Navigation Links
UCLA study finds genetic link between misery and death
Date:2/24/2010

In ongoing work to identify how genes interact with social environments to impact human health, UCLA researchers have discovered what they describe as a biochemical link between misery and death. In addition, they found a specific genetic variation in some individuals that seems to disconnect that link, rendering them more biologically resilient in the face of adversity.

Perhaps most important to science in the long term, Steven Cole, a member of the UCLA Cousins Center for Psychoneuroimmunology and an associate professor of medicine in the division of hematology-oncology, and his colleagues have developed a unique strategy for finding and confirming geneenvironment interactions to more efficiently probe what he calls the "genetic haystack."

The research appears in the current online edition of Proceedings of the National Academy of Sciences.

Using an approach that blends computational, in vivo and epidemiological studies to focus their genetic search, Cole and his colleagues looked at specific groups of proteins known as transcription factors, which regulate gene activity and mediate environmental influences on gene expression by binding to specific DNA sequences. These sequences differ within the population and may affect a gene's sensitivity to environmental activation.

Specifically, Cole analyzed transcription factor binding sequences in a gene called IL6, a molecule that is known to cause inflammation in the body and that contributes to cardiovascular disease, neurodegeneration and some types of cancer.

"The IL6 gene controls immune responses but can also serve as 'fertilizer' for cardiovascular disease and certain kinds of cancer," said Cole, who is also a member of UCLA's Jonsson Comprehensive Cancer Center and UCLA's Molecular Biology Institute. "Our studies were able to trace a biochemical pathway through which adverse life circumstances fight-or-flight stress responses can activate the IL
'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hormone study gives scientists a sense of how animals bond
2. Study shows that suffocating head lice works in new treatment
3. Michigan State uses NSF grant to study evolution in action
4. Study highlights sustainable footprint of chemical companies
5. Stress raises risk of mental decline in older diabetics, study shows
6. New study finds link between marine algae and whale diversity over time
7. Study finds variations in 1 gene may be associated with endurance running
8. Study: Crickets forewarn unborn babies about spiders
9. Study examines family lineage of King Tut, his possible cause of death
10. Butterfly vision, wing colors linked, UCI study finds
11. New study possibly links cognitive and motor delays with flat head syndrome in young babies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... , July 27, 2015   Zynx Health ... experience-based clinical improvement solutions, today announced that its ... now available on Android smartphones and tablets. With ... post-care organizations can use ZynxCarebook to securely exchange ... condition, streamline care transitions to other care settings, ...
(Date:7/21/2015)... 2015 Passwords have proven futile for ... recent U.S. Office of Personnel Management breach. Biometric ... conundrum, but developers and end-users are concerned about ... dilemma, Biometrics-as-a-Service provider HYPR Corp. announced today the ... third party integration. A video ...
(Date:7/9/2015)... , July 07, 2015 ... the addition of the "Biometrics for Banking; ... 2015-2020" report to their offering. ... contributor to this growth and the forecast is ... in revenue for companies involved in delivering biometric ...
Breaking Biology News(10 mins):Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
... Washington, DCMay 28, 2008The 2008 American Society for ... presented to Bernard Roizman, Joseph Regenstein Distinguished Service ... by Abbott Laboratories, this is ASM,s premier award ... Dr. Roizman has been a leader in ...
... American Society for Microbiology (ASM) Merck Irving S. Sigal ... Assistant Professor, Department of Microbiology and Immunology at the ... Maryland. Sponsored by Merck Research Laboratories, the Merck Irving ... Irving S. Sigal, who was instrumental in the early ...
... receive a total of $781,691 over the next two ... world,s most serious sustainability challenges, from salmon farming in ... include 22 faculty members representing a broad cross-section of ... law. This year,s grants were selected from an ...
Cached Biology News:American Society for Microbiology honors Bernard Roizman 2New round of Environmental Venture Projects from Stanford's Woods Institute 2New round of Environmental Venture Projects from Stanford's Woods Institute 3
(Date:7/30/2015)... ... July 30, 2015 , ... ... applications and designed for continuous operation up to 1500 bar. The sanitary design ... efficiency, and preventing toxic contamination. , The Pony™ NS2006L homogenizer is an ideal ...
(Date:7/29/2015)... According to a new market research report, ... , published by Mordor Intelligence, the Global market is expected ... 2020, with North America being the ... global market size. The Global market for Stem Cells is ... period of (2015-2020).      (Logo: http://photos.prnewswire.com/prnh/20150428/740799) , ...
(Date:7/29/2015)... /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ) today announced ... Officer has resigned.  The Company has hired Andrew ... in December 2014, as full time interim CFO and ... Andy Ashworth began his employment today, ... transition.  Andy was the Company,s CFO from September 2011 ...
(Date:7/29/2015)... ... July 29, 2015 , ... G-CON Manufacturing, Inc., the ... their 2nd generation cell therapy POD® design. The 2nd generation portfolio not only ... a new POD® design. , “G-CON first offered our miniPOD CT product ...
Breaking Biology Technology:GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3
... Year Guidance, SHENZHEN, China, Sept. 3 ... MR ), a leading developer, manufacturer,and marketer ... selected,unaudited financial results for the second quarter ... successfully completed the acquisition of,Datascope Corp.,s patient ...
... ... Initiatives, BEDFORD, Mass., Sept. 3 ... technology with its OmniPod(R),Insulin Management System, today announced the appointment of ... this,role, Mr. Arthur will lead the company,s business development strategy,including pursuing ...
... Ascentis Express RP-Amide provides improved selectivity for polar ... a division of,Sigma-Aldrich (Nasdaq: SIAL ), has ... a family of innovative HPLC,columns designed to provide ... with a 50% reduction in backpressure. Ascentis Express,RP-Amide, ...
Cached Biology Technology:Mindray Medical International Announces Second Quarter 2008 Results 2Mindray Medical International Announces Second Quarter 2008 Results 3Mindray Medical International Announces Second Quarter 2008 Results 4Mindray Medical International Announces Second Quarter 2008 Results 5Mindray Medical International Announces Second Quarter 2008 Results 6Mindray Medical International Announces Second Quarter 2008 Results 7Mindray Medical International Announces Second Quarter 2008 Results 8Mindray Medical International Announces Second Quarter 2008 Results 9Mindray Medical International Announces Second Quarter 2008 Results 10Mindray Medical International Announces Second Quarter 2008 Results 11Mindray Medical International Announces Second Quarter 2008 Results 12Mindray Medical International Announces Second Quarter 2008 Results 13Mindray Medical International Announces Second Quarter 2008 Results 14Mindray Medical International Announces Second Quarter 2008 Results 15Mindray Medical International Announces Second Quarter 2008 Results 16Mindray Medical International Announces Second Quarter 2008 Results 17Insulet Appoints Bill Arthur as Vice President of Business Development 2Insulet Appoints Bill Arthur as Vice President of Business Development 3Insulet Appoints Bill Arthur as Vice President of Business Development 4Supelco(R) Expands Ascentis(R) Express HPLC Columns Line for High-Speed and High-Efficiency Separations 2
... The mycobacteria in Complete Freund's adjuvant ... injection site which enhances the immuneresponse. For ... used for the initial injections; Incomplete Freund's ... Antigens (preferably in saline) are typically mixed ...
HiTrap Streptavidin HP, 5 x 1 ml. Category: Chromatography Systems & Accessories, Systems....
...
Request Info...
Biology Products: