Navigation Links
Tuberculosis genomes portray secrets of pathogen's success
Date:8/21/2013

MADISON, Wis. By any measure, tuberculosis (TB) is a wildly successful pathogen. It infects as many as two billion people in every corner of the world, with a new infection of a human host estimated to occur every second.

Now, thanks to a new analysis of dozens of tuberculosis genomes gathered from around the world, scientists are getting a more detailed picture of why TB is so prevalent and how it evolves to resist countermeasures. Writing today (Aug. 21, 2013) in the journal Public Library of Science (PLoS) Pathogens, a team led by University of Wisconsin-Madison researcher Caitlin Pepperell describes a bacterium that marches in lockstep with human population growth and history, evolving to take advantage of the most crowded and wretched human conditions.

"It's as though the bacterium places bets on human behavior," says Pepperell, formerly of Stanford University, and now a professor of medicine and medical microbiology at UW-Madison. "It always bets that humans will go to war, send people to refugee camps, and gather in miserable places. Historically, that's been a winning bet on the bacterium's part."

The PLoS Pathogens study, whose senior author is Marcus Feldman of Stanford, reveals that tuberculosis experienced a 25-fold expansion worldwide in the 17th century, a time when human populations underwent explosive growth and European exploration of Africa, the Americas, Asia and Oceania was at its peak.

"The timing is coincident with expansion, urbanization and colonial migrations of global human populations," Pepperell explains. "These findings suggest that much of the current TB pandemic has its origins in historical events of the last three centuries."

TB is only transmitted by people, and the organism cannot survive in the environment. It thrives, however, in the crowded conditions of prisons, refugee camps and slums, and TB populations tend to be dominated by the bacteria "lucky" enough to
'/>"/>

Contact: Caitlin Pepperell
cspepper@medicine.wisc.edu
608-262-5983
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biosignatures distinguish between tuberculosis and sarcoidosis
2. Targeting tuberculosis hotspots could have widespread benefit
3. MIT-designed cooler preserves tuberculosis drugs, records doses
4. Research on improvements in diagnosing and treating tuberculosis
5. Millions of diabetics could die of tuberculosis
6. New approach of resistant tuberculosis
7. Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis
8. High doses of Vitamin D help tuberculosis patients recover more quickly
9. Scientists reveal how natural antibiotic kills tuberculosis bacterium
10. Notre Dame research could provide new insights into tuberculosis and other diseases
11. Missing link discovered in the defence mechanism of the tuberculosis pathogen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... March 2, 2015  Businesses have a new ... company Tharon Rankins Enterprises has announced the launch ... ultra-safe way for businesses to protect their customers, ... Beconux is a biometric transaction ... Functioning similarly to an ATM machine, the new ...
(Date:2/24/2015)... , Feb. 24, 2015 This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ... 2020. Also, a seven-year historic analysis is provided for these markets. ...
(Date:2/18/2015)... SUNNYVALE, Calif. , Feb. 18, 2015  Cepheid (NASDAQ: ... be speaking at the following conferences, and invited investors to ... Conference, Boston, MA Tuesday, March 3, ... Institutional Investors Conference, Orlando, FL Wednesday, ... Accessing Live Webcasts To access the live webcasts for these ...
Breaking Biology News(10 mins):Personal Data Protection Company Launches New Product 2World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16Cepheid to Webcast Upcoming Financial Presentations 2
... , Irvine, Calif., May 26, 2010 UC Irvine ... embryonic stem cells, the first three-dimensional tissue structure to ... the first step toward the development of transplant-ready retinas ... macular degeneration that affect millions. "We made a ...
... University have made an important fundamental advance in robotics, in ... walk and run effectively, but use little energy in the ... studies are moving closer to robots that could take on ... that work much better, or even help some people who ...
... at Northwestern University Feinberg School of Medicine have identified ... the smallest blood vessels remove blood clots and other ... mechanisms that may be involved in age-related cognitive decline, ... These findings were described in the May 27 issue ...
Cached Biology News:UCI researchers create retina from human embryonic stem cells 2Advances made in walking, running robots 2Advances made in walking, running robots 3Researchers discover new mechanism for clearing blockages from smallest blood vessels 2
(Date:3/3/2015)...  Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will ... Miami, FL on March 10, 2015 ... , Chief Financial Officer, will provide a corporate overview. ... of Halozyme,s corporate website at www.halozyme.com , and a ... event. To access the live webcast, please log on to ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 Experts and ... schedules for one event: the Alltech REBELation exploring innovation, ... May 17-20. Now in its 31st year, Alltech’s annual ... 70 countries, and the opportunity to join the REBELation ... 7 at 11:59 p.m. EST, at which point the ...
(Date:3/3/2015)... 03, 2015 Research and Markets ( ... "Gene Therapy Market, 2015 - 2025" report to ... 2015-2025" report provides an extensive study on the marketed ... been carried out in this field for over a ... available in Asian markets; one approved in the EU). ...
(Date:3/3/2015)... March 3, 2015 /CNW/- SQI Diagnostics Inc. (TSX:V: SQD), ... technologies and products for advanced microarray diagnostics, today ... CFE  to its Management team. In his capacity ... its transition from a development stage to a ... advance the Company,s capital market strategy and to ...
Breaking Biology Technology:Halozyme Therapeutics To Present At The Barclays 2015 Global Healthcare Conference 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 2Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 3Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 5Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 6Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 7SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3
... Abbott (NYSE: ABT ),will present at the Cowen ... 17, 2008. Thomas C. Freyman, executive vice president,finance and ... the,company at 10:30 a.m. Central time., A live ... Investor Relations Web site at http://www.abbottinvestor.com . An,archived ...
... March 7 DCI-Biolafitte, (http://www.dci-bio.com ), a ... bioreactors, control systems and software, will exhibit ... Convention Center in Philadelphia,March 26-28. DCI-Biolafitte will ... next generation of single-use bioreactors.,DCI-Biolafitte will display ...
... March 6 Cadence Pharmaceuticals,Inc. (Nasdaq: CADX ... commercializing proprietary product candidates principally,for use in the ... its,fourth quarter and full year ended December 31, ... Wednesday, March 12, 2008., Cadence management will ...
Cached Biology Technology:Biotechnology Leader to Exhibit at Upcoming Trade Show 2Cadence Pharmaceuticals to Host Conference Call and Webcast to Discuss Fourth Quarter and Full Year 2007 Financial Results and Clinical Program Overview on March 12, 2008 2
Sirtuin 7 (SIRT7) Rabbit anti-Human Polyclonal Antibody Immunogen: Synthetic peptide - KLH conjugated Family: Other Recommended Storage: Long term: -20C; Short term: +4C...
... screening and binding optimization and built on ... synthesis platform. These microarrays are available as ... Service. Probe Content Our ... than 1500 known aptamer sequences. Add up ...
... Microarrays designed for RNA aptamer screening and ... and powerful Paraflo microfluidic on-chip synthesis platform. ... be synthesized on-chip and LC Sciences can ... microarrays are available as part of our ...
... ,Schistosomal glutathione-S-transferase (GST) is commonly used as ... E. coli (1). The GSTTag sequence has ... in some cases the solubility of its ... properly folded form, GSTTag fusion proteins can ...
Biology Products: