Navigation Links
UMass Amherst biochemists developing tools to stop plague and other bacterial threats
Date:6/28/2012

AMHERST, Mass. Biochemist Alejandro Heuck at the University of Massachusetts Amherst recently received a five-year, $950,000 grant from the National Institutes of Health to map the molecular structure of a needle-like tool used by deadly bacteria to drill holes in mammalian cell walls.

Once a channel is open, bacteria that cause such diseases as bubonic plague (Yersinia pestis), dysentery (Shigella), food poisoning (Salmonella) and sepsis (Pseudomonas aeruginosa) pump proteins in to destroy the body's ability to fight infection, killing millions each year worldwide. The researchers hope this advance will help to identify new targets for developing new drugs and treatment avenues

The new studies will build on a breakthrough reported last year by graduate student Fabian Romano and Heuck (pronounced Hoik), who were able to characterize enough of the bacterial needle to build a model membrane system for further experiments. This will let them study how the molecular machine known as the Type III secretion system (T3S) pokes holes, or translocons, in cell walls of warm-blooded animals and humans to inject toxic proteins.

The T3S system is used by many pathogens, but the UMass Amherst team will study it in Pseudomonas aeuginosa because unlike many bacteria, this one has only one T3S system, allowing for experiments with fewer variables. This strain of Pseudomonas causes sepsis, which easily develops resistance to antibiotics. Also, because it can infect so many different organisms from roundworms to mice to people, Pseudomonas studies conducted in a glass culture dish can be readily tested in more complex organisms.

Heuck recalls that last year's breakthrough successfully opened the door to the current work by solving "a very difficult puzzle." He adds, "It took a lot of experiments to understand how these water-soluble, water-loving proteins in the T3S translocon system could suddenly transform themselves drastically, enou
'/>"/>

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
2. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
3. Chemical engineers at UMass Amherst find high-yield method of making xylene from biomass
4. UMass Amherst wildlife researcher photographs rare Sumatran rabbit
5. UMass Medical School scientist named 2012 Pew Latin-American Fellow in the Biomedical Sciences
6. UMass Medical School researchers discover a new role for RNAi
7. Family history of liver cancer increases risk of developing the disease
8. Research4Life greatly expands peer-reviewed research available to developing world
9. Medbox Developing a Patent Pending Wall-Mounted Biometric Kiosk for Storage of Sensitive Medicine Samples and Supplies for Doctors Offices.
10. Agricultural expert outlines path for developing nations to double food production, meet 2050 demand
11. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UMass Amherst biochemists developing tools to stop  plague and other bacterial threats
(Date:9/18/2014)... form of camouflage: you don,t just blend in, the ... as uncommon as you might think. Kathryn Feller, from ... the larval life stages of many marine species are ... that most creatures cannot make transparent. Feller explains that ... individual eye unit with an opaque pigment to prevent ...
(Date:9/18/2014)... spend their entire lives nestling in the protective tentacles ... babies they sometimes travel hundreds of kilometres across the ... reef fish has been predicted, this is the first ... distant populations has been observed. , Dr Steve Simpson, ... the University of Exeter, and colleagues from the Australian ...
(Date:9/17/2014)... instrumental in the creation of the Santa Ana Wildfire ... fire threat potential of the powerful, hot, dry Santa ... inferno. The index was introduced Sept. 17 by the ... Diego Gas and Electric. , The index includes four ... be used to help fire agencies and other emergency ...
Breaking Biology News(10 mins):Transparent larvae hide opaque eyes behind reflections 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2
... Science of Food and Agriculture shows that konjac gum ... of E. coli and Salmonella bacteria. The study by ... Centre, the Netherlands, shows that these foodstuffs act as binders ... to the fibrous foods instead of the gut cells of ...
... published online today in the International Journal of Obesity ... of a reduced-calorie diet, helps overweight adults lose more weight ... breakfast of equal calories. [1] This study supports previous ... of Nutrition , which showed that people who ate eggs ...
... Dalton, professor and Georgia Research Alliance Eminent Scholar of ... awarded $9.2 million as part of a major new ... Sciences, part of the National Institutes of Health. ... molecular biology, will address the molecular underpinnings of the ...
Cached Biology News:Adults who eat eggs for breakfast lose 65 percent more weight 2Adults who eat eggs for breakfast lose 65 percent more weight 3UGA researchers win $9.2 million stem cell grant from NIH 2
(Date:9/18/2014)... , Pennsylvanie, 18 septembre 2014 /PRNewswire/ ... en 1974, a été depuis ... compléter les évaluations cliniques traditionnelles par des ... Outcomes) et sur les impacts économiques des ... A cours d,une ...
(Date:9/18/2014)... September 18, 2014 OMICS Group ... globe to participate in the ‘Open Access Week’ ... to OMICS Group Pharma Journals from ... of the fastest emerging Sciences, accelerating with a ... services across the globe. The industry is gearing ...
(Date:9/18/2014)... dysplasia is a group of rare diseases that ... cartilage. Its onset hits at the fetal stage ... in the gene encoding fibroblast growth factor receptor ... of skeletal dysplasia, thanatophoric dysplasia (TD), a skeletal ... and is often lethal, and achondroplasia (ACH), which ...
(Date:9/18/2014)... weight loss and diabetes prevention, could actually hasten the ... do it in a surprising way: by changing the ... substantial population of bacteria residing in our intestines. These ... were published today in Nature . Among other ... Immunology Department, who led this research together with Prof. ...
Breaking Biology Technology:1974 - 2014 - Mapi fête ses 40 ans 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3
... Elsevier announced today,that its flagship product Scopus, the world,s ... nearly doubling its Arts &,Humanities (A&H) titles. Access to ... April 2009. Currently the Scopus database contains 1,600,titles in ... Many countries will be better represented as ...
... Nov. 24 Imaging,Diagnostic Systems, Inc., (OTC Bulletin Board: ... pleased to announce the issuance of its,21st US Patent ... Digitization of the Temporal Point Spread,Function of the Detected ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040412/IMDSLOGO ) ...
... 24 Poniard,Pharmaceuticals, Inc. (Nasdaq: PARD ... an agreement with Baxter Oncology GmbH for the,commercial ... is developing picoplatin, its lead product candidate, as ... solid tumors. The Company is,evaluating picoplatin in ...
Cached Biology Technology:Scopus to Expand Arts & Humanities Coverage 2Scopus to Expand Arts & Humanities Coverage 3Imaging Diagnostic Systems is Recognized for Its Advanced Engineering in Time-Resolved Techniques by the US Patent Office 2Imaging Diagnostic Systems is Recognized for Its Advanced Engineering in Time-Resolved Techniques by the US Patent Office 3Poniard Pharmaceuticals Announces Commercial Supply Agreement for Picoplatin 2Poniard Pharmaceuticals Announces Commercial Supply Agreement for Picoplatin 3
... were designed for full-length gene cloning and ... identify the desired cDNA clone. The first ... "Master Plate," where each well contains plasmid ... positive well(s) by gel electrophoresis of the ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... The DSQ II (Dual-Stage Quadrupole) ... the world leader in analytical instrumentation, introduces ... the DSQ II. Based on the ... DSQ and PolarisQ GC/MS systems, the DSQ ...
... Panels were designed for full-length gene cloning ... to identify the desired cDNA clone. The ... 96-well "Master Plate," where each well contains ... the positive well(s) by gel electrophoresis of ...
Biology Products: