Navigation Links
UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
Date:2/23/2009

DALLAS Feb. 24, 2009 Sleep experts know that the mental clarity lost because of a few sleepless nights can often be restored with a good night's rest. Now, UT Southwestern Medical Center researchers have identified a key molecular mechanism that regulates the brain's ability to mentally compensate for sleep deprivation.

Working with mice, they found that a molecule called an adenosine receptor is necessary for sleep-restricted animals to attain adequate levels of slow-wave activity in the brain once normal sleep resumes. It is this increase in slow-wave activity, or SWA, during rebound sleep that helps restore normal working memory and attention skills to the sleep-deprived, the scientists report in the Feb. 4 issue of the Journal of Neuroscience.

"Normal society pushes people to burn candles at both ends going to bed late, getting up early, and somehow performing mentally with lack of adequate sleep," said senior author Dr. Robert Greene, professor of psychiatry at UT Southwestern. "We need to have our adenosine receptors intact to do that."

Adenosine receptors on nerve cells, including brain cells, are akin to docking points for the molecule adenosine. Adenosine levels increase in the brain with each hour of waking activity, and "docking" of the molecule with its receptor is shown in this study to help promote the slow-wave activity of sleep. Scientists have known that recovery from sleep deprivation involves not only an increase in sleep time, or rebound sleep, but also an elevation in this slow-wave activity.

To investigate how adenosine receptors and SWA might be linked, Dr. Greene and his team engineered mice that lacked a receptor to pair up with adenosine.

Sleep-restricted mice were kept awake by being placed on a moving treadmill. Researchers then electronically monitored sleep and waking activity of both normal and genetically engineered mice, including monitoring electronically the brain waves
'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
2. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
3. UT Southwestern scientist honored among best in Texas research
4. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
5. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
6. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
7. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
8. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
9. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
10. Limiting fructose may boost weight loss, UT Southwestern researcher reports
11. UT Southwestern researchers identify new targets for RNAs that regulate genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... one per eight hundred births, Down syndrome - or ... of intellectual disability. It results from a chromosomal abnormality ... of chromosome 21 (1% of the human genome). A ... the Department of Genetic Medicine and Development at the ... Nature , shed light on how the extra ...
(Date:4/17/2014)... Stem cells in bone marrow need to produce hydrogen ... tissue, according to a new study from the Center ... of Dentistry of USC. , Professor Songtao Shi, principal ... sulfide produced by the cells governs the flow of ... cellular signals that results in osteogenesis, or the creation ...
(Date:4/17/2014)... This news release is available in German . ... fails to pay the protection money demanded of him, he ... are seldom required, however, as fear of the consequences is ... is observed in parasitic birds, which lay their eggs in ... egg out, the brood parasites take their revenge by destroying ...
Breaking Biology News(10 mins):Trisomy 21: How an extra little chromosome throws the entire genome off balance 2Trisomy 21: How an extra little chromosome throws the entire genome off balance 3Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3
... Research to be presented at the upcoming annual ... Behavior (SSIB), the foremost society for research into all ... can become dependent on highly palatable foods and engage ... behaviors we observe in drug addicts and those with ...
... The continued growth of cropland and loss of ... the Midwest. A Great Lakes Bioenergy Research Center ... with increased crop pest abundance and insecticide use, ... crops. While the relationship between landscape simplification, ...
... cities can make a significant contribution to carbon storage and, ... authorities and gardeners planted and maintained more trees. The study, ... of Applied Ecology , is the first to quantify how ... of Europe. Using satellite data and information gathered by ...
Cached Biology News:Evidence for 'food addiction' in humans 2Landscape change leads to increased insecticide use in the Midwest 2Plants in cities are an underestimated carbon store 2
(Date:1/15/2014)... January 15, 2014 Two champions of ... their sponsorship of an annual competition for middle and ... access to, innovative STEM study. The competition presents students ... Tests of Engineering Aptitude, Mathematics, and Sciences is ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Freeslate, ... solutions, today announced that Lupin Limited, one of India’s ... CM Protégé PharmD System for high throughput ... India, is focused on a wide range of quality, ...
(Date:1/14/2014)... January 14, 2014 Carahsoft and CDS ... January 23, 2014 at 2pm EST (11am PST), “Natural ... topic focuses on how technology can turn raw, heterogeneous ... for government agencies. The online webinar will last approximately ...
(Date:1/14/2014)... New York, NY (PRWEB) January 14, 2014 ... coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an ... products to serve the wound care market. , Free ... Alliqua was restructured with a seasoned management team and ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Replidyne, Inc.,(Nasdaq: RDYN ) today announced its financial ... 2007., Replidyne reported a net loss of $16.9 million ... loss per basic and diluted common share,of $0.63 per share, ... per,basic and diluted common share, for the quarter ended December ...
... SCOTTSDALE, Ariz., Feb. 26 MedPredict Market Research,a ... has published a new report providing critical strategic ... in the market for Rheumatoid,Arthritis (RA) therapies., ... & Analysis:,Rheumatoid Arthritis Q1 2008, MedPredict,s global Thought ...
... Current Radlink Board Member ... Joins Team, ... hardware company that has emerged as an,innovative provider of medical imaging systems ... With nearly 30 years of experience, Dr. Julien is currently director ...
Cached Biology Technology:Replidyne Announces 2007 Fourth Quarter and Full Year Results 2Replidyne Announces 2007 Fourth Quarter and Full Year Results 3Replidyne Announces 2007 Fourth Quarter and Full Year Results 4Replidyne Announces 2007 Fourth Quarter and Full Year Results 5Replidyne Announces 2007 Fourth Quarter and Full Year Results 6Replidyne Announces 2007 Fourth Quarter and Full Year Results 7Unmet Needs Provide Challenges and Opportunities for Rheumatoid Arthritis Drug Developers According to MedPredict Report 2Renowned Radiologist Peter J. Julien, MD Named Radlink Chief Medical Officer 2
Request Info...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
... Quality ISO 9001:2000 Certified ... All Precedures Validated, SOP's Training ... Process for All Procedures GLP Documentation Upon ... one stop shopping point for all your ...
Biology Products: