Navigation Links
Ultrasensitive biosensor promising for medical diagnostics
Date:5/15/2012

WEST LAFAYETTE, Ind. - Researchers have created an ultrasensitive biosensor that could open up new opportunities for early detection of cancer and "personalized medicine" tailored to the specific biochemistry of individual patients.

The device, which could be several hundred times more sensitive than other biosensors, combines the attributes of two distinctly different types of sensors, said Muhammad A. Alam, a Purdue University professor of electrical and computer engineering.

"Individually, both of these types of biosensors have limited sensitivity, but when you combine the two you get something that is better than either," he said.

Findings are detailed in a paper appearing Monday (May 14) in the Proceedings of the National Academy of Sciences. The paper was written by Purdue graduate student Ankit Jain, Alam and Pradeep R. Nair, a former Purdue doctoral student who is now a faculty member at the Indian Institute of Technology, Bombay.

The device ╨ called a Flexure-FET biosensor - combines a mechanical sensor, which identifies a biomolecule based on its mass or size, with an electrical sensor that identifies molecules based on their electrical charge. The new sensor detects both charged and uncharged biomolecules, allowing a broader range of applications than either type of sensor alone.

The sensor has two potential applications: personalized medicine, in which an inventory of proteins and DNA is recorded for individual patients to make more precise diagnostics and treatment decisions; and the early detection of cancer and other diseases.

In early cancer diagnostics, the sensor makes possible the detection of small quantities of DNA fragments and proteins deformed by cancer long before the disease is visible through imaging or other methods, Alam said.

The sensor's mechanical part is a vibrating cantilever, a sliver of silicon that resembles a tiny diving board. Located under
'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Orca ears inspire Stanford researchers to develop ultrasensitive undersea microphone
2. Carbon nanotubes form ultrasensitive biosensor to detect proteins
3. Ultrasensitive imaging method uses gold-silver nanocages
4. Biosensor illuminates compounds to aid fight against TB
5. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
6. Improved characterization of nanoparticle clusters for EHS and biosensors research
7. New biosensor modelled on the immune system can detect, track and guide the clean-up of oil spills
8. New biosensor microchip could speed up drug development, Stanford researchers say
9. K-State chemists biosensor may improve food, water safety and cancer detection
10. Directed self-assembly of vertical nanotubes for biosensors, logic, nano-biofuel cells
11. Carnegie Mellon researchers create fluorescent biosensor to aid in drug development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ultrasensitive biosensor promising for medical diagnostics
(Date:9/18/2014)... people are too stressed they are often grouchy, grumpy, ... Institute (BMI) at EPFL have just highlighted a fundamental ... and the loss of social skills and cognitive impairment. ... regulatory molecule in the brain. This was revealed by ... , Carmen Sandi,s team went to look for answers ...
(Date:9/17/2014)... reproductive technologies, the justice and well-being of our ... identify key issues, articulate their values and concerns, ... defensible ways forward. But what are the best ... Hastings Center and the Presidential Commission for the ... publish a series of essays to highlight the ...
(Date:9/17/2014)... A rare genetic disorder known as Jacobsen syndrome has ... investigation by researchers at San Diego State University and ... suggesting better treatment options for people with Jacobsen syndrome, ... underpinnings of autism., Jacobsen syndrome affects approximately 1 in ... It occurs in a person when there is a ...
Breaking Biology News(10 mins):How stress tears us apart 2Why bioethics literacy matters 2Why bioethics literacy matters 3A link between Jacobsen syndrome and autism 2
... Scientists across the world are building an extensive repository ... understanding the function of the approximately 57,000 genes that ... Rice Functional Genomics Consortium recently announced the public availability ... mutations in about half of the known functional genes ...
... people are affected with retinitis pigmentosa (RP), a disease ... blindness. Now, a University of Missouri researcher has identified ... different forms of RP. This discovery will help scientists ... humans. "The same genetic mutations ...
... WASHINGTON, DC As researchers continue to examine ... ,important that people understand the differences among various ... Corn Refiners Association (CRA). Interchanging two distinctly different ... corn syrup, creates factually incorrect conclusions and misleads ...
Cached Biology News:200,000 rice mutants available worldwide for scientific investigation 2Cats' eye diseases genetically linked to diseases in humans 2Pure fructose frequently confused with high fructose corn syrup 2
(Date:9/17/2014)... Nev. , Sept. 17, 2014  PDL BioPharma, Inc. ... its independent registered accounting firm, Ernst & Young LLP ("EY") ... was confirmed in a letter delivered to the Company on ... on September 16, 2014.  PDL has issued ... "We have received a number of inquiries on the reason ...
(Date:9/17/2014)... PRINCETON, N.J. , Sept. 17, 2014 /PRNewswire/ ... developing targeted therapeutic devices to address infectious disease, cancer ... Sciences, Inc. (ESI), disclosed today that each company will ... Summit. On September 18 th , ... presentation entitled: "Exosomes: A Multiplexed Platform for Clinical Management." ...
(Date:9/17/2014)... NEWTOWN, Pa. , Sept. 17, 2014 ... services and eClinical Solutions, today announced three of its ... Conference for Clinical Data Management to be held ... Vegas, Nevada . The Company also announced the ... to raise overall quality in clinical trials acquired earlier ...
(Date:9/17/2014)... 2014 Alternative Fuels Americas, Inc. (AFAI) announced today ... Purpose Vehicle in partnership with Jatro Greentech, Inc., a ... The SPV shall be called AFAI Jatro Green Ethiopia and ... shareholder. The SPV shall pursue Jatropha planting and biofuels production ... Ethiopia . "Although we have experienced ...
Breaking Biology Technology:PDL BioPharma Issues Statement on Resignation of Ernst and Young as Corporate Auditors 2PDL BioPharma Issues Statement on Resignation of Ernst and Young as Corporate Auditors 3Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 2Aethlon Medical and Exosome Sciences To Present at the Exosomes & SingleCell Analysis Summit 3BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 2AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 3
... U.S. ... business, BOSTON, MA ... Hand, the world,s first commercially,available bionic hand, today announced that it has ... the,United States., Bill Graham has been named U.S. sales manager for ...
... PLC Systems Inc.,(Amex: PLC ) today announced that ... Conference on February 18-21, 2008 at the Ritz,Carlton Laguna Niguel ... 20th beginning at 3:30 pm local time. Presenting for the ... webcast of the presentation will be available at the company,s,website ...
... Open DICOM Standard DR and Data Management Systems Spurs ... Forty-Five Percent Growth for Company, ... a,leading developer of digital radiography (DR), PACS (Picture Archiving and,Communications ... the company,s revenues grew 45 percent,to surpass $35 million for ...
Cached Biology Technology:Touch Bionics adds to sales, marketing, production and design teams 2Touch Bionics adds to sales, marketing, production and design teams 3PLC Systems to Present at the ROTH Conference 2Eklin Medical Reports Record Revenues for 2007 2Eklin Medical Reports Record Revenues for 2007 3