Navigation Links
UNC study: Tinkering with the circadian clock can suppress cancer growth
Date:2/3/2009

ings.

Yet when scientists, including Sancar, began to tinker with the molecular mechanisms within the internal clocks of animal models, they did not always see such an effect. Circadian rhythms in humans and in mice are controlled by "clock genes," four of which are absolutely essential. In a study four years ago, Sancar found that deleting the clock gene cryptochrome in mice did not increase the incidence of cancer as had previously been expected.

While altering the clock gene did not cause cancer in otherwise normal mice, Sancar and his colleagues wanted to see if it would accelerate the development of tumors in a mouse model that is already predisposed to cancer. Therefore, in this study they modified the cryptochrome gene in mice that also had defects in a gene called P53, which is mutated in nearly half of human cancers. The researchers found that disturbing the internal clock in these mice did not speed up the onset of cancer, but instead had the opposite effect it extended their lives by 50 percent.

The researchers then wanted to know how interfering with the cryptochrome gene had reduced the incidence of cancer. By closely examining the series of biological events in the disease's development, they determined that the mutation of this clock gene reactivates the intracellular signals that can eliminate cancerous cells. Sancar said this tactic essentially makes cancer cells more likely to commit cell suicide through a process known as apoptosis in response to the stresses of UV radiation or chemotherapy.

"These results suggest that altering the function of this clock gene, at least in the 50 percent of human cancers associated with p53 mutations, may slow the progression of cancer," Sancar said. "In combination with other approaches to cancer treatment, this method may one day be used to increase the success rate of remission."

The research was supported by the National Institutes of Health. Study co-authors from S
'/>"/>

Contact: Leslie Lang
llang@unch.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study: diabetic neuropathy costs billions per year in lost work time
2. Study: Fountain of youth for your heart?
3. First-ever study: lack of critical lubricant causes wear in joints
4. Mayo Clinic study: Ossurs collars superior in immobilization and reduction of pressure
5. Study: weight-loss tips differ in African-American, mainstream magazines
6. Smithsonian study: Sediment prediction tools off the mark
7. Mouse study: When it comes to living longer, its better to go hungry than go running
8. Geisinger study: Inflammatory disease causes blindness
9. Stanford study: Bioenergy potential of reviving abandoned agricultural land
10. U-M study: Herceptin targets breast cancer stem cells
11. Study: Future snowmelt in West twice as early as expected; threatens ecosystems and water reserves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... led by researchers at the University of Massachusetts ... Miller School of Medicine (UMMSM) have identified what ... (manic depressive) disorder, a breakthrough that could lead ... as well as depression and other related mood ... week in Nature Molecular Psychiatry , show ...
(Date:10/14/2014)... takes between 10 and 20 years to develop, ... of intervention if detected early, which may be ... Australian clinical researchers. , Dr Jeremy Humphris ... of Medical Research, analysed medical histories and tumour ... cancer patients, operated on between 1994 and 20122. ...
(Date:10/14/2014)... Stanford University School of Medicine have discovered a link ... activation of muscle stem cells. Cells use autophagy to ... of nutrient deprivation. The scientists report in The ... operational it also seems to assist in the activation ... cells emerge from a quiescent state there is a ...
Breaking Biology News(10 mins):Rare genetic disease protects against bipolar disorder 2Rare genetic disease protects against bipolar disorder 3Early detection window when pancreatic cancer is in the family 2Autophagy helps fast track stem cell activation 2
... Weiblen and colleagues have found a faster way to ... Using a technique called DNA barcoding, which involves the ... and an international team of researchers studied populations of ... DNA barcodes showed that migratory patterns and caterpillar diets ...
... The humble papaya is gaining credibility in Western ... for generations. University of Florida researcher Nam Dang, ... dramatic anticancer effect against a broad range of lab-grown ... and pancreas. The researchers used an extract made from ...
... Subhash Khot, an associate professor at the Courant Institute ... 2010 Alan T. Waterman Award, which is given annually ... science and engineering supported by NSF. The honor includes ... research or advanced study in any field of science. ...
Cached Biology News:Papaya extract thwarts growth of cancer cells in lab tests 2NYU Courant professor wins NSF's Waterman Award 2
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and ... and forecast of revenue. , Browse through the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bromine market, and is ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile ...
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, Sugar ... Trend and Forecast (2011 - 2016)," analyzes the ... studies the major market drivers, restraints, and opportunities for ... , The global chocolate market is expected to grow ... at an estimated CAGR of 2.7% from 2011 to ...
(Date:10/19/2014)... 19, 2014 According to market ... Points; WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts ... the global Outdoor Wi-Fi market with analysis and ... MarketsandMarkets also identifies the drivers and the restrains ... trends, opportunities and challenges. , Browse 65 market ...
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application and By ... the global market on the basis of its ... such as the key drivers, current trends and ... 81 Market Data Tables and 29 Figures spread ... Market by Application and by Geography - Trends ...
Breaking Biology Technology:The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5
... 18 ,Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in ... will release its financial,results for the full year 2008 ... Time (CET). To discuss these results, the Company will,conduct ... , The dial-in number for ...
... NEWTOWN, Pa., Feb. 18 Jennifer Brownstein, ... been named a 2009 Rising Star by ... Stars are up-and-coming professionals in various sectors ... advertising, public relations, medical education, and market ...
... Feb. 18 A new clinical study published this month ... reports that high-quality patient outcomes for breast-conserving surgery can be ... the few and the most recent studies of its kind ... breast cancer patients in the United States are treated at ...
Cached Biology Technology:AMT to Release Full Year 2008 Results on February 24, 2009 2Jennifer Brownstein, of CONNEXION Healthcare, Honored as 'Rising Star' by Healthcare Businesswomen's Association 2New Study Reports Improved Patient Outcomes for Breast Cancer Patients 2New Study Reports Improved Patient Outcomes for Breast Cancer Patients 3
Request Info...
... CultureWell cell culture systems provide ... cultured cells for staining and ... silicone gaskets preassembled with standard ... plates. The entire system is ...
... Captivate magnetic separator for ... used in conjunction with the ... C-21476) or other magnetic particles ... 96-well microplates. Cell Biology Cell ...
ANTI L-DOPA...
Biology Products: