Navigation Links
UMass Amherst biochemists developing tools to stop plague and other bacterial threats
Date:6/28/2012

AMHERST, Mass. Biochemist Alejandro Heuck at the University of Massachusetts Amherst recently received a five-year, $950,000 grant from the National Institutes of Health to map the molecular structure of a needle-like tool used by deadly bacteria to drill holes in mammalian cell walls.

Once a channel is open, bacteria that cause such diseases as bubonic plague (Yersinia pestis), dysentery (Shigella), food poisoning (Salmonella) and sepsis (Pseudomonas aeruginosa) pump proteins in to destroy the body's ability to fight infection, killing millions each year worldwide. The researchers hope this advance will help to identify new targets for developing new drugs and treatment avenues

The new studies will build on a breakthrough reported last year by graduate student Fabian Romano and Heuck (pronounced Hoik), who were able to characterize enough of the bacterial needle to build a model membrane system for further experiments. This will let them study how the molecular machine known as the Type III secretion system (T3S) pokes holes, or translocons, in cell walls of warm-blooded animals and humans to inject toxic proteins.

The T3S system is used by many pathogens, but the UMass Amherst team will study it in Pseudomonas aeuginosa because unlike many bacteria, this one has only one T3S system, allowing for experiments with fewer variables. This strain of Pseudomonas causes sepsis, which easily develops resistance to antibiotics. Also, because it can infect so many different organisms from roundworms to mice to people, Pseudomonas studies conducted in a glass culture dish can be readily tested in more complex organisms.

Heuck recalls that last year's breakthrough successfully opened the door to the current work by solving "a very difficult puzzle." He adds, "It took a lot of experiments to understand how these water-soluble, water-loving proteins in the T3S translocon system could suddenly transform themselves drastically, enou
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
2. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
3. Chemical engineers at UMass Amherst find high-yield method of making xylene from biomass
4. UMass Amherst wildlife researcher photographs rare Sumatran rabbit
5. UMass Medical School scientist named 2012 Pew Latin-American Fellow in the Biomedical Sciences
6. UMass Medical School researchers discover a new role for RNAi
7. Family history of liver cancer increases risk of developing the disease
8. Research4Life greatly expands peer-reviewed research available to developing world
9. Medbox Developing a Patent Pending Wall-Mounted Biometric Kiosk for Storage of Sensitive Medicine Samples and Supplies for Doctors Offices.
10. Agricultural expert outlines path for developing nations to double food production, meet 2050 demand
11. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UMass Amherst biochemists developing tools to stop  plague and other bacterial threats
(Date:11/4/2014)... November 4, 2014   ... growth   Fuel3D , a developer of ... funding round totaling $6.4 million (£4 million). This funding builds ... earlier this year and paves the way for the commercial ... The funding round was led by Chimera Partners and ...
(Date:11/3/2014)... , Nov. 3, 2014 Research and ... "Cell Therapy - Technologies, Markets and Companies" to ... cell therapy technologies and methods, which have already started to ... stem cell transplantation is replacing the old fashioned bone marrow ... Cell therapy is bound to become a part of medical ...
(Date:11/3/2014)... from Australia report that low birth weight and preterm ... hip replacements in adulthood. Findings published in the American ... Research , indicate that low birth weight and pre-term ... due to OA as adults. , According to ... 25 are diagnosed with clinical OA. Symptoms of OA ...
Breaking Biology News(10 mins):Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3Preterm, low birth-weight babies may need new hips in adulthood 2
... Results from Parascript SignatureXpert confirm that signatures on financial ... Moscow to initiate forensic examination and expert study ... Colo., June 22 Parascript, LLC, the ... that it has partnered with the Moscow Law Firm ...
... June 29 Kornberg Associates | Architects ( www.kornberg.com ... to design a new Cognitive & Neurobiological Imaging Center. ... firm has worked with Stanford University since 1980 ... one of which is the two-story, 32,000 square-foot office building ...
... Eight supply chain professionals were elected in June by the ... the seven existing members of SCC,s board. Newly elected board members, ... as follows: , , , , ... Hewlett Packard , Jane Barrett, Research ...
Cached Biology News:Parascript Signature Verification Technology Used by Moscow Law Firm to Detect Signature Fraud in $160,000 Debt Collection Case 2Parascript Signature Verification Technology Used by Moscow Law Firm to Detect Signature Fraud in $160,000 Debt Collection Case 3Kornberg Associates Architects Selected to Develop Design for New Stanford University Imaging Center 2
(Date:11/21/2014)... November 19, 2014 The science of ... was shared with more than 200 primary students in ... from the University of Otago Physics Department and funded ... Otago students, members of the university’s OSA/SPIE Student Chapter ... early September, giving children from small, rural schools hands-on ...
(Date:11/21/2014)... Author Matthew J. Pallamary’s second short story ... published as a tribute to his mentor Ray ... Story” category of the 2014 USA Best Book ... USA Book News, said this year’s contest yielded over ... & Schuster, Penguin, John Wiley & Sons, Houghton Mifflin ...
(Date:11/21/2014)... November 20, 2014 The ... Chassis, Oligos, Enzymes, Cloning kits), Technology (Bioinformatics, ... (Biofuels, Pharmaceuticals, Biomaterials, Bioremediation) - Global Forecast ... market drivers, threats, opportunities, and challenges. , ... figures spread through 185 pages and in-depth ...
(Date:11/21/2014)... Fayetteville, Arkansas (PRWEB) November 20, 2014 ... partners, Pinnacle Ozone Solutions, LLC (Pinnacle), and PCI, ... equipment, announced that they have been selected to ... City of Fayetteville, Arkansas Paul R. Noland Wastewater ... feature BlueInGreen’s patented HyDOZ® gas dissolution ...
Breaking Biology Technology:Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4City of Fayetteville Leads Nation with Innovative Ozone Technology 2City of Fayetteville Leads Nation with Innovative Ozone Technology 3City of Fayetteville Leads Nation with Innovative Ozone Technology 4
... Because I used to be a corporate HR person, people ask me ... question that I get asked is: Can my company actually do that? ... did anyway. , ,Im not a lawyer. I dont send people off ... so far). Life is long. So many of these errors are clueless ...
... moved to speed up information access for officers, with the ... Aladdin Knowledge Systems . , ,It has proven to provide ... officers, who are now free to focus on protecting the ... information, said Neil Sullivan, the companys enterprise security regional manager. ...
... Stem Cell MADISONIn the first debate of Wisconsin's ... scientific research using human embryonic stem cells as little ... the 99 percent of stem cell research that uses ... the 1 percent that uses human embryonic stem cells. ...
Cached Biology Technology:Illegal business tricks: Can my company do that? 2Illegal business tricks: Can my company do that? 3Madison police adopt digital lock and key 2It's 99 percent certain: Research cannot rely on adult stem cells alone 2It's 99 percent certain: Research cannot rely on adult stem cells alone 3
Chlamydia pneumoniae (TWAR)...
Prostaglandin-E2 receptor EP2/EP3 Market Segment: GPCRs...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Biology Products: