Navigation Links
Transmission routes of spreading protein particles
Date:3/27/2013

in mammalian cells. "At first, our mouse cells produced the protein, but no particles formed," Vorberg reports. "The situation changed when we exposed the cells to aggregates of the same protein. Suddenly, the proteins which had been in solution started building clumps."

Diffusing aggregates

Once this reaction had been triggered the cells went on producing aggregates. The researchers noticed that these clumps spread into neighboring cells, where they initiated synthesis of further aggregates.

"We have experimentally shown that certain protein particles originating from the cytosol, i. e. from inside the cells, are able to spread between cells. This means that in mammalian cells there are mechanisms capable of triggering such a chain reaction. Accordingly, what we have shown in our model system may be applicable to neurodegenerative diseases," Vorberg comments.

Propagation of aggregates was most effective between adjacent cells. "At least in our model system, protein particles are not released efficiently into the medium and assimilated by neighboring cells. The most effective transmission happens by direct cell-to-cell contact. It is possible that cells form protrusions and that aggregates move from one cell to the next through this connection", says the neuroscientist. What is happening here will be the focus of further research.

Basis for potential therapies

"It is important to know how protein particles disseminate", Vorberg emphasizes. "Disease-related protein particles might propagate in a similar way to the model protein we investigated." Unraveling the mechanism for transmission between cells could lead to new methods for treatment. "If we find a way to prevent the spreading of disease-related protein particles, we might be able to interfere with the progression of the diseases," Vorberg says.


'/>"/>

Contact: Dirk Förger
dirk.foerger@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. New study discovers powerful function of single protein that controls neurotransmission
2. Analyzing disease transmission at the community level
3. A brain filter for clear information transmission
4. Pigs look healthy but test positive for flu at fairs; transmission seen between pigs and humans
5. Preventing obesity transmission during pregnancy
6. Biodiversity does not reduce transmission of disease from animals to humans
7. Sequencing tracks animal-to-human transmission of bacterial pathogens
8. How bumblebees find efficient routes without a GPS
9. New model of disease contagion ranks US airports in terms of their spreading influence
10. Flightless molecule may prevent cancer from spreading from 1 tissue to another
11. Frequent traveller: Dysentery-causing bacteria spreading from Europe to Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... that emits over a wide part of the electromagnetic ... being built in Lund, Sweden. The MAX IV facility ... putting together its component parts in a storage - ... just a few hundred metres. Nevertheless, if these various ... of experiments that require source brightness and transverse coherence ...
(Date:10/31/2014)... the war against Ebola one important hurdle has just ... at the University of North Carolina at Chapel Hill ... mice that can be infected with Ebola and display ... published in the current issue of Science , ... vaccines, which are desperately needed to curb the worldwide ...
(Date:10/31/2014)... , Oct. 30, 2014  HITLAB SM , ... to announce its inaugural HITLAB Innovators Summit SM ... Low Library. HITLAB will partner with the Clinton ... Blueprint Health, ProtoHack, Columbia Business School Alumni Club ... Columbia Industrial Engineering and Operations Research, bringing together ...
Breaking Biology News(10 mins):A new generation of storage -- ring 2Improved mouse model will accelerate research on potential Ebola vaccines, treatments 2HITLAB Announces Inaugural HITLAB Innovators Summit 2HITLAB Announces Inaugural HITLAB Innovators Summit 3
... can cause congenital heart defects has been identified by a ... discovery could lead to new treatments for those affected by ... Princeton researchers focused on identifying and studying the gene in ... with other groups studying the genetics of mice and people. ...
... Parascript, LLC, the image analysis and pattern recognition ... Xpert was awarded best performance for forensic signature ... in Handwriting Recognition (ICFHR2010) in Kolkata, India, held ... seven participants representing a total of 10 offline ...
... insects and pathogens continue to become established in US forests ... a study published in the December 2010 issue of ... Juliann E. Aukema of the National Center for Ecological Analysis ... are being newly detected in US forests at a rate ...
Cached Biology News:Scientists find gene linked to congenital heart defect 2Scientists find gene linked to congenital heart defect 3Scientists find gene linked to congenital heart defect 4Parascript SignatureXpert Wins Forensic Signature Verification Competition 2Forest pests accumulating despite regulations 2
(Date:10/31/2014)... Huge event with 36,000+ global professionals is ... analysis and forecasting   CPhI Worldwide , ... most successful show to date with pre-audit figures estimating ... year in Paris , the show ... countries representing every step of the pharmaceutical supply chain ...
(Date:10/31/2014)... October 31, 2014 Jeffrey T. Manuel, ... Historical Studies within the College of Arts and Sciences, ... record the history of alcohol-based fuels in Illinois. ... others have been working to build Illinois’ biofuels industry ... overlooked aspect of the state's agricultural and business history. ...
(Date:10/31/2014)... ENVIRON , an international ... that Dr. Harvey Clewell III has rejoined the ... closely with senior professionals in ENVIRON’s Health Sciences ... at The Hamner Institutes for Health Sciences (The ... he is Director, Center for Human Health Assessment. ...
(Date:10/30/2014)... , October 30, 2014 Investor-Edge ... Inc. (NYSE MKT: ONVO), Medivation Inc. (NASDAQ: ... Synthetic Biologics Inc. (NYSE MKT: SYN), and Ironwood Pharmaceuticals ... can be accessed at: http://investor-edge.com/register . ... at 4,549.23, down 0.33%, the Dow Jones Industrial Average ...
Breaking Biology Technology:CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 2CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 3CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 4CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 5CPhI Worldwide 2014 Announces Biggest Ever Show and Points to Pharma Growth in Brazil, Russia and Fast Emerging Africa 6SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5
... Signalife, Inc. (Amex:,SGN) and Athletes for Life Foundation ... heart monitoring and screening at the Pontotoc,Technology Center ... Bowl champion, and a founder of the Athletes ... to participate in a children,s health,education program sponsored ...
... highly efficient and fast PCR amplification ... in a ... Biosystems, Inc., a leading,developer of state-of-the-art PCR devices and Cell-based ... at the San,Diego Convention Center that it has successfully completed ...
... New York City, WASHINGTON, NEW YORK, and ... Life Science Advisors, the EBD Group and FasterCures,today ... new,partnering meeting designed to promote funding of non-profit ... partnering between,those groups and biopharmaceutical companies. The inaugural ...
Cached Biology Technology:Signalife Announces AFL Joins NIH Education Program 2Signalife Announces AFL Joins NIH Education Program 3Ahram Biosystems Completes Development of a Palm-Size Portable PCR Device 2Partnering for Philanthropy Conference Launched to Unite Innovative Non-profit Research Organizations with Philanthropists and Industry 2Partnering for Philanthropy Conference Launched to Unite Innovative Non-profit Research Organizations with Philanthropists and Industry 3
... Versatile state of the Art ... flask to dual 38,000 L fermentation. ... scale to production. Aseptic operation ... Batch, Fed-Batch, and Continuous Modes. ...
Competitors to lower non-specific signal...
... Each vial contains 200 g of lyophilized ... sequence (C-terminal amino acids 380-402; GLTPSAWEASSLRSSRHSGLSHF. ... antigen for production of Cayman's EP1 receptor ... be used in conjunction with this antibody ...
Immunogen: VDAC3 Protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: