Navigation Links
Ultrasensitive biosensor promising for medical diagnostics
Date:5/15/2012

WEST LAFAYETTE, Ind. - Researchers have created an ultrasensitive biosensor that could open up new opportunities for early detection of cancer and "personalized medicine" tailored to the specific biochemistry of individual patients.

The device, which could be several hundred times more sensitive than other biosensors, combines the attributes of two distinctly different types of sensors, said Muhammad A. Alam, a Purdue University professor of electrical and computer engineering.

"Individually, both of these types of biosensors have limited sensitivity, but when you combine the two you get something that is better than either," he said.

Findings are detailed in a paper appearing Monday (May 14) in the Proceedings of the National Academy of Sciences. The paper was written by Purdue graduate student Ankit Jain, Alam and Pradeep R. Nair, a former Purdue doctoral student who is now a faculty member at the Indian Institute of Technology, Bombay.

The device ╨ called a Flexure-FET biosensor - combines a mechanical sensor, which identifies a biomolecule based on its mass or size, with an electrical sensor that identifies molecules based on their electrical charge. The new sensor detects both charged and uncharged biomolecules, allowing a broader range of applications than either type of sensor alone.

The sensor has two potential applications: personalized medicine, in which an inventory of proteins and DNA is recorded for individual patients to make more precise diagnostics and treatment decisions; and the early detection of cancer and other diseases.

In early cancer diagnostics, the sensor makes possible the detection of small quantities of DNA fragments and proteins deformed by cancer long before the disease is visible through imaging or other methods, Alam said.

The sensor's mechanical part is a vibrating cantilever, a sliver of silicon that resembles a tiny diving board. Located under the cantilever is a transistor, which is the sensor's electrical part.

In other mechanical biosensors, a laser measures the vibrating frequency or deflection of the cantilever, which changes depending on what type of biomolecule lands on the cantilever. Instead of using a laser, the new sensor uses the transistor to measure the vibration or deflection.

The sensor maximizes sensitivity by putting both the cantilever and transistor in a "bias." The cantilever is biased using an electric field to pull it downward as though with an invisible string.

"This pre-bending increases the sensitivity significantly," Jain said.

The transistor is biased by applying a voltage, maximizing its performance as well.

"You can make the device sensitive to almost any molecule as long as you configure the sensor properly," Alam said.

A key innovation is the elimination of a component called a "reference electrode," which is required for conventional electrical biosensors but cannot be miniaturized, limiting practical applications.

"Eliminating the need for a reference electrode enables miniaturization and makes it feasible for low-cost, point-of-care applications in doctors' offices," Alam said.

A U.S. patent application has been filed for the concept.


'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Related biology news :

1. Orca ears inspire Stanford researchers to develop ultrasensitive undersea microphone
2. Carbon nanotubes form ultrasensitive biosensor to detect proteins
3. Ultrasensitive imaging method uses gold-silver nanocages
4. Biosensor illuminates compounds to aid fight against TB
5. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
6. Improved characterization of nanoparticle clusters for EHS and biosensors research
7. New biosensor modelled on the immune system can detect, track and guide the clean-up of oil spills
8. New biosensor microchip could speed up drug development, Stanford researchers say
9. K-State chemists biosensor may improve food, water safety and cancer detection
10. Directed self-assembly of vertical nanotubes for biosensors, logic, nano-biofuel cells
11. Carnegie Mellon researchers create fluorescent biosensor to aid in drug development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ultrasensitive biosensor promising for medical diagnostics
(Date:5/6/2017)... , May 5, 2017 RAM ... announced a new breakthrough in biometric authentication based ... quantum mechanical properties to perform biometric authentication. These new ... semiconductor material created by Ram Group and its ... entertainment, transportation, supply chains and security. Ram Group ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... May 17, 2017 , ... HOLLOWAY AMERICA, a leading ... and dairy, munitions, and pharmaceutical/biotech, recently introduced The Revolution Lift™, a new precision-controlled ... improvement in technology comes on the heels of HOLLOWAY’s release of the intelliVessel™, ...
(Date:5/16/2017)... ... May 16, 2017 , ... ... its new ProxiMeta™ Hi-C metagenomic deconvolution service. ProxiMeta enables researchers to obtain ... DNA extraction—speeding research insights at lower cost. , “We’re very excited about ...
(Date:5/16/2017)... ... ... On Tuesday, May 23 at 10:30 AM, James Sherley, Director of Asymmetrex ... that his company has recently achieved in collaboration with its partner, AlphaSTAR Corporation ... first partnering conference, Cell & Gene Exchange 2017 . In addition to ...
(Date:5/15/2017)... 15, 2017  IBM (NYSE: IBM ) scientists ... double-stranded DNA molecules with the potential to efficiently ... This technology complements the IBM Research,s "lab-on-a-chip" ... exosomes and which may also contain biomarkers for ... array of diamond shaped micropillars 1 to ...
Breaking Biology Technology: