Navigation Links
Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
Date:3/2/2012

The American Cancer Society estimates that 44,000 new cases of pancreatic cancer will be diagnosed this year and that 37,000 people will die from the disease. These are not strong odds. A new drug, rigosertib, allows pancreatic cancer cells to rush through replication and then stops them cold, killing them in in the middle of a step called M phase. Healthy cells that don't rush are unharmed.

Data from a phase I clinical trial of patients with advanced pancreatic cancer and additional solid tumors recently published in the journal Clinical Cancer Research shows the strategy has promise. While the goal of any phase I trial is to establish the dosage that best balances effectiveness against side effects, 11 of the 19 patients treated achieved stable disease, which lasted for a median of 113 days.

"Really, the drug takes one of cancer's greatest strengths and turns it into a weakness," says Wells Messersmith, MD, co-leader of the Developmental Therapeutics Program at the University of Colorado Cancer Center and the clinical trial's national principal investigator.

Instead of going with the flow of the natural cell cycle, cancer cells amplify two signals PLK1 and PI3K which allows them to blast through the cell cycle and divide much more quickly. In the process, they break this step of the natural cell cycle, known as the G1 regulatory mechanism, and thus depend on the kick of PLK1 and P13K to push at a frenzied pace through replication.

It's specifically these two signals, PLK1 and PI3K, that rigosertib targets. With these signals turned off, cancer cells get stuck and die in the stage of the cell cycle called M phase while healthy cells that stuck to the slower, natural method of division chug past unharmed.

Wells Messersmith, MD, co-leader of the Developmental Therapeutics Program at the University of Colorado Cancer Center

"This one-two punch, targeting these two distinct signaling pathways, allows
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Extinct for 150 years, an iconic Galpagos giant tortoise species lives
2. Tortoise populations can withstand fires every 30 years
3. Giant tortoises show rewilding can work
4. In the race of life, better an adaptable tortoise than a fit hare
5. New study shows how giant tortoises, alligators thrived in High Arctic 50 million years ago
6. Madagascars radiated tortoise threatened with extinction
7. New theory shows that neither birth nor death stops a flock
8. Path to oxygen in Earths atmosphere: long series of starts and stops
9. Athletic girls more likely to have impaired bone structure if menstrual cycle stops
10. Policing stops cheaters from dominating groups of cooperative bacteria
11. Researchers find drug that stops progression of Parkinsons disease in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2015)... CAPE TOWN, South Africa , August 24, 2015 /PRNewswire/ ... awarded Germany ,s largest biometrics manufacturer DERMALOG ... with the "2015 African Biometrics Company of the ... installation in Nigeria .   ... ) and http://www.presseportal.de/nr/8896 - On Thursday ...
(Date:8/20/2015)... SANTA CLARA, Calif. , Aug. 20, 2015 ... based company focused on improving the user experience ... voice and vision technologies, today announced that its ... and voice biometric authentication software to be ... Alliance tested TrulySecure for compliance with the FIDO ...
(Date:8/18/2015)... PRINCETON, N.J. , Aug. 18, 2015 ... be a key contributor to the Submission ... hosted by IRISS, a non-profit forum. Dedicated to ... IRISS provides a neutral platform for industry, ... to share information and work towards a ...
Breaking Biology News(10 mins):Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3
... of the Royal Society B , the research investigates ... crimson rosellas and the possible ways that these forms ... of CSIRO,s Australian National Wildlife Collection says there are ... crimson, yellow and orange which originated from the ...
... Identity,Solutions, Inc., (NYSE: ID ), a leading ... supplemental conference call for Q&A with the,investment community ... 30,2008 financial results at 2:00 p.m. (ET) today. ... 11:00 a.m. (ET) call,today were unable to queue ...
... global food crisis is the inefficiency of current irrigation methods. ... amounting to an enormous waste of water and energy. ... that turns the problem upside-down, getting to the root of ... improve their ability to find the water essential to their ...
Cached Biology News:Rosella research could rewrite 'ring theory' 2L-1 Identity Solutions to Hold Supplemental Second Quarter 2008 Financial Results Q&A Conference Call at 2:00p.m. (ET) Today 2Tel Aviv University researchers root out new and efficient crop plants 2
(Date:9/2/2015)... Israel , September 2, 2015 ... the intent of the National Institute of Allergy and Infectious ... (NIH) within the Department of Health and Human Services (HHS), ... in the United States in the ... universal flu vaccine candidate, Multimeric-001 (M-001), as a primer vaccine, ...
(Date:9/2/2015)... ... , ... Temarry Recycling's new $100,000 waste to energy capital ... continue to contribute to the sustainability of our natural resources. , Waste to ... been operating at their Mexico facility, Recicladora Temarry, for the last 7 years. ...
(Date:9/1/2015)... ... September 02, 2015 , ... Spirax Sarco , the ... its eCommerce site Spirax Sarco Anytime. This platform, offering unique online ordering capabilities, ... your next order? Log on to Spirax Sarco Anytime and within minutes you ...
(Date:9/1/2015)... (PRWEB) , ... September 01, ... ... the launch of the new ImageXpress® Micro Confocal High-Content Imaging System. This ... emerging assays that use 3D cellular models such as spheroids, tissues, and ...
Breaking Biology Technology:BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 2BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 3Temarry Recycling’s New $100,000 Waste to Energy Renovation 2Spirax Sarco Announces New Features to Anytime Platform 2ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 2ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 3
... Its one thing for a dictator to control a ... its quite another for a totalitarian regime to block ... wireless laptop. , ,Perhaps that explains why some global ... Internet away from its American roots and substitute United ...
... Madison, Wis. Wisconsin businesses and individuals are ... New Products Awards Competition, which recognizes benefits coming ... emerging technologies. , ,Governor's New Products Awards ... (1,000 or more employees); large companies (500-999 employees); ...
... Madison Area Technical College's Network Security Specialist degree ... threats to computer systems and data, has earned federal certification ... Systems . , ,It is only one of two in ... MATC had to match its curriculum precisely to what the ...
Cached Biology Technology:Democracy and the Net - How American ideals are quietly influencing the world 2Democracy and the Net - How American ideals are quietly influencing the world 3
Formula variant: With macro- and micronutrients. Physical Form: powder Suitab tst: plant cell culture tested...
BD Falcon 850 cm Smooth-surface TufRol Roller Bottle, tissue-culture treated polystyrene, blow-molded one-piece design, with easy on/off non-vented cap, packed in double bag. (20/ca) Packaging: ...
... Protein Kit is a simple and convenient method ... The kit has been optimized for use with ... used for any fungus species that is susceptible ... procedure effectively generates spheroplasts of yeast cells that ...
... is a pleiotropic cytokine produced by activated ... OSM inhibits the growth of some tumour ... muscle and Kaposis sarcoma cell proliferation, cytokine ... lipoprotein receptor expression on hepatoma cells. Mouse ...
Biology Products: