of A's Centre for Prions and Protein Folding Diseases say this research is not yet a cure, but does open a doorway for developing treatments.

"We're not ready to inject these compounds in prion-infected cattle," said David Westaway, director of the prion centre. "These initial compounds weren't created for that end-run scenario but they have passed initial tests in a most promising manner."

West notes that the most promising experimental compounds at this stage are simply too big to be used therapeutically in humans or animals.

Human exposure to prion-triggered brain disorder is limited to rare cases of Creutzfeldt-Jakob or mad cow disease. The researchers say the human form of mad cow disease shows up in one in a million people in industrialized nations, but investigating the disease is nonetheless well worth the time and expense.

"There is a strong likelihood that prion diseases operate in a similar way to neurodegenerative diseases such as Alzheimer's, which are distressingly common around the world," said West.
'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. University of Tennessee Space Institute researchers develop laser technology to fight cancer
2. University of Tennessee professor wins worlds top prize for ecology, environmental science
3. Carnegie Mellon Universitys Biometrics Center Selected To House New Pedo-Biometrics Research and Identity Automation Lab
4. Wayne State University researchers program targets safer river fishing, anglers health
5. Winemaking goes high-tech at the University of British Columbia
6. University of Miami-led study finds winds played important role in keeping oil away from S. Fla.
7. New York University scientists discover possible treatment to reduce scarring
8. Royal Astronomical Society and Oxford University Press partnership announced
9. Mainz University coordinates new EU project on the origins of human settlement
10. University of Tennessee professor receives funding for clean coal research
11. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... our ability to assess the pandemic risk from strains ... we must not allow ourselves to become complacent that ... international consortium of scientists. , Influenza pandemics arise when ... yet to develop widespread immunity – spreads in the ... the past 100 years, the worst of which – ...
(Date:10/15/2014)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... commerce market releases photos and video of the recent opening bell ... th . Gino Pereira , CEO of ... Mr. Chad A. Verdi rang the bell.  ... and employees "for their work and dedication in bringing the world,s ...
(Date:10/14/2014)... been millions of years since T. rex ... Ohio University scientists is breathing life back into dinosaurs ... snouts. The research has important implications for how dinosaurs ... enhance the sense of smell and cool their brains. ... University doctoral student Jason Bourke, lead author of the ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... Triticum aestivum ) is one of the "big three" globally ... people. Fully 35% of the world,s 7 billion people depend ... of scientists, including a group from Cold Spring Harbor Laboratory ... genome. The study reveals the evolution of bread ...
... conducting a detailed study of the potential environmental and ... drilling process known as fracking. In hydraulic fracturing, ... deep underground to break apart rock and free trapped ... decades, recent technical advances have helped unlock vast stores ...
... Picture two charged particles in a vacuum. Thanks to ... force these particles exert upon one another, and therefore ... simple medium say, water and the calculation ... water, which in turn may slow, speed, or otherwise ...
Cached Biology News:Bread wheat's large and complex genome is revealed 2Bread wheat's large and complex genome is revealed 3Fracking in Michigan: U-M researchers study potential impact on health, environment, economy 2Fracking in Michigan: U-M researchers study potential impact on health, environment, economy 3Fracking in Michigan: U-M researchers study potential impact on health, environment, economy 4Outside a vacuum: Model predicts movement of charged particles in complex media 2
(Date:10/19/2014)... The Asia-Pacific Speech Analytics market report defines ... analysis and forecast of revenue. This market is estimated ... million by 2019, at a Compound Annual Growth Rate ... through the TOC of the Asia-Pacific Speech Analytics market ... provided. It also provides a glimpse of the segmentation ...
(Date:10/19/2014)... According to market research report “Outdoor ... Wireless gateways)]- Global Advancements, Forecasts and Analysis (2013 ... Wi-Fi market with analysis and forecasting of the ... the drivers and the restrains for this market ... challenges. , Browse 65 market data tables and ...
(Date:10/18/2014)... The Asian arthroscopic devices report defines and segments ... of revenue. The arthroscopic devices market in Asia is ... a CAGR of 6.5% from 2013 to 2018. , ... market, to get an idea of the in-depth analysis ... of arthroscopic devices market in the same region, and ...
(Date:10/18/2014)... NY (PRWEB) October 18, 2014 The ... healthy rate in the five years to 2014. The ... federal renewable energy tax credits that encouraged the use ... enacted renewable portfolio standards (RPSs), which require local utilities ... of their total energy portfolio. Increased campaigning for green ...
Breaking Biology Technology:The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... , , Phase Lock Gel may be used in ... total RNA from cell and tissue samples. Increased yields are , ... , without interphase contamination. Below is a protocol outlining ... Reagent and Phase Lock Gel-Heavy. , For further details ...
... , , , , , , ... Eppendorf 5 Prime, Inc. , , , ... It is not convenient in all instances to have blood drawn for gDNA extraction. ... to extract gDNA from , saliva with only slight modifications ...
... , , , , , ... 5 Prime, Inc. , , , , , ... are the least invasive way of collecting gDNA from humans, , ... pathogens. Buccal swabs are quickly becoming the method of choice when , ...
Cached Biology Technology:Protocol for RNA Isolation Using TRIzol Reagent with Phase Lock , Gel-Heavy 2Protocol for RNA Isolation Using TRIzol Reagent with Phase Lock , Gel-Heavy 3Isolation of Genomic DNA from Saliva Using the Perfect gDNA Blood Mini , Kit 2Isolation of Genomic DNA from Saliva Using the Perfect gDNA Blood Mini , Kit 3Isolation of Genomic DNA from Saliva Using the Perfect gDNA Blood Mini , Kit 4Isolation of Genomic DNA from Saliva Using the Perfect gDNA Blood Mini , Kit 5Isolation of Genomic DNA from Saliva Using the Perfect gDNA Blood Mini , Kit 6Genomic DNA Extraction from Buccal Swabs Using the Perfect gDNA Blood , Mini Kit 2Genomic DNA Extraction from Buccal Swabs Using the Perfect gDNA Blood , Mini Kit 3Genomic DNA Extraction from Buccal Swabs Using the Perfect gDNA Blood , Mini Kit 4Genomic DNA Extraction from Buccal Swabs Using the Perfect gDNA Blood , Mini Kit 5
Large-capacity refrigerated incubator chamber holds up to 4 independently-operated shakers. Programmable heat, refrigeration, humidifcation are standard. Photosynthetic operation, optional....
...
... Advion's NanoMate 100 robotic system and ... full advantage of the capabilities of electrospray ... the NanoMate with MS allows users to ... small molecule and peptide mapping applications, or ...
... Mixes are optimised for SYBR Green I assays ... Quantitative PCR, with the exception of template and ... optimal levels of active SYBR Green I dye ... reaction buffer that enables detection of low copy ...
Biology Products: