Navigation Links
Unique pattern of gene expression can indicate acetaminophen overdose
Date:10/31/2007

differences in gene expression are linked to specific diseases, the researchers were able to determine which genes were turned on or turned off in response to the different levels of acetaminophen. Once they selected the gene sets, they tested them for accuracy, and found the signature gene lists were able to predict exposure to toxic versus nontoxic doses with very high accuracy (88.9-95.8 percent), while the more traditional predictors, of clinical chemistry, hematology and pathology were approximately 65 to 80 percent accurate.

Although it was not the main focus of our study, we wanted to see how applicable this gene expression profiling of blood cells was to humans, said Raymond W. Tennant, Ph.D., in the NIEHS Laboratory of Molecular Toxicology, and a co-author on the study.

The NIEHS researchers compared the animal data with data from RNA from blood drawn from individuals who had been admitted to the University of North Carolina emergency room for acetaminophen overdose intoxication. When they compared the toxic blood samples to the samples from normal healthy volunteers they saw a striking difference.

Although there are already some good tools available to emergency room physicians to detect liver injury, additional information concerning the level of exposures and/or the degree of liver injury could significantly help us in treating acetaminophen overdose patients, said Paul Watkins, M.D., Director, General Clinical Research Center at the University of North Carolina, Chapel Hill and co-author on the paper.


'/>"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life
2. Scientists discover unique microbe in Californias largest lake
3. Breast Cancer May Be Uniquely Sensitive To Inhibitors Of PI3K Pathway
4. Unique library of plant genes germinates, takes root at UNC
5. Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005
6. Cultural norms not unique to human societies
7. Jumping genes contribute to the uniqueness of individual brains
8. New, unique microscope for nanotech
9. Computers to save unique type of American red squirrel
10. Uniquely human component of language found in gregarious birds
11. Immune system response to viral DNA is unique
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... BATON ROUGE In a finding that has implications ... and planets elsewhere in the solar system, LSU Associate ... funded by the National Science Foundation, or NSF, this ... sediments of a lake that lies 800 meters (2600 ... sheet support "viable microbial ecosystems.", Given that more than ...
(Date:8/21/2014)... the water window? It consists of radiations in the ... by the water in biological tissues. New theoretical findings ... within the water window. These could be the basis ... of the biological samples or to be used in ... physical mechanism needed to efficiently generate the harmonic radiationswhich ...
(Date:8/21/2014)... in the journal Carcinogenesis by researchers at ... the protein adenomatous polyposis coli (APC) in suppressing colorectal ... the U.S. , Lead author Kristi Neufeld, associate professor ... the Cancer Biology program at the KU Cancer Center, ... to understand the various activities of APC, a protein ...
Breaking Biology News(10 mins):800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4Water window imaging opportunity 2Research offers insight into cellular biology of colorectal cancer 2Research offers insight into cellular biology of colorectal cancer 3
... A new genetic resource from an international research consortium ... and treatments for a wide range of human diseases. ... will increase the likelihood that experiments conducted in mice ... in the CC have 90 percent of the genetic ...
... LAKE CITY -- Climate change spells trouble for many ... forests and relatively small areas and the damage ... disease and competition among species. That is among ... studies relevant to the topic. The review was scheduled ...
... it matter whether long periods of hot weather, such as ... in June or July, August or September? Scientists studying ... when such events happen makes a big difference. Based ... Science Foundation (NSF) Konza Prairie Long-Term Ecological Research (LTER) site ...
Cached Biology News:New mouse collaborative cross resource promises new cures and treatments for diseases 2Climate change threatens tropical birds 2Climate change threatens tropical birds 3Climate change threatens tropical birds 4Climate change threatens tropical birds 5Time of year important in projections of climate change effects on ecosystems 2
(Date:8/21/2014)... Dallas, Texas (PRWEB) August 21, 2014 ... Global Seaweed Fertilizer Industry” is a professional ... Fertilizer market. The report provides basic Seaweed ... application, and industry chain structure as well ... international market analysis, including domestic market as ...
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... in Brazil and ... restrictions. The uptake of several newly approved agents, ... for this indication and the launch of emerging ... asthma markets. In particular, the emerging IL-5 inhibitors ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 Pursuit ... selling optimization technology and services for Life Sciences ... “Grading Pharma’s Use of New Commercial Sales Models” ... & Analytics. , The article examines some innovative ... that are being tested in the pharmaceutical market. ...
(Date:8/20/2014)... 20, 2014 Clintrax Global, Inc., a ... Raleigh, NC , recently announced ... Vice President of Administration. As ... corporate processes, including their alignment with company objectives ... worked as an HR executive, specializing in needs ...
Breaking Biology Technology:Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2Clintrax Global, Inc. Announces Addition to Executive Team 2
... RDEA ) today announced that preclinical data will be presented on,the ... (DDW) 2008 in San Diego., The oral presentation details ... 20, 2008 at 3:30 p.m. Pacific Time ... Ameliorates Murine Colitis ...
... ST. LOUIS, May 14 Sigma-Aldrich (Nasdaq:,SIAL) announced today ... Hogan will retire at a date to be determined ... the Company early this,year of his desire to retire ... transitioned. The Company has initiated a search to,identify a ...
... LLC,MDAC is proud to announce that it has engaged ... success optimizing investments in,the medical device market as board ... Tony Dimun, CEO of Nascent Enterprises, LLC, formerly of ... PhD, Chairman and CEO of SomaLogic Inc., and formerly ...
Cached Biology Technology:Ardea Biosciences to Present Data on Lead MEK Inhibitor, RDEA119, at Digestive Disease Week 2008 2Sigma-Aldrich (Nasdaq: SIAL) CAO & CFO Hogan Plans to Retire; Search for Successor Underway 2MEDdevice Acquisition Co., LLC Announces Board Members and Advisors 2
...
Collected from sexually matured, mixed breed, mixed sex guinea pigs....
Antibody specific for phosphorylattion of histone H3 that occurs during mitosis. Rabbit polyclonal serum. Antigen: Synthetic peptides derived from histone H3, phosphorylated at serines 10 or 28...
DTT, 25g...
Biology Products: