Navigation Links
UMass Medical School researchers discover a new role for RNAi
Date:6/26/2012

WORCESTER, MA Organisms employ a fascinating array of strategies to identify and restrain invasive pieces of foreign DNA, such as those introduced by viruses. For example, many viruses produce double-stranded (ds)RNA during their life cycle and the RNA interference (RNAi) mechanism is thought to recognize this structural feature to initiate a silencing response.

Now, UMass Medical School researchers have identified a mechanism related to RNAi that scans for intruders not by recognizing dsRNA or some other aberrant feature of the foreign sequence, but rather by comparing the foreign sequences to a memory of previously expressed native RNA. Once identified, an "epigenetic memory" of the foreign DNA fragments is created and can be passed on from one generation to the next, permanently silencing the gene.

A remarkable feature of this RNAi-related phenomenon (referred to as RNA-induced epigenetic silencing, or RNAe), is that the animal carries a memory of previous gene expression. This memory of active genes serves as an "anti-silencing" signal, which protects native genes from RNAe and under some circumstances appears to adopt foreign genes as self. These findings, described in three studies (including a study by Eric Miska and colleagues of the Gurdon Institute, University of Cambridge and Wellcome Trust, UK) published online yesterday and to appear in the July 6 issue of Cell, provide new insights into how identical organisms can have the same DNA sequence but opposite patterns of gene expression and thus dramatically different phenotypes.

"If a worm modulates gene expression by carrying a memory of the genes it expressed in previous generations, perhaps other organisms (including humans) can as well. If so, mechanisms of this type could have an important impact on evolution," said Craig C. Mello, PhD, Howard Hughes Medical Institute Investigator, Blais University Chair in Molecular Medicine and distinguished professor of mole
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. UMass Medical School scientist named 2012 Pew Latin-American Fellow in the Biomedical Sciences
2. UMass Amherst wildlife researcher photographs rare Sumatran rabbit
3. Chemical engineers at UMass Amherst find high-yield method of making xylene from biomass
4. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
5. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
6. Resveratrol may be a natural exercise performance enhancer: U of A medical research
7. Top young Latin-American scientists named Pew Biomedical Fellows
8. 22 of Americas most promising scientists selected as Pew Biomedical Scholars
9. NIST effort could improve high-tech medical scanners
10. ESMO 2012 Congress: A path for medical oncology innovations
11. Nanotechnology breakthrough could dramatically improve medical tests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... , June 17, 2015  Crossmatch™, a leading ... that its U.are.U ® 4500 fingerprint readers ... Eateries, Inc., a San Jose, ... to increase security, improve accountability and reduce fraud ... instant, non-repudiable identity confirmation for employee sign in ...
(Date:6/15/2015)... According to a new market research report ... Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) ... Natural Language Processing Market is expected to grow to ... forecast period 2015-2020. Browse 65 market ...   through 155 P ages and in-depth TOC ...
(Date:6/10/2015)... 2015 According to a ... Technology (Ultrasound, TOF, Structured Light, Stereo Vision), Type(Image, ... and by Geography - Trends & Forecast to ... is expected to reach $3,319.71 Million by 2020, ... and 2020. Browse 71 market data ...
Breaking Biology News(10 mins):Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 53D Sensor Market Worth $3,319.71 Million by 2020 23D Sensor Market Worth $3,319.71 Million by 2020 33D Sensor Market Worth $3,319.71 Million by 2020 4
... , Sludge obtained from water purification plants can be ... their acidity. The main aim of this University of the ... effects of the application of EDAR (Estacin Depuradora de Aguas ... chemical properties of the soil and on the water filtering ...
... 7 WCC Smart Search & Match, the,leading ... that Tarvinder Sembhi has joined the company as ... Mr. Sembhi is a ... He was most recently President of 4G Identity ...
... code into the proteins of life is nothing if ... reporting this week in Nature , have discovered ... translational tools called the ribosome recognizes errors, just after ... of a "delete" button. It turns out, the ...
Cached Biology News:Adding high doses of sludge to neutralize soil acidity not advisable 2Lost in translation 2
(Date:7/1/2015)... ... July 01, 2015 , ... The next-generation sequencing (NGS) clinical ... segments, including the molecular diagnostics industry. BCC Research reveals in its new report that ... lower test costs, and a growing need for better diagnostics as part of a ...
(Date:7/1/2015)... HAMILTON, Bermuda , July 1, 2015 /PRNewswire/ ... biopharmaceutical company focused on the treatment of dementia, ... investor briefing on July 22 at 5:45 p.m. ... at the Alzheimer,s Association International Conference 2015 (AAIC). ... following remarks: , Dr. Lawrence ...
(Date:7/1/2015)... July 1, 2015 InferMed ... will ... evidence-based clinical s olutions suite   ... medical information products and services, announced today the acquisition of  ... support (CDS) technology company. InferMed,s Arezzo technology supports ...
(Date:7/1/2015)... NEW YORK , July 1, 2015 /PRNewswire/ ... G ), a global leader in designing, ... the Aecus Innovation Award in recognition of their ... operational efficiencies in UCB,s global business services (GBS) ... acknowledge service providers and clients that work together ...
Breaking Biology Technology:NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5
... NorthPoint Domain, an IC Sciences,company, announced today a ... Langone Medical Center to develop a comprehensive suite,of ... on a shared commitment to excellence in vascular ... clinicians with new,tools to inform, engage, and shepherd ...
... DD ),today announced the addition of Deepak ... Biotechnology Advisory Panel. They join the ranks of,six ... to the,broad area of biotechnology and its application ... a professor of Genetics and Vice Chancellor for ...
... Mass., May 5 PLC Systems Inc.,(Amex: PLC ) ... wire its,financial results for the first quarter ended March 31, ... company plans to host a,conference call to discuss those results ... call may be joined via telephone by dialing (800) 638-4930 ...
Cached Biology Technology:NorthPoint Domain and NYU Vascular Associates Partner to Develop New Generation of Care Delivery Informatics Instruments 2NorthPoint Domain and NYU Vascular Associates Partner to Develop New Generation of Care Delivery Informatics Instruments 3DuPont Strengthens Commitment to Responsible Science with New Biotech Advisory Panel Members 2DuPont Strengthens Commitment to Responsible Science with New Biotech Advisory Panel Members 3PLC Systems to Host First Quarter Conference Call on May 15, 2008 2
... a compact, lightweight, high current power supply capable ... milliamps. It is an excellent choice for PAGE, ... is also ideal for all types of electroblotting ... to automatically end a run and wil automatically ...
Human interferon-beta (IFN-beta). Recognizes amino acids 30-47 of IFN-beta. No cross-reactivity with Human IFN-alpha or IFN-gamma....
... in Refrigerated Vapor Trap Models RVT100, RVT400, ... Models UVS400, UVS400A and UVS800DDA., A non-corrosive, ... use for temperatures ranging from -105 to ... stability and does not evaporate. Far superior ...
Acetate Plate Sealers 100/Box...
Biology Products: