Navigation Links
USC Stem Cell scientists lay a TRAP for disease
Date:7/11/2014

USC Stem Cell scientists have set a "mouse TRAP" to capture the early signs of kidney failure, as described by a recent study published in the Journal of Clinical Investigation. Their new transgenic mouse line uses a technique called TRAP to extract cellular and genetic information from a variety of solid organs.

Invented by scientists at the Rockefeller Institute for Medical Research in 2008, TRAP involves attaching a fluorescent tag to the protein-making machinery, or ribosomes, of the cell type of interest. Scientists can then collect the tagged ribosomes and determine which active genes are ordering proteins to be made by these ribosomes. (TRAP stands for "translating ribosome affinity purification.")

Following up on this breakthrough, the USC team led by Jing Liu, senior research associate in the laboratory of Andy McMahon has made the technique simpler and more accessible by engineering a TRAP mouse. When bred with any one of thousands of existing strains of transgenic mice, the TRAP mouse produces progeny with tagged ribosomes in specific organs or cell types.

To demonstrate how useful this can be, Liu and her colleagues used TRAP mice to tag four different types of kidney cells and identify early signals of acute kidney injury.

As a consequence of surgery, infections or drug toxicity, five to seven percent of all hospitalized patients experience acute kidney injury, which can lead to chronic kidney disease or death.

Currently, doctors can only detect acute kidney injury a full day after it occurs. The TRAP mouse enables earlier detection, which will greatly improve patients' health.

"The technology is simple, and the kidney field is very excited about our results," said Liu. "I anticipate that the TRAP mouse will advance our cellular and molecular understanding of a wide variety of diseases and injuries in many different organ systems."


'/>"/>

Contact: Cristy Lytal
lytal@med.usc.edu
323-442-2172
University of Southern California - Health Sciences
Source:Eurekalert  

Page: 1

Related biology news :

1. Virtual finger enables scientists to navigate and analyze complex 3D images
2. Scientists watch photosynthesis in action
3. Scripps Florida scientists shed new light on nerve cell growth
4. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
5. Scientists discover clues why weight-loss surgery cures diabetes
6. CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms
7. Rockefeller scientists first to reconstitute the DNA replication fork
8. Scripps Florida scientists uncover new compounds that could affect circadian rhythm
9. US scientists dont publish articles about potential role of innate variation in athletic performance
10. Scientists can now screen for stem cells that enhance corneal regrowth
11. Clemson scientists: Kudzu can release soil carbon, accelerate global warming
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
USC Stem Cell scientists lay a TRAP for disease
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock Inc. ... solutions, and MorphoTrust USA (Safran), a ... today announced a strategic partnership to offer comprehensive ... vehicle administration (MVA), airport screening and financial services ... solutions, MorphoTrust serves consumers through a nationwide network ...
(Date:11/12/2014)... 2014 Crossmatch™, a leading provider of biometric ... fingerprint readers have been deployed throughout Montparnasse Pasteleria, ... Mexico . The bakery chain implemented the Crossmatch ... caused by employees clocking in for each other. ... Montparnasse relied on paper timecards and a mechanical time ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... of the sexes may begin in the womb, researchers from ... a male twin can compromise the health of his ... new study recently published in the journal Pediatrics, the researchers ... found in pre-term twins. When born premature, girls who share ...
... reveals a biological link between pain and fatigue and may ... chronic pain and fatigue conditions like fibromyalgia and chronic fatigue ... Sluka, Ph.D., professor in the Graduate Program in Physical Therapy ... A. Carver College of Medicine, found that a protein involved ...
... 7, 2008 The Global Innovation Imperatives (Gii) ... for their first session at the American Chemical ... Gii, a joint collaboration between the ACS Committee ... Industry, seeks to combat worldwide health, environmental and ...
Cached Biology News:War between the sexes begins before twins' birth, TAU researchers say 2U. Iowa study finds biological link between pain and fatigue 2At ACS' national meeting, global initiative set to tackle water issues 2
(Date:11/26/2014)... ADDISON, TX (PRWEB) November 25, 2014 ... age-defying skincare products, earned three prestigious MarCom Awards for ... , Nerium received a Platinum MarCom Award, the organization’s ... Real Event in St. Louis held in April of ... for more than 14,000 attendees. Additionally, Nerium was awarded ...
(Date:11/26/2014)... November 26, 2014 CURE™ magazine ... reception on December 5, 2014, in San Francisco prior ... MPN Heroes event will honor clinicians, caregivers, and advocates ... myeloproliferative neoplasms (MPNs). , Special guest speaker Charles ... family's cancer journey at the reception. Over a ...
(Date:11/26/2014)... -- Roka Bioscience, Inc. (NASDAQ: ROKA ), a molecular ... detection of foodborne pathogens, today announced that Paul G. ... Annual Healthcare Conference on December 2, 2014 at 4:30pm ... Palace in New York, NY . ... its operations, strategies and prospects may be discussed. To listen ...
(Date:11/24/2014)... --   First published articles ... Elsevier , a world-leading provider of scientific, technical and ... launch of the latest title in the Current Opinion ... Science . Current Opinion ... platform to keep up-to-date with the expanding volume of information ...
Breaking Biology Technology:Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2Elsevier Announces Launch of New Journal: Current Opinion in Food Science 2Elsevier Announces Launch of New Journal: Current Opinion in Food Science 3
... SynCo Bio Partners B.V., one of the leading ... filling facility is again fully operational and SynCo has produced ... after the expansion of its Class A zone.   ... important milestone in SynCo,s strategy in supporting its clients with ...
... Creabilis SA, a clinical stage European biotechnology company ... today that Dr David Roblin has been appointed Chief Medical ... the pharmaceutical industry in a career spanning more than 15 ... the market. He has held leadership roles in Pfizer and ...
... novel carbon nanofiber-filled coatings devised by researchers from the ... A&M University outperformed conventional flame retardants used in the ... least 160 percent and perhaps by as much as ... the journal Polymer ,* suggest that significant fire-safety ...
Cached Biology Technology:SynCo Bio Partners Expands the Class A Zone in its Aseptic Filling Facility 2Creabilis Appoints Dr David Roblin as Chief Medical Officer 2Creabilis Appoints Dr David Roblin as Chief Medical Officer 3Novel coatings show great promise as flame retardants in polyurethane foam 2
Mouse monoclonal [3G131] to Desmoglein 1 ( Abpromise for all tested applications). entrezGeneID: 1828 SwissProtID: Q02413...
Synphilin 1 Immunogen: Synthetic peptide corresponding to residues S(829) L E L N G E K D K D K G R T L Q R T(847) of human Synphilin 1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
fli-1...
... 1;The Human Embryonic Stem Cell (hESC) Starter Kit ... to get started culturing hESCs as soon as ... in stem cell training courses around the world, ... these products has been extensively tested using GIBCO's ...
Biology Products: