Navigation Links
University Of Massachusetts Medical School scientists re-imagine how genomes are assembled
Date:11/25/2013

WORCESTER, MA Scientists at the University of Massachusetts Medical School (UMMS) have developed a new method for piecing together the short DNA reads produced by next-generation sequencing technologies that are the basis for building complete genome sequences. Job Dekker, PhD, and colleagues have shown that entire genomes can be assembled faster and more accurately by measuring the frequency of interactions between DNA segments and by using their three-dimensional shape as a guide. Employing this technique, they have been able to place 65 previously unaccounted for DNA fragments in incomplete regions of the human genome.

Details of the study appear online in Nature Biotechnology.

"The ability of next-generation sequencing technologies to produce hundreds of millions of short reads of DNA sequences has been an incredible boon for biomedical researchers," said Dr. Dekker, co-director of the Program in Systems Biology, professor of biochemistry and molecular pharmacology at UMMS and senior author of the study. "As these DNA sequences have become shorter and shorter, however, assembling complete genomes have become increasingly challenging. After 20 years of intense efforts, even the human genome still has gaps.

"Using the 3D structure of the genome as a guide, we have shown that it's possible for these snippets of DNA sequences to be assembled quickly, cheaply and more accurately than current methodologies allow. This elegant and powerful technique will allow us to complete the human genome, assemble the genomes of any other species and facilitate new genetic discoveries more quickly."

In the last decade, as the cost of high-throughput DNA sequencing has come down to as little as a few thousand dollars, sequencing of new genomes has become almost routine. Next-generation sequencing techniques can easily read hundreds of millions DNA sequences at a time. However, these sequences are randomly broken into extremely sho
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Natural compound mitigates effects of methamphetamine abuse, University of Missouri researchers find
2. Rice University method gives accurate picture of gas storage by microscopic cages
3. Mainz University collaborates with 3 Chinese universities in research and teaching
4. Research by Saint Louis University scientists offers way to disrupt fibrosis
5. Durbin, University of Illinois announce $25 million federal grant
6. University of Louisville researchers sign global licensing agreement
7. Queens University in €6m bid to find new Cystic Fibrosis treatments
8. Clemson University study points to possible treatment for brain disorders
9. University of Utah researchers receive NIH Directors New Innovator Award
10. Technical Program Announced for TSensors (Trillion Sensor) Summit at Stanford University for October 22-25, 2013
11. University of Maryland researchers studying vaccine to prevent potential bird flu pandemic
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University Of Massachusetts Medical School scientists re-imagine how genomes are assembled
(Date:11/3/2014)... low birth weight and preterm birth are linked to ... Findings published in the American College of Rheumatology (ACR) ... low birth weight and pre-term babies were not at ... adults. , According to the ACR, 27 million ... clinical OA. Symptoms of OA range from mild to ...
(Date:11/2/2014)... ORLEANS, LA (2 November 2014)—In support of a bold ... Bill & Melinda Gates Foundation today announced an award ... Malaria Vaccine Initiative (MVI) in building new vaccines that ... help realize the "accelerating to zero" agenda. Such vaccines ... what could be called an "immunological bed net." ...
(Date:11/2/2014)... into a bar and bump into a biologist . . ... some late-night nerd sketch, researchers have taken this premise and ... namely, finding meaning in the rising oceans of genomic data. ... mutations that genome-wide studies are publishing at a dizzying rate. ... the signal from the noise (and there is no shortage ...
Breaking Biology News(10 mins):Preterm, low birth-weight babies may need new hips in adulthood 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 4Mutant models 2Mutant models 3Mutant models 4
... provide statin drugs free of charge so that customers can ... Imperial College London suggest in a new study published this ... in the blood. A wealth of trial data has proven ... attack risk. In a paper published in the Sunday ...
... Mount Sinai School of Medicine, New York, has been ... receive a 2010 ICAAC Young Investigator Award. Sponsored ... an early career scientist for research excellence in microbiology ... postdoctoral training in Molecular Biology at Harvard University in ...
... 250 scientists, engineers, government advisers and groups concerned ... from August 15-20, 2010 to consider the impact ... University of Maryland is co-sponsoring the conference, The ... ), which is co-organized by University of Maryland ...
Cached Biology News:Free statins with fast food could neutralize heart risk, scientists say 2University of Maryland co-sponsors International Conference on the Effects of Noise on Aquatic Life 2University of Maryland co-sponsors International Conference on the Effects of Noise on Aquatic Life 3
(Date:11/27/2014)... Nov. 27, 2014 Research and ... "Global Palmitic Acid Industry Report 2014" report to ... The Global Palmitic Acid Industry Report 2014 ... state of the global palmitic acid industry. ... including definitions, classifications, applications and industry chain structure. The ...
(Date:11/27/2014)... November 26, 2014 Biomedical devices that ... systems to enable 3D manufacture at the micro-nanoscale, and ... are among finalists in nine categories for the ... are sponsored by SPIE, the international society for ... , Winners will be announced by industry leaders on ...
(Date:11/26/2014)... November 26, 2014 The North ... segments the market for detailed analysis of the ... market to reach $616.3 million by 2018, growing ... 2018. , Browse through the TOC of the ... get an idea of the in-depth analysis and ...
(Date:11/26/2014)... , Nov. 26, 2014 The ... results from a survey of European physicians at ... on Innovation and Biological Therapies" at the Spanish ... event, hosted by EuropaBio and the Spanish Bioindustry ... of Health, physicians from Spanish oncology and rheumatology ...
Breaking Biology Technology:Global Palmitic Acid Industry Report 2014 2Finalists Named for 2015 Prism Awards for Photonics Innovation 2Finalists Named for 2015 Prism Awards for Photonics Innovation 3Finalists Named for 2015 Prism Awards for Photonics Innovation 4Finalists Named for 2015 Prism Awards for Photonics Innovation 5The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3ASBM Presents European Physicians Survey at Spanish Ministry of Health 2
... hit universities and colleges across the country, including ... copyright infringement of both movies and music over ... several cease-and-desist notices to the Universirty of Wisconsin- ... were hosting movie downloads with content that belonged ...
... the information age similar to what the business world ... productivity of our staff, reduce costs, and improve our ... considerable engineering effort that requires hospital officials to look ... can embrace the changes that will improve healthcare. , ...
... Wisconsin has been a leader both in cutting-edge health ... nations leading research universities in UW-Madison, and leading-edge medical ... poised to lead again as the two fields merge ... engineering have long contributed to health care by providing ...
Cached Biology Technology:File Swapping: Download at your own Risk 2File Swapping: Download at your own Risk 3Im Still Waiting for the Information Age in Healthcare 2Im Still Waiting for the Information Age in Healthcare 3The Role of Engineering in Health Science and Technology 2The Role of Engineering in Health Science and Technology 3
... in-house demand is causing shortages in your ... This can cause unwanted distractions, problems and ... royalties for your hard work and endeavour! ... build it up,and market it internationally. We ...
Topoisomerase I...
...
... virus is a type I eukaryotic topoisomerase ... turns (also called right- and left-handed supercoils) ... the reaction is a covalently closed, circular ... turns. DNA Topoisomerase I does not absolutely ...
Biology Products: