Navigation Links
UMass Amherst biochemists developing tools to stop plague and other bacterial threats
Date:6/28/2012

gh to be able attach to a lipid-dominated cell membrane to form this molecular syringe for attacking cells."

Now armed with that knowledge, Heuck and graduate student Yu-zhou Tang and others plan to use a special microscope to watch the organization of the channels at the single-molecule level. The will use multiple biochemical and biophysical methods, combined with fluorescent labeling of amino acids one at a time, to map two key protein translocators, Pseudomonas outer protein (Pop) B and D, and to figure out how they are assembled and how they form a translocon channel into a target cell.

With PopB and PopD, the biochemists can create a stable pore in model membrane for studying the relative quantities of different proteins, technically known as the stoichiometric arrangement, involved in T3S translocon assembly.

"No one has any idea right now how the PopB and PopD proteins get together, what it looks like when they fit together to form the channel. But it's important knowledge. If you want to know how to block these proteins from infecting the target cell, you must know how they are getting in and how they attack," Heuck says.

In five years, Heuck and colleagues hope to be able to offer hope to cystic fibrosis patients, many of whom lose their lives to Pseudomonas bacteria because at present, doctors run out of antibiotics that are effective against it. Further, many of these pathogens are listed as bioterrorism agents by the U.S. Centers for Disease Control and Prevention. It could become very important in the future to be able to mount an entirely new defense against their extremely effective methods of infecting populations with virulent bacterial diseases.

As he embarks on this major five-year study, Heuck says he is grateful to have received a bridge grant of $15,000 from UMass Amherst's Faculty Research/Healey Endowment Grant that allowed him to keep his lab open, actively gathering preliminary data to use
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
2. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
3. Chemical engineers at UMass Amherst find high-yield method of making xylene from biomass
4. UMass Amherst wildlife researcher photographs rare Sumatran rabbit
5. UMass Medical School scientist named 2012 Pew Latin-American Fellow in the Biomedical Sciences
6. UMass Medical School researchers discover a new role for RNAi
7. Family history of liver cancer increases risk of developing the disease
8. Research4Life greatly expands peer-reviewed research available to developing world
9. Medbox Developing a Patent Pending Wall-Mounted Biometric Kiosk for Storage of Sensitive Medicine Samples and Supplies for Doctors Offices.
10. Agricultural expert outlines path for developing nations to double food production, meet 2050 demand
11. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UMass Amherst biochemists developing tools to stop  plague and other bacterial threats
(Date:7/21/2014)... Growers of annual bedding plant seedlings or plugs ... a large stem diameter and high root dry ... during shipping and transplant. To achieve these desirable ... on supplemental lighting from high-pressure sodium lamps during ... diodes (LEDs) can give greenhouse growers other lighting ...
(Date:7/21/2014)... their cells are stressed when facing temperature extremes. Worse ... in the cell are slowed down more than others, ... of whack. Yet, those cells manage to keep their ... Rochester and the European Molecular Biology Laboratory have found ... of proteins is a key process in all cells, ...
(Date:7/20/2014)... A study of 473 sets of twins followed since ... of 24-month-old identical twins had language delay compared to ... the rate of late language emergence of single-born children. ... , The results of the study were published in ... Hearing Research . , University of Kansas Distinguished ...
Breaking Biology News(10 mins):LEDs shine in bedding plant production study 2When temperatures get cold, newly-discovered process helps fruit flies cope 2Large twin study suggests that language delay due more to nature than nurture 2Large twin study suggests that language delay due more to nature than nurture 3
... things that exist underground, plant roots are out-of-sight and ... plant parts are more familiar, plant roots are equally ... crop, and dazzling ornamental lies a root system that ... for plants, extract water and nutrients from soil, and ...
... Since the terrorist attacks of 2001, the Bureau of ... water and power to millions of people, has invested ... protect its facilities and personnel, says a new report ... better communication among security staff, regional and area office ...
... WI, AUGUST 18, 2008 Serpentine soils contain highly ... farming. Successful management of serpentine soils requires accurate measurement ... in the Soil Science Society of America Journal ... accurately measure calcium content in serpentine soils. To ...
Cached Biology News:Getting to the root of the matter 2National Research Council report on security at federally managed dams 2National Research Council report on security at federally managed dams 3
(Date:7/22/2014)... Dr. Williams says, “Bush has joined ... that the greatest health care system in the world ... deadly while trying to serve the public. Unfortunately, Bush ... transform an enormous system that none of them can ... continuing series of Open Letters ( http://is.gd/wdU2CM ) provides ...
(Date:7/21/2014)... Applying just the right amount of tension to a ... metallic conductor to an insulator, according to Rice University ... a hard-to-make, one-dimensional chain of carbon atoms -- by ... in ways that engineers might find useful for mechanically ... Rice theoretical physicist Boris Yakobson and his colleagues appears ...
(Date:7/21/2014)... , July 21, 2014  Mike Patterson, CEO ... $1.6 million in Series Seed B funding to ... sensors for the life science, defense, intelligence, and ... Partners led the round and was joined by ... Said Patterson , "This round of funding ...
(Date:7/20/2014)... Richland, Wash. -- When nuclear fuel gets recycled, the ... uranium in rock contaminates basements with the related gas ... these gases, and research appearing July 20 in ... let the gases in but not out. , ... or hazardous radioactive elements from nuclear fuel or air ...
Breaking Biology Technology:Dr. Ira Williams Asks What’s Wrong With Jonathan Bush’s Book, Where Does It Hurt? 2Carbyne morphs when stretched 2Carbyne morphs when stretched 3Global Graphene Manufacturing Leader, Graphene Frontiers, Receives Series Seed B Funding To Assure Production Of The Next Generation Of Biological And Chemical Sensor Technology 2A noble gas cage 2A noble gas cage 3
... N.J., Nov. 4 Cambrex,Corporation (NYSE: CBM ) reports third ... (Logo: http://www.newscom.com/cgi-bin/prnh/20000613/CAMBREXLOGO ), -- Sales increased ... third quarter 2007. -- Adjusted EBITDA for the quarter was ... $9.7 million last year. -- Debt, net of cash was ...
... - Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced ... pursue a pivotal (Phase II/III) randomized trial ... refractory,patients with head and neck cancers. The ... by the Company,s Board of Directors from ...
... Md., Nov. 4 PharmAthene, Inc.,(NYSE Alternext US: ... and chemical threats, announced today,that David P. Wright, ... at the Rodman and Renshaw 10th Annual Healthcare ... beginning at 2:25 p.m. E.T. in the,Holmes II ...
Cached Biology Technology:Cambrex Reports Third Quarter 2008 Results 2Cambrex Reports Third Quarter 2008 Results 3Cambrex Reports Third Quarter 2008 Results 4Cambrex Reports Third Quarter 2008 Results 5Cambrex Reports Third Quarter 2008 Results 6Cambrex Reports Third Quarter 2008 Results 7Cambrex Reports Third Quarter 2008 Results 8Cambrex Reports Third Quarter 2008 Results 9Cambrex Reports Third Quarter 2008 Results 10Cambrex Reports Third Quarter 2008 Results 11Cambrex Reports Third Quarter 2008 Results 12Cambrex Reports Third Quarter 2008 Results 13Cambrex Reports Third Quarter 2008 Results 14Oncolytics Biotech Inc. Announces Decision to Pursue Phase II/III Pivotal Clinical Trial 2