Navigation Links
Tracking down the cause of mad cow disease
Date:10/8/2008

This release is available in German.

The cause of diseases such as BSE in cattle and CreutzfeldJakob disease in humans is a prion protein. This protein attaches to cell membranes by way of an anchor made of sugar and lipid components (a glycosylphosphatidylinositol, GPI) anchor. The anchoring of the prions seems to have a strong influence on the transformation of the normal form of the protein into its pathogenic form, which causes scrapie and mad cow disease. A team headed by Christian F. W. Becker at the TU Munich and Peter H. Seeberger at the ETH Zurich has now "recreated" the first GPI-anchored prion in the laboratory. As they report in the journal Angewandte Chemie, they have been able to develop a new general method for the synthesis of anchored proteins.

The isolation of a complete prion protein that includes the anchor has not yet been achieved, nor has it been possible to produce a synthetic GPI-anchored protein. The function of the GPI anchor has thus remained in the dark. A new synthetic technique has now provided an important breakthrough for the German and Swiss team of researchers.

The sugar component of natural prion GPI anchors consists of five sugar building blocks, to which further sugars are attached through branches. Details of the lipid component have not been determined before. As a synthetic target, the researchers thus chose a construct made of the five sugars and one C18-lipid chain and worked out the corresponding synthetic route. First, the anchor was furnished with the sulfur-containing amino acid cysteine. The prion protein was produced with the use of bacteria and was given an additional thioester (a sulfur-containing group). The centerpiece of the new concept is the linkage of the protein and anchor by means of a native chemical ligation, in which the cysteine group reacts with the thioester. Thi
'/>"/>

Contact: Christian F. W. Becker
christian.becker@ch.tum.de
49-892-891-3343
Wiley-Blackwell
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Tracking feline memories on the move
2. Louisiana Tech researchers investigate tracking, sensors to assist Air Force
3. NIH recognizes Clemson nanotechnology for molecule tracking
4. GestureTek/Imagination Launch AirPoint, Worlds First Hand-Tracking Unit, for Shell Group.
5. Tracking stroke
6. Tracking influenzas every movement
7. Tracking prions
8. Paleozoic sediment curve provides new tool for tracking sea-floor sediment movements
9. deCODE discovers cause of major subtype of glaucoma
10. Study begins to reveal clues to the cause and progression of sepsis
11. Bleeding, not inflammation, is major cause of early lung infection death
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracking down the cause of mad cow disease
(Date:4/20/2015)... , April 20, 2015 Huntington Memorial ... Valley to implant a new miniaturized, wireless monitoring sensor ... is the first and only FDA-approved heart failure monitoring ... admissions when used by physicians to manage heart failure. ... that is implanted in the pulmonary artery (PA) during ...
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
(Date:4/9/2015)... Calif. , April 9, 2015 Synaptics ... interface solutions, announced today that it will report financial ... Thursday, April 23, 2015, after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2
... the Bronx Zoo-based Wildlife Conservation Society (WCS) warn that ... Asia and beyond must focus on better management practices ... working with Mongolian agencies on the ground in Mongolia's ... recently contracted the virus. , "We're working with our ...
... modest suppression of growth hormone and related compounds beginning ... of several types of cancer, researchers from Wake Forest ... at ENDO 2005, the annual meeting of the Endocrine ... and insulin-like growth factor (IGF-1) also may decrease cancer ...
... researchers have discovered an inherited structural mechanism that ... some patients. The mechanism decreases a protein and ... drugs differently. Thiopurine therapies are used to treat ... transplants. The Mayo researchers say their finding advances ...
Cached Biology News:WCS says avian flu prevention should focus on farms, markets 2Suppressing growth hormone in early adulthood may prevent cancer 2Genomics researchers discover protein deficit that causes drug toxicity 2
(Date:4/23/2015)... /CNW/ - A new and innovative service has won ... North America,s largest packaging trade association. ... the "Sustainability, service" category of the PAC Global ... is a service that scores clients, packaging against ... This benchmarking process shows clients how their packaging ...
(Date:4/23/2015)... 2015  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) ... quarter 2015 results before the Nasdaq market opens on ... conference call and webcast to discuss its financial results ... 2015 at 8:00 a.m. Eastern Time (5:00 a.m. Pacific ... call by dialing 866-952-1906 (US) or 785-424-1825 (International) using ...
(Date:4/23/2015)... April 23, 2015  Cryoport, Inc. (OTCBB: CYRX) ... solutions for the life sciences industry, today announced ... logistics solutions within the animal husbandry market by ... to support the shipment of equine semen for ... horse Stallions. Animal husbandry is a ...
(Date:4/23/2015)... Glemser Technologies is ... Enterprise Content Division (ECD) Certified Solution Partner to ... for Life Sciences Solution Suite . The accreditation ... to provide life sciences companies of all sizes ... EMC Documentum Solution Suite offers four modules: Quality ...
Breaking Biology Technology:Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 2Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 3Glemser Earns Accreditation for Life Sciences Solution Suite 2
... 25 NanoBio(R) Corporation, a,biopharmaceutical company developing novel ... serious infections, today announced,the addition of four new ... Ma, PharmD, Ph.D.; Susan Ciotti, Ph.D.; Robert L. ... in developing and commercializing,its novel topical anti-infectives and ...
... Cell biologist receives $500,000 ,genius award, with ,no ... Roth, Ph.D., a cell biologist at,Fred Hutchinson Cancer ... MacArthur Fellowships, a "genius" award given annually by ... will receive $500,000 over,five years of "no-strings-attached" support. ...
... ST. LOUIS and REHOVOT, Israel, Sept. 25 ,Monsanto ... (TASE: EVGN) today announced,a collaboration to improve nitrogen ... the agreement, Monsanto gains exclusive rights to,a number ... maintain yield,with lower applications of nitrogen. Monsanto will ...
Cached Biology Technology:NanoBio Expands Drug Development Team for Its Anti-Infective Products 2NanoBio Expands Drug Development Team for Its Anti-Infective Products 3Basic Scientist Mark Roth Wins MacArthur Fellowship 2Basic Scientist Mark Roth Wins MacArthur Fellowship 3Monsanto and Evogene Collaborate on Nitrogen Use Efficiency Research 2Monsanto and Evogene Collaborate on Nitrogen Use Efficiency Research 3