Navigation Links
UCI neuroscientists create fiber-optic method of arresting epileptic seizures
Date:1/24/2013

Irvine, Calif., Jan. 24, 2013 UC Irvine neuroscientists have developed a way to stop epileptic seizures with fiber-optic light signals, heralding a novel opportunity to treat the most severe manifestations of the brain disorder.

Using a mouse model of temporal lobe epilepsy, Ivan Soltesz, Chancellor's Professor and chair of anatomy & neurobiology, and colleagues created an EEG-based computer system that activates hair-thin optical strands implanted in the brain when it detects a real-time seizure.

These fibers subsequently "turn on" specially expressed, light-sensitive proteins called opsins, which can either stimulate or inhibit specific neurons in select brain regions during seizures, depending on the type of opsin.

The researchers found that this process was able to arrest ongoing electrical seizure activity and reduce the incidence of severe "tonic-clonic" events.

"This approach is useful for understanding how seizures occur and how they can be stopped experimentally," Soltesz said. "In addition, clinical efforts that affect a minimum number of cells and only at the time of a seizure may someday overcome many of the side effects and limitations of currently available treatment options."

Study results appear online in Nature Communications.

More than 3 million Americans suffer from epilepsy, a condition of recurrent spontaneous seizures that occur unpredictably, often cause changes in consciousness, and can preclude normal activities such as driving and working. In at least 40 percent of patients, seizures cannot be controlled with existing drugs, and even in those whose seizures are well controlled, the treatments can have major cognitive side effects.

Although the study was carried out in mice, not humans, Soltesz said the work could lead to a better alternative to the currently available electrical stimulation devices.


'/>"/>
Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1

Related biology news :

1. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
2. UT Dallas researchers awarded $4.3 million to create next-generation technologies
3. Researchers create flexible, nanoscale bed of nails for possible drug delivery
4. Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
5. Powerful enzymes create ethanol from agricultural harvest waste
6. Even in same vineyard, different microbes may create variations in wine grapes
7. Protein creates paths for growing nerve cells
8. New geometries: Researchers create new shapes of artificial microcompartments
9. Rice, Texas Childrens team creates biocompatible patch to heal infants with birth defects
10. Conservationists to create blueprint for saving Malaysias elephants
11. Cells from skin create model of blinding eye disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... PHILADELPHIA (PRWEB) , ... July 17, 2017 , ... ... attorney Weihong Hsing, Ph.D. , recently participated in the BiG (Biomedical Innovation ... Shanghai, was dominated by discussions of CAR-T (chimeric antigen receptor T-cell) therapy, a ...
(Date:7/16/2017)... ... 16, 2017 , ... OHAUS Corporation, a leading worldwide manufacturer ... new line of Rocking and Waving Shakers today. , Five New Models Available ... digital) for laboratory applications in a variety of environmental conditions. Rocking shakers provide ...
(Date:7/14/2017)... ... July 14, 2017 , ... Sonic Manufacturing Technologies ... Technologies has installed a solar system on its roof top. “We will be ... of Sonic, Kenneth Raab stated. The company’s proud history of social responsibility and ...
(Date:7/14/2017)... ... July 14, 2017 , ... ... preparation of proteins to clean peptides for mass spectrometry (MS) analysis combining the ... The PreOmics iST Kit is based on proprietary technology that contains optimized buffer ...
Breaking Biology Technology: