Navigation Links
USC researchers find possible genetic clues to organ development, birth defects
Date:2/11/2013

el and the organ level," Crump said. "They have almost all the same organs that we do, which makes the fish a very relevant system for understanding human health and disease."

The pharyngeal pouches develop the gills in fish, and in human fetuses they also form gill-like structures, which later organize the head skeleton and organs such as the thymus and thyroid. Birth defects like DiGeorge syndrome can be traced back to malformations in the development of the pharyngeal pouches, Crump said.

Choe developed more than 100 different transgenic lines, transferring key genes to live zebrafish embryos where they could be studied under the microscope at the single cell level. Surprisingly, the lengthy filming doesn't harm the embryos and they can grow up to be normal fish, Crump said.

The Wnt pathways are significant because they control two separate cell behaviors. Choe discovered this by finding a way to genetically block each pathway and then making time-lapse videos of how development went wrong in each case.

"In the future as we get better at harnessing stem cells to create organs, we hope to be able to bioengineer these cells to make a particularly shaped organ," Crump said. "What we're learning in zebrafish by studying these pouches will be generally applicable and we can pursue these basic principles to come up with new types of technology involving cellular therapy."

The team is now studying other signaling pathways and their possible contributions to organ development and defects.


'/>"/>

Contact: Leslie Ridgeway
lridgewa@usc.edu
32-344-228-283
University of Southern California - Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover Achilles heel for lymphoid leukemia
2. Researchers find Asian needle ants displacing other aggressive invaders
3. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
4. UT Dallas researchers pushing the boundaries of virtual reality
5. Polar bear researchers urge governments to act now and save the species
6. Pitt researchers reveal mechanism to halt cancer cell growth, discover potential therapy
7. Researchers discover mutations linked to relapse of childhood leukemia
8. Caught in the act: Researchers capture key moments in cell death
9. Researchers harness nature to produce the fuel of the future
10. U. of Minn. researchers unveil first artificial enzyme created by evolution in a test tube
11. Prehistoric humans not wiped out by comet, says researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Nov. 20, 2014   Atmel® Corporation (NASDAQ: ... (MCU) and touch technology solutions, today launched the industry,s ... with the widest V cc range from 1.7V ... and faster I 2 C bus communication speeds, and ... memory making them ideal for consumer, industrial, computer, and ...
(Date:11/15/2014)... we may still be a few years away from the ... gain instant access to all that ailed his patients, mobile ... for monitoring and measuring our health are cropping up in ... tad Orwellian to some, but a new survey suggests that ... into their healthcare regime. These are some of ...
(Date:11/7/2014)... Calif. , Nov. 7, 2014  In conjunction with ... Police Departments, The Community Foundation of the Verdugos ... DNA JUSTICE PROJECT," a $250,000 initiative to keep ... initial phase. In its first six months of existence, the ... needed evidence support for local law enforcement. "Because ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... How do viruses get into cells? In pursuing this central ... 1997, and his team have pioneered research in this field. ... Swiss Nobel Prize in Bern, Switzerland. This award is not ... a confirmation of our long years of work, and demonstration ...
... academic entrepreneurs has teamed up with the University ... in membrane biology to pharmaceutical, biotech and agrochemical ... spin-out company Oxford Molecular into a business worth ... for Integrative Membrane Biology (CIMB) to broker research ...
... 24 years ago in Montana has,finally been identified ... Asian dinosaurs. The dinosaur would have weighed 30 to ... feet tall. The fossil,came from sediment that,s about 80 ... was published in September,s issue of the Journal,of Vertebrate ...
Cached Biology News:ETH Zurich professor Ari Helenius awarded Benoist Prize 2New partnership offers outsourced R&D in membrane biology 2New dinosaur species found in Montana 2
(Date:11/24/2014)... November 24, 2014 2014 Deep ... Industry is a professional and in-depth research report ... Dihydrazide information, like its definition, classification, application, and ... This report covers the international market analysis, including ... as the US, Europe, Asia, China, Japan etc. ...
(Date:11/22/2014)... and London (PRWEB) November 21, 2014 Two ... will explore what comes next for ALS research and how ... , After the Ice Bucket Challenge: Where Does the ... Date: Tuesday, 2 December 2014, Time: 1:30pm ET, ... , Join expert speaker Dr. Merit Cudkowicz, Julianne Dorn Professor ...
(Date:11/22/2014)... IL (PRWEB) November 21, 2014 On ... competitors at the 2014 Emerging Medical Technologies Summit in ... Innovator Awards. Widely regarded among Silicon Valley investors ... medical device innovation, the win also positions Briteseed ... MedTech Innovator competition in 2015 and compete with other ...
(Date:11/21/2014)... -- , Todd Martensen se ... Mariano Rodríguez es elegid vicepresidente senior de desarrollo empresarial y ... marcha para comenzar de forma rápida la comercialización de su ... en Europa   , KLOX Technologies ... siguientes nombramientos: Todd Martensen ha sido ...
Breaking Biology Technology:Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3DrugDev Webinars in December to Explore What Comes Next for ALS Research and How We Can Make Life Easier for Clinical Sites 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 3KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5
... High quality RNA from tissue or cells , ... Custom RNA isolations from tissue , Optimized isolation protocols , ... Use Ambion's Custom Isolation , ... quality RNA from ethically sourced donor tissue with all , ...
... RNA amplification using the Van Gelder and , ... used extensively for target , ... Amplification of RNA is clearly necessary when working with , ... it necessary when the availability of sample is not ...
... Dmitriy Ovcharenko, Rich Jarvis, , ... , ... experimental tool for reducing the expression of specific , ... for gene function analysis, target , ...
Cached Biology Technology:High Quality RNA Isolation Services 2Is RNA Amplification Necessary for Microarrays? 2Is RNA Amplification Necessary for Microarrays? 3Is RNA Amplification Necessary for Microarrays? 4Is RNA Amplification Necessary for Microarrays? 5Is RNA Amplification Necessary for Microarrays? 6Delivering siRNAs to Difficult Cell Types 2Delivering siRNAs to Difficult Cell Types 3Delivering siRNAs to Difficult Cell Types 4Delivering siRNAs to Difficult Cell Types 5Delivering siRNAs to Difficult Cell Types 6Delivering siRNAs to Difficult Cell Types 7