Navigation Links
Triple-negative breast cancer subtypes identified using microRNA
Date:2/7/2013

ular virology, immunology and medical genetics at Ohio State.

"Several of the deregulated microRNAs we found in the cancer samples are involved in chemo-resistance or radio-resistance. MicroRNA profiles can help us to improve and personalize therapies for individual patients," she says.

Triple-negative breast cancer accounts for about 15 percent of all breast cancers. It is characterized by cancer cells that lack estrogen, progesterone and HER2 receptors. For this reason, these tumors do not respond to hormone therapies or HER2-targeted treatments.

MicroRNAs help regulate the kind and amount of proteins that cells make. They do this by binding with messenger RNA (mRNA), molecular copies of genes that are translated into proteins. When microRNA is bound to an mRNA, the messenger molecule cannot be translated into a protein. Instead, it is either temporarily stored or destroyed.

This study investigated associations between microRNA expression levels, mRNA expression levels and overall survival and distant-disease-free survival in women with triple-negative breast cancer.

Shapiro, Huebner and their colleagues evaluated 59 normal, 165 tumor and 54 metastatic matched tissue samples, obtained through The Stefanie Spielman Fund for Breast Cancer Research at the OSUCCC James.

The researchers ran a complete microRNA profile and a cancer-focused panel of genes for each sample. They then generated microRNA signatures represented by certain prognostic microRNAs that, when deregulated, indicate odds of survival.

"This was a large cohort of triple-negative breast cancer cases and a major analysis effort that we believe makes this work extremely valuable," Huebner says.

To stratify the cancers, the researchers determined microRNA and mRNA expression profiles in tumor, adjacent-normal tissue and lymph-node metastatic tissue from 173 women with the triple-negative breast cancer.

"We identified microRNAs and m
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients
2. Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
3. In breast cancer metastasis, researchers identify possible drug target
4. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
5. Does your job increase your breast cancer risk?
6. Breast cancer drug could halt other tumors
7. UCLA researchers to study depression in breast cancer survivors
8. Scientists unravel resistance to breast cancer treatment
9. High levels of DDT in breast milk
10. Breast milk promotes a different gut flora growth than infant formulas
11. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2015)... , Feb. 13, 2015 ACT Genomics ... that aims to transform cancer genomic information into ... the company has raised US$ 8 million in the ... in Taipei, Taiwan , ACT ... ACTOnco™. With the aim to implement next generation ...
(Date:2/11/2015)... 2015 According to ... Market by Product (Cards and Readers, Biometrics, Controllers, Management ... Industrial, Healthcare, Education) and By Geography - Global Forecast and Analysis ... Access Control Market is expected to reach ... CAGR of 10.6% between 2014 and 2020. ...
(Date:2/5/2015)... , 5. Februar 2015 Marken ... Logistikunternehmen und hat eine neue Marketingkampagne gestartet, ... (Clinical Logistics Organization – CLO) der Branche ... lautet First , mit Schwerpunkt auf ... http://photos.prnewswire.com/prnh/20150205/173753 Logo - ...
Breaking Biology News(10 mins):ACT Genomics Raises $8 Million in its First Private Funding Round 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3
... fractures due to osteoporosis are a major cause of disability ... are patients who have already suffered one fragility fracture; they ... compared to others who have not fractured. Nevertheless ... and treat these patients, leaving them exposed to debilitating and ...
... 2013 Reportlinker.com announces that a new ... catalogue: India Biometrics Market ... http://www.reportlinker.com/p01162444/India-Biometrics-Market-Forecast-and-Opportunities-2018.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Security_Systems The biometric security ... India . With the ...
... LLC are pleased to announce a new license ... the unique characteristics of CSIRO,s Reversible Addition-Fragmentation chain ... high-end polymer development capabilities for the biotech industry., ... Hayes said the agreement would allow the company ...
Cached Biology News:New review sets international standards for best practice in fracture liaison services 2India Biometrics Market Forecast and Opportunities, 2018 2India Biometrics Market Forecast and Opportunities, 2018 3India Biometrics Market Forecast and Opportunities, 2018 4India Biometrics Market Forecast and Opportunities, 2018 5India Biometrics Market Forecast and Opportunities, 2018 6
(Date:3/6/2015)... Transparency Market Research has published a new report ... Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - ... valued at US$ 116.3 Mn in 2013 and is anticipated ... CAGR of 5.1% from 2014 to 2020. In terms of ... tons in 2013. , Isoxaflutole is widely used in the ...
(Date:3/6/2015)... , March 6, 2015   BioLife Solutions ... developer, manufacturer and marketer of proprietary clinical grade ... and precision thermal shipping products for cells ... Company,s fourth quarter and full year 2014 financial results will ... the Company will host a conference call and live ...
(Date:3/5/2015)... , March 5, 2015  DuPont (NYSE: ... Transportation and Industrials Conference held today in ... Matthew L. Trerotola discussed strategy, progress and plans ... for DuPont.  Strengthening and growing the company,s leading position ... areas of strategic priority for DuPont. Discussing ...
(Date:3/5/2015)... , March 5, 2015   HX360 ... semi-finalists in the HX360 Innovation Challenge competition. ... will compete to be chosen as one of four ... of senior health system executives and venture capitalists during ... Innovation Challenge takes place at the 2015 HIMSS Annual ...
Breaking Biology Technology:Isoxaflutole Market is Expected to Reach US$ 163.0 Mn by 2020 : Transparency Market Research 2Isoxaflutole Market is Expected to Reach US$ 163.0 Mn by 2020 : Transparency Market Research 3BioLife Solutions to Report Fourth Quarter and Full Year 2014 Financial Results and Provide Business Update on March 12, 2015 2DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 2DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 3DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 4HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 2HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 3HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 4
... Ohio, June 25 Battelle is,strengthening its ... device, and government clients, and,Kevin Xie will ... of Biomarker,Services., Battelle offers a suite ... validation services to help our clients,better define ...
... with six million, votes revoked - and no ... TORONTO, June 25 /PRNewswire/ - The Concerned Shareholders of ... today and will seek a,declaration that the Biovail Corporation ... and will request that a proper meeting be convened. ...
... GanedenBC30, to power new raisin bran probiotic muffins. , ... ... Gourmet, one of the fastest growing manufacturers of gourmet frozen bakery ... with the high-survivability probiotic, GanedenBC30 (Bacillus coagulans GBI-30, 6086). ...
Cached Biology Technology:Battelle Selects Xie to Develop Biomarker Services 2Main Street Gourmet Launches New Probiotic Muffins 2Main Street Gourmet Launches New Probiotic Muffins 3
... up to 30 minutes of walkaway time. Automatic Calibration. Five minute cooldown from turn-on. ... ... ... ...
... pipets ,Angled acrylic pipet rack offers easy access ... pipet cans. Constructed of 6 mm (1/4 in.) thick ... 76 mm H x 289 mm D (3 x ... W x 406 mm H x 292 mm D ...
...
CoverWell imaging chamber gasket with adhesive, one chamber, 20 mm diameter, 1.0 mm deep *set of 40* Cell Biology Imaging Tools and Accessories Microscope Slide Accessories...
Biology Products: