Navigation Links
USC researchers find possible genetic clues to organ development, birth defects
Date:2/11/2013

Highlights of this news release:

  • The research has determined two molecular signaling pathways that help control formation of the head and face
  • The discovery may lead to future understanding of certain birth defects and organ development.

Full news release is below.

LOS ANGELES Using cutting-edge time-lapse photography, University of Southern California (USC) researchers have discovered clues to the development of the head at the cellular level, which could point scientists to a better understanding of how organs and birth defects form in humans.

A team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC has for the first time determined the role of two important molecular signaling pathways that help control the number and position of repeated units of cells that pattern the head and face.

Two members of a "Wnt" signaling pathway are instrumental in forming pharyngeal pouches that organize the structure of the head and face. Problems with forming the pouches can result in birth defects, including the rare DiGeorge syndrome, which causes an array of symptoms including an abnormal facial appearance, cleft palate, congenital heart disease, and loss of the thyroid and thymus.

The research, "Wnt-Dependent Epithelial Transitions Drive Pharyngeal Pouch Formation," was published Feb. 11, 2013 in Developmental Cell. Principal author is Chong Pyo Choe, research associate at the Keck School of Medicine of USC.

The research, conducted over a five-year period, was accomplished by photographing live zebrafish embryos every 10 minutes for 36-hour periods with a sophisticated microscope, enabling the researchers to see the pouches forming in real time, said Gage Crump, assistant professor in cell and neurobiology, and corresponding author on the research.

"Zebrafish and humans are similar at the genetic lev
'/>"/>

Contact: Leslie Ridgeway
lridgewa@usc.edu
32-344-228-283
University of Southern California - Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover Achilles heel for lymphoid leukemia
2. Researchers find Asian needle ants displacing other aggressive invaders
3. Spanish researchers design biomarkers for the detection of dengue and West Nile virus
4. UT Dallas researchers pushing the boundaries of virtual reality
5. Polar bear researchers urge governments to act now and save the species
6. Pitt researchers reveal mechanism to halt cancer cell growth, discover potential therapy
7. Researchers discover mutations linked to relapse of childhood leukemia
8. Caught in the act: Researchers capture key moments in cell death
9. Researchers harness nature to produce the fuel of the future
10. U. of Minn. researchers unveil first artificial enzyme created by evolution in a test tube
11. Prehistoric humans not wiped out by comet, says researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Bethesda, MD FASEB MARC (Maximizing Access to Research ... the American Society of Human Genetics from October 18 ... awards are meant to promote the entry of students, ... mainstream of the basic science community and to encourage ... of Human Genetics. This year MARC conferred 16 ...
(Date:8/28/2014)... groups and clinicians is critical to the development ... of Georgia research. , A qualitative study of ... that role models for successful breastfeeding help positively ... "Mothers who received that support are more likely ... Alex Anderson, an associate professor in the College ...
(Date:8/28/2014)... (Maximizing Access to Research Careers) Program has announced ... of Sports Medicine,s Conference on Integrative Physiology of ... These awards are meant to promote the ... underrepresented groups into the mainstream of the basic ... young scientists at the American College of Sports ...
Breaking Biology News(10 mins):Breastfeeding study shows need for effective peer counseling programs 2
... Organization (EMBO) and the Federation of European Biochemical ... Friedrich Miescher Institute for Biomedical Research in Basel, ... Women in Science Award. Professor Gasser has been ... stability and epigenetics and her commitment to mentoring ...
... (New York, NY) The Alfred P. Sloan ... outstanding U.S. and Canadian researchers as recipients of Sloan ... fellowships are given to early-career scientists and scholars whose ... next generation of scientific leaders. "Today,s Sloan Research ...
... DETROIT Technology to restore vision through the use ... a Wayne State University professor and scientific director of ... Eye Institute has attracted additional funding for therapy ... grant from their affiliate, National Neurovision Research Institute, to ...
Cached Biology News:Susan M. Gasser to receive the 2012 FEBS/EMBO Women in Science Award 2Sloan Research Fellowships awarded to 126 young scholars 2Wayne State-licensed technology receives grant from the Foundation Fighting Blindness 2
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and his ... to participate in an investigational study of donor stem ... of this study is to determine if a single ... arthritically affected joints can help reduce pain and inflammation ... current investigational study must be older than nine months, ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
(Date:8/28/2014)... in spintronics, an electronic which is not only ... on their spin and the spin-related magnetism. Spin-charge ... signals and vice versa. Recently, the research group ... Physics at Johannes Gutenberg University Mainz in collaboration ... has for the first time realised a new, ...
(Date:8/28/2014)... Sterlitech is proud to announce that ... stable of products . These additional products ... include membrane filters with surface charges. , ... for our membrane process testing equipment, and correspondingly, a ... membranes,” explains Sterlitech President Mark Spatz. “The addition ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2
... ... The Chinese Biopharmaceutical Association-USA (CBA) announced today that it ... Maryland, US. ,The event will highlight current breakthroughs, new ... develop a platform for communication and collaboration among biopharmaceutical companies, ...
... organisms on earth, carry an extra coating of protection ... latest issue of the journal Current Biology . ... the bacteria that cause botulism, tetanus, and anthrax survive ... by researchers at New York University,s Center for Genomics ...
... A team from Stevens Institute of Technology, consisting ... students: Wuming Jing, Xi Chen, and Zhenbo Fu ... and Yong Shi from the Department of Mechanical ... the IEEE/National Institute of Standards and Technology (NIST) ...
Cached Biology Technology:Chinese Biopharmaceutical Association Holds 15th Annual Conference in Rockville, MD, June 12 - 13 2Chinese Biopharmaceutical Association Holds 15th Annual Conference in Rockville, MD, June 12 - 13 3Biologists discover an extra layer of protection for bacterial spores 2Stevens team places third in 2010 IEEE/NIST Mobile Microrobotics Challenge 2
... The TSQ Quantum Ultra defines a new ... environmental analysis. It features the revolutionary ... a titanium skimmer with superior skimming and ... Its redesigned ion transfer tube lens ...
... to distinguish collagen from muscle in tissue ... Trichrome stain is often used to differentiate ... identify an increase in collagenous tissue. With ... stained red, collagen - blue, fibrin - ...
... of movement counts, similar to an infrared beam ... 6 subjects at once, in two frames of ... a sync pulse to coordinate with other signals ... and timing information to control arena rotations or ...
... Ultrapure ACS Reagent Grade C 19 H ... Weight: 691.95 PRODUCT SPECIFICATIONS Form: Powder Clarity ... pH 3.0 - Yellow pH ... tracking dye in agarose and acrylamide gel ...
Biology Products: