Navigation Links
Type II diabetes and the Alzheimer's connection
Date:2/1/2013

Philadelphia, Pa. A research team in Israel has devised a novel approach to identifying the molecular basis for designing a drug that might one day decrease the risk diabetes patients face of developing Alzheimer's disease. The team will present its work at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.

A recent study suggests that people who suffer from type 2 diabetes face twice the risk of developing Alzheimer's disease later in life compared to those who do not have diabetes. The link these diseases share relates to the formation of two types of peptide deposits that aggregate, or clump together. Peptides are chains of amino acids; longer chains form proteins. One type of peptide, called amyloid beta, is found in Alzheimer plaques in neurons of the brain. The other type, amylin, is found in the pancreas and the brain. Two years ago, researchers found both molecules in the pancreas of diabetic patients, and in both diseases their presence has been linked to the progression of the disease state.

To explore the hypothesis that interactions between the two molecules might play a critical role in the self-assembly of peptides that leads to protein aggregation, Yifat Miller, assistant professor from Ben-Gurion University of the Negev, Beer-Sheva, Israel, characterized the way the two protein molecules interact with each other through an examination of their structure. It was the first analysis of its kind.

"By identifying the specific 'hot regions' of these peptides that strongly interact with each other, our study may provide insight into the link between type 2 diabetes and Alzheimer's disease," Miller says. "We believe that preventing these interactions by developing a drug will decrease the risk that type 2 diabetes patients face of developing Alzheimer's disease later life."

Collaborator Aphrodite Kapurniotu of Technische Universitt Mnchen, Freising-Weihenstephan, Ger
'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
2. Researchers identify a new gene with a key role in obesity and diabetes
3. Most-used diabetes drug works in different way than previously thought
4. UCSB researchers perform pioneering research on Type 2 diabetes
5. NTU study finds ways to prevent muscle loss, obesity and diabetes
6. Notre Dame research may have important implications for combating diabetes
7. University of Chicagos Graeme Bell receives international diabetes prize
8. Joslin researchers increase understanding of genetic risk factor for type 1 diabetes
9. Arginine and proline enriched diet may speed wound healing in diabetes
10. Diabetes Management Provider ActiveCare Announces Cost Savings Of Over $4,000 Per Year Per Diabetic Member
11. Purple corn compound may aid in developing future treatments for Type 2 diabetes, kidney disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2014)... BEACH GARDENS, Fla. , Dec. 3, 2014 ... management solutions, today announced that its DigitalPersona ® ... 4500 fingerprint readers have been deployed throughout First ... , South Carolina ... headquartered in Southern Pines, North Carolina ...
(Date:12/3/2014)... -- As part of our commitment to offering the ... announce the release of a new reader that will ... data that they need. The Atlas 2000 ... readers. Many such devices have serious shortcomings when it ... models force users to navigate numerous complicated steps in ...
(Date:11/21/2014)... 2014  Earlier this year Donald Spector , ... one of the most prolific inventors in the world, ... from Smartphones to third party agencies. Spector envisioned this ... of the earliest known patents in this area. Now ... military, child care, elder care and hospital applications. This ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Inception Technologies to Release New Biometric Reader 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... 2008 -- Rice University bioengineer Jennifer West is being ... highest scientific honors, the O,Donnell Award from The Academy ... The O,Donnell Awards, given for excellence in medical, scientific ... and an inscribed statue. West, a pioneer in the ...
... University Program in Biodesign have released a review ... medical device regulation in the United States. ... of the Journal of Medical Devices, highlights the ... and underscores the complexity of the approval process ...
... out of the University of Alberta for those who may have ... medical researchers have found a way to reduce the amount of ... from food the body metabolizes, a key discovery that could lead ... 2 diabetes and heart disease related to obesity. In ...
Cached Biology News:Rice's West honored as one of Texas' best researchers 2Rice's West honored as one of Texas' best researchers 3Stanford researchers publish review of US medical device regulation 2Stanford researchers publish review of US medical device regulation 3University of Alberta researchers report breakthrough in lowering bad cholesterol, fatty acid levels 2
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/fhh9rj/technology ) ... Innovations in Smart Fabrics (Technical Insights)" report ... http://photos.prnewswire.com/prnh/20130307/600769 The Research Service titled ... assessment on technological advancements and market for Smart ... 1. The Smart Fabrics market is expected to ...
(Date:12/19/2014)... CAMBRIDGE, MA (PRWEB) December 18, 2014 ... adults in the United States suffer from one or ... arthritis, asthma, or cancer. Medication can address some of ... to daily activities that many sufferers face. While implanted ... surgery and stimulate the whole nerve, which can induce ...
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group ... dental biomaterial market will grow moderately through 2023 as ... and growing awareness of dental biomaterials all spur procedure ... such as China and ... bring dental procedures within reach for a larger proportion ...
(Date:12/17/2014)... Based on the revenues gained from surgical imaging ... by four major players contributing to approximately 74% ... GE Healthcare (U.K.), Siemens AG (Germany), Philips (Netherlands), ... Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html , The leading ... its strong product portfolio, which includes its flagship ...
Breaking Biology Technology:Technology Innovations in Smart Fabrics (Technical Insights) 2Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... Held on November 18, 2008, WITTEN, Germany, October ... for its fiscal year,ended June 30, 2008, on October ... with the SEC the company yielded sales of its ... USD 207,000 a decrease,of 44% as compared with sales ...
... Twelve finalist teams vie for cash prizes awarded for nation,s ... ... Oct. 22 The National Inventors Hall of,Fame Foundation today ... group of finalists includes,undergraduate and graduate students from across the ...
... Corporation,(Nasdaq: GENZ ) has announced findings from ... following,viscosupplementation treatments with Synvisc and Hyalgan in patients ... that Synvisc,provided longer knee pain relief and a ... by orthopaedic surgeon Raghu Raman and a team ...
Cached Biology Technology:Sangui Biotech International, Inc., Reports Sales Decrease, Continued Losses 2Collegiate Inventors Competition(R) Recognizes Top Student Inventors 2Collegiate Inventors Competition(R) Recognizes Top Student Inventors 3Collegiate Inventors Competition(R) Recognizes Top Student Inventors 4Independent Study Reveals SYNVISC(R) Offers Longer Knee Pain Relief and Greater Patient Satisfaction for Those Suffering from Osteoarthritis of the Knee 2Independent Study Reveals SYNVISC(R) Offers Longer Knee Pain Relief and Greater Patient Satisfaction for Those Suffering from Osteoarthritis of the Knee 3
...
Standard 2" and 3" Fiberboard Boxes can be sold separately or with 16, 25, 36, 49, 64, 81 or 100 cell dividers. Fiberboard boxes can also be ordered with corresponding freezer racks...
Whole blood is collected from mice (Swiss Webster, 8-10 weeks old,either sex) and processed within 45 minutes of collection. The complement is then filtered and pooled on ice, bottled and stored at -...
... Immunogen : Recombinant human ... 5mg/ml BSA, 0.15M NaCl, 0.05% ... of glycerol to 30% Quality ... on acid extracts of murine ...
Biology Products: