Navigation Links
Treatment corrects severe insulin imbalance in animal studies
Date:7/31/2008

Researchers have used a drug to achieve normal levels of blood sugar in animals genetically engineered to have abnormally high insulin levels. If this approach succeeds in humans, it could become an innovative medicine for children with congenital hyperinsulinism, a rare but potentially devastating genetic disease in which insulin levels become dangerously high.

"There is currently no effective medical treatment for children with the most common type of congenital hyperinsulinism," said study leader Diva D. De Len, M.D., a pediatric endocrinologist at The Children's Hospital of Philadelphia. "This type of congenital hyperinsulinism is caused by mutations in genes that encode important potassium channels in the pancreatic beta cells." The study team, from Children's Hospital and the University of Pennsylvania School of Medicine, published their report online on July 17 in the Journal of Biological Chemistry.

In congenital hyperinsulinism (HI), genetic mutations damage the insulin-secreting beta cells in the pancreas. Insulin levels rage out of control and severely reduce blood glucose, a condition called hypoglycemia. If untreated, hypoglycemia may cause irreversible brain damage or death in children. Congenital HI occurs in an estimated one in 50,000 U.S. children, with a somewhat higher incidence among certain groups, such as Ashkenazic Jews.

For the past 20 years, the standard medical treatment for some forms of HI has been the drug diazoxide, which controls insulin secretion by opening up crucial potassium channels in beta cells. However, this drug does not work in the most common and severe forms of HI, in which mutations prevent those channels from forming.

When the abnormal beta cells are confined to a discrete portion of the pancreas, as occurs in approximately half of HI cases, precise surgery on the tiny organ can remove the lesion and cure HI. The Children's Hospital of Philadelphia is a world leader in diagn
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6050
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Video released of rapid Alzheimers improvement after new immune-based treatment
2. Fertility treatment in developing countries; a cycle of IVF for less than $200
3. New treatment approach promising for lymphoma patients in the developing world
4. Treatment delays result in poor outcomes for men with breast cancer
5. Counting tumor cells in blood predicts treatment benefit in prostate cancer
6. Stroke study reveals key target for improving treatment and suggests that Gleevec may help
7. Hypertension treatment effective in reversing vascular damage
8. Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment
9. Source of drug-tolerant tuberculosis possibly behind TB relapses, intensity of treatment
10. Novel therapeutic strategy for colon cancer treatment
11. New ballast treatment could protect Great Lakes fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... a newly coined term for novels and films which focus ... of Copenhagen shows how these fictions serve as a mental ... climate change and imagine other living conditions. , "Global ... the atmosphere; it is also a cultural phenomenon in which ... the films we see. And there are so many of ...
(Date:4/23/2014)... University of Exeter researcher has shed light on how ... in Australia,s remote outback have become reviled as pests ... of the Environment and Sustainability Institute at the University ... camel in Australia, from their historic role helping to ... as unwelcome "invader." , The deserts of the Australian ...
(Date:4/23/2014)... leading a 2 million Food Standards Agency (FSA) project ... and industry workers. , Norovirus outbreaks can rapidly ... batch of frozen strawberries infected 11,000 people in Germany, ... of which strains cause infection and which foods are ... , Researchers will produce data that will help the ...
Breaking Biology News(10 mins):Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3How Australia got the hump with 1 million feral camels 2How Australia got the hump with 1 million feral camels 3
... that allowing babies to swim is possibly not as ... till now," underlines Dr. Joachim Heinrich. He leads ... for Epidemiology. Prof. Dr. Dr. H. Erich ... This is a first indication. Nevertheless, it requires other ...
... receives funding from Hope Against Cancer (formerly The ... bilberries can prevent or delay the onset of ... University of Leicester, is leading an investigation ... produced substance Mirtoselect (extracted from bilberries), with the ...
... Mich. Scientists have identified and described stem cells specific ... master cells that give rise to the specialized cell types ... possible to pinpoint functioning stem cells in the stomach, either ... of University of Michigan Medical School researchers has succeeded in ...
Cached Biology News:Bilberry extract -- can it help prevent certain cancers? 2Bilberry extract -- can it help prevent certain cancers? 3Stomach stem cell discovery could bring cancer insights 2Stomach stem cell discovery could bring cancer insights 3
(Date:1/15/2014)... Canada (PRWEB) January 15, 2014 This ... on nonclinical and clinical safety assessment in biosimilars. , ... path for biosimilar drug development, however the complex nature ... to quality, safety and efficacy extremely challenging. Based on ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 The Microcompetition with ... major disease. One of these latent viruses is the Epstein ... arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease ... a study found that RA patients have high concentrations of ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched ... tinnitus. Patients listen to sound therapy that is tailor-made ... weeks to months, their tinnitus volume decreases. , AudioNotch has ... and Notched White Noise. Now, AudioNotch is pleased to announce ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine company developing ... simulated embryonic conditions, today announced that they have entered ... for physician-dispensed aesthetic products containing Histogen’s proprietary multipotent cell ... an amendment to the existing license between Histogen and ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... about IT project failure rates. Youve probably heard mention of ... poor requirements and scope definition, lack of business relevance or ... of this hand wringing is the real root cause. Its ... For each one, the source is the failure of specific ...
... Welcome to the global village called BIO 03. Lets ... , ,Starting at the Wisconsin Pavilion in the cavernous exhibit ... 100 the anniversary Harley-Davidson motorcycle parked in the corner. OK, ... its a great way to lure people into our aisle. ...
... Note: The Wisconsin Technology Council has published ... The 24-page publication highlights the states research base, ... contacts and the I-Q Corridor that joins Chicago, ... Technology Network has arranged to post excerpts from ...
Cached Biology Technology:Analog people in the digital revolution 2Analog people in the digital revolution 3On Location at BIO 2003 2Life Science: From the arts to the outdoors: Living and Playing in Wisconsin 2Life Science: From the arts to the outdoors: Living and Playing in Wisconsin 3Life Science: From the arts to the outdoors: Living and Playing in Wisconsin 4Life Science: From the arts to the outdoors: Living and Playing in Wisconsin 5
B2-Microgloulin...
... utilizies CTI Molecular Imaging's proprietary Focus™ detector ... volume as the R4. The microPET ... any commerically avaiable PET scanner. Focus ... of any scinitallor based PETsystems. The ...
...
... product has been developed to significantly increase ... proteins. Stability is increased at room ... centigrade. This product is subjected to ... or azide. This formulation insures consistently ...
Biology Products: