Navigation Links
Treatment corrects severe insulin imbalance in animal studies
Date:7/31/2008

osing such lesions and performing the curative surgery on newborns.

However, when abnormal cells are distributed throughout the pancreas in so-called diffuse HI, surgeons must remove nearly all the pancreas. This relieves HI in about a quarter of cases, but leaves the majority of patients at high risk for insulin imbalance, in which blood glucose levels are too low (hypoglycemia) or too high, resulting in diabetes.

The new study makes use of a peptide (an amino acid compound) called exendin-(9-39) that blocks the action of a specific hormone receptor in beta cells. Building on their previous work using exendin-(9-39) on normal mice, De Len's study team studied the peptide's effect on a strain of mice that had been genetically engineered to mimic the defect found in children with congenital HI.

When researchers withhold food from those mice, their blood glucose levels become low, a condition called fasting hypoglycemia. Mice who had received exendin-(9-39), however, had significantly higher levels of fasting blood glucose compared to mice that were not treated with the peptide, and reached levels comparable to those in normal, healthy animals. Further studies identified the mechanisms in the hormone signaling system that malfunctions in HI.

The next step, says De Len, is a pilot study now under way to test the effect of exendin-(9-39) in children and adults with congenital HI. If results from the pilot study are promising, her study team expects to progress to a larger clinical trial. "If this peptide can be developed into a treatment for children with this common form of HI, we may have a new tool for controlling their insulin levels and managing their disease," added De Len.

The Congenital Hyperinsulinism Center at Children's Hospital has worldwide prominence in diagnosing and treating this genetic disease. Much of its work builds on pioneering research by Charles A. Stanley, M.D., in identifying the specific gene defec
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6050
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Video released of rapid Alzheimers improvement after new immune-based treatment
2. Fertility treatment in developing countries; a cycle of IVF for less than $200
3. New treatment approach promising for lymphoma patients in the developing world
4. Treatment delays result in poor outcomes for men with breast cancer
5. Counting tumor cells in blood predicts treatment benefit in prostate cancer
6. Stroke study reveals key target for improving treatment and suggests that Gleevec may help
7. Hypertension treatment effective in reversing vascular damage
8. Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment
9. Source of drug-tolerant tuberculosis possibly behind TB relapses, intensity of treatment
10. Novel therapeutic strategy for colon cancer treatment
11. New ballast treatment could protect Great Lakes fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2014)... Florida State University researchers have identified a new syndrome ... density and muscle mass with obesity. , "It used ... the better your bones would be because the bones ... Stiebeling Professor of Nutrition at Florida State. "But, that,s ... outlined in the May issue of Ageing Research ...
(Date:4/16/2014)... - Geoscientists from the north-central U.S. and beyond will ... discuss new science, expand on existing science, and explore ... with a special emphasis on applied geology, paleontology, and ... p.m. on Thursday by Dr. Kirk Johnson, Sant Director ... , The meeting is hosted by the University of ...
(Date:4/16/2014)... the world? Surprisingly, bacteria also face this problem. ... now shown how these organisms should decide how ... Bacillus subtilis is quite adaptable. It ... by means of flagella. Alternatively, it can stick ... most effectively in this stationary state, while motile ...
Breaking Biology News(10 mins):Researchers: Obesity can amplify bone and muscle loss 2Walking with mammoths and exploring mid-continental geology 2Walking with mammoths and exploring mid-continental geology 3Walking with mammoths and exploring mid-continental geology 4Theoretical biophysics: Adventurous bacteria 2
... about 6 percent of total births worldwide -- are born ... origin, according to a new report from the March of ... serious birth defects of post-conception origin due to maternal exposure ... the March of Dimes Global Report on Birth Defects: ...
... discovered that some type of protective system goes into ... is deficient. This discovery indicates a hidden safety net ... the immune system such as AIDS. The Mayo Clinic-led ... and is reported in the early online edition of ...
... uncovered part of the genetic mechanism that causes new arteries ... led by SFVAMC vascular surgeon Rajabrata Sarkar, MD, PhD, has ... the growth of new arteries when the femoral (leg) artery ... for the first time, the specific DNA sequences of the ...
Cached Biology News:Birth defects: 8 million annually worldwide 2Birth defects: 8 million annually worldwide 3Birth defects: 8 million annually worldwide 4Birth defects: 8 million annually worldwide 5Infant transplant patients resist infections that kill adult AIDS patients 2Infant transplant patients resist infections that kill adult AIDS patients 3Genetic key to growth of new arteries is identified 2Genetic key to growth of new arteries is identified 3
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... , , , , Vincent ... Westbury, New York , , , ... Perhaps the most critical parameter for successful , PCR is ... primer can result in a PCR reaction that will not work. The primer sequence , ...
... , , , , Karen Sermon, M.D., PhD ... Hospital and Medical School of the Dutch-speaking Brussels Free , University, , ... , , , , ... Preimplantation diagnosis (PGD) is a very early form of prenatal diagnosis: , ...
... Ends , Using the Eppendorf Mastercycler gradient , ... Ulrich Genschel , Institute of General Botany, University ... , , , , ... In many research projects, cDNA isolation forms the basis for detailed , ...
Cached Biology Technology:General Notes on Primer Design in PCR* 2General Notes on Primer Design in PCR* 3General Notes on Primer Design in PCR* 4General Notes on Primer Design in PCR* 5General Notes on Primer Design in PCR* 6The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 2The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 3The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 4The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 5Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 2Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 3Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 4Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 5
HybriWell™ hybridization sealing system, 20 mm diameter chamber, 0.15 mm deep *set of 100*...
Recombinant Equine IL-6...
Recombinant Equine TNF-alpha/TNFSF1A, CF...
... Express Cloning Checker Kits provide two ... after transformation without time-consuming plasmid preparation. By ... I, all you need to do is ... bacteria directly from the transformation plates into ...
Biology Products: