Navigation Links
UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
Date:4/13/2012

The Center for NeuroGenetics at the University of Florida has received a competitive $1 million grant from the W.M. Keck Foundation to study a new idea that challenges conventional understanding of how proteins in cells are made, and their impact on inherited diseases.

Scientists have long understood the role of messenger RNA, known as mRNA, in translating instructions from DNA to make protein. Inherited diseases are caused by faulty genetic instructions, but a study led by Laura Ranum, Ph.D., director of the Center for NeuroGenetics and a professor of molecular genetics and microbiology, has introduced a new twist to the plot.

"Our research disputes the conventional dogma about what causes proteins to be expressed within cells and why," said Ranum, whose original study was done while she was at the University of Minnesota. "We discovered that proteins can be made across some repetitive disease-causing mutations in the absence of 'green light' or 'start' signals, previously thought to be required. This discovery has the potential to change the course of scientific investigation on human disease because we may have been grossly underestimating the number of proteins cells express."

Ranum specializes in the study of myotonic dystrophy the most common form of muscular dystrophy in adults and ataxia, a rare brain disease that robs people of their coordination and motor control. She and colleagues set out to study how proteins are made and to dig for the disease-causing genes hidden within the human genome.

A lot of DNA is made up of repetitive sequences, called genomic stuttering, said Maurice Swanson, Ph.D., the associate director of the center and a professor of molecular genetics and microbiology at the UF College of Medicine. Fifty percent of human DNA is made up of repetitive sequences, which historically have been dismissed as unimportant information, he said.

"The discovery that unusual, potentially harmful proteins are translated within these regions adds another layer to the basic biological process," said Swanson, who will help lead the new study. "The discovery leads to a whole new way of looking at disease."

Keck funding will help researchers determine how this repeat-associated non-ATG translation, or RAN translation, works, if it is a key to neurological disease and whether other repetitive sequences in the genome are translated into proteins.

"This prestigious award is significant news for the university," said UF medical Dean Michael L. Good, M.D. "It is very exciting that an influential organization such as the W.M. Keck Foundation recognizes the strength of the research program at the College of Medicine, particularly the cutting-edge expertise of Dr. Ranum and Dr. Swanson and their colleagues."

The Keck Foundation's history is to invest in scientific pursuits that have great promise, but that are outside-the-box and viewed by some as risky, Ranum said.

"We are grateful for this opportunity and excited about what we will learn," she said.

Based in Los Angeles, the foundation was established in 1954 by the late W.M. Keck, founder of the Superior Oil Company. The foundation's grant making is focused primarily on pioneering efforts in the areas of medical research, science and engineering. The Keck Foundation is known for funding high-risk, high-return projects. Keck awards fall outside the mission of public funding agencies and support transformative ideas that are investments in the future.

The Center for NeuroGenetics is located within UF's College of Medicine and affiliated with the department of molecular genetics and microbiology, the McKnight Brain Institute and the Genetics Institute. In addition to Ranum and Swanson, the research team includes Tao Zu, Ph.D., John Cleary, Ph.D., and Tammy Reid, M.Sc.


'/>"/>

Contact: Karen Dooley
dooleyk@ufl.edu
352-273-5865
University of Florida
Source:Eurekalert

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
3. Kount Receives Patent for Device Fingerprinting
4. American College of Medical Genetics receives $13.5M NIH contract
5. Penn State receives new NASA astrobiology grant
6. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
7. Vidaza receives positve opinion from European CHMP
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. Montana State partnership receives $66.9M for carbon sequestration
10. Oklahoma EPSCoR receives $20 million for biofuels research
11. UC Riverside rice geneticist receives high honor from US Department of Agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... New York , June 15, 2016 /PRNewswire/ ... a new market report titled "Gesture Recognition Market by ... and Forecast, 2016 - 2024". According to the report, ... USD 11.60 billion in 2015 and is estimated ... reach USD 48.56 billion by 2024.  ...
(Date:6/2/2016)... -- The Department of Transport Management (DOTM) of ... US Dollar project, for the , Supply and ... and IT Infrastructure , to Decatur ... of Identity Management Solutions. Numerous renowned international vendors participated in ... was selected for the most compliant and innovative solution. ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Charm Sciences, Inc. is pleased to announce ... Research Institute approval 061601. , “This is another AOAC-RI approval of the Peel ... President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably to ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... Durham, NC (PRWEB) , ... June 23, 2016 , ... ... Odense University Hospital in Denmark detail how a patient who developed lymphedema after being ... (fat) tissue. The results could change the paradigm for dealing with this debilitating, frequent ...
(Date:6/23/2016)... , June 23, 2016 ... Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published ... the peer-reviewed journal from touchONCOLOGY, Andrew D ... cost of cancer care is placing an increasing ... of expensive biologic therapies. With the patents on ...
Breaking Biology Technology: