Navigation Links
UCSF transgenic mouse mimics Parkinson's earliest symptoms
Date:5/3/2010

UCSF researchers have created the first transgenic mouse to display the earliest signs of Parkinson's disease using the genetic mutation that is known to accompany human forms of the disease.

The mouse model, which expresses the same mutant proteins as human Parkinson's patients, also displays early signs of constipation and other gastrointestinal problems that are a common harbinger of the disease in humans.

As a result, researchers say, these animals could serve as a means of investigating therapies for reversing the neurological dysfunction of the disease at its earliest stages.

The findings are featured as the cover story in the May 1, 2010 issue of the journal, "Human Molecular Genetics" and are available online at http://hmg.oxfordjournals.org/cgi/content/full/19/9/1633.

Researchers have long suspected that the neurological component of Parkinson's, which causes tremors and stiffness among other symptoms, is actually a late-stage effect of a larger, systemic problem, according to UCSF geneticist Robert L. Nussbaum, MD, who was senior author on the paper.

"This new model validates that theory by mimicking what we know to be the genetic pathway leading to Parkinson's, while also displaying the earliest symptoms that occur in humans," said Nussbaum, who is the Holly Smith Distinguished Professor in Medicine and chief of the UCSF Division of Medical Genetics. "This will give us an important tool in identifying an early intervention for this devastating disease."

Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's, affecting 1.5 percent of adults over 55 years of age, and is typically characterized by motor disorders such as tremors, rigidity and postural instability.

Several non-motor abnormalities also frequently accompany Parkinson's, including depression, sleep disorders and ga
'/>"/>

Contact: Kristen Bole
kbole@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Yerkes researchers create first transgenic prairie voles
2. Transgenic songbirds provide new tool to understand the brain
3. Risks involved with transgenic fish
4. First draft of transgenic papaya genome yields many fruits
5. Is transgenic cotton more profitable?
6. Transgenics transformed
7. Transgenic maize is more susceptible to aphids
8. Intentional variation increases result validity in mouse testing
9. Mouse work: New insights on a fundamental DNA repair mechanism
10. Stem cells restore sight in mouse model of retinitis pigmentosa
11. Penn biologists determine microRNA activity is suppressed in mouse ovum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... compete with members of their own species. However, ... into their competitive ability. Some individuals are highly ... resources, while others seem to avoid competition, instead ... are left over for them. Moreover, the degree ... to fluctuate considerably over time. A theoretical study ...
(Date:10/29/2014)... A new study on a large cohort of kidney ... architecture of the disease -- and reveals an apparent ... kidney cancer, particularly in Romania. , The research, by ... University and Genome Quebec Innovation Centre in Montreal, underscores ... aristolochic acid. The compound, found in plants of the ...
(Date:10/28/2014)... North America, Europe and China have published a paper ... Sciences that reveals important details about key transitions ... From strange and exotic algae, mosses, ferns, trees and ... and vegetables we eat and the ornamental plants adorning ... a billion years of history., "Our study generated DNA ...
Breaking Biology News(10 mins):Evolution of competitiveness 2Evolution of competitiveness 3Study sheds light on genetic architecture of kidney cancer 2Study sheds light on genetic architecture of kidney cancer 3New study uses DNA sequences to look back in time at key events in plant evolution 2New study uses DNA sequences to look back in time at key events in plant evolution 3
... Two nurses have won recognition as emerging leaders in ... for Nursing Informatics (ANI) to participate in a jointly ... based on a number of criteria, including a mid-level ... current license to practice as a registered nurse, and ...
... An orchid researcher based on the island of Reunion in ... Botanic Gardens, Kew (RBG Kew) has used motion sensitive night ... functioning as a pollinator of flowering plants. Not only is ... a member of the Orthoptera order of insects who ...
... STATION - Mango. If you know little about this fruit, ... colon and breast cancer cells in the lab. ... food scientists, who examined the five varieties most common in ... Though the mango is an ancient fruit heavily consumed in ...
Cached Biology News:2 nurses emerge as leaders in informatics 2First known instance of a cricket as an orchid pollinator captured on film by Kew scientist 2Mango effective in preventing, stopping certain colon, breast cancer cells 2
(Date:10/31/2014)... Jeffrey T. Manuel, assistant professor in Southern Illinois ... of Arts and Sciences, is teaming up with the ... fuels in Illinois. , “Farmers, researchers, business ... build Illinois’ biofuels industry for decades,” Manuel said. “This ... agricultural and business history. , “Fuel alcohol has ...
(Date:10/31/2014)... The report "Dairy Alternative (Beverage) Market ... Sweetened, Unsweetened), Channel (Supermarket, Health Store, Pharmacy, Convenience ... to 2018," defines and segments the dairy alternative ... revenue and volume for plant-based dairy alternative beverages. ... $14 Billion by 2018 with the Asia-Pacific region ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 Stronger ... healthcare, construction, finance and consumer electronics will help ... reason, industry research firm IBISWorld has added a ... its growing industry report collection. , The Biometrics ... for biometric technologies such as fingerprint, iris, retina ...
(Date:10/30/2014)... 30, 2014 The report “Fragrance Ingredients ... Application (Cosmetics & Toiletries, and Soaps & Detergents) & ... has defined and segmented the Fragrance Ingredients Market with ... terms of value. The market has been segmented on ... Europe, Asia-Pacific, Latin America, and Rest of the World ...
Breaking Biology Technology:SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 4Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5
... 1, 2012   Reportlinker.com announces that a ... its catalogue: Cell ... http://www.reportlinker.com/p0203537/Cell-Therapy---Technologies-Markets-and-Companies.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biological_Therapy This ... and methods, which have already started to ...
... Force Research Laboratory in Dayton, Ohio, has experimentally confirmed ... foretold a pair of interesting properties about nanotube growth: ... of its growth, and that armchair nanotubes should grow ... toward defining all the mysteries inherent in what Yakobson ...
... , Graphene leaves a rather modest impression at a ... ordered in a mono-layered "carpet". Yet, what makes graphene ... This property is particularly useful in the development of ... and transform it into electrical signals. Graphene,s ...
Cached Biology Technology:Cell Therapy - Technologies, Markets and Companies 2Cell Therapy - Technologies, Markets and Companies 3Cell Therapy - Technologies, Markets and Companies 4Cell Therapy - Technologies, Markets and Companies 5Cell Therapy - Technologies, Markets and Companies 6Cell Therapy - Technologies, Markets and Companies 7Cell Therapy - Technologies, Markets and Companies 8Cell Therapy - Technologies, Markets and Companies 9Cell Therapy - Technologies, Markets and Companies 10Cell Therapy - Technologies, Markets and Companies 11Cell Therapy - Technologies, Markets and Companies 12Cell Therapy - Technologies, Markets and Companies 13Cell Therapy - Technologies, Markets and Companies 14Cell Therapy - Technologies, Markets and Companies 15Cell Therapy - Technologies, Markets and Companies 16Rice professor's nanotube theory confirmed 2Rice professor's nanotube theory confirmed 3Ultra-fast photodetector and terahertz generator 2
...
Fetal Calf Serum Replacement (Bistec) serum...
NEWBORN CALF SERUM AND PLASMA...
... phase reagent for Virus ... & unique water insoluble ... detergents and chaotropes; Engineered ... non-envelop viruses while preserving ...
Biology Products: