Navigation Links
University of Alberta's designer compounds inhibit prion infection
Date:7/23/2012

(Edmonton) A team of University of Alberta researchers has identified a new class of compounds that inhibit the spread of prions, misfolded proteins in the brain that trigger lethal neurodegenerative diseases in humans and animals.

U of A chemistry researcher Frederick West and his team have developed compounds that clear prions from infected cells derived from the brain.

"When these designer molecules were put into infected cells in our lab experiments, the numbers of misfolded proteins diminishedand in some cases we couldn't detect any remaining misfolded prions," said West.

West and his collaborators at the U of A's Centre for Prions and Protein Folding Diseases say this research is not yet a cure, but does open a doorway for developing treatments.

"We're not ready to inject these compounds in prion-infected cattle," said David Westaway, director of the prion centre. "These initial compounds weren't created for that end-run scenario but they have passed initial tests in a most promising manner."

West notes that the most promising experimental compounds at this stage are simply too big to be used therapeutically in humans or animals.

Human exposure to prion-triggered brain disorder is limited to rare cases of Creutzfeldt-Jakob or mad cow disease. The researchers say the human form of mad cow disease shows up in one in a million people in industrialized nations, but investigating the disease is nonetheless well worth the time and expense.

"There is a strong likelihood that prion diseases operate in a similar way to neurodegenerative diseases such as Alzheimer's, which are distressingly common around the world," said West.
'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. University of Tennessee Space Institute researchers develop laser technology to fight cancer
2. University of Tennessee professor wins worlds top prize for ecology, environmental science
3. Carnegie Mellon Universitys Biometrics Center Selected To House New Pedo-Biometrics Research and Identity Automation Lab
4. Wayne State University researchers program targets safer river fishing, anglers health
5. Winemaking goes high-tech at the University of British Columbia
6. University of Miami-led study finds winds played important role in keeping oil away from S. Fla.
7. New York University scientists discover possible treatment to reduce scarring
8. Royal Astronomical Society and Oxford University Press partnership announced
9. Mainz University coordinates new EU project on the origins of human settlement
10. University of Tennessee professor receives funding for clean coal research
11. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Territories in Canada and have sent smoke drifting down ... NASA,s Aqua satellite collected this natural-color image with ... 26, 2014. Actively burning areas, detected by MODIS,s thermal ... are drifting northward in this image. Smoke is ... has caused power outages in the area and because ...
(Date:7/29/2014)... University of Kent has shown for the first time ... breakthrough that could have a major impact on cancer ... Biosciences uncovered the mechanism whereby the physical properties of ... filaments are ,fine-tuned, to undertake different functions. , ... stable, providing a framework for the cell, others are ...
(Date:7/29/2014)... A ground breaking new book that brings together two ... to raise the profile of insect fossils through stunning ... David Penney and James E Jepson, details the incredible ... world, setting the scene for what these remarkable fossils ... and even the future of our planet. Like the ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2
... Fred Kraus from Bishop Museum, Honolulu has ... makes them the world,s smallest tetrapods (non-fish vertebrates). The frogs belong ... extremely small, with adults of the two new species - named ... 8-9 mm in length. The study was published in the open ...
... could be helped with alternative scanning techniques that provide ... University of Edinburgh used an imaging technique that could ... to replace their heart valves, and improve treatments to ... the heart,s aortic valve a common condition known ...
... Dec. 12, 2011  The Evermedia Group, Inc. (Pinksheets: ... Markets last month, raising the Company,s listing from ... Current Information tier, the highest level of reporting ... Evermedia submitted an Initial Company Information and Disclosure ...
Cached Biology News:World's smallest frogs discovered in New Guinea 2New scanning strategy could help develop heart disease treatments 2The Evermedia Group, Inc. Advances Corporate Transparency Efforts 2The Evermedia Group, Inc. Advances Corporate Transparency Efforts 3
(Date:7/30/2014)... 30, 2014 LayerBio, Inc., an MIT ... its first round of seed financing from friends and ... efforts to develop a novel sustained-release product for ophthalmology. ... investors and their commitment to this important work," said ... is one of many areas in which innovations in ...
(Date:7/29/2014)... “PharmaSphere: Emerging Biotech Investment Report Strategic ... report provides in-depth analysis of the current trends ... capital segments of the financial industry, bearing in ... impact on the future of emerging biotechnology companies ... identifies regions of the world that are attracting ...
(Date:7/29/2014)... 29, 2014 The advanced optical methods ... that are driving a revolution in the neurosciences were ... journal published by SPIE, the international society for ... with the launch of the BRAIN Initiative in the ... lay out a vision for and provide examples of ...
(Date:7/29/2014)... , July 29, 2014 Human Longevity, Inc. ... company focused on extending the healthy, high performance human ... Och , Ph.D., an expert in machine learning and ... comes to HLI from Google where he was Distinguished ... will report directly to HLI Co-Founder and CEO, ...
Breaking Biology Technology:Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 2Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 3Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 4SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3
... ... Supplies Procurement, CARY, N.C., April ... and research-centric organizations realize,the potential of strategic procurement, today announced ... chosen SciQuest,s eprocurement platform to automate,procurement functions for each of ...
... Premier Research Group plc (AIM:,PRG), the international ... a leader in the electronic transformation of ... announce the formalization of a,partnership agreement to ... new partnership combines Octagon,s expertise in electronic,submissions ...
... is a leader,in vision healthcare -- serving people ... years., According to Dr. Tara A Cortes, ... a dramatic breakthrough in gene therapy that could ... According to Yocasta Urena, 28, an employee ...
Cached Biology Technology:Array BioPharma Selects SciQuest to Automate Procurement and Enable Agile Drug Development 2Premier Research Group plc and Octagon Research Solutions, Inc. Announce Strategic Partnership 2
...
... Custom Synthesis Service provides you ... to knockdown any gene. We ... base pairs with terminal dT ... other lengths of your choice. ...
...
...
Biology Products: