Navigation Links
Triple-negative breast cancer subtypes identified using microRNA
Date:2/7/2013

ular virology, immunology and medical genetics at Ohio State.

"Several of the deregulated microRNAs we found in the cancer samples are involved in chemo-resistance or radio-resistance. MicroRNA profiles can help us to improve and personalize therapies for individual patients," she says.

Triple-negative breast cancer accounts for about 15 percent of all breast cancers. It is characterized by cancer cells that lack estrogen, progesterone and HER2 receptors. For this reason, these tumors do not respond to hormone therapies or HER2-targeted treatments.

MicroRNAs help regulate the kind and amount of proteins that cells make. They do this by binding with messenger RNA (mRNA), molecular copies of genes that are translated into proteins. When microRNA is bound to an mRNA, the messenger molecule cannot be translated into a protein. Instead, it is either temporarily stored or destroyed.

This study investigated associations between microRNA expression levels, mRNA expression levels and overall survival and distant-disease-free survival in women with triple-negative breast cancer.

Shapiro, Huebner and their colleagues evaluated 59 normal, 165 tumor and 54 metastatic matched tissue samples, obtained through The Stefanie Spielman Fund for Breast Cancer Research at the OSUCCC James.

The researchers ran a complete microRNA profile and a cancer-focused panel of genes for each sample. They then generated microRNA signatures represented by certain prognostic microRNAs that, when deregulated, indicate odds of survival.

"This was a large cohort of triple-negative breast cancer cases and a major analysis effort that we believe makes this work extremely valuable," Huebner says.

To stratify the cancers, the researchers determined microRNA and mRNA expression profiles in tumor, adjacent-normal tissue and lymph-node metastatic tissue from 173 women with the triple-negative breast cancer.

"We identified microRNAs and m
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients
2. Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
3. In breast cancer metastasis, researchers identify possible drug target
4. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
5. Does your job increase your breast cancer risk?
6. Breast cancer drug could halt other tumors
7. UCLA researchers to study depression in breast cancer survivors
8. Scientists unravel resistance to breast cancer treatment
9. High levels of DDT in breast milk
10. Breast milk promotes a different gut flora growth than infant formulas
11. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... FRANKLIN LAKES , N.J. and NEW YORK ... and Company) and Guidepoint today announced ... selected start-up healthcare companies with free access to Guidepoint,s ... mentoring several start-ups that are developing cutting-edge technologies to ... of a dedicated Guidepoint research manager, each start-up entrepreneur ...
(Date:7/7/2015)... July 7, 2015  Based on its recent ... Sullivan recognizes Credence ID, LLC with the 2015 ... of the Year Award. Credence ID has developed ... its mission of offering enrollment and identification solutions ... Credence ID was formed by experts from the ...
(Date:7/2/2015)... , July 2, 2015 Fingerprint Cards ... FPC1035, FPC1145 and FPC1155 from the distributor World Peace Industrial ... FPC,s distributors in Asia . Deliveries are ... sensors will be used by smartphone manufacturers in ... included in the communicated revenue guidance of approximately 2,200 MSEK ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... one way to get children to eat more whole grains, ... Federal nutrition guidelines recommend at least three servings a day ... typically only eat about one serving per day, largely because ... In this study, researchers served graham snacks with four ...
... EAST LANSING, Mich. A Michigan State University researcher ... parkin may help nerve cells fight off damage from ... therapies for the degenerative ailment. John Goudreau, an ... Unit, believes parkin can rescue certain neurons from injury ...
... programmed cell death, is essential to normal development, ... process dramatically transforms cellular structures but the limitations ... this structural reorganization a mystery. , Now, in ... issue of Proceedings of the National Academy ...
Cached Biology News:Specific protein may help neurons fix themselves in Parkinson's patients 2How do cells die? Biophotonic tools reveal real-time dynamics in living color 2How do cells die? Biophotonic tools reveal real-time dynamics in living color 3
(Date:7/30/2015)... , July 30, 2015 AACC welcomed ... the 2015 AACC Annual Meeting & Clinical Lab ... July 26–30. The meeting showcased revolutionary advancements in ... ability of healthcare providers to diagnose patients quickly ... medical treatment. As of Wednesday, ...
(Date:7/30/2015)... Grenoble, France and Dallas, TX, USA (PRWEB) , ... ... ... manufacturer of innovative nano and microsystems, has appointed Francois Vieillard as Sales & ... & Marketing at executive positions, Francois Vieillard will be responsible for reinforcing Tronics’ ...
(Date:7/30/2015)... Washington , July 30, 2015 ... Market, by Product (Software, Molecular Modeling, PB/PK, PKPD, Trial ... Discovery & Development, Preclinical, Clinical Trial), by End Users ... Biosimulation Market is expected to reach USD 2,107.99 million ... a CAGR of 15.29%. Browse more ...
(Date:7/30/2015)... 2015   Aratana Therapeutics, Inc . (NASDAQ: ... on the licensing, development and commercialization of innovative ... its strategic partner VetStem Biopharma, Inc. has shared ... AT-016, an adipose-derived allogeneic stem cell product exclusively ... pain in dogs. The double-blinded, multi-site, ...
Breaking Biology Technology:Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Tronics appoints Francois Vieillard as Sales and Marketing Director 2Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5
... for Biologically Inspired Engineering at Harvard University have developed ... seek out specific cell targets within a complex mixture ... as telling cancer cells to self-destruct. Inspired by the ... might one day be used to program immune responses ...
... ORLANDO, Fla., Feb. 16, 2012   GeneLink ... biotech company, has completed the sale of the ... Life Sciences, Inc. (GeneWize)  to Capsalus Corp. (OTCBB: ... and wellness marketplace.  As previously disclosed, GeneLink and ...
... -- FirstMark today announced the completion of the clinical ... These clinical results demonstrate the extraordinary effectiveness of the ... myocardial infarction and death in patients with suspected or ... final data was well received in an oral presentation, ...
Cached Biology Technology:Harvard's Wyss Institute develops DNA nanorobot to trigger targeted therapeutic responses 2Harvard's Wyss Institute develops DNA nanorobot to trigger targeted therapeutic responses 3GeneLink Biosciences Completes Sale of GeneWize Life Sciences 2FirstMark's Landmark Clinical Study Successfully Completed that Fulfills the Unmet Need to Access the Risk of Near Term MI 2
XEDAR Antibody...
Pharmalyte, narrow range pH 4.2-4.9, 25 ml. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Immobiline for IEF and Carrier Ampholytes....
...
...
Biology Products: