Navigation Links
UMass Amherst researchers develop powerful new technique to study protein function
Date:6/19/2013

AMHERST, Mass. In the cover story for the journal Genetics this month, neurobiologist Dan Chase and colleagues at the University of Massachusetts Amherst describe a new experimental technique they developed that will allow scientists to study the function of individual proteins in individual cell types in a living organism.

The advance should allow deeper insights into protein function, Chase says, "because we can only get a true understanding of what that single protein does when we isolate its function in a living organism. There was no tool currently available to do this."

The journal's cover art uses a jigsaw puzzle of a worm to illustrate how knockdown strategies in this organism have evolved over time to achieve more and more cell-type specificity, culminating in the new approach developed by the Chase lab, which can restrict knockdown to a single cell type.

"This strategy is super cool and it works great," he says. "We've already used it to tease apart some of the mechanisms of dopamine signaling, but the strategy can be adapted to study the function of any protein involved in any biological process."

There are more than 1 trillion cells in the human body, yet only 20,000 to 25,000 genes are expressed in them, Chase explains, so each gene must be expressed in many different cells. Understanding the function of 20,000 genes and whether this differs by cell type has been difficult, but over the last 10 years, he adds, "we have learned that the answer to this last question is a resounding yes. Gene function can differ by cell type."

Pursuing this further, however, was hampered by the fact that traditional approaches for studying protein function rely on genetic mutations that act on DNA, so they disrupt protein function in ALL cells. And to understand what a protein really does, it must be studied in an individual cell in a living organism.

Specifically, Chase's lab uses the roundworm C
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UMass Amherst researchers reveal mechanism of novel biological electron transfer
2. UMass Medical School faculty elected to the American Association for the Advancement of Science
3. UMass Amherst biochemists developing tools to stop plague and other bacterial threats
4. UMass Medical School researchers discover a new role for RNAi
5. UMass Medical School scientist named 2012 Pew Latin-American Fellow in the Biomedical Sciences
6. UMass Amherst wildlife researcher photographs rare Sumatran rabbit
7. Chemical engineers at UMass Amherst find high-yield method of making xylene from biomass
8. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
9. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
10. Saint Louis University researchers discover a way to detect new viruses
11. OU researchers collaborate on $20 million NSF EPSCoR grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... June 30, 2015 To bolster its efforts and ... Corp. announced today the addition of two new team members. ... board advisor and David Raviv will act as ... HYPR Corp.,s commitment to providing the most secure solutions for ... co-founded Layer 7 Technologies, a provider of security and ...
(Date:6/30/2015)... June 30, 2015 Genisphere announced ... CEO to help further develop Genisphere,s therapeutics capabilities and ... experience, having spent much of the last 25 years ... Baxter Bioscience, and Johnson & Johnson. Tom started his ... and Biotech Corporate Finance. He graduated from Dartmouth College ...
(Date:6/29/2015)... June 24, 2015 Research ... the "Latin America Biomedical Sensors Market - Growth, ... The Latin America Biomedical Sensors market is ... of 2.04% over the period 2014-2020 The ... to the genetic formulation of each individual. These sensors ...
Breaking Biology News(10 mins):HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Latin America Biomedical Sensors Market Report 2015-2020 2
... JISC Collections has purchased the archive content of ... protocols. With immediate effect the SpringerProtocols archive content ... of charge to UK Higher and Further Education ... than 31,000 protocols, most of which come from ...
... , May 2, 2013 CDX Diagnostics, Inc ... ), filed a patent infringement action against Histologics, LLC, ... Pathology, LLP d/b/a Avero Diagnostics (collectively, "Defendants") in the ... New York . According to court ...
... New discoveries of the way plants transport important substances ... pests, increase salt and drought tolerance, control water loss ... the supply of food and energy for our rapidly ... 12 leading plant biologists from around the world whose ...
Cached Biology News:JISC Collections purchases SpringerProtocols 2Shared Medical Resources, LLC files suit against Histologics, LLC, Women's Health Laboratories and Avero Diagnostics for Willful Patent Infringement 2New plant protein discoveries could ease global food and fuel demands 2New plant protein discoveries could ease global food and fuel demands 3New plant protein discoveries could ease global food and fuel demands 4
(Date:7/1/2015)... N.C. and PARIS ... firm AgBiome, and Genective, key developer of biotech ... the discovery of new generations of insect control ... insect control to counter the realities of advancing ... Genective, aligning AgBiome,s unique insect control technology with ...
(Date:7/1/2015)... July 1, 2015   Decision Resources Group ... advantages of Otezla are its oral administration, alternative ... reported by surveyed rheumatologists. Otezla was the first ... treatment of active psoriatic arthritis in ... of care includes conventional oral treatments including disease-modifying ...
(Date:7/1/2015)... , ... July 01, 2015 , ... The next-generation sequencing ... key market segments, including the molecular diagnostics industry. BCC Research reveals in its new ... NGS-based tests, lower test costs, and a growing need for better diagnostics as part ...
(Date:7/1/2015)... India , July 1, 2015  Strand Life ... generation sequencing technology to empower cancer care, today announced ... chief executive officer. In his expanded role as now ... strategy, business expansion and worldwide operations effective immediately.  Dr. ... chairman and CEO since its founding in 2000, will ...
Breaking Biology Technology:AgBiome and Genective collaborate to create novel insect-resistant crops 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3
... (NYSE AMEX: IBIO) announced today the pricing of an ... for gross proceeds of approximately $10 million.  Each unit consists ... warrant to purchase one share of common stock.  The warrants ... be exercisable beginning one year and one day from the ...
... 10, 2012 Northwest Biotherapeutics (OTC.BB: NWBO) (NW Bio) today ... 10:45 am (PST) in the Windsor Room of the Sir ... SF 2012 Conference for emerging biotech companies held over 3 ... Conference.  Over one thousand attendees are expected to be listening ...
... $650,000 awarded to Innovative Libraries, New Scholars and Nurse Faculty ... the 2011 grant recipients for the Innovative Libraries in Developing ... been committed to nine institutions around the world in addition ...  The Elsevier Foundation is funded by Elsevier , a ...
Cached Biology Technology:iBio, Inc. Prices $10 Million Public Offering 2iBio, Inc. Prices $10 Million Public Offering 3iBio, Inc. Prices $10 Million Public Offering 4NW Bio to Present Today at the OneMedForum SF 2012 Conference 2NW Bio to Present Today at the OneMedForum SF 2012 Conference 3Elsevier Foundation Awards 2011 Grants to Advance Women in Science and Support Libraries in Developing Countries 2Elsevier Foundation Awards 2011 Grants to Advance Women in Science and Support Libraries in Developing Countries 3Elsevier Foundation Awards 2011 Grants to Advance Women in Science and Support Libraries in Developing Countries 4Elsevier Foundation Awards 2011 Grants to Advance Women in Science and Support Libraries in Developing Countries 5Elsevier Foundation Awards 2011 Grants to Advance Women in Science and Support Libraries in Developing Countries 6Elsevier Foundation Awards 2011 Grants to Advance Women in Science and Support Libraries in Developing Countries 7Elsevier Foundation Awards 2011 Grants to Advance Women in Science and Support Libraries in Developing Countries 8Elsevier Foundation Awards 2011 Grants to Advance Women in Science and Support Libraries in Developing Countries 9Elsevier Foundation Awards 2011 Grants to Advance Women in Science and Support Libraries in Developing Countries 10
... emerging as a powerful new tool for ... only amino groups have been able to ... as our Sulfo-SBED. Sulfhydryl-reactive Mts-Atf-Biotin and its ... to the protein interaction tool chest that ...
... a compact benchtop and stackable multi-function ... with a large display screen to ... Air circulation inside to evenly distribute ... be easily calibrated from the microprocessor ...
... Nonanoyl-N-methylglucamide White solid. ... be readily removed by dialysis. Useful ... ≥98% by HPLC. Absorbance (10%, ... 2 O. CMC 19 - 25 ...
...
Biology Products: