Navigation Links
Transmission routes of spreading protein particles
Date:3/27/2013

Bonn, Germany 27 March 2013 In diseases like Alzheimer's and Parkinson's endogenous proteins accumulate in the brain, eventually leading to the death of nerve cells. These deposits, which consist of abnormally formed proteins, are supposed to migrate between interconnected areas of the brain, thereby contributing to the development of the illness. Now, a new laboratory study by scientists from Germany and the US shows that certain protein particles are indeed capable of multiplying and spreading from one cell to the next. The investigation was conducted by researchers of the German Center for Neurodegenerative Diseases (DZNE) in Bonn and Munich who cooperated with scientists from the US and from other German institutions. The results are now published in the "Proceedings of the National Academy of Sciences of the USA" (PNAS).

Are particles consisting of deformed proteins capable of moving from one cell's interior to the next, multiplying and spreading as in a chain reaction? The team of scientists headed by Ina Vorberg, who is a researcher at the DZNE site in Bonn and a professor at the University of Bonn, investigated this hypothesis. The scientists did so with the help of cell cultures, which allowed them to adapt experiments to specific questions.

The researchers used cultured brain cells that originated from mice. The genetic code of a model protein was transferred into these cells, enabling the scientists to control production of the protein.

A yeast particle

The blueprint of the molecule was extracted from yeast DNA. This protein does not exist in humans. Nevertheless, the scientists chose this particular protein because it had several properties that were relevant for the study: In its natural environment the yeast cell it is capable of forming replicating "aggregates" (i. e. large protein particles). The protein deforms during this process. Now, the question was, whether something similar would happen
'/>"/>

Contact: Dirk Förger
dirk.foerger@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. New study discovers powerful function of single protein that controls neurotransmission
2. Analyzing disease transmission at the community level
3. A brain filter for clear information transmission
4. Pigs look healthy but test positive for flu at fairs; transmission seen between pigs and humans
5. Preventing obesity transmission during pregnancy
6. Biodiversity does not reduce transmission of disease from animals to humans
7. Sequencing tracks animal-to-human transmission of bacterial pathogens
8. How bumblebees find efficient routes without a GPS
9. New model of disease contagion ranks US airports in terms of their spreading influence
10. Flightless molecule may prevent cancer from spreading from 1 tissue to another
11. Frequent traveller: Dysentery-causing bacteria spreading from Europe to Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... , March 12, 2015 IriTech, a leading ... member of the Texas Instruments Design Network, announced today ... has demonstrated its IriShield USB MK2120U device during a ... for pension distribution. The iris scanner ... be marketed in India through ...
(Date:3/12/2015)... -- Beta Systems today announced Fast ... (IAM) solution for a fixed price and with ... IAM package, customers benefit from the 30 years, ... implementations across different industries. The new fixed-price IAM ... necessary services and consulting. It spans the implementation ...
(Date:3/11/2015)... 11, 2015 Research and Markets ( ... "Access Control Market by Product, Application & By Geography ... to their offering. , This report predicts ... $10.4 billion by 2020, with an estimated CAGR of ... the products types such as contact cards & readers, ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2
... University of Adelaide study has identified the risk of ... reproductive technology. In the most comprehensive study of ... Robinson Institute have compared the risk of ... commonly available internationally, such as: IVF (in vitro fertilization), ...
... treatment and display heightened tumor-generating capacity can be identified by ... cells, a research team led by scientists at The University ... 3 edition of Cell Stem Cell . ... first time to separate low-PSA and high-PSA prostate cancer cells. ...
... a donated human retina to an Indiana University researcher ... helped uncover a previously undetected mechanism causing the disease. ... how millions of dollars are spent investigating the cause ... neovascularization. Working at IU,s Biocomplexity Institute, postdoctoral ...
Cached Biology News:Higher risk of birth defects from assisted reproduction 2Higher risk of birth defects from assisted reproduction 3Higher risk of birth defects from assisted reproduction 4Scientists identify prostate cancer stem cells among low-PSA cells 2Scientists identify prostate cancer stem cells among low-PSA cells 3Scientists identify prostate cancer stem cells among low-PSA cells 4Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease 2Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease 3Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease 4
(Date:3/26/2015)... March 26, 2015 Ale Gicqueau, Founder ... Director of Clinical Affairs at Align Technology, on “ ... the upcoming ACRP 2015 Global Conference and Exhibition on ... Utah. , During the poster presentation, Ale Gicqueau ... and running a Postmarket Registry, the requirements and resources ...
(Date:3/25/2015)... Agnition announced today that it will be featured ... the first time at 7:30 a.m. CST March 31 ... the extremely important role soil microbes perform in crop ... Catalyst™ technology that enhances soil and plant health for ... again on April 28. , A biochemist at Agnition ...
(Date:3/25/2015)... 25, 2015 The surging prevalence ... have fuelled social media growth, with over 50% ... in social networking. Insurance companies are making use ... clients and promote a diversity of their services ... increasingly exploiting social networking services as part of ...
(Date:3/25/2015)... ROCKVILLE, Md. , March 25, 2015 ... been named a finalist for "Best Contract Research Organization" ... by the World Vaccine Congress. This ... as a finalist for the award, winning for "Best ... receiving a "Highly Recommended" distinction in 2013. ...
Breaking Biology Technology:Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Accelovance Nominated for 2015 Vaccine Industry Excellence (ViE) Awards 2
... 5, 2011 Cord Blood America, Inc . ( ... umbilical cord blood stem cell preservation company focused ... families nationwide and internationally, is pleased to announce that the ... lawsuit filed by Cryo-Cell International against Cord Blood America, which ...
... 3, 2011 -- Researchers at the Hebrew University of Jerusalem ... successfully altering nanocrystal properties with impurity atoms -- a process ... of improved semiconductor nanocrystals. Semiconductor nanocrystals consist of ... than the width of a human hair. These tiny particles ...
... Calif., April 4, 2011 Ambry Genetics announced today ... (CSP) in Ion Torrent,s new service provider program. Ion ... are trusting with their samples has been trained and ... sequence data. (Logo: http://photos.prnewswire.com/prnh/20110307/LA59848LOGO ) ...
Cached Biology Technology:Cord Blood America: Court Grants Motion to Dismiss at Lawsuit Aimed at Blocking Acquisition 2'Nanocrystal doping' developed by Hebrew University researchers enhances semiconductor nanocrystals 2Ambry Genetics is First Authorized Customer Service Provider in New Ion Torrent CSP Program 2Ambry Genetics is First Authorized Customer Service Provider in New Ion Torrent CSP Program 3
... The new MALDI O-TOF creates a new ... an orthogonal platform that has been licensed ... University of Manitoba. , As the first ... design and collisional cooling, the prOTOF 2000 ...
Rat Lung Fibroblasts (RLF) (>500,000 cells)...
Rat Aortic Endothelial Cells (RAOEC) (>500,000 cells)...
...
Biology Products: