Navigation Links
UAlberta medical researchers discover how immune system kills healthy cells
Date:9/10/2013

Medical scientists at the University of Alberta have made a key discovery about how the immune system kills healthy cells while attacking infections. This finding could one day lead to better solutions for cancer and anti-viral treatments.

Faculty of Medicine & Dentistry researcher Colin Anderson recently published his team's findings in the peer-reviewed journal, Journal of Immunology. His team included colleagues from the United States and the Netherlands, and graduate students from the U of A.

Previous research has shown that when the immune system launches an aggressive attack on infected cells, healthy tissues and cells can be killed or damaged in the process. Anderson and his team discovered the mechanisms in the immune system that cause this "overkill" response.

"This opens the opportunity that one might be able to manipulate the immune system response to block collateral damage without blocking the killing of infected cells," Anderson explained.

"In the future this might be important in the development of clinical treatments in cases where the immune system response needs to be harnessed. For example, in treating various viral infections, the collateral damage caused during the immune system attack is a large part of the illness.

"In other cases, such as cancer or tumour treatments, one may want to increase the immune system's ability to kill collateral cells, in hopes of killing tumour cells that would otherwise escape during treatment and spread elsewhere in the body. Our research suggests there are other mechanisms that could improve cancer therapy and make it more efficacious. This finding could also help us understand why certain cancer treatments are more successful than others."

Anderson's team discovered "the weaponry the immune system uses to try and kill an infected or cancerous cell is not exactly the same as the weaponry that causes collateral damage to innocent bystander cells that
'/>"/>

Contact: Raquel Maurier
rmaurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. Diets high in salt could deplete calcium in the body: UAlberta research
2. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
3. Miniature pressure sensors for medical touch
4. Research!America says house funding levels for FY13 could undermine medical progress
5. Mainz University Medical Center attracts funding of Alexander von Humboldt Professorship
6. Medical device, health professionals attend first national conference on value-driven engineering
7. Ultrasensitive biosensor promising for medical diagnostics
8. UH Case Medical Center, CardioKinetix reveal promising data for treatment for heart failure
9. Tufts Medical Center researchers finds marker in premies saliva predicts readiness to feed by mouth
10. CDS Monarch Deploys DigitalPersona Strong Authentication Solutions for Secure Access to Electronic Medical Records
11. Nuisance seaweed found to produce compounds with biomedical potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... [Brown University] Asteroid and comet impacts can cause ... regional or even global scales. But new research from ... signatures of ancient life at the time of an ... Pete Schultz has found fragments of leaves and preserved ... ancient impacts in Argentina. The material could provide a ...
(Date:4/17/2014)... was a word for chili peppers. Information about archaeological ... a study of the appearance of words for chili ... jalapeos were domesticated and highlight the value of multi-proxy ... et al.) of nine papers presented in a special ... Academy of Sciences on plant and animal domestication ...
(Date:4/17/2014)... ALBUQUERQUE, N.M. A credit-card-sized anthrax detection cartridge developed ... small business makes testing safer, easier, faster and cheaper. ... causes anthrax, is commonly found in soils all over ... illness in both humans and animals. The bacteria can ... to B. anthracis may occur through skin ...
Breaking Biology News(10 mins):Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3Chickens to chili peppers 2Chickens to chili peppers 3Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... the mechanism that binds skin cells tightly together, which ... and debilitating skin diseases and also lethal heart defects. ... Sciences, has found that the glue molecules bind only ... very tough, resilient structure. Further investigation on why the ...
... NASA,s newest Earth-observing research mission is nearing launch. The ... sun and tiny atmospheric particles called aerosols affect Earth,s ... solar measurements needed to address key uncertainties about climate ... Vandenberg Air Force Base in California on Feb. 23 ...
... little more than a conventional photocopier and transparency film, ... local Cambridge high school physics teacher invented the process; ... Harvard,s School of Engineering and Applied Sciences (SEAS), students ... The Microfluidics Lab, developed by Dr. Anas Chalah, Director ...
Cached Biology News:Cell binding discovery brings hope to those with skin and heart problems 2NASA prepares to launch next Earth-observing satellite mission 2NASA prepares to launch next Earth-observing satellite mission 3Simple, ingenious way to create lab-on-a-chip devices could become a model for teaching and research 2Simple, ingenious way to create lab-on-a-chip devices could become a model for teaching and research 3
(Date:1/15/2014)... The Pittcon Organizing Committee is pleased to announce that ... an e-Journal and producer of Food Labs Conference ... for the co-location of Food Labs Conference to be held ... registration fee to attend the two-day Food Lab Conference, March ...
(Date:1/15/2014)... 2014 ­ RedBrick Health , a fast-growing leader ... announces that EmblemHealth , the New ... now providing the RedBrick Compass health assessment, combined with ... of its members. EmblemHealth is among the first health ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how latent ... viruses is the Epstein Barr Virus (EBV), and one of ... a chronic inflammatory disease that destroys the body’s joints. As ... have high concentrations of EBV DNA in their bodies (1). ...
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, Limited ... agreement with R-Pharm, a leading Russian pharmaceutical company, to ... Russian Federation , Turkey ... States (CIS). Nemonoxacin is a novel antibiotic for the treatment ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Trius Therapeutics, Inc. today announced that it has been ... the Defense Threat Reduction Agency (DTRA), an agency within the ... directed against gram-negative bacterial pathogens. Trius may receive up to ... the new DTRA contract, which is funded as part of ...
... the United States, over the past four decades, have ... them involving bombs or explosives, says a new report ... Study of Terrorism and Responses to Terrorism (START). ... from the Center,s Global Terrorism Database (GTD), the world,s ...
... , May 18 Patient and professional ... marketplace on new medicines. Effectively collaborating with advocacy groups ... and is especially critical for socially sensitive conditions/therapies. " ... " is a 125-page report from Best Practices, LLC ...
Cached Biology Technology:Trius Therapeutics Awarded U.S. Department of Defense Contract to Develop Novel Antibiotics 2Trius Therapeutics Awarded U.S. Department of Defense Contract to Develop Novel Antibiotics 3US terror concentrated in New York City; bombs weapon of choice 2Educating the Marketplace Through Collaborations with Patient Advocacy Groups 2Educating the Marketplace Through Collaborations with Patient Advocacy Groups 3
Purified anti-PI3K p110 delta...
Biotin anti-mouse Ly-49C/F/I/H...
... Antigen Afinity Purified Tyrosine Hydroxylase ... antibody was raised against synthetic ... residues surrounding the phospho-Ser40 of ... antibody was purified by sequential ...
Mouse Wnt-9b Biotinylated Affinity Purified PAb ENTREZ GeneID: 22412...
Biology Products: