Navigation Links
USC researchers find possible genetic clues to organ development, birth defects
Date:2/11/2013

el and the organ level," Crump said. "They have almost all the same organs that we do, which makes the fish a very relevant system for understanding human health and disease."

The pharyngeal pouches develop the gills in fish, and in human fetuses they also form gill-like structures, which later organize the head skeleton and organs such as the thymus and thyroid. Birth defects like DiGeorge syndrome can be traced back to malformations in the development of the pharyngeal pouches, Crump said.

Choe developed more than 100 different transgenic lines, transferring key genes to live zebrafish embryos where they could be studied under the microscope at the single cell level. Surprisingly, the lengthy filming doesn't harm the embryos and they can grow up to be normal fish, Crump said.

The Wnt pathways are significant because they control two separate cell behaviors. Choe discovered this by finding a way to genetically block each pathway and then making time-lapse videos of how development went wrong in each case.

"In the future as we get better at harnessing stem cells to create organs, we hope to be able to bioengineer these cells to make a particularly shaped organ," Crump said. "What we're learning in zebrafish by studying these pouches will be generally applicable and we can pursue these basic principles to come up with new types of technology involving cellular therapy."

The team is now studying other signaling pathways and their possible contributions to organ development and defects.


'/>"/>

Contact: Leslie Ridgeway
lridgewa@usc.edu
32-344-228-283
University of Southern California - Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover Achilles heel for lymphoid leukemia
2. Researchers find Asian needle ants displacing other aggressive invaders
3. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
4. UT Dallas researchers pushing the boundaries of virtual reality
5. Polar bear researchers urge governments to act now and save the species
6. Pitt researchers reveal mechanism to halt cancer cell growth, discover potential therapy
7. Researchers discover mutations linked to relapse of childhood leukemia
8. Caught in the act: Researchers capture key moments in cell death
9. Researchers harness nature to produce the fuel of the future
10. U. of Minn. researchers unveil first artificial enzyme created by evolution in a test tube
11. Prehistoric humans not wiped out by comet, says researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... , June 23, 2015   Valencell, ... the results of a recent study that illustrates ... the wrist during activity. In a study conducted ... compared along with the Apple Watch against a ... heart rate during activity. The study demonstrated that ...
(Date:6/17/2015)... Germany , June 17, 2015 ... today launched new Investigator ® STR assay kits for ... the United States . The new genetic fingerprint kits ... markers (short tandem repeats or STRs) for DNA matching. They ... quality of DNA in each sample, a novel QIAGEN technology ...
(Date:6/16/2015)... Fingerprint Cards has received an order ... company,s portfolio from one of its module partners in ... place during the third quarter 2015. The sensors will be ... Jörgen Lantto, CEO of FPC, comments: " This ... interest from smartphone OEMs in integrating touch fingerprint sensors in ...
Breaking Biology News(10 mins):Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2
... AKRON, Ohio Researchers, health care engineers and ... inaugural National Conference on Value-driven Engineering to Improve ... the Austen BioInnovation Institute in Akron (ABIA) and ... from some of the nation,s leading biomedical device ...
... a breath of fresh air may be a city bus, if ... has created a system for public transit that would continually clear ... and pneumonia. The CityBusters Joseph Spinella, Jerry Lue, ... installed a $500 device on a METRO bus in Houston that ...
... Researchers at the Centre for Addiction and Mental Health (CAMH) ... of intellectual disability, as well as how it likely affects ... Dr. John Vincent and his team found a mutation in ... finding to be published in the May issue of the ...
Cached Biology News:Medical device, health professionals attend first national conference on value-driven engineering 2Medical device, health professionals attend first national conference on value-driven engineering 3College students work to sterilize air, kill pathogens on buses 2College students work to sterilize air, kill pathogens on buses 3College students work to sterilize air, kill pathogens on buses 4New form of intellectual disability discovered 2
(Date:6/30/2015)... June 30, 2015 /PRNewswire/ - RepliCel Life Sciences ... regenerative medicine company focused on the development of ... in its Phase 1/2 clinical trial of RCT-01, ... Achilles tendinosis, has been enrolled and their tissue ... injections. RCT-01 is comprised of non-bulbar dermal sheath ...
(Date:6/30/2015)... Florida (PRWEB) , ... June 30, 2015 , ... ... cannabis digital media company, launched “Cannavoices,” an unprecedented digital video and broadcast ... largest but also the most dynamic collection of legal medical cannabis stories ever ...
(Date:6/29/2015)... (PRWEB) , ... June 29, 2015 , ... ... significant CAGR of around 19% during the forecast period (2015 to 2020). The ... and upsurge in government and corporate funding for R&D. However, lack of adequate ...
(Date:6/29/2015)... Md. , June 29, 2015  Neuralstem, Inc. ... cell technology to develop small molecule and cell therapy ... it has been approved for listing on the NASDAQ ... stock will continue to trade on the NYSE MKT ... on the NASDAQ Capital Market is expected to commence ...
Breaking Biology Technology:RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 2RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 3RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 4Cannavoices Launches a Legal Medical Cannabis Documentary Initiative 2Cannavoices Launches a Legal Medical Cannabis Documentary Initiative 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 2Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 3
... Firstlogic, Inc., announced today an expansion of its OEM ... Firstlogic's Data Quality Link for Informatica. , ,The Data ... than 160 companies, Firstlogic reported. Among them are Carnival ... Firstlogic provides enterprise data quality software and services ...
... Wis. -- A report is due this fall ... and how to proceed with an IT project that was ... to implement it over a five-year period. The project was ... good project management. , ,The Appointments, Payroll and Benefits Systems ...
... -- One of my son's prized possessions from our summer ... we bought at the National Air and Space Museum in ... so even after successive trips to the museum he was ... about airplanes and rockets. , ,Our family toured the Air ...
Cached Biology Technology:UW working to salvage multi-million HR software project 2UW working to salvage multi-million HR software project 3UW working to salvage multi-million HR software project 4UW working to salvage multi-million HR software project 5We need the challenges of space exploration 2We need the challenges of space exploration 3
Mouse polyclonal antibody to QDPR - quinoid dihydropteridine reductase...
The AVR9-8 stream-select valve is a 9-port, 8-position valve for use with the BioLogic DuoFlow system. This valve is used for high-pressure stream selection....
... Multimode Detectors provide unmatched value and ... and automation needs. Capable of performing ... the same instrument, the DTX Series ... can be integrated seamlessly with Beckman ...
Dual-bay Dyad thermal cycler chassis, does not include the Alpha units (requires 2)...
Biology Products: