Navigation Links
Truly sick or simply scared?
Date:8/19/2007

BOSTON Scientists at Pacific Northwest National Laboratory have discovered a way to increase the sensitivity of test strips that will enable creation of a portable biosensor that can address a major concern associated with incidents involving chemical or nerve agents the need to quickly distinguish between individuals who have been exposed and the worried well.

The sensor components resemble a pregnancy test strip and a small glucose testing meter. Its development will be discussed by principal investigator Yuehe Lin at the national meeting of the American Chemical Society.

Every disease has biomarkers, a change in the proteins that announces something is wrong. Lin and his team are creating a nanoparticle label that can increase the ability of a sensor to detect and interpret the message of biomarkers.

Current test strip based-immunoassay technology has very good selectivity, but it can only give a positive or negative response, Lin said.

The researchers are working with an electrochemical immunoassay approach. This involves using the antibody of a specific disease a protein produced in response to an invading bacterium or other foreign substance to attract the biomarker. Lin found that labeling a second antibody with a nanoparticle amplifies the biomarkers signal. Greater amplification means more precise readings.

Researchers at PNNL are developing a portable biomonitor to rapidly evaluate tiny samples of blood or saliva for exposure to nerve agents.

Lin achieves this by removing the iron from a nanoparticle-sized ball of the protein ferrin, creating an empty cage called apoferritin, which he then loads with another metal, such as cadmium. The cadmium-fi lled cage is attached to one end of the reporting antibody, and the immuno-reaction product becomes electroactive.

The electrochemical signal is amplified several hundreds to thousand times because of the metal ions, Lin said. This level of sensitivity will allow detectors to be very precise in identifying the concentration of biomarkers in biological samples.


'/>"/>

Contact: Geoff Harvey
geoffrey.harvey@pnl.gov
509-372-6083
DOE/Pacific Northwest National Laboratory
Source:Eurekalert

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/8/2016)... , January 8, 2016 NXTD ... and WorldVentures ® , a privately held leading direct ... Inc. 5000 fastest-growing company announced that on ... of $2 million in Nxt-ID to develop a proprietary ... Nxt-ID,s Wocket ® , a unique smart wallet that ...
(Date:1/7/2016)... 7, 2016 Various factors have contributed ... such as biologics and biosimilars. Some of these ... expenditure, growing demand for cost-effective alternatives, growing burden ... are similar versions of their corresponding patented biologic ... quality, safety, and efficacy. The global biosimilars market ...
(Date:1/6/2016)... 6, 2016  Varam Capital, a provider of micro-finance ... to deliver advanced authentication solutions to their clients. Varam ... poor. A loan of a few thousand rupees may ... the ability to purchase livestock or equipment for a ... stock for a local store. ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... ... February 04, 2016 , ... Shimadzu Scientific Instruments will ... live demos and poster sessions, and present on the analysis of mycotoxins and ... March 6 to 10 at the Georgia World Congress Center in Atlanta, Georgia. ...
(Date:2/4/2016)... PARK, Calif. , Feb. 4, 2016   DelMar ... biopharmaceutical company focused on the development and commercialization of new ... 18 th Annual BIO CEO & Investor Conference ... in New York, NY . ... an update on the ongoing clinical trial of VAL-083 ...
(Date:2/4/2016)... Sinovac Biotech Ltd. ("Sinovac" or the "Company") (NASDAQ: ... China , today announced that the ... February 4, 2016 a preliminary non-binding proposal letter, dated ... V-Ming ( Shanghai ) Investment Holdings Co., ... Shenzhen ) Fund Management Co., Ltd., Beijing ...
(Date:2/3/2016)... SAN DIEGO , Feb. 3, 2016 /PRNewswire/ ... medicine company with the first pluripotent stem cell-derived ... 1 diabetes in clinical-stage development, today announced that ... Janssen Pharmaceutical Companies of Johnson & Johnson, have ... BetaLogics group into ViaCyte.  The agreement provides ViaCyte ...
Breaking Biology Technology: