Navigation Links
UCLA study finds genetic link between misery and death
Date:2/24/2010

6 gene.

"We also identified the specific genetic sequence in this gene that serves as a target of that signaling pathway, and we discovered that a well-known variation in that sequence can block that path and disconnect IL6 responses from the effects of stress."

To confirm the biochemical link between misery and death, and the genetic variation that breaks it, the researchers turned to epidemiological studies to prove that carriers of that specific genetic variation were less susceptible to death due to inflammation-related mortality causes under adverse social-environmental conditions.

They found that people with the most common type of the IL6 gene showed an increased risk of death for approximately 11 years after they had been exposed to adverse life events that were strong enough to trigger depression. However, people with the rarer variant of the IL6 gene appeared to be immune to those effects and showed no increase in mortality risk in the aftermath of significant life adversity.

This novel method of discovery using computer modeling and then confirming genetic relationships using test-tube biochemistry, experimental stress studies and human genetic epidemiology could speed the discovery of such gene and environmental relationships, the researchers say.

"Right now, we have to hunt down genetic influences on health through blind searches of huge databases, and the results from that approach have not yielded as much as expected," Cole said. "This study suggests that we can use computer modeling to discover geneenvironment interactions, then confirm them, in order to focus our search more efficiently and hopefully speed the discovery process.

"This opens a new era in which we can begin to understand the influence of adversity on physical health by modeling the basic biology that allows the world outside us to influence the molecular processes going on inside our cells."


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hormone study gives scientists a sense of how animals bond
2. Study shows that suffocating head lice works in new treatment
3. Michigan State uses NSF grant to study evolution in action
4. Study highlights sustainable footprint of chemical companies
5. Stress raises risk of mental decline in older diabetics, study shows
6. New study finds link between marine algae and whale diversity over time
7. Study finds variations in 1 gene may be associated with endurance running
8. Study: Crickets forewarn unborn babies about spiders
9. Study examines family lineage of King Tut, his possible cause of death
10. Butterfly vision, wing colors linked, UCI study finds
11. New study possibly links cognitive and motor delays with flat head syndrome in young babies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... (Apr. 23 2014) A team of ... cells (hNSCs) into the brains of nonhuman primates ... and 24 months found that the hNSCs had ... not cause tumors. , The study will be ... Transplantation but is currently freely available on-line ...
(Date:4/23/2014)... -- Researchers have found evidence of an interaction ... increase aggressive behavior in children, especially in girls. ... children exposed to prenatal smoking will have behavioral ... said Brian Boutwell, Assistant Professor at Sam Houston ... author on the study. "One possible explanation ...
(Date:4/23/2014)... Climate fiction, or simply cli-fi, is a newly coined term ... global warming. New research from University of Copenhagen shows how ... to simulate the potential consequences of climate change and imagine ... than scientific data on changes in the atmosphere; it is ... by the books we read and the films we see. ...
Breaking Biology News(10 mins):Study finds long-term survival of human neural stem cells transplanted into primate brain 2Genetics risk, prenatal smoking may predict behavioral problems 2Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3
... brain consists of about 100 billion (1011) neurons, which ... each other. A crucial mechanism for the generation of ... branches. The neurobiologists Dr. Hannes Schmidt and Professor Fritz ... Medicine (MDC) Berlin-Buch, Germany, have now discovered a molecule ...
... sea creatures suggests that the transition from egg-laying to live-born ... to adapt to and thrive in open oceans. ... Nature by scientists at Harvard University and the ... live-born young depended crucially on the advent of genes -- ...
... researchers have discovered that a combination of drugs, electrical ... walk and even run again while supporting their full ... in the online edition of Nature Neuroscience, the findings ... not required for paraplegic rats to learn to walk ...
Cached Biology News:MDC researchers discover molecule responsible for axonal branching 2Genetic sex determination let ancient species adapt to ocean life 2UCLA scientists make paralyzed rats walk again after spinal-cord injury 2
(Date:1/14/2014)... DC (PRWEB) January 14, 2014 Carahsoft ... for Thursday, January 23, 2014 at 2pm EST (11am ... Knowledge.” The topic focuses on how technology can turn ... critical decisions for government agencies. The online webinar will ...
(Date:1/14/2014)... 2014 The largest international professional organization of ... therapeutic derivatives thereof has endorsed an educational program ... the challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural ...
(Date:1/14/2014)... Global Record Systems, LLC, (GRS), ... solutions for patients, physicians, the biopharmaceutical industry, regulators, ... the signing of a three-year Research Collaboration Agreement ... (FDA). This initiative is designed to generate ...
(Date:1/14/2014)... CA (PRWEB) January 14, 2014 Independent ... County), California, and Montreal, Canada, has big ideas for ... non-fiction. The press's goals are to produce high-quality, low-cost, ... to support local businesses. , The first major ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... SEATTLE, Oct. 6 Glencoe Software, Inc., The ... University Press are pleased to announce the release of ... first scientific image data publication system. First released in ... been under continuous development to support new image data ...
... ... if ... var shortURL = ""; BitlyCB.alertResponse = ... to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; } for ...
... Researchers at the Georgia Institute of Technology have ... nanometer-scale graphene devices. The method addresses what ... of this promising material in future generations of ... patterns into the silicon carbide surfaces on which ...
Cached Biology Technology:Glencoe Software and The Journal of Cell Biology Pioneer Online Publishing of Scientific Image Data: New Version of JCB DataViewer Released 2Glencoe Software and The Journal of Cell Biology Pioneer Online Publishing of Scientific Image Data: New Version of JCB DataViewer Released 3Elsevier Introduces Article-Based Publishing to Increase Publication Speed 2Elsevier Introduces Article-Based Publishing to Increase Publication Speed 3Elsevier Introduces Article-Based Publishing to Increase Publication Speed 4Elsevier Introduces Article-Based Publishing to Increase Publication Speed 5Elsevier Introduces Article-Based Publishing to Increase Publication Speed 6Elsevier Introduces Article-Based Publishing to Increase Publication Speed 7Elsevier Introduces Article-Based Publishing to Increase Publication Speed 8New graphene fabrication method uses silicon carbide templates to create desired growth 2New graphene fabrication method uses silicon carbide templates to create desired growth 3