Navigation Links
UCI researchers find epigenetic tie to neuropsychiatric disorders
Date:7/21/2014

Irvine, Calif., July 21, 2014 Dysfunction in dopamine signaling profoundly changes the activity level of about 2,000 genes in the brain's prefrontal cortex and may be an underlying cause of certain complex neuropsychiatric disorders, such as schizophrenia, according to UC Irvine scientists.

This epigenetic alteration of gene activity in brain cells that receive this neurotransmitter showed for the first time that dopamine deficiencies can affect a variety of behavioral and physiological functions regulated in the prefrontal cortex.

The study, led by Emiliana Borrelli, a UCI professor of microbiology & molecular genetics, appears online in the journal Molecular Psychiatry.

"Our work presents new leads to understanding neuropsychiatric disorders," Borrelli said. "Genes previously linked to schizophrenia seem to be dependent on the controlled release of dopamine at specific locations in the brain. Interestingly, this study shows that altered dopamine levels can modify gene activity through epigenetic mechanisms despite the absence of genetic mutations of the DNA."

Dopamine is a neurotransmitter that acts within certain brain circuitries to help manage functions ranging from movement to emotion. Changes in the dopaminergic system are correlated with cognitive, motor, hormonal and emotional impairment. Excesses in dopamine signaling, for example, have been identified as a trigger for neuropsychiatric disorder symptoms.

Borrelli and her team wanted to understand what would happen if dopamine signaling was hindered. To do this, they used mice that lacked dopamine receptors in midbrain neurons, which radically affected regulated dopamine synthesis and release.

The researchers discovered that this receptor mutation profoundly altered gene expression in neurons receiving dopamine at distal sites in the brain, specifically in the prefrontal cortex. Borrelli said they observed a remarkable decrease in expre
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... how to produce enough food to feed the world ... Organization of the United Nations predicts that food production ... feed a growing global population, and plants are one ... Plants—grains, cereals, fruits, vegetables, and more—feed humans directly ... tap into our knowledge of how plants work to ...
(Date:10/14/2014)... doses of fish oil supplements, rich in omega-3 fatty acids, ... heartbeat in which the heart can beat as fast as ... led by the Montreal Heart Institute were published in the ... October 7th. , For the trial, 337 patients with atrial ... 4 grams of fish oil a day or to placebo ...
(Date:10/14/2014)... WORCESTER, MA – A team of scientists led ... School (UMMS) and the University of Miami Miller ... likely a key genetic pathway underlying bipolar (manic ... better drugs for treating bipolar affective disorder, as ... , The new findings, published online this week ...
Breaking Biology News(10 mins):Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3Rare genetic disease protects against bipolar disorder 2Rare genetic disease protects against bipolar disorder 3
... The Nature Conservancy and Conservation International (CI) have joined ... in one of the largest debt-for-nature swaps in history. ... Ricas most critically threatened tropical forests, with the United ... Costa Rica spending that amount on tropical forest conservation ...
... of Warwick and Astra Zeneca have found a new way ... hydrogen atoms and thus spot unwanted polymorphs in pharmaceuticals. ... which an active drug can actually exist in more than ... to act in very different ways. Now researchers at the ...
... important regulator of blood glucose levels, now has a ... University Medical Center researchers, working with colleagues in Texas, ... systems, which are involved in drug addiction and many ... targets for treating drug abuse, the findings raise questions ...
Cached Biology News:Costa Rica, US announce historic debt-for-nature swap 2Costa Rica, US announce historic debt-for-nature swap 3NMR researchers unlock hydrogen's secrets to spot polymorphism in pharmaceuticals 2Insulin's brain impact links drugs and diabetes 2Insulin's brain impact links drugs and diabetes 3
(Date:10/18/2014)... According to a new market research ... - Global Trends & Forecasts up till 2017”, hydraulic ... 2011. This value is expected to increase from $40 ... 10% CAGR during the same period. North America is ... in terms of hydraulic horse power supplied by the ...
(Date:10/18/2014)... The “Global Diagnostic Electrocardiograph (ECG) Market by Product ... Research Center, Physician Office, Nursing Homes), by Lead ... provides a detailed overview of the major drivers, ... impacting the global diagnostic ECG market along with ... share analysis. , The global diagnostic ECG market ...
(Date:10/17/2014)... 16—As in Alice,s journey through the looking-glass to Wonderland, ... surprising and unexpected ways, including a new class of ... reported today in The Optical Society,s (OSA) new high-impact ... for the first time, a new type of mirror ... reflects infrared light by using an unusual magnetic property ...
(Date:10/17/2014)... For the seventh consecutive year, DuPont ... today’s print issue of Science magazine. , The ... polled employees in the biotechnology, pharmaceutical and related ... Rankings were determined based on responses from 5,394 ... on 23 characteristics, including financial strength, leadership and ...
Breaking Biology Technology:Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5Magnetic mirrors enable new technologies by reflecting light in uncanny ways 2Magnetic mirrors enable new technologies by reflecting light in uncanny ways 3Magnetic mirrors enable new technologies by reflecting light in uncanny ways 4DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... Massachusetts Governor Mitt Romney has drawn a thoughtful ethical line ... stem cell research in his state and to oppose another. ... news coverage of his announcement, it could define a more ... , ,In fact, if Romney's position became law in Wisconsin ...
... visualize thought? , ,Well, by pressing the open tip of ... hair against the membrane of an individual brain cell, ... flowing through individual ion channels on a cell's membrane. This ... a peek at the electrical activity of individual cells. , ...
... the DEMO conference last week in Scottsdale. Many of the ... 15 years have been introduced at this confab, which celebrated ... more than 250 million readers, listeners and viewers worldwide. , ... we can look at the state of the industry," said ...
Cached Biology Technology:Massachusetts stem-cell plan reflects status quo for Wisconsin research 2Massachusetts stem-cell plan reflects status quo for Wisconsin research 3Prairie Technologies works with UW engineer to visualize the brain 2In search of the next big thing at DEMO 2In search of the next big thing at DEMO 3
... 12 amino acid synthetic peptide whose sequence is derived from ... (amino to carboxy terminus): C - S(338) - K ... - V - A - P - A(348). ... with the polyclonal antibody that reacts with this product and ...
... Dual-Binary Analytical System more than doubles the ... LC/MS. The fast analysis cycles of the ... to 100% in tandem mode. Difficult separations ... Using backflush or heartcut configurations, on-line sample ...
... are prepared with pure chemicals according to ... Kit is designed to isolating intact and ... way. One kit is consisted of reagents ... from 10 20 g tissue or ...
... DNA preparations are prepared from customers ... 1mg to multi-gram scales. Small-scale ... preparations are made according to customer ... according to customer needs, and glycerol ...
Biology Products: