Navigation Links
Triple-negative breast cancer subtypes identified using microRNA
Date:2/7/2013

  • Triple-negative breast cancer is an aggressive form of breast cancer that has few treatment options;
  • This large-scale study shows that abnormal levels of small molecules called microRNA can be used to classify this malignancy into four subtypes;
  • The findings could lead to new ways to identify the best therapy for individual patients and to more effective therapies in the future.

COLUMBUS, Ohio A new, large-scale study of triple-negative breast cancer shows that small molecules called microRNA can be used to define four subtypes of this aggressive malignancy.

The findings, by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) working with collaborators in Italy, could lead to new screening methods, prognostic markers and perhaps new targeted treatments for this aggressive and often-fatal form of breast cancer.

The study is published in the journal PLOS ONE.

"The treatment of women with triple-negative breast cancer is challenging because this malignancy can be very different genetically from one patient to another," says co-senior investigator Dr. Charles Shapiro, director of Breast Medical Oncology and professor of internal medicine at the OSUCCC James.

"We believe these microRNA signatures define novel sub-sets of triple-negative breast cancer and offer new insights into the biology of the disease and better ways to treat these patients," Shapiro says.

The microRNAs that compose the signatures are involved in regulating cell growth, proliferation and survival, and in cell movement and migration.

"These findings strongly suggest that microRNAs play an important role in triple-negative breast cancer and might be used to better identify the most effective treatment for a patient's tumor," says co-senior investigator and researcher Dr. Kay Huebner, professor of molec
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients
2. Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
3. In breast cancer metastasis, researchers identify possible drug target
4. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
5. Does your job increase your breast cancer risk?
6. Breast cancer drug could halt other tumors
7. UCLA researchers to study depression in breast cancer survivors
8. Scientists unravel resistance to breast cancer treatment
9. High levels of DDT in breast milk
10. Breast milk promotes a different gut flora growth than infant formulas
11. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Geologists are letting the air out of a nagging mystery ... have long speculated as to why animal species didn,t flourish ... to prosper at the end of the Proterozoic period, about ... stretch before that, when most researchers think there also was ... so great then, after all. , In a study published ...
(Date:10/31/2014)... has just been cleared – by a mouse. ... Chapel Hill and colleagues have developed the first genetic ... and display symptoms similar to those that humans experience. ... Science , will significantly improve basic research on Ebola ... the worldwide public health and economic toll of the ...
(Date:10/31/2014)... have been studying the behavior of approximately 300 ... years. They observed that ravens slowly build alliances ... However, they also observed that these affiliative interactions ... in about 50 % of the cases these ... affiliating ravens, intervening can be potentially risky when ...
Breaking Biology News(10 mins):Lack of oxygen delayed the rise of animals on Earth 2Improved mouse model will accelerate research on potential Ebola vaccines, treatments 2
... is available in German . , Metabolomics aims ... cell or a tissue. The exponents of bioinformatics analyzed data ... healthy and diabetic mice. In each case, a subgroup of ... more than 800 metabolites were quantitatively determined in a blood ...
... flower and plant growers know all too well that ... and deterring healthy growth of potted ornamental plants. To ... expensive practice of paying workers to hand-weed containers. Some ... on the wide range of plant species produced in ...
... July/August 2008 issue of BioScience are as follows: ... Joan Burnside, and Scott V. Edwards. , An increasingly broad ... expanding what has been learned from studies based on the ... of the whole class. ***************, Penguins as Marine ...
Cached Biology News:Healthy or diseased? 2Ethanol byproduct produces green results 2BioScience tip sheet July/August 2008 2BioScience tip sheet July/August 2008 3
(Date:10/30/2014)... Calif. , Oct. 30, 2014  Ardelyx, ... biopharmaceutical company focused on cardio-renal, gastrointestinal and metabolic ... quarter 2014 financial results on Thursday, November 6, ... will host a live conference call and webcast ... results and provide a business update. ...
(Date:10/30/2014)... 2014 SoundConnect , an ... Office 365 end users the key to turning ... system by adding voice enablement and hybrid audio ... Online, a communication tool that includes presence, instant ... voice, O365 becomes a comprehensive unified communications solution. ...
(Date:10/30/2014)... New York, NY (PRWEB) October 30, 2014 ... investment plan for its ICH Stability Testing and Package ... companies, this investment centers on a dramatic increase in ... larger volume of stability, storage and aging samples to ... first stage of this major capital expenditure has already ...
(Date:10/30/2014)... -- A new report, commissioned by BioCrossroads and conducted ... look at Indiana,s capital market ... different time frames: 1993 to 2002 and 2003 to ... for investment growth.  The Life Science Innovation Capital ... in innovation dollars as well as an increase in ...
Breaking Biology Technology:Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5
... 14 Bionovo, Inc.,(Nasdaq: BNVI ) announced ... Board of Directors. Mr. Drapeau has extensive financial,management ... "We are quite excited to have access to ... CEO. "Lou is particularly well versed,in the unique ...
... CALGARY, March 14 /PRNewswire-FirstCall/ - SemBioSys Genetics ... portfolio of therapeutic,proteins for metabolic and cardiovascular ... an important step forward in the,commercialization of ... an,exclusive global alliance with Bioriginal Food and ...
... Express, the advance online publication of the journal ... mark an important step toward understanding a longstanding ... presented their findings at the annual meeting of ... problem the physicists addressed is how a fundamental ...
Cached Biology Technology:Louis Drapeau Joins Bionovo's Board of Directors 2Louis Drapeau Joins Bionovo's Board of Directors 3SemBioSys' GLA Partner Enters Strategic Alliance for the Sales and Marketing of GLA-Rich Safflower Oil 2SemBioSys' GLA Partner Enters Strategic Alliance for the Sales and Marketing of GLA-Rich Safflower Oil 3Physicists discover how fundamental particles lose track of quantum mechanical properties 2Physicists discover how fundamental particles lose track of quantum mechanical properties 3
... amino acid synthetic peptide whose sequences are derived from mouse resistin ... terminus): S(21) - S - M - P - L - ... - I - D - K - K - I - ... may be used for neutralization and control experiments with the polyclonal ...
... 2D Proteomic Imaging System, Basic Package ... Wide Dynamic Range: The ProXPRESS 2D Proteomic ... imaging system for both proteomic and general ... unparalleled flexibility, enabling the use of all ...
... designed for quantitative assays using recombinant ... on the flexible and powerful Paraflo ... specified sequences can be synthesized on-chip ... with custom sequence design. These microarrays ...
... These extended-length microarrays are custom designed to ... configurations are available: 8,455 features per array ... 22,575 features per array (1 array/slide). ... probe length - This extended length ...
Biology Products: