Navigation Links
UTSW study identifies potential therapeutic target for incurable, rare type of soft-tissue cancer
Date:12/26/2013

, the tumors shrank.

"These treatments suppressed tumor growth and caused the cancer cells to undergo apoptosis, or cell death. This is why BRD4 inhibition is exquisitely effective against MPNSTs and may represent a paradigm shift in therapy for these patients," Dr. Le said.

The same class of drug used in the experiments is currently being evaluated in phase 1 and 2 trials for treatment of leukemia and a subtype of lung cancer. Meanwhile, UT Southwestern is working with a pharmaceutical company to develop a similar BRD4-inhibiting drug to launch a clinical trial for MPNST patients.

New drugs are desperately needed to treat MPNST and provide hope to NF1 patients at highest risk for this cancer, said Dr. Le, who also serves as Co-director of UT Southwestern's Comprehensive Neurofibromatosis Clinic. The clinic offers neurofibromatosis patients access to the latest clinical trials and treatments. Co-directed by Dr. Laura Klesse, Assistant Professor of Pediatrics, the clinic is part of the Harold C. Simmons Comprehensive Cancer Center and serves patients with all three types of hereditary neurofibromatosis, including the dominant NF1 type and rarer NF2 and Schwannomatosis forms.


'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UTSW study identifies potential therapeutic target  for incurable, rare type of soft-tissue cancer
(Date:9/18/2014)... 18, 2014 New research into the Crimean-Congo hemorrhagic ... severe hemorrhagic disease in humans similar to that caused ... CCHFV infection. This discovery has the potential to lead ... , The research, reported in a paper ... and conducted by scientists at the Texas Biomedical Research ...
(Date:9/18/2014)... No matter how many times it,s demonstrated, ... communicating creatures. , But by using a ... radically alter their behavior to suit their population. ... them are present, and act accordingly. , Once ... it may change from innocuous to pathogenic, or ...
(Date:9/18/2014)... researchers and their colleagues have built the first ... academic performance and behavioral trends. In other words, ... even if you don,t -- and how that ... students, happiness, stress, depression and loneliness to their ... general population for example, to monitor mental ...
Breaking Biology News(10 mins):Research milestone in CCHF virus could help identify new treatments 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4
... for colorectal cancer was reported today (Thursday, Oct. 24) ... in Boston. The interaction may shed light on the ... associated with consumption of red and processed meat, the ... relevant public health significance because diet is a modifiable ...
... operating principles of a genetic switch that cancer cells use ... the body. The study found that the on-off switch,s dynamics ... and "off." The extra setting both explains previously confusing experimental ... treatment. The study appears online this week in the ...
... breast cancer from families severely affected with the disease have ... vast majority of those patients were told that their gene ... genomics sequencing tools, the discovery of additional genes implicated in ... genetic testing for BRCA1 and BRCA2, it is now possible ...
Cached Biology News:Gene-diet interaction may help explain link between eating meat & colorectal cancer risk 2Gene-diet interaction may help explain link between eating meat & colorectal cancer risk 3Physicists decode decision circuit of cancer metastasis 2Physicists decode decision circuit of cancer metastasis 3Physicists decode decision circuit of cancer metastasis 4BROCA sequencing approach evaluates all 24 genes implicated in breast cancer 2BROCA sequencing approach evaluates all 24 genes implicated in breast cancer 3
(Date:9/19/2014)... Minnesota (PRWEB) September 19, 2014 ... related food industries will gather October 5–8, 2014, ... the Rhode Island Convention Center in Providence, Rhode ... feature the work of food scientists, chemists, microbiologists, ... control, and food production management. To date, 1,000 ...
(Date:9/19/2014)... -- , The first grants awarded to ... (ESPE) Meeting  Investment supports innovative projects for ... field of growth  , EMD Serono, a ... , today announced the first recipients of the Grant ... announced during a Satellite Symposium organized by EMD Serono ...
(Date:9/18/2014)... 2014 Bipartisan passage this week by ... to stimulate development and commercialization of new technologies and ... leaders of SPIE, the international society for optics ... and Innovation (RAMI) Act, now moves to the full ... they are optimistic that it will win passage there ...
(Date:9/18/2014)... LONDON , Sept. 18, 2014 ... near-patient testing, is performed outside a clinical laboratory. ... hence in administrating appropriate treatments and medication. POCT ... and prevalence of lifestyle diseases such as diabetes, ... and user-friendly. POCT devices are standardized to minimize ...
Breaking Biology Technology:Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3POCT Market in China 2014-2018 2
... of online usability challenged businesses to better meet the ... Wednesday at a Web usability conference titled Are Your ... conference, which was hosted by the Madison chapter ... topics ranging from e-course standards to designing Web pages ...
... choice! , ,So what does government have to do ... -- I meant governance ! Theres ... that government caused governance or, at least, the recent emphasis on ... -- Enron, Worldcom, Tyco -- have reduced the publics trust in ...
... Wis. startups, biotech , ,Entrepreneurship, nanotechnology and biomedical ... 1-4 in Madison and Milwaukee, giving substance to what ... Week. , , Tips for Entrepreneurs , ,Established ... Wisconsin Entrepreneurs Conference , which runs June 1-2 at ...
Cached Biology Technology:Special needs addressed at Web Usability Conference 2Part 4 Project Performance Get on the path to continuous improvement 2Part 4 Project Performance Get on the path to continuous improvement 3Doyles Entrepreneurs and Research week nears 2Doyles Entrepreneurs and Research week nears 3
Mouse monoclonal [TONI-1] to Angiotensin II Type 1 Receptor (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 185 SwissProtID: P30556...
TGF-beta 1,-2,-3 MAb (Clone 1D11)...
HSV-1 gE Envelope Protein (9H3)...
... by their capacity to self renew and ... progenitor cells, which can commit to further ... (NSCs) are capable of differentiating into multiple ... During the isolation and expansion of NSCs, ...
Biology Products: