Navigation Links
USC researchers find possible genetic clues to organ development, birth defects

Highlights of this news release:

  • The research has determined two molecular signaling pathways that help control formation of the head and face
  • The discovery may lead to future understanding of certain birth defects and organ development.

Full news release is below.

LOS ANGELES Using cutting-edge time-lapse photography, University of Southern California (USC) researchers have discovered clues to the development of the head at the cellular level, which could point scientists to a better understanding of how organs and birth defects form in humans.

A team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC has for the first time determined the role of two important molecular signaling pathways that help control the number and position of repeated units of cells that pattern the head and face.

Two members of a "Wnt" signaling pathway are instrumental in forming pharyngeal pouches that organize the structure of the head and face. Problems with forming the pouches can result in birth defects, including the rare DiGeorge syndrome, which causes an array of symptoms including an abnormal facial appearance, cleft palate, congenital heart disease, and loss of the thyroid and thymus.

The research, "Wnt-Dependent Epithelial Transitions Drive Pharyngeal Pouch Formation," was published Feb. 11, 2013 in Developmental Cell. Principal author is Chong Pyo Choe, research associate at the Keck School of Medicine of USC.

The research, conducted over a five-year period, was accomplished by photographing live zebrafish embryos every 10 minutes for 36-hour periods with a sophisticated microscope, enabling the researchers to see the pouches forming in real time, said Gage Crump, assistant professor in cell and neurobiology, and corresponding author on the research.

"Zebrafish and humans are similar at the genetic lev

Contact: Leslie Ridgeway
University of Southern California - Health Sciences

Page: 1 2

Related biology news :

1. Researchers discover Achilles heel for lymphoid leukemia
2. Researchers find Asian needle ants displacing other aggressive invaders
3. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
4. UT Dallas researchers pushing the boundaries of virtual reality
5. Polar bear researchers urge governments to act now and save the species
6. Pitt researchers reveal mechanism to halt cancer cell growth, discover potential therapy
7. Researchers discover mutations linked to relapse of childhood leukemia
8. Caught in the act: Researchers capture key moments in cell death
9. Researchers harness nature to produce the fuel of the future
10. U. of Minn. researchers unveil first artificial enzyme created by evolution in a test tube
11. Prehistoric humans not wiped out by comet, says researchers
Post Your Comments:
(Date:5/11/2015)... May 11, 2015  Through a well-rounded UAS delegation representing ... had a strong showing at AUVSI,s Unmanned 2015 conference last ... Ohio,s UAS industry met with over ... all points along the UAS ecosystem. "Our ... Vice President for Aerospace Rich Knoll . "If you ...
(Date:5/6/2015)... TEL AVIV, Israel , May 6, 2015 /PRNewswire/ ... the world,s most established helmet producer, announced today that ... LifeBEAM Smart Helmet, the world,s first bio-sensing cycling helmet ... will be released in two new colors in order ... demand for the product. In addition, LifeBEAM and Lazer ...
(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
Breaking Biology News(10 mins):Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... can counteract the effects of tumor-promoting molecules in skin ... University of Pennsylvania School of Medicine. Using animal models, ... in epithelial cells, preventing uncontrolled cell growth caused by ... published online in the Journal of Biological Chemistry, suggests ...
... suffering chronic obstructive pulmonary disease (COPD) attempt to ... contradicts the conventional wisdom on the capabilities of ... attempted regional elastic fiber repair in severe emphysema," ... Patterson and Richard Pierce of Washington University, St. ...
... neurons may have been a key factor in why ... primate relatives. In a study comparing the genomes of ... U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley ... high degree of genetic differences in DNA sequences that ...
Cached Biology News:Signal protein shows promise for blocking tumor promoters in skin cells 2Lungs try to repair damaged elastic fibers 2Neuron cell stickiness may hold key to evolution of the human brain 2Neuron cell stickiness may hold key to evolution of the human brain 3Neuron cell stickiness may hold key to evolution of the human brain 4
(Date:6/1/2015)... May 29, 2015 Research and ... addition of the "2015 Strategies in ... to their offering. This new ... immunoprotein diagnostic market, including emerging tests, technologies, ... profiles of leading suppliers. Companies ...
(Date:6/1/2015)... 29, 2015 Research and Markets( ... the "2015 Strategies in the US ... their offering. This new 373-page ... comprehensive analysis of the POC clinical chemistry ... requirements, technological trends, competitive landscape, and emerging ...
(Date:6/1/2015)... , May 29, 2015 Research ... addition of the "2015 Assessments of ... Suppliers and Recent Market Entrants" report ... 90-page report from provides insightful profiles ... market entrants. The report presents ...
(Date:6/1/2015)... England , June 1, 2015 ... next important stage of development Creabilis ... targeted topical treatment in development for chronic pruritus ... Moukheibir as Chairman of its Board of Directors. ... in aligning corporate goals with financial strategy, allowing ...
Breaking Biology Technology:Assessments of Leading Microbiology Market Players 2015 - Profiles of Major Suppliers and Recent Market Entrants 2Creabilis Appoints Catherine Moukheibir as Chairman of its Board of Directors 2Creabilis Appoints Catherine Moukheibir as Chairman of its Board of Directors 3
... fighting breast cancer, and GE Medical Systems, headquartered in ... and Second Look Digital are computer-aided detection (CAD) technologies ... mammography system. CADx Systems, Inc. developed the Second Look ... review of breast exams. , ,GE is committed ...
... $50,000 planning grant from the Ewing Marion Kauffman ... plan for cross-campus entrepreneurship in a national competition among ... was selected by the Foundation to compete for further ... Entrepreneurial Initiative. , ,Provost Peter Spear and School ...
... SOFO ) will hold its annual meeting at which shareholders ... its entire desktop software business including its Sound Forge, ... to a subsidiary of Sony Pictures Digital for $19 million ... and capital leases associated with the desktop software business. SPD ...
Cached Biology Technology:New Technology in Fight against Breast Cancer 2UW-Madison Receives Grant to Develop Entrepreneurship Proposal 2Sony Bets Heavy on Wisconsin Digital Entertainment Presence 2Sony Bets Heavy on Wisconsin Digital Entertainment Presence 3Sony Bets Heavy on Wisconsin Digital Entertainment Presence 4Sony Bets Heavy on Wisconsin Digital Entertainment Presence 5
... nature of proteomics demands the detection of ... performance of the AXIMA-CFRplus with improved resolution ... ppm) provides increased confidence in protein identification. ... enhanced sensitivity, automated sample target handling and ...
... for users requiring mass detection but ... MALDI TOF Mass spectrometer is ideally ... and for high performance mass analysis. ... SNP analysis, protein detection, micro-satellite DNA ...
Rat Aortic Endothelial Cells (RAOEC) (>500,000 cells)...
... System is a compact, versatile & modular instrument ... purposes including: Intracellular, Extracellular, Transducer & Multi-channel ... NeuroLog Case & Power Supply unit (NL900D) forms ... are not only powered by this unit, but ...
Biology Products: