Navigation Links
UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
Date:4/13/2012

The Center for NeuroGenetics at the University of Florida has received a competitive $1 million grant from the W.M. Keck Foundation to study a new idea that challenges conventional understanding of how proteins in cells are made, and their impact on inherited diseases.

Scientists have long understood the role of messenger RNA, known as mRNA, in translating instructions from DNA to make protein. Inherited diseases are caused by faulty genetic instructions, but a study led by Laura Ranum, Ph.D., director of the Center for NeuroGenetics and a professor of molecular genetics and microbiology, has introduced a new twist to the plot.

"Our research disputes the conventional dogma about what causes proteins to be expressed within cells and why," said Ranum, whose original study was done while she was at the University of Minnesota. "We discovered that proteins can be made across some repetitive disease-causing mutations in the absence of 'green light' or 'start' signals, previously thought to be required. This discovery has the potential to change the course of scientific investigation on human disease because we may have been grossly underestimating the number of proteins cells express."

Ranum specializes in the study of myotonic dystrophy the most common form of muscular dystrophy in adults and ataxia, a rare brain disease that robs people of their coordination and motor control. She and colleagues set out to study how proteins are made and to dig for the disease-causing genes hidden within the human genome.

A lot of DNA is made up of repetitive sequences, called genomic stuttering, said Maurice Swanson, Ph.D., the associate director of the center and a professor of molecular genetics and microbiology at the UF College of Medicine. Fifty percent of human DNA is made up of repetitive sequences, which historically have been dismissed as unimportant information, he said.

"The discovery that unusual, potentially harmful pro
'/>"/>

Contact: Karen Dooley
dooleyk@ufl.edu
352-273-5865
University of Florida
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
3. Kount Receives Patent for Device Fingerprinting
4. American College of Medical Genetics receives $13.5M NIH contract
5. Penn State receives new NASA astrobiology grant
6. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
7. Vidaza receives positve opinion from European CHMP
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. Montana State partnership receives $66.9M for carbon sequestration
10. Oklahoma EPSCoR receives $20 million for biofuels research
11. UC Riverside rice geneticist receives high honor from US Department of Agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)...   LaunchKey , the first decentralized mobile authentication and ... Things era, today announced the close of $3 million ... by Metamorphic Ventures with participation from ENIAC Ventures, Crosslink ... LaunchKey has raised $4 million to date, and will ...
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ...
(Date:12/11/2014)... 09, 2014 Research and Markets , ... ) has announced the addition of the "Biometrics ... offering. One major trend emerging in ... in technology, it is important to upgrade biometric solutions ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... Calgary researchers, published today in PLoS ONE, demonstrates the ... human activity. The research was conducted by ... Post-Doctoral Fellow and two University of Calgary professors from ... the Schulich School of Engineering and the Faculty of ...
... of the Division of Sleep Medicine at Brigham and Women,s ... Space Biomedical Research Institute (NSBRI) for a postdoctoral fellowship. ... the United States has to offer. These new fellows will ... health and to improve health care on Earth," said Dr. ...
... our landscape consuming insects, but they do this in secret, ... unable to bring their ecosystem out of the dark but ... Bristol and Biodiversity Institute of Ontario, Canada, have been able ... Working at three sites in Southern Ontario (Canada) the team ...
Cached Biology News:Humans give prey the edge in food web 2Brigham and Women's Hospital researcher named National Space Biomedical Research Institute Fellow 2Food forensics: DNA links habitat quality to bat diet 2
(Date:1/23/2015)... 23, 2015 Portal Solutions , a ... on Microsoft Office 365 and SharePoint platforms , today ... program for being one of the region’s fastest-growing mid-sized companies ... growth. , “To be recognized a second year in ...
(Date:1/22/2015)... 2015 Shimadzu Scientific Instruments today ... UV-visible spectrophotometer. Offering wavelength scanning from 190 to ... for applications in a variety of industries, including ... user-friendly UV-1280 enables intuitive operation, while the enhanced ...
(Date:1/22/2015)... January 22, 2015 GEA Niro Soavi ... top laboratory homogenizer, the PandaPLUS 2000, which is ideal ... , and cell disruption . This compact laboratory ... fruit juices, liquid food, food additives and ingredients as ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart ... 2014 was a record-breaking year across the board for the ... Smart Data Platform and our Smart Data solutions, our customers ... data which led to record growth for the company in ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Cambridge Semantics Announces Record Results for 2014 2
... Systems Inc. (Other,OTC: BMXSF), is pleased to announce ... Ltd., for the provision of the design, manufacture,and ... engagement,letter, Alcofuel Technologies has agreed, subject to the ... and manufacture a small,scale ethanol micro-refinery capable of ...
... 16 ADVENTRX Pharmaceuticals,Inc. (Amex: ANX ... on commercializing proprietary product candidates for the ... that the U.S. Food and,Drug Administration (FDA) ... CoFactor(R) injection, which is currently being investigated ...
... Application in the Fourth ... Quarter, ... results from a 12-week, Phase 3 clinical,trial of FENTORA(R) (fentanyl buccal tablet) ... non-cancer pain,conditions. The study achieved statistical significance on the primary,endpoint. Results across ...
Cached Biology Technology:BioMaxx Systems Inc. Signs Engagement Letter With Alcofuel Technologies for Provision of an Ethanol Micro-Refinery 2ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer 2ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer 3Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain 2Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain 3Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain 4Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain 5
Reported to support murine B lymphocytes, hematopoietic tissue from bone marrow, B cells stimulated with lipopolysaccharide, T lymphocytes, and a variety of hybrid cells....
... F-12 was developed for culturing hybrid cells ... modification consists of doubling the amino acids ... salt concentrations have been altered as well. ... per liter, which may render it unsuitable ...
... Alsevers solution is an isotonic, balanced salt ... preservative, which permits the storage of whole blood ... usage, an equal volume of blood is collected ... but thoroughly, mixed. The solution is placed in ...
... or individual RNA sequences from high throughput synthesis ... RNAs from LC Sciences. These products provide a ... of DESIGNED sequences delivered in a microtube as ... a single verified RNA sequence. This is a ...
Biology Products: