Navigation Links
Tracking down the cause of mad cow disease
Date:10/8/2008

This release is available in German.

The cause of diseases such as BSE in cattle and CreutzfeldJakob disease in humans is a prion protein. This protein attaches to cell membranes by way of an anchor made of sugar and lipid components (a glycosylphosphatidylinositol, GPI) anchor. The anchoring of the prions seems to have a strong influence on the transformation of the normal form of the protein into its pathogenic form, which causes scrapie and mad cow disease. A team headed by Christian F. W. Becker at the TU Munich and Peter H. Seeberger at the ETH Zurich has now "recreated" the first GPI-anchored prion in the laboratory. As they report in the journal Angewandte Chemie, they have been able to develop a new general method for the synthesis of anchored proteins.

The isolation of a complete prion protein that includes the anchor has not yet been achieved, nor has it been possible to produce a synthetic GPI-anchored protein. The function of the GPI anchor has thus remained in the dark. A new synthetic technique has now provided an important breakthrough for the German and Swiss team of researchers.

The sugar component of natural prion GPI anchors consists of five sugar building blocks, to which further sugars are attached through branches. Details of the lipid component have not been determined before. As a synthetic target, the researchers thus chose a construct made of the five sugars and one C18-lipid chain and worked out the corresponding synthetic route. First, the anchor was furnished with the sulfur-containing amino acid cysteine. The prion protein was produced with the use of bacteria and was given an additional thioester (a sulfur-containing group). The centerpiece of the new concept is the linkage of the protein and anchor by means of a native chemical ligation, in which the cysteine group reacts with the thioester. Thi
'/>"/>

Contact: Christian F. W. Becker
christian.becker@ch.tum.de
49-892-891-3343
Wiley-Blackwell
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Tracking feline memories on the move
2. Louisiana Tech researchers investigate tracking, sensors to assist Air Force
3. NIH recognizes Clemson nanotechnology for molecule tracking
4. GestureTek/Imagination Launch AirPoint, Worlds First Hand-Tracking Unit, for Shell Group.
5. Tracking stroke
6. Tracking influenzas every movement
7. Tracking prions
8. Paleozoic sediment curve provides new tool for tracking sea-floor sediment movements
9. deCODE discovers cause of major subtype of glaucoma
10. Study begins to reveal clues to the cause and progression of sepsis
11. Bleeding, not inflammation, is major cause of early lung infection death
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracking down the cause of mad cow disease
(Date:10/18/2014)... 2,000 patients referred for evaluation of suspected genetic ... for 25 percent, including detection of a number ... to disease, according to a study appearing in ... to coincide with the American Society of Human ... exons or coding regions of thousands of genes ...
(Date:10/17/2014)... release is available in German . ... a very few drugs. When treating overdoses, doctors are often ... especially difficult if there is a combination of drugs involved. ... and accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux ... to find an answer to this question. "The task was ...
(Date:10/16/2014)... are anything but sustainable: environmental damage to soil ... increasingly evident. Despite their disadvantages, however, monocultures remain ... the sole possibility of achieving higher yields in ... an ecology professor at the University of Zurich, ... forestry. After all, a new study carried out ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... NEWTOWN SQUARE, Pennsylvania, September 27, 2011 An ... U.S. Forest Service,s Forest Inventory and Analysis (FIA) program ... eastern United States is increasing despite infestations of hemlock ... The information comes from an e-Science Update co-authored by ...
... ROUGE A research team led by LSU Associate Professors ... the results of a combined field and laboratory study showing ... living in Louisiana marshes. , The study, funded ... the Gulf of Mexico Research Initiative is being published in ...
... ... Presidential Early Career Award for Scientists and Engineers (PECASE). The award ... scientists and engineers in the early stages of their careers. ... significant award," said Jane Lubchenco, Ph.D., under secretary of commerce for ...
Cached Biology News:US Forest Service study finds hemlock still abundant despite adelgid infestation 2LSU researchers find impact of oil spill in marsh fish species 2President to honor high achieving, early career NOAA scientists 2
(Date:10/20/2014)... PARK, Calif. , Oct. 20, 2014 /PRNewswire/ ... today that the Company has signed a Notice ... of Regenerative Medicine (CIRM), effective October 1, 2014.  ... Clinical Development payments and the release of additional ... million CIRM grant award for clinical development of ...
(Date:10/20/2014)... , Oct. 20, 2014 PureTech ... company tackling big healthcare problems, announced today the ... round, with participation from Invesco Perpetual, a $120 ... used to drive PureTech,s existing pipeline forward and ... "PureTech has the scientific creativity to really go ...
(Date:10/19/2014)... 19, 2014 The Latin American hardware ... in Latin America with analysis and forecast of revenue. ... and is expected to reach $2,366.8 million by 2018, ... , Browse through the TOC of the Latin American ... the in-depth analysis provided. It also provides a glimpse ...
(Date:10/19/2014)... The Asian Automatic patient billing report defines and ... of revenue. The Automatic patient billing market in Asia ... 2018, at a developing CAGR of 7.2% from 2013 ... Asian Automatic patient billing market, to get an idea ... glimpse of the segmentation of this market in the ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... YORK, Aug. 24 The DNA sequencing equipment ... and 2012, spiraling upward from,$335 million to $528 ... Sequencing Equipment and Service Markets, a new report ... been relatively stable for the last,several years, with ...
... Conference Call Originally Scheduled for 9:00 a.m. Eastern Time ... Be Rescheduled After Private Placement Closes -, FREMONT, ... (Nasdaq: CIPH ), today announced that it,has entered ... with a group of existing and new investors. Under ...
... DIEGO, Aug. 23 eBioscience Corporation announced,the appointment ... eBioscience, effective,immediately. Dr. Nelson comes to eBioscience from ... Development. Dr. Nelson will assume the role ... as President during a transition period. Nelson will,also ...
Cached Biology Technology:DNA Sequencing Equipment Market to Fragment and Grow as Competition, New Technologies Develop 2Vermillion (Formerly Ciphergen) Announces $20.5 Million Private Placement of Common Stock 2Vermillion (Formerly Ciphergen) Announces $20.5 Million Private Placement of Common Stock 3Todd R. Nelson Named Chief Executive Officer of eBioscience, Inc. 2
Request Info...
... Cell Expansion Kit - Neurosphere is a system ... cell expansion as neurospheres in a serum free ... Plus Media Supplement, which has been optimized for ... al . (1996) Genes & Development 10 ...
... Source: Calf thymus Description: Topoisomerase I ... a transient breakage and rejoining of phosphodiester bonds ... allows molecules to be differentiated by a single ... I is active in the absence of Mn ...
... Topo I, Wild Type ... 1 mM DTT, 200 µM EDTA, 20% glycerol, ... I (Topo I) is a monomeric protein of ... It catalyzes the relaxation of both positive and ...
Biology Products: