Navigation Links
U of T-led study cracks universal RNA code, suggests a new cause for autism
Date:7/12/2013

The discovery cracks the "RNA control code," which dictates how RNA a family of molecules that mediates DNA expression moves genetic information from DNA to create proteins.

"For the first time, we understand the language of a code that is essential to gene processing," said Quaid Morris, a Professor in U of T's Donnelly Centre for Cellular and Biomolecular Research and the Banting and Best Department of Medical Research. "Many human diseases are due to defects in this code, so figuring out what it means is crucial to creating new treatments for many conditions."

The scientific journal Nature published the study results in its July 11, 2013 issue.

The researchers translated the code with a biochemical technique developed by a research scientist in Hughes' lab, Debashish Ray, and a student in Morris's lab, Hilal Kazan. The team defined the meaning of "words" in RNA, allowing identification of patterns in RNA molecules that proteins use to control RNA processing and movement, which are often altered in disease.

One protein they looked at may explain some of the symptoms in children with autism. The researchers found that RBFOX1, a protein often turned off in the brains of patients, ensures the activity of genes important for the function of nerve cells in the brain.

"This was a surprising finding, because we knew RBFOX1 controls gene expression, but had no idea it also stabilizes RNA," said Tim Hughes, a Professor in the Department of Molecular Genetics and the Donnelly Centre. "It's a good example of the predictive power of the RNA control code, which we think will really open up the field of gene regulation."

Hughes said the work also shows that the RNA control code may be easier to interpret than a similar control code in DNA. Researchers have been struggling for years to understand this DNA control code, but the new results suggest RNA control could offer a more fruitful area of inquiry, with aut
'/>"/>

Contact: Jim Oldfield
jim.oldfield@utoronto.ca
416-946-8423
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. Vanderbilt-led team to develop microbrain to improve drug testing
2. Study finds surprising benefits about diary cow inflammation
3. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
4. Journal highlights Arctic sea ice study by UM professor
5. Innovative MIT study estimates extent to which air pollution in China shortens human lives
6. Temperature increases causing tropical forests to blossom, according to study
7. New study reveals important role of insulin in making breast milk
8. Study reveals ancient jigsaw puzzle of past supercontinent
9. Reproductive BioMedicine Online publishes study on assisted reproduction
10. Lifesaving HIV treatment could reach millions more people following landmark study
11. Low levels of toxic proteins linked to brain diseases, study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... July 8, 2015 Summary Pancreatic cancer ... fourth most fatal, with a mortality rate of 10.9 ... of pancreatic cancer patients has highlighted a significant need ... not being met by the current market. A ... products with varying molecule types and mechanisms of action, ...
(Date:7/8/2015)... SAN DIEGO , July 8, 2015 /PRNewswire/ ... of cell-free molecular diagnostics, today announced the launch ... of the Company,s Precision Cancer Monitoring℠ (PCM) technology ... patients receiving one or a combination of the ... and Opdivo® (nivolumab), a PD-1 inhibitor. The 50-patient ...
(Date:7/7/2015)... June 30, 2015 ... the addition of the "Capacitive Fingerprint Sensors ... To this date, fingerprint sensing technology is ... fingerprint sensors are well developed. This patent landscape ... The domain of capacitive fingerprint sensors ...
Breaking Biology News(10 mins):Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2
... headway against a major public health threat, Dartmouth College researchers ... records data in real time, a new study in the ... researchers expect to soon convert the prototype, which is smaller ... reusable device that helps to enforce no smoking regulations and ...
... activity data wirelessly for more than a year in early ... National Institutes of Health. In addition to allowing for more ... device represents a potential major step toward cord-free control of ... report is in the April 2013 issue of the ...
... The Massachusetts Life Sciences Center (MLSC) announced a $4.1 ... newly-created Forsyth Center for Salivary Diagnostics (FCSD). The grant ... a facility that will seek to revolutionize the way ... in December, 2012, more than $400,000 in equipment and ...
Cached Biology News:Wireless, implanted sensor broadens range of brain research 2Wireless, implanted sensor broadens range of brain research 3Forsyth Institute receives $4.1 million grant for new center 2Forsyth Institute receives $4.1 million grant for new center 3
(Date:7/27/2015)... , July 27, 2015   Inocucor ... produces sustainable biological accelerators for farmers, has received ... and Trademark Office for its patent application to ... accelerate plant growth and enhance yields on farms ... relates to Inocucor,s live IN-M1 microbial consortium and ...
(Date:7/27/2015)... FORT WORTH, Texas , July 27, 2015 ... Biopreservation Media Market by Type (Home-brew Media, Pre-formulated Media), by ... North America , Europe , ... & Forecast to 2019", The global biopreservation media market was ... grow to around $571.5 million by 2019, at a CAGR ...
(Date:7/27/2015)... , July 27, 2015 IDEXX Laboratories, ... than 8,000 clinics have submitted over 100,000 specimens to ... in just the first 10 days since the breakthrough ... disease (CKD) is a leading cause of suffering and ... submitted specimens are consistent with generally accepted kidney disease ...
(Date:7/25/2015)... ... July 25, 2015 , ... ... refractometer series. It precisely checks and adjusts the surface temperature of the measuring ... In the pharmaceutical industry, data traceability and documentation are key requirements. It is ...
Breaking Biology Technology:Inocucor Technologies Receives Groundbreaking U.S. Patent for Proprietary Biological Processes that Stimulate Plant Growth 2Inocucor Technologies Receives Groundbreaking U.S. Patent for Proprietary Biological Processes that Stimulate Plant Growth 3Global Biopreservation Media Market to be Worth $571.5 Million by 2019 2Global Biopreservation Media Market to be Worth $571.5 Million by 2019 3Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 2Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 3Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 4Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 5It’s T-Time for Refractometers: On-site Temperature Check Now Available 2
... Richard Duffey, M.D., to its LASIK Directory. ... also serves patients from Pensacola, Florida and from ... Mississippi.,Trusted LASIK Surgeons launched its revolutionary Trusted LASIK ... consumers at www.TrustedLASIKSurgeons.com . What sets the ...
... Varian, Inc.,(NasdaqGS: VARI) introduced its new dual wavelength ... proteins. The SuperNova(TM) is the,first dual wavelength diffraction ... It includes innovations in both X-ray,technology and data ... crystals., Single crystal X-ray diffraction is used ...
... Quality and process,improvement efforts gained new momentum ... higher efficiencies fueled by a stagnating economy.,Biopharmaceutical companies ... pipelines are affecting the bottom line, competition for ... brought more scrutiny to R&D,and New Product Development ...
Cached Biology Technology:Trusted LASIK Surgeons Welcomes Mobile Alabama Expert Refractive Eye Surgeon Richard Duffey, M.D. to Its LASIK Directory For Consumers 2Trusted LASIK Surgeons Welcomes Mobile Alabama Expert Refractive Eye Surgeon Richard Duffey, M.D. to Its LASIK Directory For Consumers 3Trusted LASIK Surgeons Welcomes Mobile Alabama Expert Refractive Eye Surgeon Richard Duffey, M.D. to Its LASIK Directory For Consumers 4Trusted LASIK Surgeons Welcomes Mobile Alabama Expert Refractive Eye Surgeon Richard Duffey, M.D. to Its LASIK Directory For Consumers 5Trusted LASIK Surgeons Welcomes Mobile Alabama Expert Refractive Eye Surgeon Richard Duffey, M.D. to Its LASIK Directory For Consumers 6New Dual Wavelength X-ray Diffractometer From Oxford Diffraction, Now a Part of Varian, Inc., Allows Increased Throughput for Challenging Single Crystal Analyses 2Leading Biopharmas Will Deliver Case Studies on Achieving Productivity Excellence through Engagement, Technology, Other Tools 2
... are supplied as 10X concentrated solutions. REact Buffer ... of the REact buffers and one 250 microl ... four 1 ml vials of REact 1 Buffer ... four 1 ml vials of REact 3 Buffer ...
This Malachite Green Phosphate Detection Kit...
Request Info...
Request Info...
Biology Products: