Navigation Links
USC researchers discover genetic mutation causing excessive hair growth
Date:6/3/2011

Los Angeles, Calif., June 2, 2011Researchers in the Keck School of Medicine of the University of Southern California (USC), together with scientists in Beijing, China, have discovered a chromosomal mutation responsible for a very rare condition in which people grow excess hair all over their bodies. Investigators hope the finding ultimately will lead to new treatments for this and less severe forms of excessive hair growth as well as baldness.

The study, "X-linked congenital hypertrichosis syndrome is associated with interchromosomal insertions mediated by a human-specific palindrome near SOX3," will appear in the June 2, 2011 issue of the American Journal of Human Genetics.

Pragna Patel, professor in the Keck School, the USC Institute for Genetic Medicine, and the Herman Ostrow School of Dentistry of USC, is a co-investigator of the study, and Sunju Choi, a research associate in Patel's lab, is a co-first author. The principal investigator is Xue Zhang, professor and chair of medical genetics at the Peking Union Medical College.

The initial discovery of the mutation came from Zhang's lab, which examined the condition, known as CGH, in a Chinese family. Researchers there worked with Choi to confirm the finding in a Mexican family that Patel first began studying in 1993. Males with this disorder have hair covering their entire face including their eyelids and their upper body, while females have thick patches of hair on their bodies.

"In 1995, we traced the approximate location of the mutation responsible for CGH to a section of the X chromosome in the Mexican family," said Patel, whose laboratory focuses on understanding the genetic basis of inherited diseases. "We sequenced nearly 100 genes but could not find any mutations. Then recently, Xue Zhang and his colleagues in Beijing were able to pinpoint the exact location, discovering that there was an insertion of chromosome 5 into the X chromosome in the Chinese fami
'/>"/>

Contact: Leslie Ridgeway
leslie.ridgeway@usc.edu
323-442-2823
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Eating dirt can be good for the belly, researchers find
2. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
3. UNH researchers receive grant for pioneering carbon cycle model
4. Penn researchers help nanoscale engineers choose self-assembling proteins
5. Researchers from the Viikki Biocenter discover how plants control the formation of wood cells
6. Researchers solve mammoth evolutionary puzzle: The woollies werent picky, happy to interbreed
7. What is a laboratory mouse? Jackson, UNC researchers reveal the details
8. MDC researchers discover key molecule for stem cell pluripotency
9. Researchers track the secret lives of feral and free-roaming house cats
10. UTHealth researchers find diabetics at higher risk of tuberculosis infection
11. UT Southwestern researchers find protein breakdown contributes to pelvic organ prolapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... 2015  It is gratifying to see that the ... genomic science as a means to better understand human ... I was honored to participate in today,s White House ... Since the 1980s my teams have ... first sequenced genome of a free living organism, the ...
(Date:1/22/2015)... /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics industry news, ... website design. "When we launched FindBiometrics 12 years ... O,Neill , founder and CEO of FindBiometrics. "Now it,s maturing ... the key players on a very broad scale.  We are ...
(Date:1/22/2015)...  A man-made form of insulin delivered by nasal spray ... adults with mild cognitive impairment and Alzheimer,s disease dementia, ... Wake Forest Baptist Medical Center. The study,s ... impairment (MCI) or mild to moderate Alzheimer,s dementia (AD). ...
Breaking Biology News(10 mins):J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3
... forms far deeper than geologists previously thought, according to new ... of Rice University put very small samples of peridotite, rock ... The scientists found that the rock can and does ... those found as deep as 250 kilometers down in the ...
... conditions lead to what kinds of bacterial infections? If doctors ... pre-treatment with certain kinds of antibiotics. A University of Colorado ... International Journal of Infectious Diseases shows the answer: ... especially prevalent in patients with lung and GI cancers, more ...
... Kan. -- A competitive grant is helping a Kansas ... spreading one of the worst plant diseases into a ... Badillo-Vargas, a plant pathology doctoral student, Puerto Rico, recently ... $71,000 from the U.S. Department of Agriculture,s National Institute ...
Cached Biology News:Magma in Earth's mantle forms deeper than once thought 2Magma in Earth's mantle forms deeper than once thought 3Planning for bacteria in cancer patients may help hospitals fight infections 2USDA grant advancing deadly plant disease, insect research 2
(Date:3/6/2015)... , March 6, 2015   InspireMD, Inc. (NYSE ... protection systems, announced today that it will release its full ... 31, 2014 on Thursday, March 12 th after market ... to review its financial results and business outlook. ... ) or (412) 542-4135 (International) and request the InspireMD call. ...
(Date:3/6/2015)... , March 6, 2015 BioSpecifics Technologies ... developing first in class collagenase-based products marketed as XIAFLEX ... U.S. and XIAPEX ®  in the EU, announced today ... audio webcast at 8:30 a.m. ET on Friday, March ... year 2014 financial results and provide a corporate update. ...
(Date:3/6/2015)... March 6, 2015 ... 2011 von der Assistance Publique - Hôpitaux ... Sie ist eine französische, gemeinschaftliche, randomisierte Kontrollstudie ... rekrutiert wurden. Verglichen werden Patienten mit fortgeschrittenem ... Harz-Mikrosphären oder Sorafenib behandelt wurden. Die Ergebnisse ...
(Date:3/5/2015)... 05, 2015 Plant disease specialists from ... at the Annual Meeting of The American Phytopathological Society. ... released online now at APSnet.org/meet . , The ... meeting, to be held August 1-5, 2015 in Pasadena, ... Field Trips, Workshops, and committee meetings, all carefully balanced ...
Breaking Biology Technology:InspireMD to Report Financial Results for the Fourth Quarter and Year Ended December 31, 2014 on Thursday, March 12th 2BioSpecifics Technologies Corp. to Host Conference Call to Report Fourth Quarter and Full Year 2014 Financial Results on Friday, March 13, 2015 2Behandlung von primärem Leberkrebs: SARAH-Studie schließt Rekrutierung ab, Ergebnisse werden für Ende 2016 erwartet 2Behandlung von primärem Leberkrebs: SARAH-Studie schließt Rekrutierung ab, Ergebnisse werden für Ende 2016 erwartet 3Behandlung von primärem Leberkrebs: SARAH-Studie schließt Rekrutierung ab, Ergebnisse werden für Ende 2016 erwartet 4Behandlung von primärem Leberkrebs: SARAH-Studie schließt Rekrutierung ab, Ergebnisse werden für Ende 2016 erwartet 5Behandlung von primärem Leberkrebs: SARAH-Studie schließt Rekrutierung ab, Ergebnisse werden für Ende 2016 erwartet 6American Phytopathological Society Announces Annual Meeting Daily Schedule 2
... 15, 2010 Ocera Therapeutics, Inc. announced today ... safety and pharmacokinetics of OCR-002 (ornithine phenylacetate) which ...  OCR-002 recently received Orphan Drug status and Fast ... Drug Administration for the treatment of hyperammonemia (excessive ...
... brain-machine interface designed to help paralyzed subjects move objects with ... arm providing sensory feedback, a new study from the University ... into the movement of a computer cursor or an external ... these early systems, vision was the only tool a subject ...
... 2010 The Association for Career and Technical Education ... Role in Worker Retraining" that describes how career and ... adults and providing them the skills needed to re-enter the ... not only focus on local employment needs, but are also ...
Cached Biology Technology:Ocera Therapeutics Completes First in Human Studies with OCR-002 for the Treatment of Hyperammonemia and Hepatic Encephalopathy 2Ocera Therapeutics Completes First in Human Studies with OCR-002 for the Treatment of Hyperammonemia and Hepatic Encephalopathy 3Robot arm improves performance of brain-controlled device 2Robot arm improves performance of brain-controlled device 3ACTE Releases Issue Brief Outlining Critical Role CTE Plays in Worker Retraining 2
... The product contains 5 ml of ... to release mouse CD4+ T cells from ... isolated mosue CD4+ T cells from Dynabeads ... isolated cells are suitable for any downstream ...
Porcine IFN-gamma ELISpot Development Module...
...
Request Info...
Biology Products: