Navigation Links
U of M researchers: Newly discovered genetic markers could signal colon cancer development
Date:8/24/2012

MINNEAPOLIS/ST. PAUL (August 23, 2012) University of Minnesota Medical School and Masonic Cancer Center researchers have partnered with geneticists from Genentech, Inc., to discover how some proteins may cause the development of some forms of colon cancers.

The proteins part of R-spondin family normally help activate cell proliferation during embryonic development. Now, University of Minnesota researchers have discovered that when two types of R-spondins RSPO2 and RSPO 3 are reactivated in adults through certain gene mutations, they can signal cells to restart the cell proliferation process, which can lead to tumor growth in the colon.

The discovery, which involved multiple researchers from the University's Masonic Cancer Center, could lead the way to more personalized colon cancer therapy designed around the genetics of a patient's specific cancer. The results are available online now, in the journal Nature.

"These results suggest there is a potential for personalized therapies based on knowing a tumor's specific genetics," said David Largaespada, Ph.D., associate director of Basic Sciences and professor in the Department of Genetics, Cell Biology and Development. "And because these R-spondins are related to embryonic growth, and seem to not have major roles in the adult, targeting them would likely be low in side effects."

To arrive at the results, researchers analyzed more than 70 pairs of human colon tumors and a mouse model engineered using the Sleeping Beauty transposon by Largaespada. Through a series of investigations, researchers identified 36 rearrangements that result in gene fusions, including two recurrent ones involving R-spondin family members RSPO2 and RSPO3.

While the results could generate more personalized approaches to the treatment of colon cancer, researchers stress more research is needed before these results can be applied to actual patient care.

Caitlin Conboy, an M.D./Ph.D. student studying at
'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UCSD researchers: Where international climate policy has failed, grassroots efforts can succeed
2. Newly released FDA draft guidelines for biosimilar drugs to be discussed at conference
3. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
4. Newly discovered foot points to a new kid on the hominin block
5. Newly found protein helps cells build tissues
6. Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
7. Key proteins newly discovered form and function may provide novel cancer treatment target
8. Newly discovered breast milk antibodies help neutralize HIV
9. Newly discovered dinosaur implies greater prevalence of feathers
10. Unexpected crustacean diversity discovered in northern freshwater ecosystems
11. University of Alberta led research may have discovered how memories are encoded in our brains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... some surprising discoveries about the body,s initial responses ... the team found that specialized cells in the ... viral invasion and are the source of gut ... (IL-1β). , Though aimed at the presence ... epithelium that provides a barrier to protect the ...
(Date:8/29/2014)... over the last 120,000 years may have influenced ... researchers led by City College of New York ... metric called "phylogeographic endemism." , It quantifies the ... is restricted in geographical space. , Dr. Carnaval, ... researchers from institutions in Brazil, Australia and the ...
(Date:8/29/2014)... prolific bloomer Emiliania huxleyi , can grow without ... contradicts the common view that E. huxleyi ... of thiamine in the ocean to survive. , "It,s ... says CIFAR Senior Fellow Alexandra Worden , co-author ... fellows John Archibald (Dalhousie University), Adrin ...
Breaking Biology News(10 mins):The early cost of HIV 2CCNY team defines new biodiversity metric 2Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3
... Fingerprinting for Kids" event on April 18 at ... CHESAPEAKE, Va., April 2 Turner Network Sales ... System, Inc. (TBS, Inc.), and truTV, are partnering with Cox ... "Digital Fingerprinting for Kids" event , a service designed ...
... Wins Gold Innovation Award; Senior Scientist Dr. Caleb ... Receives Certificate of RecognitionBOSTON, April 6 ... revolutionary biometric media research firm specializing in Emotional ... Awards from the Advertising Research Foundation.The Innovation Awards, ...
... Aware, Inc. (Nasdaq: AWRE ), a ... announced the preliminary results of its modified Dutch Auction ... City time, on Friday, April 17, 2009.In accordance with ... based on the preliminary count by Computershare Trust Company, ...
Cached Biology News:truTV and Cox Offer Free Digital Fingerprinting to Help Prevent Crimes Against Children 2truTV and Cox Offer Free Digital Fingerprinting to Help Prevent Crimes Against Children 3Innerscope Research(R) Receives Three Great Minds Innovation Awards from the Advertising Research Foundation 2Aware, Inc. Announces Preliminary Results of Dutch Auction Tender Offer 2Aware, Inc. Announces Preliminary Results of Dutch Auction Tender Offer 3
(Date:9/2/2014)... 2, 2014  Synthetic Biologics, Inc. (NYSE MKT: ... drug candidates targeting specific pathogens that cause serious ... its final preclinical toxicology study of SYN-004. Per ... bridging study was required to move the Company,s ... the devastating effects of Clostridium difficile (C. ...
(Date:9/2/2014)... 2, 2014 Culot brings life ... lab management services  BioData, producer of Labguru, ... to announce the appointment of Louis Culot ... as VP Marketing and Business Development at BioDiscovery Inc., ... clinical applications. Previously, Culot worked for 17 ...
(Date:9/1/2014)... The Collaborative R&D Terms and ... comprehensive understanding and unprecedented access to the collaborative ... worlds leading life science companies. , The report ... and why companies enter collaborative R&D deals. , ... deals terms provides critical insight into the negotiation ...
(Date:8/31/2014)... August 31, 2014 This is ... state of the Epoxy Hardener industry in ... overview of the industry, including definitions, applications and ... domestic market analysis are provided with a focus ... the market. A comparison between the international and ...
Breaking Biology Technology:Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 3Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 5Louis Culot Appointed as BioData's CEO 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3
... MEDdevice Acquisition Co., LLC,MDAC is proud to announce that ... experience and proven success optimizing investments in,the medical device ... announced include:, Tony Dimun, CEO of Nascent Enterprises, ... Larry Gold, PhD, Chairman and CEO of SomaLogic ...
... May 14 Biodel Inc. (Nasdaq:,BIOD) today announced that ... and Treasurer of Biodel, will present a,corporate update at ... May 22, 2008 at 1:00 p.m. Eastern Time. The,conference ... New York, New York., Interested parties may access ...
... Company employees in nearly 50 nations are rolling up ... celebration of Lilly,s,first-ever Global Day of Service, possibly the ... day., Beginning at sunrise in New Zealand, Lilly ... energy to improve the health and,well-being of communities around ...
Cached Biology Technology:MEDdevice Acquisition Co., LLC Announces Board Members and Advisors 2Lilly Employees from Nearly 50 Nations Participate in Company's First-Ever Global Day of Service 2
... (MUC3) is a glycoprotein. distributed in ... extent in breast, lung and salivary gland ... cross-reaction with MUC1 and MUC2. ... Immunogen: MUC3 tandem repeat peptide ...
... bottoms,• Nonreversible lids with ... contamination,• Individual alphanumerical codes ... footprint for ease in ... cell attachment,• Sterilized by ...
Rabbit polyclonal to GABA A Receptor gamma 2 ( Abpromise for all tested applications). entrezGeneID: 2566 SwissProtID: P18507...
Rabbit polyclonal to VPAC2 ( Abpromise for all tested applications). entrezGeneID: 7434 SwissProtID: P41587...
Biology Products: