Navigation Links
UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
Date:1/30/2009

DALLAS Jan. 30, 2009 Screening a chemical library of 200,000 compounds, researchers at UT Southwestern Medical Center have identified two new classes that can be used to study and possibly manipulate a cellular pathway involved in many types of cancer and degenerative diseases.

"The identification of these chemicals and their targets within this cellular pathway represents an important step in developing therapeutic agents," said Dr. Lawrence Lum, assistant professor of cell biology and senior author of the study, available at Nature Chemical Biology.

The researchers studied biochemical reactions within cells controlled by a class of proteins called Wnt (pronounced "wint"). Wnt proteins help control embryonic development in many animals, including humans. In adults, these proteins also sustain the vital supply of stem cells that replenish various body tissues. Misregulation of cellular responses to Wnt proteins, however, is associated with a broad range of diseases including Alzheimer's and polycystic kidney disease, cancer and type 2 diabetes.

In the current study, the researchers used cultured mouse cells that were engineered to glow green when Wnt-controlled pathways were active. A robotic device then tested 200,000 compounds to measure their effects on the cells.

Nine compounds that inactivated Wnt-controlled systems thus preventing the cells from glowing were earmarked for further research. The researchers then found that five of these compounds stopped cells from responding to Wnt, and four prevented Wnt from being produced in the first place.

"The ability to attack this disease pathway at two distinct regulatory steps is an important step toward realizing personalized medicine that aims to tailor the use of drugs for specific genetic mutations," Dr. Lum said.

Importantly, the action of these compounds is reversible, the researchers found. "This may allow us to target diseased cells without permanently altering the function of normal stem cells," Dr. Lum said.

Despite these encouraging results, there is a long way to go before these compounds could be the basis of new drugs, Dr. Lum said. The researchers plan to make variations of these compounds to see if they can be effective at lower doses, and they also will perform additional studies in whole animals, he said.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related biology news :

1. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
2. UT Southwestern scientist honored among best in Texas research
3. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
4. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
5. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
6. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
7. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
8. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
9. Limiting fructose may boost weight loss, UT Southwestern researcher reports
10. UT Southwestern researchers identify new targets for RNAs that regulate genes
11. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... India , May 3, 2016 /PRNewswire/ ... (DNA Chip (Genomics, Drug Discovery, Gene Expression) ... End user (Academics Institutes, Diagnostics Centers), Fabrication ... published by MarketsandMarkets, the market is expected ... from USD 7.63 Billion in 2015, growing ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... development, skill-building and compliance training platform on mobile devices, today released a new ... Regulatory Requirements for Medical Devices. The course is essential for owners or operators ...
(Date:5/3/2016)... ... May 03, 2016 , ... In a list published ... of the state’s 76 fastest-growing private companies; a small percentage of the state's 615,000+ ... organizations on the percent change in revenue from 2012 to 2015. , ...
(Date:5/3/2016)... Boston, Massachusetts (PRWEB) , ... May 03, 2016 ... ... communities will gather at Boston CEO 2016 on May 31st and June 1st ... off-the-record networking forum for leading executives in the life sciences, offering exclusive access ...
Breaking Biology Technology: