Navigation Links
UT Southwestern scientists make mouse model of human cancer, demonstrate cure
Date:3/5/2013

DALLAS March 5, 2013 UT Southwestern Medical Center scientists report the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer.

"To my knowledge, this is the first time that a mouse model of a genetically defined malignant human cancer has been generated in which the formation of the tumor from beginning to end can be monitored and in which blocking the pathway cures the mouse of the tumor," said Dr. Luis Parada, chair of the department of developmental biology at UT Southwestern and senior author of the study published in Cell and online. The study's first author is Dr. Wei Mo, a postdoctoral researcher in the department.

"We showed that blocking the activity of a receptor molecule named CXCR4 in these tumors through genetic manipulation or by chemical blockade inhibited tumor development. Together, these data reveal a potential target for therapy of these uncommon but currently untreatable malignant peripheral nerve sheath tumors (MPNSTs)," Dr. Parada added.

The study is a collaboration between Dr. Parada's laboratory and that of Dr. Lu Q. Le, co-senior author of the study and assistant professor of dermatology. Dr. Le also is co-director of the adult Comprehensive Neurofibromatosis Clinic at UT Southwestern, the first such clinic in North Texas, which is part of the Simmons Comprehensive Cancer Center. The researchers noted that co-authors at The University of Texas MD Anderson Cancer Center and Baylor College of Medicine, Houston, greatly accelerated the research effort.

MPNSTs are rare but highly aggressive tumors that are resistant to therapy and are typically fatal. The malignancies can occur sporadically or in a subset of patients with a condition called neurofibromatosis 1 (
'/>"/>

Contact: Deborah Wormser
deborah.wormser@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Mesquite trees displacing Southwestern grasslands
2. Sea lamprey genome mapped with help from scientists at OU
3. Sequestration will be a devastating blow to the nations research institutions and scientists
4. Scientists explore topical health issues at meeting in Texas
5. Stanford scientists help shed light on key component of Chinas pollution problem
6. Fat worms inch scientists toward better biofuel production
7. Scientists create new maps depicting potential worldwide coral bleaching by 2056
8. Scientists find surprising new influence on cancer genes
9. Scientists find bone-marrow environment that helps produce infection-fighting T and B cells
10. MBL scientists find genes linked to human neurological disorders in sea lamprey genome
11. Scientists identify molecular system that could help develop treatments for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern scientists make mouse model of human cancer, demonstrate cure
(Date:7/8/2015)... YORK , July 8, 2015  BD (Becton, ... BD & Guidepoint Mentor, a new program ... Guidepoint,s expert network services. BD is ... to improve healthcare delivery and outcomes and, with the ... entrepreneur will be able to directly engage with industry ...
(Date:7/7/2015)... 7, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... mobile commerce market announces a revised version of one of its ... will air on CNBC in New York , ... and San Francisco metro areas.    ... Wocket,s ability to replace all the cards in your wallet and ...
(Date:6/30/2015)... HATFIELD, Pa. , June 30, 2015 ... joined the company as CEO to help further develop ... a wealth of partnering experience, having spent much of ... companies including Therakine, Amgen, Baxter Bioscience, and Johnson & ... a focus on Technology and Biotech Corporate Finance. He ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3
... Pennsylvania State University College of Medicine, Hershey, Pennsylvania have ... growth factor receptor (OGFr), which mediates the inhibitory action ... a key to understanding the progression and treatment of ... cells that were molecularly engineered to have a reduced ...
... A small population of rattlesnakes that already is ... unexpected threat in the form of a fungus rarely ... reports of rattlesnake deaths in the northeast United States. ... catenatus ), a candidate for protection under the federal ...
... receptive to donating blood or other genetic material for scientific ... Dallas. In what appears to be the first study ... biobank, the study surveyed 250 male and female undergraduate and ... they were willing to donate to a biobank, said study ...
Cached Biology News:A breakthrough in understanding the biology and treatment of ovarian cancer 2A breakthrough in understanding the biology and treatment of ovarian cancer 3Rare fungus kills endangered rattlesnakes in southern Illinois 2Study finds college students willing to donate genetic material to biobanks for research 2
(Date:7/29/2015)... CT (PRWEB) , ... July 29, 2015 , ... ... Biological Industries’ (BI) advanced cell culture products, announces the availability of BI’s line ... launched by Biological Industries, these stem cell differentiation media offer a complete system ...
(Date:7/29/2015)... ... July 29, 2015 , ... Nearly everyone has heard of ... few people realize that a rich source of these cells is teeth—baby teeth that ... that need to be pulled to make room for braces. These potent stem ...
(Date:7/28/2015)... ... , ... Strong Animals™ announced today that research conducted by South Dakota State ... ADSA-ASAS Joint Annual Meeting held July 12-16 in Orlando, FL showed feed additive Stay ... content. Also, feed containing Stay Strong™ for Dairy Cows took longer than 7.7 hours ...
(Date:7/28/2015)... , July 28, 2015  PDL BioPharma, Inc. (PDL, ... that the Company will release its second quarter 2015 ... on Wednesday, August 5, 2015, after market close. PDL,s ... day at 4:30 p.m. Eastern Time to discuss the ... will be available via the webcast link on the ...
Breaking Biology Technology:Rainbow Scientific, Inc. Announces Availability of Human Mesenchymal Stem Cell Differentiation Media 2Rainbow Scientific, Inc. Announces Availability of Human Mesenchymal Stem Cell Differentiation Media 3Advanced Oral and Maxillofacial Surgery (AOMS) in Elmhurst, IL Partners with Provia Labs to make Store-A-Tooth™ Dental Stem Cell Banking Available to their Patients 2Strong Animals™ Announces South Dakota State University Research Demonstrates Stay Strong™ for Dairy Cows Improves Performance and Feed Stability 2PDL BioPharma to Announce Second Quarter 2015 Financial Results on August 5, 2015 2
... Former U.S. President Bill Clinton will,participate as one of the ... June 1 and 3 in Sao Paulo, Brazil. The event ... one of the most,important gatherings focused on biofuels in the ... first Democratic president awarded a second term,in six decades. After ...
... expert in ion channels and GPCRs (G-protein coupled receptors) ... is one of eight organizations slated to receive funding ... Ted Strickland and Interim Director of the Ohio Department ... Commission, Mark Barbash, announced the competitive grants last week, ...
... May 6 SpectraScience, Inc. (OTC Bulletin ... company, today announced that The Wall Street ... Chief Executive Officer Jim Hitchin. The interview, ... company,s website at http://www.spectrascience.com/tinymce/jscripts/tiny_mce/plugins/ajaxfilemanager/uploaded/Wall%20Street%20Transcript.pdf Mr. ...
Cached Biology Technology:President Bill Clinton to Speak at the Ethanol Summit in Brazil 2ChanTest Awarded $4.8 Million Through the Ohio Third Frontier Research and Commercialization Program 2ChanTest Awarded $4.8 Million Through the Ohio Third Frontier Research and Commercialization Program 3SpectraScience CEO Jim Hitchin Featured in Interview With The Wall Street Transcript 2SpectraScience CEO Jim Hitchin Featured in Interview With The Wall Street Transcript 3
Recombinant Feline IL-12/IL-23 p40 (C-Terminus), CF...
HybriWell™ hybridization sealing system, 20 mm diameter chamber, 0.15 mm deep *set of 100*...
dithiothreitol (DTT) Reactive Dyes and Chemicals Thiol-Reactive Dyes, Haptens and Quenchers Reducing Agents...
... Butcher (1998). • The major histocompatibility complex ... the immunology area. There is great interest ... in their function as antigen-presenting molecules. Many ... prospect of tackling biochemical and genetic techniques ...
Biology Products: