Navigation Links
UT Southwestern scientists make mouse model of human cancer, demonstrate cure
Date:3/5/2013

DALLAS March 5, 2013 UT Southwestern Medical Center scientists report the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer.

"To my knowledge, this is the first time that a mouse model of a genetically defined malignant human cancer has been generated in which the formation of the tumor from beginning to end can be monitored and in which blocking the pathway cures the mouse of the tumor," said Dr. Luis Parada, chair of the department of developmental biology at UT Southwestern and senior author of the study published in Cell and online. The study's first author is Dr. Wei Mo, a postdoctoral researcher in the department.

"We showed that blocking the activity of a receptor molecule named CXCR4 in these tumors through genetic manipulation or by chemical blockade inhibited tumor development. Together, these data reveal a potential target for therapy of these uncommon but currently untreatable malignant peripheral nerve sheath tumors (MPNSTs)," Dr. Parada added.

The study is a collaboration between Dr. Parada's laboratory and that of Dr. Lu Q. Le, co-senior author of the study and assistant professor of dermatology. Dr. Le also is co-director of the adult Comprehensive Neurofibromatosis Clinic at UT Southwestern, the first such clinic in North Texas, which is part of the Simmons Comprehensive Cancer Center. The researchers noted that co-authors at The University of Texas MD Anderson Cancer Center and Baylor College of Medicine, Houston, greatly accelerated the research effort.

MPNSTs are rare but highly aggressive tumors that are resistant to therapy and are typically fatal. The malignancies can occur sporadically or in a subset of patients with a condition called neurofibromatosis 1 (
'/>"/>

Contact: Deborah Wormser
deborah.wormser@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Mesquite trees displacing Southwestern grasslands
2. Sea lamprey genome mapped with help from scientists at OU
3. Sequestration will be a devastating blow to the nations research institutions and scientists
4. Scientists explore topical health issues at meeting in Texas
5. Stanford scientists help shed light on key component of Chinas pollution problem
6. Fat worms inch scientists toward better biofuel production
7. Scientists create new maps depicting potential worldwide coral bleaching by 2056
8. Scientists find surprising new influence on cancer genes
9. Scientists find bone-marrow environment that helps produce infection-fighting T and B cells
10. MBL scientists find genes linked to human neurological disorders in sea lamprey genome
11. Scientists identify molecular system that could help develop treatments for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern scientists make mouse model of human cancer, demonstrate cure
(Date:11/18/2014)... Nov. 17, 2014 The Parenteral Drug Association (PDA) ... agencies will speak and at least seven more will participate ... the Omni Shoreham Hotel in Washington D.C. ... to have significant support from the regulatory agencies in ... in our effort to help advance the use ...
(Date:11/10/2014)... on U.S. store shelves in early 2010, and people ... small packets can be tossed into a washing machine ... powder. The convenience, though, has come with risks for ... Nationwide Children,s Hospital found that from 2012 through 2013, ... younger than 6 years of age swallowing, inhaling, or ...
(Date:11/6/2014)... yet progress in preventing and treating migratory cancer ... challenging to design drugs that work against metastasis," ... at Harvard Medical School. , "Unfortunately, many ... , Gujral and colleagues have now identified a ... how metastasis begins. Their findings may also inform ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Study finds laundry detergent pods, serious poisoning risk for children 2Migration negation 2Migration negation 3
... 15, 2013  Medbox, Inc. (OTC Markets: MDBX) ( www.medboxinc.com ... and patented systems to various medical and retail related ... corporate governance and transparency in the mushrooming legal marijuana industry and ... the status of past, present, and future projects. ...
... 15, 2013   Evolution Marketing Research , a leading supplier ... three new industry professionals. Ian Fureman ... as Associate Methodologist; and Shannon Sesa ... Fureman brings to Evolution more than 14 years of ...
... 14, 2013) Through a collaborative genome-wide study on ... are associated with heart rate. Since heart rate ... provide a better understanding of genetic regulation of heart ... for new drugs to treat cardiovascular disease. The ...
Cached Biology News:Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 2Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 3Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 4Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 5Evolution Marketing Research Grows its Practice with Addition of Three Key Industry Professionals 2Evolution Marketing Research Grows its Practice with Addition of Three Key Industry Professionals 3Mount Sinai study identifies new gene variations associated with heart rate 2
(Date:11/24/2014)... November 24, 2014 2014 Deep ... Industry is a professional and in-depth research report ... Dihydrazide information, like its definition, classification, application, and ... This report covers the international market analysis, including ... as the US, Europe, Asia, China, Japan etc. ...
(Date:11/22/2014)... and London (PRWEB) November 21, 2014 Two ... will explore what comes next for ALS research and how ... , After the Ice Bucket Challenge: Where Does the ... Date: Tuesday, 2 December 2014, Time: 1:30pm ET, ... , Join expert speaker Dr. Merit Cudkowicz, Julianne Dorn Professor ...
(Date:11/22/2014)... IL (PRWEB) November 21, 2014 On ... competitors at the 2014 Emerging Medical Technologies Summit in ... Innovator Awards. Widely regarded among Silicon Valley investors ... medical device innovation, the win also positions Briteseed ... MedTech Innovator competition in 2015 and compete with other ...
(Date:11/21/2014)... -- , Todd Martensen se ... Mariano Rodríguez es elegid vicepresidente senior de desarrollo empresarial y ... marcha para comenzar de forma rápida la comercialización de su ... en Europa   , KLOX Technologies ... siguientes nombramientos: Todd Martensen ha sido ...
Breaking Biology Technology:Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3DrugDev Webinars in December to Explore What Comes Next for ALS Research and How We Can Make Life Easier for Clinical Sites 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 3KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5
... - Human neural stem cells, exposed in a lab dish ... rates, suggesting that the hormone may play a role in ... study published this week in the online editions of the ... new work, conducted by a team of scientists at the ...
... Lands End, Inc., , Wisconsin-based online clothing retailer, introduced Thursday ... effort to take the guesswork out of online shopping. , ... men and women find clothes that fit correctly by modeling ... more life-like model that closely resembles the customer. , ,Our ...
... and Chemicon International, Inc. announced today ... and apply Madison-based Promegas DNA-directed, RNA interference (ddRNAi) ... division of Serologicals Corporation, will have the right ... ddRNAi-based products and reagents for life science research. ...
Cached Biology Technology:DHEA Boosts Growth Rate of Human Neural Stem Cells 2DHEA Boosts Growth Rate of Human Neural Stem Cells 3