Navigation Links
USC researchers find possible genetic clues to organ development, birth defects
Date:2/11/2013

el and the organ level," Crump said. "They have almost all the same organs that we do, which makes the fish a very relevant system for understanding human health and disease."

The pharyngeal pouches develop the gills in fish, and in human fetuses they also form gill-like structures, which later organize the head skeleton and organs such as the thymus and thyroid. Birth defects like DiGeorge syndrome can be traced back to malformations in the development of the pharyngeal pouches, Crump said.

Choe developed more than 100 different transgenic lines, transferring key genes to live zebrafish embryos where they could be studied under the microscope at the single cell level. Surprisingly, the lengthy filming doesn't harm the embryos and they can grow up to be normal fish, Crump said.

The Wnt pathways are significant because they control two separate cell behaviors. Choe discovered this by finding a way to genetically block each pathway and then making time-lapse videos of how development went wrong in each case.

"In the future as we get better at harnessing stem cells to create organs, we hope to be able to bioengineer these cells to make a particularly shaped organ," Crump said. "What we're learning in zebrafish by studying these pouches will be generally applicable and we can pursue these basic principles to come up with new types of technology involving cellular therapy."

The team is now studying other signaling pathways and their possible contributions to organ development and defects.


'/>"/>

Contact: Leslie Ridgeway
lridgewa@usc.edu
32-344-228-283
University of Southern California - Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover Achilles heel for lymphoid leukemia
2. Researchers find Asian needle ants displacing other aggressive invaders
3. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
4. UT Dallas researchers pushing the boundaries of virtual reality
5. Polar bear researchers urge governments to act now and save the species
6. Pitt researchers reveal mechanism to halt cancer cell growth, discover potential therapy
7. Researchers discover mutations linked to relapse of childhood leukemia
8. Caught in the act: Researchers capture key moments in cell death
9. Researchers harness nature to produce the fuel of the future
10. U. of Minn. researchers unveil first artificial enzyme created by evolution in a test tube
11. Prehistoric humans not wiped out by comet, says researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... 1, 2014, 10:20 AM EDT) It may be ... foods over unhealthy higher-calorie foods, according to new research ... Research Center on Aging (USDA HNRCA) at Tufts University ... the journal Nutrition & Diabetes , a brain ... it is possible to reverse the addictive power of ...
(Date:9/1/2014)... WASHINGTON About 50 years ago, electron microscopy revealed ... cells, move around and disappear. But scientists still don,t ... cloud-like collections of proteins are believed to be crucial ... offer a new approach to disease treatment., In the ... issuing a call to investigators from various backgrounds, from ...
(Date:9/1/2014)... and decisions of the Nomenclature Section of the XVIII ... July 2011. This meeting is held every six years ... the rules for naming algae, fungi and plants get ... naming the organisms they study. This is the primary ... for algae, fungi, and plants, which was published in ...
Breaking Biology News(10 mins):Training your brain to prefer healthy foods 2Scientists call for investigation of mysterious cloud-like collections in cells 2Week-long meeting on naming algae, fungi, and plants recorded for posterity 2
... Philip R. LeDuc and his collaborators in Massachusetts and ... that could ultimately unlock the mystery of how these ... the mechanics of biological processes in people. "What ... a protein that helps control cell behavior from a ...
... researcher based on the island of Reunion in the Indian ... Kew (RBG Kew) has used motion sensitive night cameras to ... a pollinator of flowering plants. Not only is this the ... of the Orthoptera order of insects who are better ...
... of scientists are merging methods and results from different disciplines ... of researchers in a recent issue of Evolution . ... data, however, researchers who want to analyze previous findings may ... authors say. In a commentary piece in the journal ...
Cached Biology News:Carnegie Mellon's Philip LeDuc discovers new protein function 2First known instance of a cricket as an orchid pollinator captured on film by Kew scientist 2Biologists merge methods, results from different disciplines to find new meaning in old data 2Biologists merge methods, results from different disciplines to find new meaning in old data 3
(Date:8/29/2014)... A major challenge before new biotechnology ... realm of Boston-Cambridge, is gaining visibility that can lead ... the Director of Boston’s Adult Stem Cell Technology Center, ... visibility of his company an important priority since he ... to a social media marketing campaign launched ...
(Date:8/28/2014)... 28, 2014 “This kit has an improved ... from 0 to 150 ppb,” said Mark Tess, PhD, Mycotoxin ... benefit to plant owners and USDA-GIPSA inspection agencies that have ... Testing can take place in a matter of minutes with ... plant test the feed and grain before accepting it, but ...
(Date:8/28/2014)... 28, 2014  Next month, executives from clinical trial marketing ... events beginning with Patient-Centered Clinical Trials 2014 , to ... Boston , September 4-5. Patient recruitment experts Bonnie ... Fleishman will share insights on the benefits of employing ... tactics – from media to mobile apps – can be ...
(Date:8/28/2014)... August 27, 2014 Scientists, researchers, and ... SPIE Laser Damage 2014 symposium. Marking its ... high-power lasers will run 14-17 September. The event is ... and photonics . , The premier conference for basic ... damage to optical materials will engage researchers and engineers ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4BBK Worldwide Leads Sessions at Key September Events 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3
... Company Announces 2009 Graeme Clark Scholarship WinnersDENVER, March ... advanced hearing technologies, today announced the winners of ... the Graeme Clark Cochlear Scholarship Foundation has recognized ... a Nucleus(R) cochlear implant - a small electronic ...
... molecular diagnostics for lung cancer, has announced that Stephen Chubb has ... joined the company as Vice President of Operations and Quality Systems. ... ... Allegro Diagnostics, a leader in the field of molecular diagnostics for ...
... evaluating the predictive value of VENDYS®, the new FDA-approved cardiovascular test, ... American College of Cardiology in Orlando, Florida. The studies, amazingly, show ... fingertips can help detect hidden coronary artery disease. , ... ...
Cached Biology Technology:Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 2Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 3Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 4Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 5Allegro Diagnostics Expands Board and Executive Team 2Allegro Diagnostics Expands Board and Executive Team 3Allegro Diagnostics Expands Board and Executive Team 4New Discoveries on a Fingertip Test for Screening Silent Heart Disease Promising Results of Recent Clinical Studies to be Presented during the 2009 American College of Cardiology Conference, March 29th - April 1st in Orlando 2New Discoveries on a Fingertip Test for Screening Silent Heart Disease Promising Results of Recent Clinical Studies to be Presented during the 2009 American College of Cardiology Conference, March 29th - April 1st in Orlando 3New Discoveries on a Fingertip Test for Screening Silent Heart Disease Promising Results of Recent Clinical Studies to be Presented during the 2009 American College of Cardiology Conference, March 29th - April 1st in Orlando 4New Discoveries on a Fingertip Test for Screening Silent Heart Disease Promising Results of Recent Clinical Studies to be Presented during the 2009 American College of Cardiology Conference, March 29th - April 1st in Orlando 5
Gloves are 9.25 long, latex, powder free, smooth and ambidextrous....
Request Info...
Prepared with distilled water. Yeast extract solution is autolyzed at 150 g/L....
Streptomycin sulfate an aminoglycoside used for bacterial selection binds to the small ribosomal subunit and interferes with protein biosynthesis.21H39N7O12)2x3H2SO4Formula weight:...
Biology Products: