Navigation Links
Understanding immune system memory -- in a roundabout way
Date:11/11/2013

mised memory cells from Hyper IgE patients are functional. This breakthrough finding is published in the Journal of Experimental Medicine, now online.

"This study helped explain why patients who have mutations in STAT3 can't generate an effective secondary response to infection," said Associate Professor Tangye.

"STAT 3 directly affects the creation of memory cells, and so while these patients have a few, they are reduced tenfold."

"When people mount a normal primary or secondary immune response, various messenger molecules known as 'cytokines' bind to receptors on the cell surface and activate STAT3."

"Many structurally different cytokines, with complementary roles in antibody production, converge at STAT3 it's literally like a roundabout, showing cytokines which route to take next within the cell."

"This study has shown us that memory cells are much more sensitive to the cytokine signals they receive. They are more robust and efficient, and the magnitude of their response is much greater than that of nave cells."

"B cells fundamentally change their biology between the nave state and the memory state. STAT3 appears to be the key to this molecular rewiring because without it, memory cells cannot form properly."

"These findings explain a lot to me about how immunological memory works, and also throw more light on Hyper IgE Syndrome. They also tell us that if you want to improve antibody responses, there are certain pathways and cell types that can be targeted."

"We can see the future potential to amplify the potency of vaccines, as well as help Hyper IgE patients."


'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study amplifies understanding of hearing in baleen whales
2. New genetically engineered mice aid understanding of incurable neuromuscular disease
3. New data improve understanding of breast cancers multiple varieties
4. Understanding why some people have propensity to disease
5. Understanding the RNAi Reagents Market Overlap with Drug Discovery and Therapeutic Development is Critical for Pharmaceutical Leaders
6. Zebrafish could hold the key to understanding psychiatric disorders
7. A trained palate: Understanding complexities of taste, smell could lead to improved diet
8. New understanding of terrestrial formation has significant and far reaching future implications
9. Understanding faults and volcanics, plus life inside a rock
10. Discovery increases understanding how bacteria spread: U of A study
11. Stem cell research aids understanding of cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... N.C. -- Pollution in urban and farm runoff in ... new study finds. , The study, published Tuesday ... that nitrogen in the runoff ends up in algae ... on the animals, eyes, flippers and internal organs. , ... the National Oceanic and Atmospheric Administration (NOAA) conducted the ...
(Date:9/30/2014)... hope: A new research report published in October 2014 ... explains how scientists developed a synthetic version of a ... in human and mouse eggs similar to the natural ... fertilization. , "We believe that the results of this ... of human fertilization by providing a precise answer to ...
(Date:9/30/2014)... People who suffer from asthma may think there,s ... asthma besides properly taking medications and avoiding allergic triggers. ... Annals of Allergy, Asthma and Immunology , the ... and Immunology (ACAAI), asthma sufferers can learn lessons about ... described in the Annals article improved her asthma once ...
Breaking Biology News(10 mins):Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Synthetic sperm protein raises the chance for successful in vitro fertilization 2Asthma symptoms kicking up? Check your exposure to air pollution 2
... Environmental Research UFZ present CLIMBER: Climatic niche ... dataset on the climatic niche characteristics of 397 European ... information provided in this dataset is of great relevance ... of high quality standards and open access, data ready ...
... fins with self-adaptive flaps, the feathers on a diving peregrine ... a study published in PLOS ONE on February ... and Fluid Dynamics in Germany and colleagues., Peregrine falcons are ... to 200 miles per hour when diving. Scientists studying the ...
... 6, 2014 -- Advances in neonatal care for very ... for these fragile infants. However, preterm infants have ... serious lung disease, which is a major cause of ... scheduled for publication in The Journal of Pediatrics ...
Cached Biology News:Unique new dataset CLIMBER: Climatic niche characteristics of the butterflies in Europe 2Stem cells to treat lung disease in preterm infants 2
(Date:10/1/2014)... (PRWEB) September 30, 2014 New applications ... arrangements that have evolved in nature over millennia are ... bioinspired materials for applications in biophotonics in the ... . The journal is published by SPIE, the international ... Library. Several of the peer-reviewed articles are accessible via ...
(Date:10/1/2014)... -- This report analyzes the worldwide markets ... the following Product Segments: Proteases, Polymerases, Carbohydrases, ... also analyzed are Pharmaceuticals & Diagnostics, Research/Biotechnology, ... separate comprehensive analytics for the US, Canada, ... America. Annual estimates and forecasts are provided ...
(Date:9/30/2014)... analog of one of nature,s most efficient light-harvesting ... led by Alejandro Briseno of the University of ... developing long-sought polymer architecture to boost power-conversion efficiency ... devices. , Briseno, with colleagues and graduate ... University and Dresden University of Technology, Germany, report ...
(Date:9/30/2014)... Over the last decade, the laboratory filtration market is ... increased acceptance of new filtration technologies in end users ... also catalyzing the growth of laboratory filtration market. , ... at a strong CAGR during the forecast period of ... by 2019. The market is mainly driven by the ...
Breaking Biology Technology:Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5
... Isis,Pharmaceuticals, Inc. (Nasdaq: ISIS ) today announced ... Parshall, J.D. to Chief Operating Officer,effective immediately. Ms. ... is a Director of the Company., "This ... Lynne,s responsibilities at Isis," commented Stanley Crooke, M.D.,Ph.D., ...
... WuXi PharmaTech (NYSE:,WX), China,s premier provider of ... Deval L. Patrick of the Commonwealth of,Massachusetts, ... Official Delegation, paid a visit to the ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ), Massachusetts ...
... Pharmaceutical announced,today that the Avon Foundation Breast Cancer ... to conduct multicenter clinical studies,focused on measuring levels ... and tissue samples from breast cancer patients. Results ... a blood test that would,enable early detection of ...
Cached Biology Technology:Isis Announces Appointment of B. Lynne Parshall as Chief Operating Officer 2Isis Announces Appointment of B. Lynne Parshall as Chief Operating Officer 3Massachusetts Governor Deval L. Patrick Pays Visit to WuXi PharmaTech 2Massachusetts Governor Deval L. Patrick Pays Visit to WuXi PharmaTech 3A&G Pharmaceutical Receives $870,000 Grant from Avon Foundation to Advance Innovative Blood Diagnostic Test for Early Detection of Breast Cancer 2A&G Pharmaceutical Receives $870,000 Grant from Avon Foundation to Advance Innovative Blood Diagnostic Test for Early Detection of Breast Cancer 3
Recombinant Mouse Wnt-3a...
... at least 20 structurally and functionally related ... superfamily. BMPs were originally identified as protein ... are also involved in embryogenesis and morphogenesis ... the growth, differentiation, chemotaxis and apoptosis of ...
RABBIT ANTI HUMAN TRRAP (CT) Immunogen: Recombinant C-terminal kinase-related domain of human TRRAP....
RABBIT ANTI HUMAN CHYMOTRYPSIN...
Biology Products: