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UCI researchers find epigenetic tie to neuropsychiatric disorders
Date:7/21/2014

ssion levels of some 2,000 genes in this area, coupled with a widespread increase in modifications of basic DNA proteins called histones particularly those associated with reduced gene activity.

Borrelli further noted that the dopamine receptor-induced reprogramming led to psychotic-like behaviors in the mutant mice and that prolonged treatment with a dopamine activator restored regular signaling, pointing to one possible therapeutic approach.

The researchers are continuing their work to gain more insights into the genes altered by this dysfunctional dopamine signaling.


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Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

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