Navigation Links
UMass Amherst biochemists developing tools to stop plague and other bacterial threats
Date:6/28/2012

AMHERST, Mass. Biochemist Alejandro Heuck at the University of Massachusetts Amherst recently received a five-year, $950,000 grant from the National Institutes of Health to map the molecular structure of a needle-like tool used by deadly bacteria to drill holes in mammalian cell walls.

Once a channel is open, bacteria that cause such diseases as bubonic plague (Yersinia pestis), dysentery (Shigella), food poisoning (Salmonella) and sepsis (Pseudomonas aeruginosa) pump proteins in to destroy the body's ability to fight infection, killing millions each year worldwide. The researchers hope this advance will help to identify new targets for developing new drugs and treatment avenues

The new studies will build on a breakthrough reported last year by graduate student Fabian Romano and Heuck (pronounced Hoik), who were able to characterize enough of the bacterial needle to build a model membrane system for further experiments. This will let them study how the molecular machine known as the Type III secretion system (T3S) pokes holes, or translocons, in cell walls of warm-blooded animals and humans to inject toxic proteins.

The T3S system is used by many pathogens, but the UMass Amherst team will study it in Pseudomonas aeuginosa because unlike many bacteria, this one has only one T3S system, allowing for experiments with fewer variables. This strain of Pseudomonas causes sepsis, which easily develops resistance to antibiotics. Also, because it can infect so many different organisms from roundworms to mice to people, Pseudomonas studies conducted in a glass culture dish can be readily tested in more complex organisms.

Heuck recalls that last year's breakthrough successfully opened the door to the current work by solving "a very difficult puzzle." He adds, "It took a lot of experiments to understand how these water-soluble, water-loving proteins in the T3S translocon system could suddenly transform themselves drastically, enou
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
2. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
3. Chemical engineers at UMass Amherst find high-yield method of making xylene from biomass
4. UMass Amherst wildlife researcher photographs rare Sumatran rabbit
5. UMass Medical School scientist named 2012 Pew Latin-American Fellow in the Biomedical Sciences
6. UMass Medical School researchers discover a new role for RNAi
7. Family history of liver cancer increases risk of developing the disease
8. Research4Life greatly expands peer-reviewed research available to developing world
9. Medbox Developing a Patent Pending Wall-Mounted Biometric Kiosk for Storage of Sensitive Medicine Samples and Supplies for Doctors Offices.
10. Agricultural expert outlines path for developing nations to double food production, meet 2050 demand
11. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UMass Amherst biochemists developing tools to stop  plague and other bacterial threats
(Date:10/16/2014)... thinking on how the bowel lining develops and, in ... cancer starts. , The researchers produced evidence that stem ... that are a feature of the bowel lining, and ... development, a controversial finding as scientists are still divided ... technologies, Dr Chin Wee Tan and Professor Tony Burgess ...
(Date:10/16/2014)... respiratory tract infections and worldwide claims the lives ... and Ghent University have succeeded in developing a ... infection. , Xavier Saelens (VIB/UGent): "We discovered ... for the development of a novel approach to ... in numerous small children and elderly people." , ...
(Date:10/16/2014)... 16, 2014 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... including Wocket™, the Smart Wallet, at the 13 th ... a leading global conference on the intersection of technology ... Mark Anderson , founder and publisher of the Strategic ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2New perspectives for development of an RSV vaccine 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... honors four leaders in biomedical and health informatics ... Annual Symposium, Oct. 22-26, an event expected to ... over the coming week. The Signature Awards highlight ... sector have had significant, positive impact. , ...
... 20 OCTOBER 2011 EMBO today acknowledges the outstanding ... by awarding them life-long EMBO membership. Election to ... excellence and the exceptional achievements made by a life ... 1,500 of the best researchers in Europe and around ...
... COLUMBIA, Mo. The face and brain develop ... the embryo and continuing through adolescence. Now, University of ... characteristics of children with autism compared to those of ... the origins of autism. "There is ...
Cached Biology News:AMIA honors informatics professionals who are improving health, changing the world 2AMIA honors informatics professionals who are improving health, changing the world 346 outstanding life scientists elected to EMBO membership 2Autistic facial characteristics identified 2
(Date:10/25/2014)... , October 24, 2014 Investor-Edge ... (NASDAQ: CYTR ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ALXN ), Peregrine Pharmaceuticals Inc. (NASDAQ: ... on these five companies can be accessed at: ... October 23, 2014, ended on a positive note as ...
(Date:10/22/2014)... , Oct. 22, 2014  Actavis plc (NYSE: ... company, and Rhythm, a biopharmaceutical company, today announced that ... Rhythm,s wholly owned subsidiary, Rhythm Health, Inc., which is ... treatment of diabetic gastroparesis and other GI functional disorders. ... 2 trial of relamorelin for the treatment of diabetic ...
(Date:10/22/2014)... 2014 WriteResult, LLC – a ... been working with a team of researchers from Yale ... Community Farming Collaborative to provide electronic questionnaire data collection ... study, which started in May, aims to evaluate the ... weekly exposure to and participation in urban agriculture to ...
(Date:10/22/2014)... , Oct. 22, 2014   Synthetic Biologics, Inc. ... pathogen-specific therapies for serious infections and diseases, announced today ... a Notice of Allowance for a composition of matter ... C. difficile program, SYN-004. This is Synthetic Biologics, ... the U.S. and adds to the Company,s extensive ...
Breaking Biology Technology:Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 4Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 5Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4
... Calif., March 30 Oxygen Biotherapeutics, Inc. (OTC Bulletin ... shareholders, prospective investors and interested parties in Zurich, Switzerland ... will be to update the investment community on the ... be available to answer shareholder questions along with ...
... Amicus Therapeutics (Nasdaq: FOLD ) today announced ... be presenting at the upcoming 16th ... at New York City,s Millennium Broadway Hotel and Conference Center. ... April 2, 2009 at 9:30 a.m. EDT.Individuals can listen to ...
... Graeme Clark Scholarship WinnersDENVER, March 30 Cochlear ... today announced the winners of the 2009 Graeme ... Cochlear Scholarship Foundation has recognized the remarkable achievements ... implant - a small electronic device that can ...
Cached Biology Technology:Webcast Alert: Oxygen Biotherapeutics, Inc. Investor Meeting in Zurich, Switzerland 2Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 2Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 3Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 4Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 5
... Genome-pULSe Kit delivers a novel procedure for ... labeling of whole genome DNA from small ... provide a quick and highly reproducible amplification ... consists of a REPLI-g Mini Kit module ...
... Introduction of a protein into cells permits ... signaling pathways, apoptotic pathways, and transcription factor-mediated ... studying the effects of a specific protein ... the protein directly into the cell. ProteoJuice ...
... ST-190-XY is an automated instrument with a ... in real-time using light or fluorescence microscopy. ... muscle, and fibroblast cells can be simulated ... X and Y axis of our strain ...
... Our Smart Solutions has now entered the ... (HCS) by partnering up with Cellomics, Inc. ... the integration of Beckman Coulter‘s automated solutions ... deeper biological information at the sub-cellular level. ...
Biology Products: