Navigation Links
USC researchers discover genetic mutation causing excessive hair growth
Date:6/3/2011

Los Angeles, Calif., June 2, 2011Researchers in the Keck School of Medicine of the University of Southern California (USC), together with scientists in Beijing, China, have discovered a chromosomal mutation responsible for a very rare condition in which people grow excess hair all over their bodies. Investigators hope the finding ultimately will lead to new treatments for this and less severe forms of excessive hair growth as well as baldness.

The study, "X-linked congenital hypertrichosis syndrome is associated with interchromosomal insertions mediated by a human-specific palindrome near SOX3," will appear in the June 2, 2011 issue of the American Journal of Human Genetics.

Pragna Patel, professor in the Keck School, the USC Institute for Genetic Medicine, and the Herman Ostrow School of Dentistry of USC, is a co-investigator of the study, and Sunju Choi, a research associate in Patel's lab, is a co-first author. The principal investigator is Xue Zhang, professor and chair of medical genetics at the Peking Union Medical College.

The initial discovery of the mutation came from Zhang's lab, which examined the condition, known as CGH, in a Chinese family. Researchers there worked with Choi to confirm the finding in a Mexican family that Patel first began studying in 1993. Males with this disorder have hair covering their entire face including their eyelids and their upper body, while females have thick patches of hair on their bodies.

"In 1995, we traced the approximate location of the mutation responsible for CGH to a section of the X chromosome in the Mexican family," said Patel, whose laboratory focuses on understanding the genetic basis of inherited diseases. "We sequenced nearly 100 genes but could not find any mutations. Then recently, Xue Zhang and his colleagues in Beijing were able to pinpoint the exact location, discovering that there was an insertion of chromosome 5 into the X chromosome in the Chinese fami
'/>"/>

Contact: Leslie Ridgeway
leslie.ridgeway@usc.edu
323-442-2823
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Eating dirt can be good for the belly, researchers find
2. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
3. UNH researchers receive grant for pioneering carbon cycle model
4. Penn researchers help nanoscale engineers choose self-assembling proteins
5. Researchers from the Viikki Biocenter discover how plants control the formation of wood cells
6. Researchers solve mammoth evolutionary puzzle: The woollies werent picky, happy to interbreed
7. What is a laboratory mouse? Jackson, UNC researchers reveal the details
8. MDC researchers discover key molecule for stem cell pluripotency
9. Researchers track the secret lives of feral and free-roaming house cats
10. UTHealth researchers find diabetics at higher risk of tuberculosis infection
11. UT Southwestern researchers find protein breakdown contributes to pelvic organ prolapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Toronto Scarborough research shows that male black widow spiders ... a rare example of mate preference by male spiders. ... Emily MacLeod and Maydianne Andrade, a professor in UTSC,s ... studies and the wild that males overwhelmingly chose to ... black widows can tell whether a potential mate is ...
(Date:4/23/2014)... Scientists have conclusive evidence that the source of a ... Ocean and called the "bio-duck," is the Antarctic minke ... by submarine personnel in the 1960s who thought it ... recorded at various locations in the Southern Ocean, but ... In February 2013, an international team of researchers deployed ...
(Date:4/23/2014)... accurate group decision increases with the abundance of brains ... a variety of factors as often happens in ... smaller groups actually tend to make more accurate decisions ... certain pieces of information. , The findings present a ... or the "wisdom of crowds," wherein individual observations ...
Breaking Biology News(10 mins):Picky male black widow spiders prefer well-fed virgins 2Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3
... ARBOR, Mich. Researchers from the University of Michigan ... overexpressed in 90 percent of pancreatic cancers, the most ... Ataxia Telangiectasia Group D Complementing gene, called ATDC, is ... than in cells from a normal pancreas. What,s more, ...
... Germany March 2, 2009 >> Genomatix Software, a ... Next Generation Sequencing (NGS) data, announced today that Boehringer ... Mining Station and a Genomatix Genome Analyzer at its ... the only complete and integrated analysis solution for NGS ...
... of Illinois plant geneticist Stephen Moose has developed a corn ... that would make good silage, Moose said, due to a ... make it a good energy crop. The gene known ... giving corn seedlings a waxy coating that acts like a ...
Cached Biology News:U-M researchers ID gene involved in pancreatic cancer 2Boehringer Ingelheim uses Genomatix' Next Generation Sequencing data analysis systems 2Doubling a gene in corn results in giant biomass 2
(Date:1/15/2014)... RedBrick Health , a fast-growing leader in consumer ... EmblemHealth , the New York ... the RedBrick Compass health assessment, combined with the RedBrick ... members. EmblemHealth is among the first health plans in ...
(Date:1/15/2014)... VA (PRWEB) January 15, 2014 Two ... have continued their sponsorship of an annual competition for ... in, and access to, innovative STEM study. The competition ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... Freeslate, Inc ., the leading provider ... Limited, one of India’s top five pharmaceutical companies, has ... for high throughput solid form screening. , ... wide range of quality, affordable generic and branded formulations ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have ... at 2pm EST (11am PST), “Natural Language Processing: Converting ... how technology can turn raw, heterogeneous data into actionable ... The online webinar will last approximately one hour. , ...
Breaking Biology Technology:EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... Mass. and SYDNEY, Sept. 14, 2011 HeartWare International, ... a leading innovator of less invasive, miniaturized circulatory support ... failure, today announced that CEO Doug Godshall is scheduled ... at 10:30 a.m. ET on Wednesday, September 21, 2011. ...
... Sept. 14, 2011 Tengion, Inc. (NASDAQ: TNGN ... Davis, Vice President Finance and Chief Financial Officer of Tengion, ... on Monday, September 19, 2011, at 1:30 pm EDT. ... accessed under "Calendar of Events" in the Investors section of ...
... 13Researchers at Vanderbilt University have developed a new technique that ... tissue at multiple points simultaneously, a method that could help ... and change shape. UV lasers are a commonly-used ... incisions by vaporizing one point at a time in a ...
Cached Biology Technology:HeartWare to Present at the UBS Global Life Sciences Conference 2Tengion to Present at UBS Global Life Sciences Conference 2
... purified from egg white. The extinction coefficient , ... in 10 mM phosphate-buffered saline, pH ... sodium azide and 50% glycerol. Avidin (from egg ... is purified by molecular sieving and ...
Request Info...
Request Info...
... CELLection Dynabeads (4.5 m) coated with the ... EpCAM and DNase Releasing Buffer. For ... tumour cells directly from blood, bone marrow ... enriched from bone marrow. Enriched cells are ...
Biology Products: