Navigation Links
UIC scientists discover how some bacteria survive antibiotics
Date:4/30/2008

Researchers at the University of Illinois at Chicago have discovered how some bacteria can survive antibiotic treatment by turning on resistance mechanisms when exposed to the drugs. The findings, published in the April 24 issue of the journal Molecular Cell, could lead to more effective antibiotics to treat a variety of infections.

"When patients are treated with antibiotics some pathogenic microbes can turn on the genes that protect them from the action of the drug," said Alexander Mankin, professor and associate director of the University of Illinois at Chicago's Center for Pharmaceutical Biotechnology and lead investigator of the study. "We studied how bacteria can feel the presence of erythromycin and activate production of the resistance genes."

Erythromycin and newer macrolide antibiotics azithromycin and clarithromycin are often used to treat respiratory tract infections, as well as outbreaks of syphilis, acne and gonorrhea. The drugs can be used by patients allergic to penicillin.

Macrolide antibiotics act upon the ribosomes, the protein-synthesizing factories of the cell. A newly-made protein exits the ribosome through a tunnel that spans the ribosome body. Antibiotics can ward off an infection by attaching to the ribosome and preventing proteins the bacterium needs from moving through the tunnel.

Some bacteria have learned how to sense the presence of the antibiotic in the ribosomal tunnel, and in response, switch on genes that make them resistant to the drug, Mankin said. The phenomenon of inducible antibiotic expression was known decades ago, but the molecular mechanism was unknown.

Mankin and his team of researchers -- Nora Vazquez-Laslop, assistant professor in the Center for Pharmaceutical Biotechnology, and undergraduate student Celine Thum -- used new biochemical and genetic techniques to work out the details of its operation.

"Combining biochemical data with the knowledge of the structure
'/>"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists aim to boost world energy supplies -- with microbes!
2. Scientists determine drug target for the most potent botulinum neurotoxin
3. Scientists make chemical cousin of DNA for use as new nanotechnology building block
4. Scientists find stem cells for the first time in the pituitary
5. Brown scientists say biodiversity is crucial to ecosystem productivity
6. Scientists urged to make a stand on climate change
7. Scientists clarify a mechanism of epigenetic inheritance
8. Scientists to explore global change-public health connection
9. Scientists test device to track medication adherence in patients with HIV/AIDS
10. Scientists discover how nanocluster contaminants increase risk of spreading
11. Smithsonian scientists find evidence that could rewrite Hawaiis botanical history
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)...  Today, FreeWavz ( www.FreeWavz.com ), the developer of ... Fundable, https://www.fundable.com/freewavz . FreeWavz will be expanding ... meet customer demand. Logo - ... Invented by Dr. Eric ...
(Date:1/22/2015)... Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD and ... reports on the recent success of the Wocket™ smart wallet at CES ... smart wallet was named as one of the "11 Hot Products at ... Products Launched At CES So Far" by Newseveryday.com and "The top 10 ...
(Date:1/22/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ... "Global Wearable Technologies Market and Applications, Opportunities, Industry ... Forecast 2014-2020" report to their offering. ... that can be worn on the user,s body ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... The ferocious Tyrannosaurus rex has been depicted as the top ... and claiming the role of apex predator, much as the ... new census of all dinosaur skeletons unearthed over a large ... to have subsisted solely on the dinosaurs it tracked and ...
... to eat healthy and live sustainably have a ... environment: a Web-based tool [ http://n-print.org/sites/n-print.org/files/footprint_sql/index.html#/home ] that ... created by University of Virginia environmental scientist James ... at U.Va.; and colleagues from the Netherlands and ...
... Spanish participation, has discovered a new species of mollusc, ... The researchers say this species, which is the oldest in ... took place while it was in existence. This process could ... new species Polyconites hadriani , which was discovered in ...
Cached Biology News:T. rex more hyena than lion 2T. rex more hyena than lion 3T. rex more hyena than lion 4New free, hands-on tool supports sustainable living choices 2New free, hands-on tool supports sustainable living choices 3Oldest species of a marine mollusc discovered 2
(Date:2/26/2015)... Angeles, CA (PRWEB) February 26, 2015 ... an online demonstration to support life extension technologies and ... 8pm UTC, Universal Coordinated Time, on March 21st 2015, ... the world. , Eric Schulke, Founder of MILE, ... must act with urgency. The Movement for Indefinite Life ...
(Date:2/26/2015)... , Feb. 26, 2015  NuGene International, ... aesthetic products for skin and hair rejuvenation, has ... as agency of record for investor relations and ... improve our distribution, sales and diversification strategies – ... current and prospective shareholders," stated Ali Kharazmi CEO ...
(Date:2/26/2015)... , Feb. 26, 2015 BioEnterprise today announced ... have attracted more than $2 billion in growth funding ... and national investors, strategic sources, state – including the ... of the $2 billion has been raised in the ... on the heels of the BioEnterprise Midwest Healthcare ...
(Date:2/26/2015)... Already well respected for accuracy, HEIDENHAIN ... its Length Gauge offerings with new variants of its ... Specifically, HEIDENHAIN’s pencil probe-style SPECTO length gauge series now ... new 1Vpp, 12mm stroke length variants of the SPECTO ... a variant with a weak spring, 0.4N of gauging ...
Breaking Biology Technology:Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 2More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 4Accuracy and Versatile Gauging Go Hand in Hand at HEIDENHAIN 2
... 15 Forest,Laboratories, Inc. (NYSE: FRX ), ... to discuss aclidinium bromide clinical and pre-clinical,data findings ... webcast, which will include a slide presentation and ... 2008 at 9:30am New York time, 3:30pm CET,2:30pm ...
... Israel, May 15 Modigene Inc. (OTC,Bulletin Board: ... develop longer-acting versions of already approved,therapeutic proteins, today ... upcoming Acumen BioFin Rodman & Renshaw 5th Annual ... Central European Summer Time),on May 20, 2008., ...
... MOUNT LAUREL, N.J., May 15 MedQuist ... clinical documentation,workflow technology and services, and StructuRad ... today they have agreed to,integrate and use ... for Radiology(TM) speech recognition solution product., ...
Cached Biology Technology:Forest Laboratories, Inc. and Laboratorios Almirall, S.A. to Host Webcast to Discuss Aclidinium Bromide Data Presentations at the American Thoracic Society Annual Congress 2MedQuist and StructuRad Form Partnership to Integrate Report Macros into SpeechQ for Radiology(TM) 2
This SMAD antibody sampler pack contains 5 Polyclonal ,SMAD antibodies....
Phosphate-Buffered Saline (PBS) 7.4 (1X) liquid...
... Rat Antibody to Human CD66 ... is expressed by human neutrophils and ... carcinoma. Clone YTH71.3 reacts with transfectants ... are CEA subfamily members(2). ...
... GOAT ANTI-MOUSE IgG+IgA+IgM (H+L) ... with highly purified horseradish ... antibody has been absorbed ... fetal bovine, horse, goat, ...
Biology Products: