Navigation Links
UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
Date:1/30/2009

DALLAS Jan. 30, 2009 Screening a chemical library of 200,000 compounds, researchers at UT Southwestern Medical Center have identified two new classes that can be used to study and possibly manipulate a cellular pathway involved in many types of cancer and degenerative diseases.

"The identification of these chemicals and their targets within this cellular pathway represents an important step in developing therapeutic agents," said Dr. Lawrence Lum, assistant professor of cell biology and senior author of the study, available at Nature Chemical Biology.

The researchers studied biochemical reactions within cells controlled by a class of proteins called Wnt (pronounced "wint"). Wnt proteins help control embryonic development in many animals, including humans. In adults, these proteins also sustain the vital supply of stem cells that replenish various body tissues. Misregulation of cellular responses to Wnt proteins, however, is associated with a broad range of diseases including Alzheimer's and polycystic kidney disease, cancer and type 2 diabetes.

In the current study, the researchers used cultured mouse cells that were engineered to glow green when Wnt-controlled pathways were active. A robotic device then tested 200,000 compounds to measure their effects on the cells.

Nine compounds that inactivated Wnt-controlled systems thus preventing the cells from glowing were earmarked for further research. The researchers then found that five of these compounds stopped cells from responding to Wnt, and four prevented Wnt from being produced in the first place.

"The ability to attack this disease pathway at two distinct regulatory steps is an important step toward realizing personalized medicine that aims to tailor the use of drugs for specific genetic mutations," Dr. Lum said.

Importantly, the action of these compounds is reversible, the researchers found. "This may allow us to target diseased cells w
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
2. UT Southwestern scientist honored among best in Texas research
3. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
4. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
5. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
6. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
7. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
8. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
9. Limiting fructose may boost weight loss, UT Southwestern researcher reports
10. UT Southwestern researchers identify new targets for RNAs that regulate genes
11. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... with critical security-authentication needs, today announced the beginning of ... (FFD) solution. The company, based in ... at the three-day Connect:ID Expo, which began here today ... NexID said version 2.0 of its SDK boosts the ...
(Date:3/23/2015)... NEW YORK , March 23, 2015   ... digital property management company, today announced that the Company ... platform for both enterprise and consumers at Connect:ID on ... D.C. HOYOS Labs will highlight the IEEE ... 1U TM ; and enterprise access control system. ...
(Date:3/20/2015)... , Mar. 20, 2015 Research and Markets ... addition of the "India Sensors Market Forecast ... The sensor market is projected to ... Consumer electronics, automotive, industrial and healthcare ... in the country. In addition, adoption of MEMS ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... BioNano Genomics , the developer of the Irys™ System for genome ... , Ph.D. as vice president, Commercial Operations EMEA. Dr. Amini will ... possible for researchers and clinicians in Europe , ... to access BioNano,s recently launched Irys platform. "As ...
... C virus have only been partially successful. A major problem ... Dankook University, Yongin, Republic of Korea and his collaborators have ... critical protein, disabling it so successfully that no resistance has ... of the Journal of Virology . The ...
... over 15,000 species are threatened by extinction, and the ... surrounding some of the species behavior are resolved, more ... protection. The case of the loggerhead sea turtle is ... of kilometers to eventually come back to their place ...
Cached Biology News:BioNano Genomics Appoints Dr. Fahim Amini As Vice President Commercial Operations EMEA 2BioNano Genomics Appoints Dr. Fahim Amini As Vice President Commercial Operations EMEA 3Going home 2
(Date:4/23/2015)... Athena San Diego, an organization that ... in San Diego’s technology and life science sectors, will ... at their Gala on April 30, 2015 from 5-9pm ... http://athenasd.org/events/ , The Pinnacle Awards recognize individuals ... vision of fostering networking, risk taking and diversity of ...
(Date:4/23/2015)... 23, 2015 Six startups from ... April 4-17 as part of the U.S.-Russia Innovation ... group of biotechnology startups to participate in the ... (UNN) and the University of Maryland (UMD) signed ... their respective universities in the biomedical industry in ...
(Date:4/23/2015)... Calif. , April 23, 2015  Cryoport, ... advanced cryogenic logistics solutions for the life sciences ... established its cryogenic logistics solutions within the animal ... with Yancey Farms to support the shipment of ... German Sport horse Stallions. Animal ...
(Date:4/23/2015)... (PRWEB) April 23, 2015 ... in Personalized Medicine, is excited to announce the ... profile . This profile assesses 62 genetic variations ... dosing information for commonly prescribed non-opioid pain medications, ... name Neurontin), alprazolam (brand name Xanax) and acetaminophen ...
Breaking Biology Technology:Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 2Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 3Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 2Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 3
... For future generations of Native Americans in Wisconsin, the ... corridors. , ,An effort to diversify Potawatomi tribe casino ... that has contributed to both the nation's technology industry ... Midwestern companiesan ethanol plant and an IT firmthe ...
... Organizers of Financial Executives International , a 15,000-peer ... committee members, has announced the formation of a local ... offers an opportunity for professional peers to share information ... finance. , ,"A handful of us realized that the ...
... fighting AT&T about Project Lightspeed and others are looking at ... these fiber investments have paid off in Utah as we ... don't hear much about in the Midwest. As one CIO ... 5 percent of buildings and homes worldwide have a broadband ...
Cached Biology Technology:Potawatomis to ramp up their investing 2Potawatomis to ramp up their investing 3Fiber-optic infrastructure spurring city economic development 2Fiber-optic infrastructure spurring city economic development 3Fiber-optic infrastructure spurring city economic development 4
... . The sensitive conductivity detector CE 4710, ... the measuring cell in a thermostatted environment. ... Data processing is provided by the CE 4900 ... high pressure CE 4100 dual piston pump. ...
... media and other fluid sources for 4 ... speed of each individual pump is controlled ... are exactly maintained. ,High-precision controlled peristaltic ... types, which allows flow rates between 0.01 ...
... cassette is designed to allow ampicillin selection ... gb2 driving the gene for ampicillin resistance ... Em7 promoter. It mediates higher transcription efficiency ... synthetic polyadenylation signal terminates the ampicillin expression. ...
... for the fast and simple integration of ... position (for the generation of transgenic mouse ... to allow neomycin / kanamycin selection in ... prokaryotic promoter (gb2) for expression of kanamycin ...
Biology Products: