Navigation Links
UMass Amherst biochemists developing tools to stop plague and other bacterial threats
Date:6/28/2012

gh to be able attach to a lipid-dominated cell membrane to form this molecular syringe for attacking cells."

Now armed with that knowledge, Heuck and graduate student Yu-zhou Tang and others plan to use a special microscope to watch the organization of the channels at the single-molecule level. The will use multiple biochemical and biophysical methods, combined with fluorescent labeling of amino acids one at a time, to map two key protein translocators, Pseudomonas outer protein (Pop) B and D, and to figure out how they are assembled and how they form a translocon channel into a target cell.

With PopB and PopD, the biochemists can create a stable pore in model membrane for studying the relative quantities of different proteins, technically known as the stoichiometric arrangement, involved in T3S translocon assembly.

"No one has any idea right now how the PopB and PopD proteins get together, what it looks like when they fit together to form the channel. But it's important knowledge. If you want to know how to block these proteins from infecting the target cell, you must know how they are getting in and how they attack," Heuck says.

In five years, Heuck and colleagues hope to be able to offer hope to cystic fibrosis patients, many of whom lose their lives to Pseudomonas bacteria because at present, doctors run out of antibiotics that are effective against it. Further, many of these pathogens are listed as bioterrorism agents by the U.S. Centers for Disease Control and Prevention. It could become very important in the future to be able to mount an entirely new defense against their extremely effective methods of infecting populations with virulent bacterial diseases.

As he embarks on this major five-year study, Heuck says he is grateful to have received a bridge grant of $15,000 from UMass Amherst's Faculty Research/Healey Endowment Grant that allowed him to keep his lab open, actively gathering preliminary data to use
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
2. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
3. Chemical engineers at UMass Amherst find high-yield method of making xylene from biomass
4. UMass Amherst wildlife researcher photographs rare Sumatran rabbit
5. UMass Medical School scientist named 2012 Pew Latin-American Fellow in the Biomedical Sciences
6. UMass Medical School researchers discover a new role for RNAi
7. Family history of liver cancer increases risk of developing the disease
8. Research4Life greatly expands peer-reviewed research available to developing world
9. Medbox Developing a Patent Pending Wall-Mounted Biometric Kiosk for Storage of Sensitive Medicine Samples and Supplies for Doctors Offices.
10. Agricultural expert outlines path for developing nations to double food production, meet 2050 demand
11. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UMass Amherst biochemists developing tools to stop  plague and other bacterial threats
(Date:4/2/2015)... , April 2, 2015 ... tests DERMALOG by far outperforms the strongest competitors, ... maintaining high accuracy, the system is capable of ... the speed proves up to be ten times ... than its runner-up performance.      (Photo: ...
(Date:4/2/2015)... 2, 2015 Fingerprint Cards (FPC) ... FPC1025 from the distributor World Peace Industrial Group (WPI), ... 2015 although the major part of the shipments will ... used by smartphone manufacturers in China ... in the communicated revenue guidance of + 1 000 MSEK ...
(Date:3/31/2015)... 31, 2015  Elephant Talk Communications Corp. (NYSE MKT: ... of Software Defined Network Architecture (ET Software DNA® 2.0) ... of approximately $20.4 million for the year ended December ... for the year ended December 31, 2013. ... had completed its multi-year transition away from its legacy ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
... Sweden and the University of Glasgow, Scotland, has identified a ... gastrointestinal bacteria. In a study published as a letter to ... suggesting that the human genome may play a role in ... human gastrointestinal tract collectively known as the gut microbiota. ...
... a classic example of evolutionary adaptation, with beaks that vary ... While living birds have a beak to manipulate their food, ... discovery shows some fossil birds evolved teeth adapted for specialized ... a new species of early bird, Sulcavis geeorum , ...
... by senior author Morris J. Birnbaum, MD, PhD, the ... Institute for Diabetes, Obesity, and Metabolism, Perelman School of ... metformin works in a different way than previously understood. ... liver hormone glucagon,s ability to generate an important signaling ...
Cached Biology News:International study suggests human genes influence gut microbial composition 2First fossil bird with teeth specialized for tough diet 2Most-used diabetes drug works in different way than previously thought 2
(Date:4/24/2015)... Mirego, leader in mobile strategies and solutions, is proud to ... for the all new Apple Watch. Made in ... these extensions will reinvent the way users receive and interact ... Available today in Canada ... that makes for an excellent buddy for business, health and ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Seoul ... technology for various applications in the lighting market. ... successful installations of this technology in emerging markets ... for a wide range of applications such as ... and decorative lighting. , First launched in 2005 ...
(Date:4/23/2015)... Mount Dora, Florida (PRWEB) April 23, 2015 ... announced that it intends to conduct a groundbreaking ... can begin to be reversed in as little ... researchers—using the science of metabolic and nutritional medicine—will ... conditions that cripple and destroy our aging brain. ...
(Date:4/23/2015)... Six startups from Russia traveled ... as part of the U.S.-Russia Innovation Corridor (USRIC) ... biotechnology startups to participate in the program since ... the University of Maryland (UMD) signed a Memorandum ... universities in the biomedical industry in 2013. , ...
Breaking Biology Technology:Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Acrich Technology from Seoul Semiconductor Adopted in Installations Worldwide 2New Study Looks to Reverse Alzheimer’s Disease 2New Study Looks to Reverse Alzheimer’s Disease 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4
... whose MBA and undergraduate degree were minted at the ... Clear Software's North American operations, the company said on ... ,Cape Clear, headquartered in Massachusetts, provides "enterprise service bus" ... State of Wisconsin Department of Administraiton. , ,Though its ...
... are interested in bio and life science investments in ... Meanwhile the University of Wisconsin-Madison is introducing two new ... 30, 2005 Listen to this episode ... with companies in Madison ...
... Genzyme Corp. said on Wednesday it has agreed ... Wisconsin-Madison biotech spinoff, for $600 million in cash. , ,Bone ... more than $2 billion and almost 7,000 employees worldwide, plan ... companies recently reported healthy quarterly profits and revenues. Bone Care ...
Cached Biology Technology:Massachusetts firm to buy UW spinoff Bone Care for $600 million 2Massachusetts firm to buy UW spinoff Bone Care for $600 million 3