Navigation Links
Truly sick or simply scared?
Date:8/19/2007

BOSTON Scientists at Pacific Northwest National Laboratory have discovered a way to increase the sensitivity of test strips that will enable creation of a portable biosensor that can address a major concern associated with incidents involving chemical or nerve agents the need to quickly distinguish between individuals who have been exposed and the worried well.

The sensor components resemble a pregnancy test strip and a small glucose testing meter. Its development will be discussed by principal investigator Yuehe Lin at the national meeting of the American Chemical Society.

Every disease has biomarkers, a change in the proteins that announces something is wrong. Lin and his team are creating a nanoparticle label that can increase the ability of a sensor to detect and interpret the message of biomarkers.

Current test strip based-immunoassay technology has very good selectivity, but it can only give a positive or negative response, Lin said.

The researchers are working with an electrochemical immunoassay approach. This involves using the antibody of a specific disease a protein produced in response to an invading bacterium or other foreign substance to attract the biomarker. Lin found that labeling a second antibody with a nanoparticle amplifies the biomarkers signal. Greater amplification means more precise readings.

Researchers at PNNL are developing a portable biomonitor to rapidly evaluate tiny samples of blood or saliva for exposure to nerve agents.

Lin achieves this by removing the iron from a nanoparticle-sized ball of the protein ferrin, creating an empty cage called apoferritin, which he then loads with another metal, such as cadmium. The cadmium-fi lled cage is attached to one end of the reporting antibody, and the immuno-reaction product becomes electroactive.

The electrochemical signal is amplified several hundreds to thousand times because of the metal ions, Lin said. This
'/>"/>

Contact: Geoff Harvey
geoffrey.harvey@pnl.gov
509-372-6083
DOE/Pacific Northwest National Laboratory
Source:Eurekalert

Page: 1 2

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... June 25, 2015 Research ... the "Next Generation Biometrics Market by Application, Technology, ... report to their offering. The next generation ... 2020, at a CAGR of 17.9% between 2015 and ... application for the market. Safran SA ( ...
(Date:6/29/2015)... 24, 2015 Research and ... "Latin America Biomedical Sensors Market - Growth, Trends ... The Latin America Biomedical Sensors market is estimated ... 2.04% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
(Date:6/25/2015)... N.J. , June 25, 2015  TAKE Solutions ... a patent by the United States Patent and Trademark ... Standardization". This process leverages TAKE Solutions, Clinical Accelerators to ... over 50% (when compared to standardization without the accelerators), ... At the heart of ...
Breaking Biology News(10 mins):Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Latin America Biomedical Sensors Market Report 2015-2020 2TAKE Solutions Awarded Patent By USPTO 2
... experts on climate change is warning that if humans don,t ... possibility that we will face the environmental, societal and economic ... them. Lonnie Thompson, distinguished university professor in the School ... in a just-released special climate-change edition of the journal ...
... The enzyme that makes fireflies glow is lighting up the ... better monitor treatment with heparin, the blood thinner that millions ... are reporting. Their study appears in the ACS, monthly journal ... describe a need for new medical imaging agents that emit ...
... Latino faculty at the University of Illinois College of ... lead to mentor the next generation of Latino scientists ... to Gustavo Caetano-Anolls, Sandra Rodriguez Zas, Maria Villamil, and ... as part of the Undergraduate Research and Mentoring program ...
Cached Biology News:Climate scientist warns world of widespread suffering if further climate change is not forestalled 2Climate scientist warns world of widespread suffering if further climate change is not forestalled 3University of Illinois awarded National Science Foundation grant to mentor Latino students 2University of Illinois awarded National Science Foundation grant to mentor Latino students 3
(Date:7/29/2015)... -- US-Australian drug discovery company, Novogen Limited (ASX: NRT; ... to progressing its ground-breaking technology platforms to Phase 1 ... the Company delivers the best value for shareholders. ... said the Company currently had an extensive program of ... and academic partnerships and initiatives, and he was working ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: ... the Company,s Chief Financial Officer has resigned.  The Company ... Financial Officer who retired in December 2014, as full ... a permanent successor.     Andy Ashworth ... and ensure a smooth transition.  Andy was the Company,s ...
(Date:7/29/2015)... July 29, 2015  AsureQuality and Ubiquitome have ... for applications in food and primary production sectors. ... real-time PCR device, the Freedom4. AsureQuality ... to the supermarket shelf for producers, processors and ... in animal disease control and pest management and ...
(Date:7/29/2015)... -- Research and Markets ( ... "Global Biosimilars Market, 2015 - 2025" ... Biosimilars Market, 2015 - 2025, report provides an ... With the blockbuster biologics losing patent protection and ... being viewed as viable substitutes to the highly ...
Breaking Biology Technology:Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3
... WASHINGTON, Oct. 3, 2011 Brainlab announced today the ... command and control center for information-guided surgery, is unveiling ... "Curve represents thousands of enhancements based ... feedback has always been a priority for Brainlab and ...
... NIGUEL, Calif., Oct. 3, 2011 Inspiration Biopharmaceuticals, Inc. ... has validated and accepted the filing of the Marketing ... IX (FIX) product for the treatment and prevention of ... the EMA has verified that it will begin its ...
... This information is being released by SCM: Dr. ... C trial in Nevada, was called to the stand today ... defense, Dr. Reingold testified transference of the deadly virus hepatitis ... ungloved hands, bite blocks, biopsy equipment, gowns and aprons, and ...
Cached Biology Technology:Brainlab Launches Newest Innovation in Image Guided Surgery Technology 2Brainlab Launches Newest Innovation in Image Guided Surgery Technology 3Inspiration Biopharmaceuticals Announces Acceptance of European Marketing Authorization Application for IB1001 for the Treatment of Hemophilia B 2Inspiration Biopharmaceuticals Announces Acceptance of European Marketing Authorization Application for IB1001 for the Treatment of Hemophilia B 3Defense Witness In Second Hepatitis C Trial In Nevada, Dr. Arthur Reingold, Testimony on Plausible Cause for Contamination Impeached 2
... is a modular confocal system that gives ... ultra-compact and lightweight design. The improved scan ... performance to 400nm andits bi-directional scanner provides ... X and Y scan axes rotation and ...
... digital microscope and camera system that does ... adjustment or software installation. Built on Nikon's ... simplicity and advanced technology for users of ... of a macro image and a micro ...
... provides complete components including positive and ... of DNA fragmentation in cultured cells ... BrdU in the procedure provides greater ... Results can be analyzed by fluorescence ...
... LAS-3000 imaging system combines new CCD ... interface, providing significantly improved system sensitivity ... The system is especially dedicated to ... system for Western blotting applications.,Fuiji's LAS-3000 ...
Biology Products: