Navigation Links
Trial aims to advance prenatal diagnosis of genetic defects
Date:8/21/2013

NEW YORK (August 21, 2013) Reproductive genetics researchers at Columbia University Medical Center (CUMC) are leading a multicenter prospective clinical study investigating the effects of chromosomal abnormalities (duplicative or missing material) found prenatally through microarray analysis. The goal of the study is to gain further information on genetic variances previously not well reported in the medical literature and share it with parents during pregnancy.

Led by principal investigator Ronald J. Wapner, MD, professor and vice chair for research at CUMC's Department of Obstetrics and Gynecology and director of reproductive genetics at NewYork-Presbyterian Hospital/Columbia, the research is the next phase of a project to advance clinicians' ability to diagnose in utero conditions such as developmental delays, structural abnormalities, and treatable or life-threatening diseases.

"Parents of children found to have a genetic variance want a better understanding of what it means. Our goal is to give them as much information and support as possiblefrom detailed genetic counseling to ways to connect with other people expecting children with the same variance," said Dr. Wapner.

In December 2012, Dr. Wapner and colleagues published in the New England Journal of Medicine (NEJM) findings of a trial involving 4,400 patients at 29 centers nationwide. That study showed that microarray analysis of a fetus's DNA gave significantly more clinically relevant information than the standard method of analysis, known as karyotypinga visual analysis of the fetus's chromosomes. [Click here for a news release about that study.]

In the current studywhich has ongoing clinical recruitmentdata on babies included in the NEJM article will be augmented by data on patients recruited by 10 major prenatal diagnostic centers around the country that offer microarray to all their patients. Each center aims to recruit 1,000 patients. Of the anticipated 10,00
'/>"/>

Contact: Elizabeth Streich
eas2125@cumc.columbia.edu
212-305-3689
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Ultrasound patch heals venous ulcers in human trial
2. UCLA stem cell gene therapy for sickle cell disease advances toward clinical trials
3. New sickle cell anemia therapy advances to Phase II clinical trials
4. Alios BioPharma initiates Phase 1 clinical trial for respiratory syncytial virus infection
5. Intermountain Medical Center reseachers develop new 3-D technology to treat atrial fibrillation
6. Elseviers Maturitas publishes clinical guide on endometrial assessment in postmenopausal women
7. Ecology, economy and management of an agro-industrial Amazon frontier
8. FDA approves Phase II of stem cell trial for ALS led by U-Ms Dr. Eva Feldman
9. A trial to find out the effectiveness of biocides against Vespa velutina
10. Sea level rise: Jeopardy for terrestrial biodiversity on islands
11. Mummy CT scans show preindustrial hunter gatherers had clogged arteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... Lithuania , Oct. 15, 2014   ... technologies, today announced the availability of the ... VeriLook Surveillance 3.0 provides real-time biometric face identification ... high-resolution digital surveillance cameras. The new version not ... and differentiates people from objects while they are ...
(Date:10/14/2014)... Research shows SIRT6—a protein known to inhibit the ... of skin cancers by turning on an enzyme that ... , Previously considered protective, SIRT6 is part of a ... genomic stability and prevent some of the genetic flaws ... can lead to cancer. This study, in the journal,s ...
(Date:10/14/2014)... N.Y. – Scientists have sequenced the house fly genome ... one might expect from an insect that thrives in ... published Oct. 14 in the journal Genome Biology ... biology and of how flies quickly adapt to resist ... Adult house flies (Musca domestica) carry and transmit more ...
Breaking Biology News(10 mins):VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2House fly genome reveals expanded immune system 2
... the brain, cells called neurons go through a cycle ... Fernando Nottebohm, Ph.D., shows that these replaceable neurons share ... people with diseases such as Alzheimer's and Parkinson's: both ... , "It would be ironic if the shortfall in ...
... into the brain, researchers have treated a naturally occurring ... disease affecting the central nervous system to be successfully ... If this approach can be successfully applied to humans, ... entire class of diseases called lysosomal storage disorders which ...
... marine sponge is inspiring cutting-edge research in the design ... Barbara. , A report about these exciting new results ... story of the current issue of the scientific journal, ... Morse, professor of molecular, cellular and developmental biology at ...
Cached Biology News:One gene links newborn neurons with those that die in diseases such as Alzheimer's 2One gene links newborn neurons with those that die in diseases such as Alzheimer's 3One gene links newborn neurons with those that die in diseases such as Alzheimer's 4Genetic therapy reverses nervous system damage in animal model of inherited human disease 2Genetic therapy reverses nervous system damage in animal model of inherited human disease 3Marine sponge yields nanoscale secrets 2Marine sponge yields nanoscale secrets 3
(Date:10/20/2014)... Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or ... brings Q3 orders to $5.8 million and provides a good start ... North America and one in the ... new projects at record levels," said Peter Bruijns , President ... the end of Q3 than they have been for any complete ...
(Date:10/20/2014)... OncLive® is pleased to ... Thomas Jefferson University has joined its Strategic Alliance ... Partnership program, the Sidney Kimmel Cancer Center at ... of the Center’s cutting-edge research programs, comprehensive approach ... other health care professionals from the Sidney Kimmel ...
(Date:10/19/2014)... OCTOBER 20-22, 2014: The 9th Annual ... take place at the Congress Center Basel, ... now available at http://www.abim.ch . ... from all over the globe will exchange ... products and developments on the world market. ...
(Date:10/19/2014)... October 19, 2014 The Asia-Pacific Speech ... market in Asia-Pacific with analysis and forecast of revenue. ... in 2014 to $208 million by 2019, at a ... to 2019. , Browse through the TOC of the ... of the in-depth analysis provided. It also provides a ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4
... One of the more hopeful promises of stem cells is ... that is not being met by organ donation. But experts expressed ... lead to backlash: among patients if cures do not materialize, and ... transplants are just one way that stem cells could be used ...
... like a man on the hot seat, at least not ... manage the State of Wisconsin's information technology consolidation gave a ... of a state audit, during a "Consolidation for Optimization" program ... Despite criticism of the results, Miszewski said the challenges facing ...
... the core of such major product suites as Microsoft's .NET, ... However, the very openness of SOA can disrupt the internal ... Oxley Act (SOX), the 2002 federal law that was enacted ... , ,A typical internal control over financial reporting for ...
Cached Biology Technology:Stem cells raise hopes, but is there money in them? 2Stem cells raise hopes, but is there money in them? 3Miszewski touts benefits of IT integration 2Miszewski touts benefits of IT integration 3Managing SOX in the age of SOA 2Managing SOX in the age of SOA 3Managing SOX in the age of SOA 4
Mouse monoclonal [CIG 3A11/5] to Cig2 (rating: *****) ( Abpromise for all tested applications)....
Rabbit polyclonal to CAMK 1D beta ( Abpromise for all tested applications). entrezGeneID: 57118 SwissProtID: Q5SQQ7...
Goat polyclonal to HNF4 ( Abpromise for all tested applications). Antigen: Synthetic peptide: RLSKTLVDMDMADY (Human) N terminal. Entrez GeneID: 3172 Swiss Protein ID: P41235...
IkappaB-alpha (112B2) Mouse mAb...
Biology Products: