Navigation Links
UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
Date:2/23/2009

DALLAS Feb. 24, 2009 Sleep experts know that the mental clarity lost because of a few sleepless nights can often be restored with a good night's rest. Now, UT Southwestern Medical Center researchers have identified a key molecular mechanism that regulates the brain's ability to mentally compensate for sleep deprivation.

Working with mice, they found that a molecule called an adenosine receptor is necessary for sleep-restricted animals to attain adequate levels of slow-wave activity in the brain once normal sleep resumes. It is this increase in slow-wave activity, or SWA, during rebound sleep that helps restore normal working memory and attention skills to the sleep-deprived, the scientists report in the Feb. 4 issue of the Journal of Neuroscience.

"Normal society pushes people to burn candles at both ends going to bed late, getting up early, and somehow performing mentally with lack of adequate sleep," said senior author Dr. Robert Greene, professor of psychiatry at UT Southwestern. "We need to have our adenosine receptors intact to do that."

Adenosine receptors on nerve cells, including brain cells, are akin to docking points for the molecule adenosine. Adenosine levels increase in the brain with each hour of waking activity, and "docking" of the molecule with its receptor is shown in this study to help promote the slow-wave activity of sleep. Scientists have known that recovery from sleep deprivation involves not only an increase in sleep time, or rebound sleep, but also an elevation in this slow-wave activity.

To investigate how adenosine receptors and SWA might be linked, Dr. Greene and his team engineered mice that lacked a receptor to pair up with adenosine.

Sleep-restricted mice were kept awake by being placed on a moving treadmill. Researchers then electronically monitored sleep and waking activity of both normal and genetically engineered mice, including monitoring electronically the brain waves
'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
2. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
3. UT Southwestern scientist honored among best in Texas research
4. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
5. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
6. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
7. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
8. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
9. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
10. Limiting fructose may boost weight loss, UT Southwestern researcher reports
11. UT Southwestern researchers identify new targets for RNAs that regulate genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... , May 11, 2015  Synaptics Incorporated (NASDAQ: ... interface solutions, today announced the appointment of ... Chief Financial Officer, reporting to Rick Bergman ... current Chief Financial Officer, Kathleen Bayless , ... Mr. Ali brings extensive financial management ...
(Date:5/10/2015)... GOTHENBURG, Sweden , May 11, 2015 ... touch fingerprint sensors FPC1025 and FPC1155 from the distributor World ... one of FPC,s distributors in Asia . ... the sensors will be used by smartphone manufacturers in ... is included in the communicated revenue guidance of + 1 000 ...
(Date:5/6/2015)... , May 6, 2015 LifeBEAM, a ... established helmet producer, announced today that they will expand ... the world,s first bio-sensing cycling helmet and the first ... in two new colors in order to give cyclists ... product. In addition, LifeBEAM and Lazer announced their plan ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3
... it instinctively avoids the feline or risks becoming dinner. How? ... sense of smell, provides evidence that a single gene is ... neurobiologist Thomas Bozza has shown that removing one olfactory receptor ... The gene, called TAAR4, encodes a receptor that responds to ...
... songs in tropical waters during the winter breeding season, ... times of the year. NOAA researchers have provided ... acoustic behavior on a feeding ground in the Northwest ... in the journal PLOS ONE , demonstrate the ...
... Institutet in Sweden have managed to obtain detailed images of ... into cells. Since tumours are highly dependent on the transportation ... the researchers are hoping that the study published in the ... form the basis for new strategies to fight cancer cells. ...
Cached Biology News:Cat and mouse: A single gene matters 2Cat and mouse: A single gene matters 3Researchers track singing humpback whales on a Northwest Atlantic feeding ground 2Mapping of cancer cell fuel pumps paves the way for new drugs 2
(Date:5/30/2015)... May 30, 2015  Caris Life Sciences® today ... in which researchers identified biomarker changes, including key ... tumors, indicating changes in response to therapy as ... was a subset of a larger study analyzing ... the cancer. These data utilizing Caris Molecular Intelligence®, ...
(Date:5/29/2015)... CA (PRWEB) May 29, 2015 ... addressing multi-drug-resistant organisms (MDROs), announced that initial feasibility ... same-shift bacterial detection and susceptibility testing from positive ... on May 31, 2015 in New Orleans, ... class of molecular diagnostics that can quickly detect ...
(Date:5/29/2015)... 2015 Delcath Systems, Inc. (NASDAQ: ... company focused on oncology with an emphasis on ... announces that results of a large, European single-center ... with hepatic metastases with the Delcath Hepatic CHEMOSAT ... on-line abstract at the American Society of Clinical ...
(Date:5/29/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/7bf7ff/cytogenetics ... new report "Cytogenetics - Technologies, Markets and ... report deals with cytogenetics in a broader sense ... the chromosome structure and identify abnormalities related to ... is also referred to as molecular cytogenetics. The ...
Breaking Biology Technology:Caris Life Sciences Paired Tumor Data Identifies Key Driver Mutations and Confirms Tumor Heterogeneity in High-Grade Glioma Samples 2Caris Life Sciences Paired Tumor Data Identifies Key Driver Mutations and Confirms Tumor Heterogeneity in High-Grade Glioma Samples 3Caris Life Sciences Paired Tumor Data Identifies Key Driver Mutations and Confirms Tumor Heterogeneity in High-Grade Glioma Samples 4Data Highlighting GeneWEAVE’s Smarticles™ Technology to be Presented at the 115th General Meeting of the American Society for Microbiology (asm2015) 2Data Highlighting GeneWEAVE’s Smarticles™ Technology to be Presented at the 115th General Meeting of the American Society for Microbiology (asm2015) 3Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 2Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 3Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 4Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 5Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 2Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 3
... , , Zdechlik ... , , NEW YORK, ... molecular oncology diagnostics to aid in early cancer detection and ... Chief Operating Officer. As COO, Zdechlik will be responsible ...
... ... Holden to present the keynote address , ... Parsipany, NJ (PRWEB) July 22, 2009 -- Vistaar Technologies, ... finance groups, today announced the company will partner with the Professional Pricing Society (PPS), ...
... , LYNBROOK, N.Y., July 22 ... developing first in class collagenase-based products, today announced that BioSpecifics, President, ... Small-Cap Investor Conference on Wednesday, July 29, 2009, at 9:30am CT ... , A live webcast of the presentation can be ...
Cached Biology Technology:Exosome Diagnostics Appoints Former Roche Executive Greg Zdechlik as Chief Operating Officer 2Vistaar and the Professional Pricing Society Partner to Present Premier Symposium for Pricing Practitioners 2Vistaar and the Professional Pricing Society Partner to Present Premier Symposium for Pricing Practitioners 3
... The Model 1575 immunowash microplate washer ... microplates that have flat-, U-, or V-bottom ... of horizontal and vertical needle positions to ... washing, crosswise aspiration, and overflow washing. It ...
... compact benchtop and stackable multi-function incubator. ... a large display screen to accurately ... circulation inside to evenly distribute temperature ... easily calibrated from the microprocessor controller. ...
... specifically designed as a high tech shaker ... mass compensation allows high shaking speed even ... and, therefore, faster growth and higher cell ... when high reproducibility is critical ...
...
Biology Products: