Navigation Links
Type II diabetes and the Alzheimer's connection
Date:2/1/2013

Philadelphia, Pa. A research team in Israel has devised a novel approach to identifying the molecular basis for designing a drug that might one day decrease the risk diabetes patients face of developing Alzheimer's disease. The team will present its work at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.

A recent study suggests that people who suffer from type 2 diabetes face twice the risk of developing Alzheimer's disease later in life compared to those who do not have diabetes. The link these diseases share relates to the formation of two types of peptide deposits that aggregate, or clump together. Peptides are chains of amino acids; longer chains form proteins. One type of peptide, called amyloid beta, is found in Alzheimer plaques in neurons of the brain. The other type, amylin, is found in the pancreas and the brain. Two years ago, researchers found both molecules in the pancreas of diabetic patients, and in both diseases their presence has been linked to the progression of the disease state.

To explore the hypothesis that interactions between the two molecules might play a critical role in the self-assembly of peptides that leads to protein aggregation, Yifat Miller, assistant professor from Ben-Gurion University of the Negev, Beer-Sheva, Israel, characterized the way the two protein molecules interact with each other through an examination of their structure. It was the first analysis of its kind.

"By identifying the specific 'hot regions' of these peptides that strongly interact with each other, our study may provide insight into the link between type 2 diabetes and Alzheimer's disease," Miller says. "We believe that preventing these interactions by developing a drug will decrease the risk that type 2 diabetes patients face of developing Alzheimer's disease later life."

Collaborator Aphrodite Kapurniotu of Technische Universitt Mnchen, Freising-Weihenstephan, Ger
'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Joslin scientists find first human iPSC from patients with maturity onset diabetes of the young
2. Researchers identify a new gene with a key role in obesity and diabetes
3. Most-used diabetes drug works in different way than previously thought
4. UCSB researchers perform pioneering research on Type 2 diabetes
5. NTU study finds ways to prevent muscle loss, obesity and diabetes
6. Notre Dame research may have important implications for combating diabetes
7. University of Chicagos Graeme Bell receives international diabetes prize
8. Joslin researchers increase understanding of genetic risk factor for type 1 diabetes
9. Arginine and proline enriched diet may speed wound healing in diabetes
10. Diabetes Management Provider ActiveCare Announces Cost Savings Of Over $4,000 Per Year Per Diabetic Member
11. Purple corn compound may aid in developing future treatments for Type 2 diabetes, kidney disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2015)... , Feb. 9, 2015  Lintec of America recently ... for carbon nanotube (CNT) macrostructures, including sheets, yarns and ... (UTD). Leveraging the vast industrial resources of ... Japan , Lintec of America is forming the ... TX , focusing on scaling up the manufacturing ...
(Date:2/5/2015)... , Jan. 26, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... corporate website ( http://www.nxt-id.com/ ) as part of its ... wallet. The Company launched its new consumer website for ... Pereira , CEO of NXT-ID said, "Our new corporate ...
(Date:2/5/2015)... , Jan. 28, 2015 Research and ... the addition of the "Global Biometrics Market ... Regions and Countries " report to their offering. ... Asia-Pacific is anticipated to ... 2015, owing to increasing government spending towards IT ...
Breaking Biology News(10 mins):Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3
... the prism of our senses, the human brain has ways ... is seen, for example, in the placebo effect, when simple ... seen to ease pain or have some other beneficial physiological ... the body to respond is largely a mystery of neuroscience. ...
... of Japanese scientists has discovered that cannabinoids can cause some ... the sites of infection and inflammation. These findings, which ... Biological Chemistry, could have potential use in the development of ... chemicals that include marijuana. These compounds bind to and ...
... are potentially limitless. In the long term it will ... to combat neurological disorders. What's more, it could allow ... as their CPU. , Those applications are potentially decades ... technology could enable very advanced and sophisticated drug screening ...
Cached Biology News:Great (taste) expectations: Study shows brain anticipates taste, shifts gears 2Researchers get neurons and silicon talking 2
(Date:2/27/2015)... 2015 A paper published today, " ... " in Science Translational Medicine, demonstrates ... reduce the risk associated with investing in the ... levels of funding for developing so-called "orphan" drugs. ... collaboration between scientists at the National Center for ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 The ... system (Nexera UC) can sequentially analyze up to ... combined with high-sensitivity detection of targets by mass ... designed to fulfill the measurement requirements of a ... food products, drug delivery and search for disease ...
(Date:2/27/2015)... 2015 FamilyFarms Group is pleased to ... State Line Farms, received the 2015 Tomorrow’s Top Producer ... the age of 35, who has demonstrated excellence in ... to win the Tomorrow's Top Producer Horizon Award. Every ... Top Producer Award and learning from their experiences. It ...
(Date:2/27/2015)... , Feb. 27, 2015   PureTech , ... inventing and commercializing disruptive products and technologies in the ... Viehbacher , former CEO and Member of the Board ... "It,s has been a pleasure to ... excited that we will be working together more closely ...
Breaking Biology Technology:New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 2Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 3Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 4
... Colo. , May 11 N30 Pharma (N30), a biopharmaceutical company focused ... endogenous, bioactive nitric oxide, announced today that it has completed a $10 million ... , , ... Deerfield Management. , , , ...
... SAN DIEGO , May 11 ... Biomatrica Connect™, a solution-centric partnership program established with ... room temperature storage and management of nucleic acids. ... scientific/industry partnership for the development, testing, validation and ...
... at the University of Gothenburg, Sweden, have managed, with the ... of atoms during photosynthesis an achievement that has been ... European Synchrotron Radiation Facility in Grenoble is home to one ... beams are used by researchers to photograph and study life,s ...
Cached Biology Technology:Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 2Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 3Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 4Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 5Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 6
... chamber assembly (1 each) Components (chamber ... user guide plastic tweezersChambers are stainless ... and reused. The chamber is designed for ... and all custom oligo microarrays, in conjunction ...
Formula variant: With the macro- and micronutrients as described by Lloyd and McCown (1981). Preparation Quantity Equivalency: Formulated to contain 2.3 grams of powder per liter of medium. Physical ...
... Staining Kit is a very sensitive immunohistochemical ... cells, containing both anti-von Willebrand Factor and ... a variety of species. This AP kit ... staining of frozen and paraffin-embedded sections in ...
... For separation and ... Efficient separation of nuclei from ... in sample complexity, greatly facilitating ... Subfractionation of nucleic acid binding ...
Biology Products: