Navigation Links
U of Alberta researcher steps closer to understand autoimmune diseases
Date:3/6/2012

Understanding why immune cells, called T-cells, attack the body is vital in the war against autoimmune diseases like diabetes. University of Alberta researcher Troy Baldwin is a step closer to understanding why the body's T-cells sometimes attack healthy cells causing autoimmune diseases.

Baldwin and graduate student Alex Suen looked at a specific molecule, Bim, which is vital in regulating T-cell death. When they removed Bim they found that the autoreactive T-cells, which are normally eliminated from the blood, were able to survive but were left inactive.

The other part of this study, which is published in the Proceedings of the National Academy of Sciences, is that there is another mechanism controlling these T-cells above and beyond Bim.

"When the autoreactive [T-cells] survived because Bim was absent, they weren't able to kill the insulin producing cells in the pancreas," said Baldwin, who is looking specifically at the T-cells that target the pancreas, which causes diabetes.

"Our future work is going to look at what those mechanisms are that are controlling these cells," said Baldwin. "Even though they [T-cells] are present in the body and should be able to target, in this case, the pancreas and cause diabetes, they don't."

This work has big potential. Understanding why these cells didn't target the pancreas and why they are inactive could lead to new therapies to control auto-reactive T-cells and help people with autoimmune diseases.

"Something is telling them not to become active," said Baldwin. "If we can figure out what that something is, we could then potentially use that information to try and either suppress cells that would normally become activated and cause autoimmunity or vice versa. We could now take T-cells that are not active and make them more active.

"Cancer therapies, for example, are one place where we want to boost the T-cell response. So if we turn that suppressive m
'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-248-2048
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. U of Alberta research group recognized with national chemistry awards
2. Mountain pine beetle marching east from Alberta
3. U of Alberta researcher discovers potential cancer therapy target
4. U of Alberta researchers discover important mechanism in fighting infection
5. U Alberta-led team studies T cell activation with nanoparticles
6. U Alberta find could shield humans from influenza virus
7. U of Alberta researchers find mechanism that could prevent or treat deadly peroxisome diseases
8. U Alberta researcher in same group as Darwin and Hawking
9. New dinosaur species possible in Northwestern Alberta
10. A new dinosaur species, Pachyrhinosaur lakustai, unveiled from Pipestone Creek, Alberta, Canada
11. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... a non-traditional biophysics textbook and it describes how life ... of discovery into biological systems and provides an understanding ... is about how our genes make proteins that control ... cells in an organism. It quantifies the principles of ... be found on both large and small scales. The ...
(Date:10/15/2014)... be awarded the 44th Rosenstiel Award for Distinguished Work ... research exploring the mechanisms of genomic instability and its ... is the second alumnus to win the Rosenstiel Award; ... 2003. , Alt is the Charles A. Janeway Professor ... School and an investigator at the Howard Hughes Medical ...
(Date:10/14/2014)... have sequenced the house fly genome for the first ... from an insect that thrives in pathogen-rich dung piles ... in the journal Genome Biology , will increase ... how flies quickly adapt to resist insecticides, which could ... (Musca domestica) carry and transmit more than 100 human ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2House fly genome reveals expanded immune system 2
... choice but to adapt to them. Plants have to do ... unusual strengths, accustomed as they are to living in a ... on this capacity to adapt, researcher Ms Lur Epelde used ... current level of contamination in the soil, caused by human ...
... who understand the geological age of the Earth (4.5 billion ... evolution, according to a University of Minnesota study published in ... The finding could give educators a new strategy for teaching ... rather than biological science classes. Researchers Sehoya Cotner and ...
... of large mammals in India by the Wildlife Conservation ... country,s protected area system and human cultural tolerance for ... elephants, and other large mammals. According to ... in the midst of rapid economic growth will require ...
Cached Biology News:Plants in mining areas can cure soil affected by contamination in very short time 2Plants in mining areas can cure soil affected by contamination in very short time 3Students' perceptions of Earth's age influence acceptance of human evolution, says U of Minn. study 2India's shrinking animal ark needs more parks, corridors 2
(Date:10/18/2014)... 2014 The Asia-Pacific Liquid Crystal on ... concerned market in Asia-Pacific with analysis and forecast of ... 2013, and is expected to reach $380.0 million by ... 2018. , Browse through the TOC of the Asia-Pacific ... the in-depth analysis provided. This also provides a glimpse ...
(Date:10/18/2014)... The Biomass Power industry has ... to 2014. The industry's expansion has been propelled in ... encouraged the use of biomass power. Furthermore, the majority ... require local utilities to generate electricity from renewable power ... campaigning for green technology also influenced industry performance by ...
(Date:10/18/2014)... The report " Cloud Analytics Market [Cloud BI; ... Video; Predictive Analytics: Global Advancements, Delivery Models, Market ... - 2018) ", defines and segments the global ... an in-depth analysis and forecasting of market sizes. ... market, various restraints, and opportunities impacting it along ...
(Date:10/17/2014)... UT Arlington engineering professors have received a $451,781 Air ... material surface at the micro- and nano-scale level that ... Haiying Huang, professor of Mechanical and Aerospace Engineering, said ... more efficient than taking X-rays of an aircraft,s wing., ... early stages when we look at it on this ...
Breaking Biology Technology:The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5UT Arlington project to detect possible damages in aircraft parts early in process 2
... are developing a new type of computer memory that ... use far less power than flash memory devices. ... a material that switches polarity when electric fields are ... "It,s in a very nascent stage," said doctoral ...
... 27, 2011 Neogen Corporation (Nasdaq: NEOG ) ... FY 2012, which ended Aug. 31, increased 6.5% to $45,697,000, ... current year,s revenue increase is almost entirely comprised of products ... quarter net income increased 3.1% from the prior year to ...
... Circassia Ltd, a specialty biopharmaceutical company focused ... results showing that its ToleroMune® hay fever vaccine ... on placebo.  The treatment was extremely well tolerated. ... phase II study conducted in 50 hay fever ...
Cached Biology Technology:New 'FeTRAM' is promising computer memory technology 2Neogen Reports First Quarter Revenue and Net Income Increases 2Neogen Reports First Quarter Revenue and Net Income Increases 3Neogen Reports First Quarter Revenue and Net Income Increases 4Neogen Reports First Quarter Revenue and Net Income Increases 5Circassia's Hay Fever Treatment Improves Patients' Allergy Symptoms in Phase II Clinical Trial 2Circassia's Hay Fever Treatment Improves Patients' Allergy Symptoms in Phase II Clinical Trial 3
assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and DNA....
EnzChek cellulase substrate *blue fluorescent, 339/452...
... for sizing single-stranded RNA ranging from 0.5 kb to ... ladder consists of nine bands in even increments (0.5 ... kb) to simplify size estimation. The 1.5 kb band ... orientation and identification of RNA bands on the gel. ...
...
Biology Products: