Navigation Links
USC researchers discover genetic mutation causing excessive hair growth
Date:6/3/2011

Los Angeles, Calif., June 2, 2011Researchers in the Keck School of Medicine of the University of Southern California (USC), together with scientists in Beijing, China, have discovered a chromosomal mutation responsible for a very rare condition in which people grow excess hair all over their bodies. Investigators hope the finding ultimately will lead to new treatments for this and less severe forms of excessive hair growth as well as baldness.

The study, "X-linked congenital hypertrichosis syndrome is associated with interchromosomal insertions mediated by a human-specific palindrome near SOX3," will appear in the June 2, 2011 issue of the American Journal of Human Genetics.

Pragna Patel, professor in the Keck School, the USC Institute for Genetic Medicine, and the Herman Ostrow School of Dentistry of USC, is a co-investigator of the study, and Sunju Choi, a research associate in Patel's lab, is a co-first author. The principal investigator is Xue Zhang, professor and chair of medical genetics at the Peking Union Medical College.

The initial discovery of the mutation came from Zhang's lab, which examined the condition, known as CGH, in a Chinese family. Researchers there worked with Choi to confirm the finding in a Mexican family that Patel first began studying in 1993. Males with this disorder have hair covering their entire face including their eyelids and their upper body, while females have thick patches of hair on their bodies.

"In 1995, we traced the approximate location of the mutation responsible for CGH to a section of the X chromosome in the Mexican family," said Patel, whose laboratory focuses on understanding the genetic basis of inherited diseases. "We sequenced nearly 100 genes but could not find any mutations. Then recently, Xue Zhang and his colleagues in Beijing were able to pinpoint the exact location, discovering that there was an insertion of chromosome 5 into the X chromosome in the Chinese fami
'/>"/>

Contact: Leslie Ridgeway
leslie.ridgeway@usc.edu
323-442-2823
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Eating dirt can be good for the belly, researchers find
2. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
3. UNH researchers receive grant for pioneering carbon cycle model
4. Penn researchers help nanoscale engineers choose self-assembling proteins
5. Researchers from the Viikki Biocenter discover how plants control the formation of wood cells
6. Researchers solve mammoth evolutionary puzzle: The woollies werent picky, happy to interbreed
7. What is a laboratory mouse? Jackson, UNC researchers reveal the details
8. MDC researchers discover key molecule for stem cell pluripotency
9. Researchers track the secret lives of feral and free-roaming house cats
10. UTHealth researchers find diabetics at higher risk of tuberculosis infection
11. UT Southwestern researchers find protein breakdown contributes to pelvic organ prolapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... week that the U.S. surgeon general issued a 101-page ... Montana State University published a paper breaking new ground ... cell responds when exposed to ultraviolet (UV) light. ... by the UV rays found in sunlight. This damage ... eye diseases. , "Our paper advances foundational knowledge ...
(Date:7/31/2014)... Most people are familiar with Hibiscus flowers- they ... where they are commonly planted in the landscape. ... - are endangered species. , Only a relatively ... aware of an equally beautiful and intriguing related ... literally "brother of Hibiscus". , Brother of Hibiscus ...
(Date:7/31/2014)... , July 31, 2014 ... unique and innovative smart technologies; companies turn towards digital ... EBAY ), Amazon.com Inc. (NASDAQ: AMZN ... Inc. (NASDAQ: GOOG ) and Microsoft Corporation ... company focused on the growing m-commerce market, announces a ...
Breaking Biology News(10 mins):New paper describes how DNA avoids damage from UV light 2New paper describes how DNA avoids damage from UV light 3Brother of Hibiscus is found alive and well on Maui 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 3Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 4Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 5Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 6
... cancer have remained largely unchanged over the past 60 years, ... disease with a very different theory of its origin that ... a billion years ago. In this month,s ... "physics of cancer", Paul Davies, principal investigator at Arizona State ...
... In the world, there are a lot of small ... at least convert to something useful, according to University ... dioxide, the greenhouse gas most responsible for far-reaching effects ... that can be transformed into the valuable agricultural fertilizer ...
... Ann Liebert, Inc., publishers announces the launch of ... innovative, peer-reviewed journal on this rapidly growing disruptive technology. ... 2013, and quarterly thereafter in 2014. Editor-in-Chief Hod Lipson, ... Lab at the Sibley School of Mechanical and Aerospace ...
Cached Biology News:Cancer is a result of a default cellular 'safe mode,' physicist proposes 2Diamond catalyst shows promise in breaching age-old barrier 2
(Date:7/31/2014)... July 31, 2014 According to ... "Electrodes for Medical Devices Market (Diagnostic Electrodes - ECG, ... - TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - ... 2013 - 2019," the global electrodes market for medical ... and is estimated to reach a market worth USD ...
(Date:7/31/2014)... Senomyx , Inc. (NASDAQ: ... taste science technologies to discover, develop, and commercialize ... ingredient supply industries, today reported financial results for ... second quarter with $33.6 million in cash and ... past quarter Senomyx achieved another important milestone with ...
(Date:7/31/2014)... Calif. (PRWEB) July 31, 2014 Held ... diagnosed patients with an overview of the disease and ... of drug side effects, as well as updates on ... grateful to Dr. Sandy Srinivas for organizing this educational ... of kidney cancer. “Sandy and her colleagues have put ...
(Date:7/31/2014)... Canada (PRWEB) July 31, 2014 ... some of the first transcriptome-wide analyses appearing around ... standard assay for RNA measurement. In the last ... throughput, more specific, work with smaller input amounts, ... tissues (eg, blood samples). On the bioinformatics side, ...
Breaking Biology Technology:Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2
... agents is time-consuming and expensive. Pharmaceutical companies may have ... bind a target molecule before they hit upon a ... Munich led by Professor Dieter Braun, a member of ... a partner in NanoTemper (an LMU spin-off), have now ...
... New ... ... 2010 -- Model N , Inc., the leader in Revenue Management solutions, today ... Model N Revenue Management Suite by allowing business users to rapidly develop contract documents ...
... ... ... ... ...
Cached Biology Technology:A hot road to new drugs 2Model N Extends its Industry-Leading Contract Management Offerings with Contract Authoring Capabilities 2Model N Extends its Industry-Leading Contract Management Offerings with Contract Authoring Capabilities 3Model N Extends its Industry-Leading Contract Management Offerings with Contract Authoring Capabilities 4Model N Extends its Industry-Leading Contract Management Offerings with Contract Authoring Capabilities 5Transgenomic Licenses IP From IntegraGen to Develop Genetic Test for Autism 2Transgenomic Licenses IP From IntegraGen to Develop Genetic Test for Autism 3Transgenomic Licenses IP From IntegraGen to Develop Genetic Test for Autism 4Transgenomic Licenses IP From IntegraGen to Develop Genetic Test for Autism 5Transgenomic Licenses IP From IntegraGen to Develop Genetic Test for Autism 6
... for the use of small interfering RNA ... the RNA interference (RNAi) pathway have generated ... biology fields. siRNA for experimental use can ... enzymatically, and then transfected into the target ...
... potential applications for the use of small ... expression via the RNA interference,(RNAi) pathway have ... molecular biology fields. siRNA for experimental use ... enzymatically, and then transfected into the target ...
... The HybArray 12™ is an automated hybridization ... The system automates both the hybridization and ... glass slides. A single instrument can process ... in pairs and has multi-protocol software, enabling ...
... is commonly used as a fusion partner ... The GSTTag sequence has been reported to ... the solubility of its fusion partners. When ... GSTTag fusion proteins can be purified with ...
Biology Products: