Navigation Links
USC research shows critical role of placenta in brain development
Date:4/21/2011

Research at the Keck School of Medicine of the University of Southern California's (USC) Zilkha Neurogenetic Institute shows for the first time that the human placenta plays an active role in synthesizing serotonin, paving the way to new treatment strategies that could mitigate health impacts such as cardiovascular disease and mental illness.

The groundbreaking findings, conducted with researchers from Vanderbilt University as part of a Silvio Conte Center of Excellence grant from the National Institute of Mental Health, offer conclusive evidence that the placenta provides serotonin to the fetal forebrain, not through the mother's blood supply, as theorized for the past 60 years. The research, "A transient placental source of serotonin for the fetal forebrain," will be published in the journal Nature on April 21, 2011.

"Our research indicates that the placenta actually synthesizes serotonin, and the serotonin is released from the placenta into the fetal bloodstream where it can reach the fetal brain," said lead author Alexandre Bonnin, Ph.D. "The placenta was seen as a passive organ, but we now know that it has significant synthetic capabilities and has a much more critical role in developmental programming of the fetus than previously thought."

Bonnin's work with Pat Levitt, Ph.D., director of the Zilkha Neurogenetic Institute and corresponding author on the paper, included the invention of a unique technology known as a "placentometer" that monitors substances that pass through the mouse placenta from mother to fetus. This technology can incorporate genetic models of human disease, and could lead to targeted therapies that treat the mother without affecting the fetus, or vice versa.

"The findings by Dr. Bonnin and his collaborators open the door for future studies examining the potential role for targeted interventions in high-risk pregnancies where a perturbed intrauterine environment might negatively impact fetal
'/>"/>

Contact: Leslie Ridgeway
leslie.ridgeway@usc.edu
323-442-2823
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. White Mountain Research Station to host climate change conference
4. Stevens awarded $1M for advanced biofuels research
5. Researchers find animal with ability to survive climate change
6. Researchers find an essential gene for forming ears of corn
7. Researchers note differences between people and animals on calorie restriction
8. Researcher working on destruction of chemical weapons
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. The Rett Syndrome Research Trust launches operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... September 29: Between 1970 and 2010 populations of ... globe dropped 52 percent, says the 2014 Living ... (WWF). This biodiversity loss occurs disproportionately in low-income ... high-income countries. , In addition to the precipitous ... to other warning signs about the overall health ...
(Date:9/29/2014)... pizza in school? According to a new Food and ... chef-made meals can increase participation in the National School ... consumption of vegetables by 16%! , Chefs Move to ... campaign, pairs chefs with schools in order to provide ... school food service workers. , A CMTS event was ...
(Date:9/29/2014)... at Arlington research team says recently identified radiation detection ... could open doors for homeland security and medical advances. ... Oct. 1 issue of Optics Letters , UT ... a new method to fabricate transparent nanoscintillators by heating ... transparent ceramic is formed. A scintillator refers to ...
Breaking Biology News(10 mins):Half of global wildlife lost, says new WWF report 2Chefs move to schools can increase school meal participation and vegetable intake among students 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3
... something from a horror movie, the swarm of bacteria ripples ... Researchers at the University of Iowa are studying this behavior ... found in soil, which preys on other bacteria. Despite ... is harmless to humans and might one day be ...
... An Arizona State University research team headed by School ... in more than $6.3 million in awards from the ... of the studies will examine the ecology and evolution ... genetic mysteries behind the host shift of retroviral disease ...
... Congress on Osteoporosis, the largest scientific conference devoted primarily ... with a special session focused on four key topics ... Cooper, Director of the MRC Epidemiology Resource Centre at ... Musculoskeletal Sciences at the University of Oxford, will speak ...
Cached Biology News:Predatory bacterial swarm uses rippling motion to reach prey 2Predatory bacterial swarm uses rippling motion to reach prey 3ASU researchers receive NIH awards for studies of malaria and emergent disease 2ASU researchers receive NIH awards for studies of malaria and emergent disease 3ASU researchers receive NIH awards for studies of malaria and emergent disease 4Nutrition and bone health session to open the IOF World Congress on Osteoporosis in Bangkok 2
(Date:9/30/2014)... in German . ... dots in a semiconductor layer. Quantum dots are small structures ... If a short laser pulse is fired at the photonic ... experiences a change in the electromagnetic field around it. This ... light by the dot. As soon as the refractive index ...
(Date:9/30/2014)... Using a bio-mimicking analog of one of nature,s ... international research team led by Alejandro Briseno of ... major step in developing long-sought polymer architecture to ... use in electronic devices. , Briseno, with ... others at Stanford University and Dresden University of ...
(Date:9/30/2014)... 30, 2014 Shimadzu Scientific Instruments ... easy-to-use and highly precise tool for measuring displacement ... elongation. With 1000-mm maximum movement distance, the DSES-1000 ... a gauge length of 10 mm. In addition, ... above 50-mm stroke and within +/- 100 µm ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Proove ... medicine, is excited to announce a new genetic test ... The Proove Pain Perception Test will provide physicians ... and why pain tolerance levels are stratified between individuals. ... identify whether a person has a genetic predisposition that ...
Breaking Biology Technology:Ultrafast remote switching of light emission 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3
... Rich Nations To ... in Less Affluent Nations, MT. LAUREL, N.J., Aug. ... Declaration of Istanbul on Organ,Trafficking and Transplant Tourism. The ... May 2, 2008, at an International Summit,of more than ...
... ChemAxon, a software,solutions provider for cheminformatics today announced ... Marvin & JChem. As well as,other improvements, the ... for OLE 2 format useful for integrating with ... software suite of application programming,interfaces (API,s) and graphic ...
... 19 Omeros Corporation, a,Seattle-based clinical-stage biopharmaceutical ... therapeutics company, today announced that they,have entered ... development of fully,human antibodies for Omeros, MASP-2 ... activation of the complement,system via the lectin ...
Cached Biology Technology:AST Endorses Istanbul Declaration to End Organ Trafficking and Transplant Tourism 2ChemAxon Launches Marvin and JChem Version 5.1; Name to Structure Generation, OLE 2 and JavaScript Integration 2Affitech and Omeros Enter Into Antibody Discovery and Development Agreement 2Affitech and Omeros Enter Into Antibody Discovery and Development Agreement 3
Lipid Phosphate Phosphohydrolase 2...
Request Info...
Chicken polyclonal to Thioredoxin domain containing 9 ( Abpromise for all tested applications). Antigen: Full length protein (Human) Entrez Gene ID: 10190 Swiss Protein ID: O14530...
... Timp-4 has been reported in heart ... fibroblasts in cell culture conditions. ... TPA stimulates production of TIMP-4 in ... protein levels produced often require concentration ...
Biology Products: