Navigation Links
Transmission routes of spreading protein particles
Date:3/27/2013

Bonn, Germany 27 March 2013 In diseases like Alzheimer's and Parkinson's endogenous proteins accumulate in the brain, eventually leading to the death of nerve cells. These deposits, which consist of abnormally formed proteins, are supposed to migrate between interconnected areas of the brain, thereby contributing to the development of the illness. Now, a new laboratory study by scientists from Germany and the US shows that certain protein particles are indeed capable of multiplying and spreading from one cell to the next. The investigation was conducted by researchers of the German Center for Neurodegenerative Diseases (DZNE) in Bonn and Munich who cooperated with scientists from the US and from other German institutions. The results are now published in the "Proceedings of the National Academy of Sciences of the USA" (PNAS).

Are particles consisting of deformed proteins capable of moving from one cell's interior to the next, multiplying and spreading as in a chain reaction? The team of scientists headed by Ina Vorberg, who is a researcher at the DZNE site in Bonn and a professor at the University of Bonn, investigated this hypothesis. The scientists did so with the help of cell cultures, which allowed them to adapt experiments to specific questions.

The researchers used cultured brain cells that originated from mice. The genetic code of a model protein was transferred into these cells, enabling the scientists to control production of the protein.

A yeast particle

The blueprint of the molecule was extracted from yeast DNA. This protein does not exist in humans. Nevertheless, the scientists chose this particular protein because it had several properties that were relevant for the study: In its natural environment the yeast cell it is capable of forming replicating "aggregates" (i. e. large protein particles). The protein deforms during this process. Now, the question was, whether something similar would happen
'/>"/>

Contact: Dirk Förger
dirk.foerger@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. New study discovers powerful function of single protein that controls neurotransmission
2. Analyzing disease transmission at the community level
3. A brain filter for clear information transmission
4. Pigs look healthy but test positive for flu at fairs; transmission seen between pigs and humans
5. Preventing obesity transmission during pregnancy
6. Biodiversity does not reduce transmission of disease from animals to humans
7. Sequencing tracks animal-to-human transmission of bacterial pathogens
8. How bumblebees find efficient routes without a GPS
9. New model of disease contagion ranks US airports in terms of their spreading influence
10. Flightless molecule may prevent cancer from spreading from 1 tissue to another
11. Frequent traveller: Dysentery-causing bacteria spreading from Europe to Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... State University researcher found that bacteria in the Gulf ... the oil released during the Deepwater Horizon spill in ... toxic contaminants. , In two new studies conducted in ... a species of bacteria called Colwellia likely ... xylene compounds that were released as part of the ...
(Date:7/31/2014)... 2014 NXT-ID, Inc., (NXTD: OTCQB) a biometric authentication ... investors and consumers wanting to learn more about ... be on-air today, July 31 st . ... be featured in a segment of NewsWatch, a ... on the History Channel, FYI Network today. ...
(Date:7/30/2014)... the way for a breakthrough that may prevent ... to poisonous chemicalsparticularly those in pesticides and chemical ... issue of the journal ChemBioChem outlines ... commonly used in pesticides and warfare agents. The ... Engineering Associate Professor of Chemical and Biological Engineering ...
Breaking Biology News(10 mins):NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 2NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 3Engineering a protein to prevent brain damage from toxic agents 2
... ARBORWorking beneath the towering oaks and maples on the ... their faculty adviser helped explain an observation that had ... caterpillars. The caterpillars, which defoliate and sometimes kill ... Northeast, are especially fond of oaks, but sugar maple ...
... Escocia, 30 de enero de 2013 Life ... anunció que proveerá una solución de laboratorio íntegra para ... comunes en Libia a raíz de la insurrección de ... durante el régimen de 42 años de Muammar Gaddafi. Se ...
... U.S. Antarctic Program (USAP) and Antarctica New Zealand have jointly ... Antarctic aircraft crash after examination of the plane indicated that ... the wreckage that is largely embedded in snow and ice ... able to recover some equipment from the exposed tail of ...
Cached Biology News:Campus as laboratory: U-M student biologists use Diag trees to help solve gypsy moth mystery 2Campus as laboratory: U-M student biologists use Diag trees to help solve gypsy moth mystery 3Life Technologies ayudará a identificar 20.000 restos humanos encontrados en fosas comunes en Libia 2Life Technologies ayudará a identificar 20.000 restos humanos encontrados en fosas comunes en Libia 3Life Technologies ayudará a identificar 20.000 restos humanos encontrados en fosas comunes en Libia 4US, New Zealand search-and-rescue teams recalled from Antarctic plane crash site 2
(Date:7/31/2014)... Calif. , July 31, 2014 Rogne ... San Francisco Bay Area , has acquired a ... of Oxford,s commercialisation company. The potent anti-inflammatory activity of ... at the University of Oxford,s Sir William ... company, which has raised over $1.5 million in seed ...
(Date:7/31/2014)... July 31, 2014 Research and Markets ... Genomics Market 2014-2018" report to their offering. ... is the study of the genetic material or genomes ... strong basis for the discovery and development of diagnostic ... or health conditions. Genomics is supported by three major ...
(Date:7/31/2014)... China , July 31, 2014 ... Irys™System by BGI , the world,s ... comprehensive exploration of human structural variation (SV) and to ... including those where no reference exists. In addition, BioNano ... for multiplexing on the Irys System, enabling significantly higher ...
(Date:7/31/2014)... 31, 2014 Although RNA-Sequencing is ... first transcriptome-wide analyses appearing around 2008, RNA-Sequencing has ... RNA measurement. In the last several years, assays ... work with smaller input amounts, process degraded RNA, ... samples). On the bioinformatics side, there have been ...
Breaking Biology Technology:Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2BioNano Genomics Announces the Purchase of the Irys System by BGI 2BioNano Genomics Announces the Purchase of the Irys System by BGI 3BioNano Genomics Announces the Purchase of the Irys System by BGI 4The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2
... Stephen Simes, chief executive,officer of BioSante Pharmaceuticals, ... be featured in an exclusive interview with, http://www.wallst.net ... EDT. The interview,will be posted on http://www.wallst.net ... The interview will cover topics including BioSante,s ...
... MONTEREY, Calif., Sept. 24 Today, the ... that utilize PARI,s,eFlow electronic nebulizer for aerosol ... acquisition of Corus Pharma in,August 2006, this ... a,licensed eFlow is featured prominently in the ...
... WEST BRIDGEWATER, Mass., Sept. 24 Pressure,BioSciences, Inc. ... update on,various corporate activities, including the expansion of ... stock on the Frankfurt Stock Exchange, and,reaffirmation of ... Barocycler instruments. 1) Domestic Sales Force: the ...
Cached Biology Technology:WallSt.net Announces Upcoming Interview with CEO of BioSante Pharmaceuticals 2Pediatric Asthma Programs Featuring PARI Pharma's eFlow Acquired by AstraZeneca 2Pressure BioSciences, Inc. Provides Corporate Update 2Pressure BioSciences, Inc. Provides Corporate Update 3
Anti-Digoxigenin-AP, Fab fragments; from sheep...
...
... Immunogen: Partially purified chicken ... detects vitamin D receptor (VDR) from ... and fish tissues. This antibody ... glucocorticoid receptors. MA1-710 detects both ...
... AccuPrime™ Pfx DNA Polymerase is ideal ... for downstream applications such as cloning ... provided by a proprietary enzyme preparation ... sp. with proofreading (3'Cut Site5' exonuclease) ...
Biology Products: