Navigation Links
UCI study reveals new mechanism for estrogen suppression of liver lipid synthesis
Date:5/23/2013

By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.

With this finding, Dr. Ellis Levin and colleagues believe they are changing long-held views in the field. Study results appear in the May 21 issue of the journal Science Signaling.

"The dogma in the steroid receptor field for 50 years has been that only receptors located in the nucleus respond to steroid hormones by regulating genes that produce the developmental, functional and pathological effects of steroid hormones," said Levin, Professor of Medicine, biological chemistry and pharmacology, and Chief of endocrinology, diabetes and metabolism at UC Irvine and the VA Long Beach Healthcare System.

"In our study, we show that an estrogenic receptor compound acting at the cell membrane-based estrogen receptor alpha in the liver of transgenic and wild type mice suppresses all lipid synthesis. This includes cholesterol, triglycerides and fatty acids."

Levin said this occurs through AMP kinase signaling, which inhibits the processing of the key transcription factor for many lipid-synthesis pathways genes. This causes the transcription factor to be retained in cytoplasm and prevents lipid synthesis gene expression.

"This action occurs without any participation of the nuclear receptor pool," he added. "Thus, the membrane ER-alpha can regulate genes that produce a metabolic phenotype entirely unrelated to the nuclear receptor contributing."

Estrogen plays a role in liver functions, and may be a deterrent to liver cancer, as men get this type of cancer at a rate of four-to-six times more than women and animals models of this cancer show clear suppression by estrogen. The hormone also helps suppress the development of fatty liver, which can lead to liver damage and failure, and inflammatory liver disease that resul
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Landscapes of Resilience to study how people use nature as a source of recovery
2. Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens
3. Study reveals how fishing gear can cause slow death of whales
4. Gym class reduces probability of obesity, study finds for first time
5. Study provides insight into nesting behavior of dinosaurs
6. TGen and Riddell announce partnership for biomarker study of concussive injuries
7. Alligator stem cell study gives clues to tooth regeneration
8. Study identifies possible new acute leukemia marker, treatment target
9. Women altering menstruation cycles in large numbers, UO study shows
10. Study finds that bacteria organize according to rich-get-richer principle
11. Study finds brain system for emotional self-control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... launch in December 2014, the 1U™ app has ... to remember their usernames and passwords through replacing the antiquated ... assist people who have struggled to remember usernames and passwords, ... focuses on redefining identity, announced today that it is offering ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the ... Security Systems Market" report to their offering. ... perimeter security market is estimated to grow at a CAGR ... holds a larger share in this market, Canada ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM announced today ... to confirm its adherence to current U.S. Food and ... conduct regulated smart device and smart phone application trials ... quality. "HITLAB is determined to improve global ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... this week,s issue of "New Scientist" magazine, research by Rice ... is on one,s mind about politics may be influenced by ... this topic for a number of years, and his team ... in the United States and supplemented it with findings from ...
... Quest Product Development, teaming with,Ball Aerospace & ... successfully demonstrated a new thermal insulation. NASA has ... II grant to develop and,commercialize this advanced thermal ... NASA,s new,spacecraft and exploration missions would preserve rocket ...
... Rochet, a research scientist at IFREMER (The French Research ... the prestigious Pew Fellowship in Marine Conservation to determine ... to the delicately balanced marine ecosystem. She will use ... use of that technique, and to further improve its ...
Cached Biology News:Colorado Engineering Firms Win NASA Grant to Develop Innovative Insulation for Next Generation Spacecraft - Super-Insulation May Allow Future Energy Efficient Appliances 22008 Pew Fellowship in Marine Conservation awarded to Dr. Marie-Joëlle Rochet from IFREMER 22008 Pew Fellowship in Marine Conservation awarded to Dr. Marie-Joëlle Rochet from IFREMER 32008 Pew Fellowship in Marine Conservation awarded to Dr. Marie-Joëlle Rochet from IFREMER 4
(Date:1/22/2015)... GEA Niro Soavi the leader in high ... PandaPLUS 2000, which is ideal for new applications for ... disruption . This compact laboratory homogenizer is the perfect ... food additives and ingredients as well as for the ...
(Date:1/22/2015)... CAMBRIDGE, Mass (PRWEB) January 21, 2015 Cambridge ... Semantic Web technology, today announced that 2014 was a record-breaking ... expanding the capabilities of the Anzo Smart Data Platform and ... discover and utilize insights from diverse data which led to ...
(Date:1/22/2015)... 22, 2015 Protocol Networks brings independent ... team of brand-neutral, independent consultants, Protocol Networks has recently ... that over the years, his company has attracted several ... of Plainfield, as well as others. With the success ...
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Pipette.com ... Offer to their comprehensive portfolio of Eppendorf products. ... customers to purchase a Centrifuge 5424/5424 R and receive ... of either Eppendorf Research plus or Eppendorf Reference 2 ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Cambridge Semantics Announces Record Results for 2014 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2
... , Revamilast is a PDE4 inhibitor, under ... The molecule successfully completed pre-clinical trials and Phase I studies ... in the UK , , Glenmark has initiated global ... Huge unmet medical need as globally they are over 300 ...
... 9, 2011 Accuray Incorporated (Nasdaq: ARAY ), ... is scheduled to present at the Wedbush Life Sciences: Management ... at 9:10 a.m. ET/6:10 a.m. PT. A live ... investor relations page of the Company,s Web site at ...
... 2011 Reportlinker.com announces that a new ... catalogue: Biochips: Genosensors, Microarrays, ... http://www.reportlinker.com/p0591346/ Biochips-Genosensors-Microarrays-Labs-On-The-Chip .html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic ... Microarrays and Labs-on-the-Chip are extensions of biosensor ...
Cached Biology Technology:Glenmark Initiates Phase IIb Human Trials Globally for its Novel Molecule 'Revamilast' 2Glenmark Initiates Phase IIb Human Trials Globally for its Novel Molecule 'Revamilast' 3Glenmark Initiates Phase IIb Human Trials Globally for its Novel Molecule 'Revamilast' 4Biochips: Genosensors, Microarrays, Labs-On-The-Chip 2
iNOS/NOS Type II Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 150 µg Consult technical datasheet for details....
... 100-240 V, uses multiplex suspension array technology ... up to 100 proteins and peptides in ... is composed of up to 100 color-coded ... conjugated with a unique reactant specific to ...
... (HTF) system, 100-240 V, is an optional ... that automates delivery of up to 20 ... array reader. The HTF system automatically draws ... container to constantly maintain a reservoir of ...
Cell Culture Flask, 75 cm, nontreated polystyrene...
Biology Products: