Navigation Links
UT Southwestern scientists make mouse model of human cancer, demonstrate cure
Date:3/5/2013

DALLAS March 5, 2013 UT Southwestern Medical Center scientists report the first successful blocking of tumor development in a genetic mouse model of an incurable human cancer.

"To my knowledge, this is the first time that a mouse model of a genetically defined malignant human cancer has been generated in which the formation of the tumor from beginning to end can be monitored and in which blocking the pathway cures the mouse of the tumor," said Dr. Luis Parada, chair of the department of developmental biology at UT Southwestern and senior author of the study published in Cell and online. The study's first author is Dr. Wei Mo, a postdoctoral researcher in the department.

"We showed that blocking the activity of a receptor molecule named CXCR4 in these tumors through genetic manipulation or by chemical blockade inhibited tumor development. Together, these data reveal a potential target for therapy of these uncommon but currently untreatable malignant peripheral nerve sheath tumors (MPNSTs)," Dr. Parada added.

The study is a collaboration between Dr. Parada's laboratory and that of Dr. Lu Q. Le, co-senior author of the study and assistant professor of dermatology. Dr. Le also is co-director of the adult Comprehensive Neurofibromatosis Clinic at UT Southwestern, the first such clinic in North Texas, which is part of the Simmons Comprehensive Cancer Center. The researchers noted that co-authors at The University of Texas MD Anderson Cancer Center and Baylor College of Medicine, Houston, greatly accelerated the research effort.

MPNSTs are rare but highly aggressive tumors that are resistant to therapy and are typically fatal. The malignancies can occur sporadically or in a subset of patients with a condition called neurofibromatosis 1 (
'/>"/>

Contact: Deborah Wormser
deborah.wormser@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Mesquite trees displacing Southwestern grasslands
2. Sea lamprey genome mapped with help from scientists at OU
3. Sequestration will be a devastating blow to the nations research institutions and scientists
4. Scientists explore topical health issues at meeting in Texas
5. Stanford scientists help shed light on key component of Chinas pollution problem
6. Fat worms inch scientists toward better biofuel production
7. Scientists create new maps depicting potential worldwide coral bleaching by 2056
8. Scientists find surprising new influence on cancer genes
9. Scientists find bone-marrow environment that helps produce infection-fighting T and B cells
10. MBL scientists find genes linked to human neurological disorders in sea lamprey genome
11. Scientists identify molecular system that could help develop treatments for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern scientists make mouse model of human cancer, demonstrate cure
(Date:4/20/2014)... cells demonstrate a bizarre property never before seen ... today from scientists at the University of Cambridge. The ... may have application as wide-ranging as soundproofing, super-absorbent sponges ... For example, if one pulls on an elastic band, ... also true: squeeze a material and it will expand ...
(Date:4/20/2014)... April 20, 2014 -- Using corn crop residue to ... can generate more greenhouse gases than gasoline, according to ... Climate Change . , The findings by a University ... corn residue can be used to meet federal mandates ... emissions. , Corn stover -- the stalks, leaves and ...
(Date:4/18/2014)... adds a twist to the story of how barnyard chickens ... 21 in the journal Proceedings of the National Academy ... chickens that lived 200-2300 years ago in Europe, researchers report ... have looked far different from the chickens we know today. ... associate with modern domestic chickens -- such as their yellowish ...
Breaking Biology News(10 mins):Bulletproof nuclei? Stem cells exhibit unusual absorption property 2Study casts doubt on climate benefit of biofuels from corn residue 2Study casts doubt on climate benefit of biofuels from corn residue 3Ancient DNA offers clues to how barnyard chickens came to be 2
... gene influences taste sensitivity of children and adults, accounting ... report a team of researchers from the Monell Chemical ... also contribute to taste preferences, at times overriding the ... explain why some children are more attracted to sweet-tasting ...
... appears to play a key role in the development of ... a disease that affects about one million people in the ... findings, which they say could lead to new drug interventions ... of the American Chemical Society, the world's largest scientific society. ...
... density appears to recover in adolescent females once they ... according to a study funded by the National Institute ... Institutes of Health. , Previous studies had shown that ... Depo-Provera, experience a loss of bone mineral density during ...
Cached Biology News:Children's taste sensitivity and food choices influenced by taste gene 2Children's taste sensitivity and food choices influenced by taste gene 3Towards precise classification of cancers based on robust gene functional expression profiles 2Towards precise classification of cancers based on robust gene functional expression profiles 3Bone Density Recovers After Teens Stop Injected Contraceptive 2Bone Density Recovers After Teens Stop Injected Contraceptive 3
(Date:1/15/2014)... and SAN JOSE, California , January 15, ... developing antibody-drug conjugates for cancer, today announced the appointment of ... Dr Reynolds has over 20 years, development experience gained in ... Seattle Genetics. "I am delighted to welcome Tom ...
(Date:1/15/2014)... More than 5 million Americans are currently ... seniors will die with Alzheimer’s or another dementia, according ... shocked many Americans into looking for ways to improve ... age-related cognitive disorders. Jonathan Weisman, president of Biohack Pure, ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 2013 was ... Scottsdale’s Brain State Technologies®. They saw continued independent research ... Center who were awarded a $1 million grant from ... in “Brain and Behavior” a peer reviewed journal, Amy ...
(Date:1/14/2014)... 2014 Date: Friday, April 11, 2014 , ... Club, 1360 Almshouse Road, Warrington, Pa. , Details: ... dedicated to finding a cure for hepatitis B and improving ... its annual Crystal Ball on Friday, April 11 at Warrington ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... about being disappointed by not being able to visit a ... view of their services after an executive scheduled a meeting with ... I would get. Several calls came in within 15 minutes of ... a lot to say about watching claims made within the data ...
... - In 2000, so-called cleantech investments made up only one ... By late 2006, that slice of the venture capital pie ... markets are warming to technologies that produce alternative fuels, keep ... ,And while some environmentalists or policymakers may prefer to pick ...
... has completed its $185 million sale of ... Ind. , ,The sale, subject to federal and state regulatory ... complete. , ,Journal Communications said it will use the proceeds ... taxes and transaction expenses - to reduce debt. , ...
Cached Biology Technology:Data centers: Buyers beware of over-hyped facilities 2Data centers: Buyers beware of over-hyped facilities 3Data centers: Buyers beware of over-hyped facilities 4Bio-energy and cleantech grab attention of investors 2Bio-energy and cleantech grab attention of investors 3Bio-energy and cleantech grab attention of investors 4
BAI-1 (T-20)...
MOUSE ANTI HUMAN CYTOKERATIN 1-8...
GOAT ANTI HUMAN PSA (ISOFORM 1)...
... ZMD.437. Immunogen: Synthetic peptide derived from ... and rat ZO-1. Specificity: Specific for ... protein. Reactivity: Human Dog Rat Mouse ... cells frozen mouse liver heart blood vessel ...
Biology Products: