Understanding why immune cells, called T-cells, attack the body is vital in the war against autoimmune diseases like diabetes. University of Alberta researcher Troy Baldwin is a step closer to understanding why the body's T-cells sometimes attack healthy cells causing autoimmune diseases.
Baldwin and graduate student Alex Suen looked at a specific molecule, Bim, which is vital in regulating T-cell death. When they removed Bim they found that the autoreactive T-cells, which are normally eliminated from the blood, were able to survive but were left inactive.
The other part of this study, which is published in the Proceedings of the National Academy of Sciences, is that there is another mechanism controlling these T-cells above and beyond Bim.
"When the autoreactive [T-cells] survived because Bim was absent, they weren't able to kill the insulin producing cells in the pancreas," said Baldwin, who is looking specifically at the T-cells that target the pancreas, which causes diabetes.
"Our future work is going to look at what those mechanisms are that are controlling these cells," said Baldwin. "Even though they [T-cells] are present in the body and should be able to target, in this case, the pancreas and cause diabetes, they don't."
This work has big potential. Understanding why these cells didn't target the pancreas and why they are inactive could lead to new therapies to control auto-reactive T-cells and help people with autoimmune diseases.
"Something is telling them not to become active," said Baldwin. "If we can figure out what that something is, we could then potentially use that information to try and either suppress cells that would normally become activated and cause autoimmunity or vice versa. We could now take T-cells that are not active and make them more active.
"Cancer therapies, for example, are one place where we want to boost the T-cell response. So if we turn that suppressive m
|Contact: Quinn Phillips|
University of Alberta Faculty of Medicine & Dentistry