Navigation Links
Triple-negative breast cancer subtypes identified using microRNA
Date:2/7/2013

ular virology, immunology and medical genetics at Ohio State.

"Several of the deregulated microRNAs we found in the cancer samples are involved in chemo-resistance or radio-resistance. MicroRNA profiles can help us to improve and personalize therapies for individual patients," she says.

Triple-negative breast cancer accounts for about 15 percent of all breast cancers. It is characterized by cancer cells that lack estrogen, progesterone and HER2 receptors. For this reason, these tumors do not respond to hormone therapies or HER2-targeted treatments.

MicroRNAs help regulate the kind and amount of proteins that cells make. They do this by binding with messenger RNA (mRNA), molecular copies of genes that are translated into proteins. When microRNA is bound to an mRNA, the messenger molecule cannot be translated into a protein. Instead, it is either temporarily stored or destroyed.

This study investigated associations between microRNA expression levels, mRNA expression levels and overall survival and distant-disease-free survival in women with triple-negative breast cancer.

Shapiro, Huebner and their colleagues evaluated 59 normal, 165 tumor and 54 metastatic matched tissue samples, obtained through The Stefanie Spielman Fund for Breast Cancer Research at the OSUCCC James.

The researchers ran a complete microRNA profile and a cancer-focused panel of genes for each sample. They then generated microRNA signatures represented by certain prognostic microRNAs that, when deregulated, indicate odds of survival.

"This was a large cohort of triple-negative breast cancer cases and a major analysis effort that we believe makes this work extremely valuable," Huebner says.

To stratify the cancers, the researchers determined microRNA and mRNA expression profiles in tumor, adjacent-normal tissue and lymph-node metastatic tissue from 173 women with the triple-negative breast cancer.

"We identified microRNAs and m
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients
2. Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
3. In breast cancer metastasis, researchers identify possible drug target
4. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
5. Does your job increase your breast cancer risk?
6. Breast cancer drug could halt other tumors
7. UCLA researchers to study depression in breast cancer survivors
8. Scientists unravel resistance to breast cancer treatment
9. High levels of DDT in breast milk
10. Breast milk promotes a different gut flora growth than infant formulas
11. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ) has ... Watermarking and Fingerprinting Markets" report to their ... This insight provides an overview of ... Watermarking aims to control and monitor piracy by ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the ... Security Systems Market" report to their offering. ... perimeter security market is estimated to grow at a CAGR ... holds a larger share in this market, Canada ...
(Date:12/17/2014)... Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) has announced the ... Button Synaptics Fingerprint Sensor Technology Analysis" report to ... Based on a totally different sensing technology ... time a fingerprint sensor in its product. ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... keeps urchin populations in check, allowing kelp a favorite ... were harvested to near extinction for their fur? The resulting ... food or shelter for fish and invertebrates. And so it ... affect others. Such is the potential trickle-down effect on ...
... imposed a ban on importing foreign ash trees in order ... the trees and has entered the country via imports from ... trade, horticultural stakeholders and the plant buying public need to ... by imported plant pathogens. They say it is far better ...
... the on-line publication by the European Journal of Human ... led by Dr. Robert Cook-Degan, a former member of the ... of the BRCA1/2 genetic test in the US, has amassed ... Cornel, chair of the European Society of Human Genetics, Professional ...
Cached Biology News:New study to examine ecological tipping points in hopes of preventing them 2New study to examine ecological tipping points in hopes of preventing them 3Action needed to prevent more devastating tree diseases entering the UK 2Privately owned genetic databases may hinder diagnosis and bar the way to the arrival of personalized medicine 2
(Date:12/24/2014)... AUSTIN, Texas , Dec. 24, 2014  Vermillion, ... focused on gynecologic disease, announced today that the ... investors including Oracle Investment Management, Jack W. ... directors. Total proceeds were $10.5 million, before offering ...
(Date:12/24/2014)... December 23, 2014 GMO corn cases filed ... are in the process of being consolidated in a Kansas ... Re: Syngenta AG MIR 162 Corn Litigation, MDL No. 2591 ... , Management of the Syngenta GMO corn multidistrict litigation (MDL) ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 On Friday, ... 83, the Omnibus and Continuing Resolution Appropriations Act of ... condition eligible to receive funding through the Congressionally Directed ... Defense (DoD). The Hydrocephalus Association (HA), working in conjunction ...
(Date:12/24/2014)... Nashville, Tenn. (PRWEB) December 23, 2014 Nashville ... was elected treasurer for the American Society for Reproductive Medicine ... research in reproductive medicine. In his new role as ... board and will have a voice in furthering the mission ...
Breaking Biology Technology:Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... - These are not your parents' generation of corporate ... rarely heard to cross the lips of gray-haired, gray-suited ... problem is that Wisconsin doesn't yet have it. , ... of business, civic, academic and arts groups met to ...
... General Electric Co.'s GE Healthcare division rose 17 ... in total orders, the company reported Friday. , ,GE Healthcare ... -- reported revenue of $3.6 billion for the second quarter, ... period a year ago. , ,Profits for GE Healthcare rose ...
... private colleges and universities in Wisconsin will work toward ... Jenzabar, Inc. of Cambridge, Mass. , ,Jenzabar ... Association of Independent Colleges and Universities to use ... EX ERP System, Jenzabar's Internet Campus Solution and Jenzabar's ...
Cached Biology Technology:Tech leaders call for more creativity 2
Guanylate Kinase Purified Anti-Mouse, Anti-Rat clone 28, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
...
Proliferin (C-14)...
... The Turn & Cast submarine gel systems used gasketed ... the gel in the tank. Turn it back and ... For added convenience, each Turn & Cast tray is ... near the edge of the tray and one in ...
Biology Products: