Navigation Links
USC Stem Cell scientists lay a TRAP for disease
Date:7/11/2014

USC Stem Cell scientists have set a "mouse TRAP" to capture the early signs of kidney failure, as described by a recent study published in the Journal of Clinical Investigation. Their new transgenic mouse line uses a technique called TRAP to extract cellular and genetic information from a variety of solid organs.

Invented by scientists at the Rockefeller Institute for Medical Research in 2008, TRAP involves attaching a fluorescent tag to the protein-making machinery, or ribosomes, of the cell type of interest. Scientists can then collect the tagged ribosomes and determine which active genes are ordering proteins to be made by these ribosomes. (TRAP stands for "translating ribosome affinity purification.")

Following up on this breakthrough, the USC team led by Jing Liu, senior research associate in the laboratory of Andy McMahon has made the technique simpler and more accessible by engineering a TRAP mouse. When bred with any one of thousands of existing strains of transgenic mice, the TRAP mouse produces progeny with tagged ribosomes in specific organs or cell types.

To demonstrate how useful this can be, Liu and her colleagues used TRAP mice to tag four different types of kidney cells and identify early signals of acute kidney injury.

As a consequence of surgery, infections or drug toxicity, five to seven percent of all hospitalized patients experience acute kidney injury, which can lead to chronic kidney disease or death.

Currently, doctors can only detect acute kidney injury a full day after it occurs. The TRAP mouse enables earlier detection, which will greatly improve patients' health.

"The technology is simple, and the kidney field is very excited about our results," said Liu. "I anticipate that the TRAP mouse will advance our cellular and molecular understanding of a wide variety of diseases and injuries in many different organ systems."


'/>"/>

Contact: Cristy Lytal
lytal@med.usc.edu
323-442-2172
University of Southern California - Health Sciences
Source:Eurekalert  

Page: 1

Related biology news :

1. Virtual finger enables scientists to navigate and analyze complex 3D images
2. Scientists watch photosynthesis in action
3. Scripps Florida scientists shed new light on nerve cell growth
4. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
5. Scientists discover clues why weight-loss surgery cures diabetes
6. CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms
7. Rockefeller scientists first to reconstitute the DNA replication fork
8. Scripps Florida scientists uncover new compounds that could affect circadian rhythm
9. US scientists dont publish articles about potential role of innate variation in athletic performance
10. Scientists can now screen for stem cells that enhance corneal regrowth
11. Clemson scientists: Kudzu can release soil carbon, accelerate global warming
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
USC Stem Cell scientists lay a TRAP for disease
(Date:2/16/2017)... Feb. 16, 2017  Genos, a community for ... it has received Laboratory Accreditation from the College ... presented to laboratories that meet stringent requirements around ... rigorous processes. "Genos is committed to ... practices. We,re honored to be receiving CAP accreditation," ...
(Date:2/10/2017)... Research and Markets has announced ... - Scientific and Commercial Aspects" to their offering. ... Biomarkers ... with therapy for selection of treatment as well for monitoring ... of disease in modern medicine. Biochip/microarray technologies and next generation ...
(Date:2/8/2017)... YORK , Feb. 7, 2017 Report Highlights ... The ... should reach $11.4 billion by 2021, growing at a compound ... Includes - An overview of the global markets for synthetic ... 2015, estimates for 2016, and projections of compound annual growth ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... -- Financial Highlights ... unaudited)Three Months Ended December 31,Twelve Months Ended December 31,20162015% ... $           300$   ... Product Revenue 3539(10)%9498(4)%Kuvan Net Product ... 756025%297303(2)%Vimizim Net Product Revenue ...
(Date:2/23/2017)... , Feb. 23, 2017  Seattle,s upscale Capitol Hill neighborhood, ... strange place for a head lice treatment salon to set ... a Tuscan restaurant and a French bistro on E Madison ... "We aren,t just any old lice clinic, we pride ourselves ... comfortable, and release some of the stigma associated with lice. ...
(Date:2/23/2017)... ... February 23, 2017 , ... Today, researchers can fast-track ... uric acid, and/or other biomarkers or SNPs of interest) using one, easy-to-collect saliva ... , the relationship between insulin and other relevant biomarkers can be extensively studied ...
(Date:2/23/2017)... ... February 22, 2017 , ... Seventy-one ... been named Fellows of the Society this year, the Fellows Committee has announced. ... fields of optics, photonics, and imaging as well as their service to the ...
Breaking Biology Technology: