Navigation Links
Timely technology sees tiny transitions
Date:6/23/2010

like "sensing volume," the dielectric environment in which changes can be read by a spectrometer.

Hafner and his colleagues borrowed bioconjugate chemistry techniques, coating the bipyramids with antibodies and then adding antigens that strongly bind to them. Then the antigens were rinsed off. Whenever one was released from its bond to the bipyramid antibody, the researchers detected a slight shift toward the blue in the red light naturally scattered by gold bipyramids.

The process is "label-free," meaning the molecule itself is being detected, rather than a fluorescent tag that requires modification of the molecule, Hafner said. Also, the dielectric property being detected is permanent, so molecules could be tracked for more than 10 hours, as compared with only minutes with current methods.

"The ability to measure over long time scales opens the possibility to study systems with strong affinity at the single-molecule limit, such as lectin-carbohydrate interactions responsible for cell recognition and adhesion," Hafner said. "Other single-molecule methods based on fluorescence are limited by photo bleaching, and those based on force measurements are limited by radiation damage and mechanical instabilities."

Work needs to be done before LSPR becomes an ideal biological sensor, he said. The team plans to tweak the bipyramids and will test other particles.

"With this bipyramid, we went a little too red," he said. "It's a compromise. Make them long and they're really sensitive, but so red that we don't get much signal. Make them shorter, they're somewhat less sensitive but you have more signal.

"If we can get the signal-to-noise ratio up by a factor of two or three, we think it will be a powerful method for biological research."


'/>"/>

Contact: David Ruth
druth@rice.edu
713-348-6327
Rice University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gold Standard/Elsevier offers timely, reliable drug pricing data, including average wholesale price
2. Free Webinar to Focus on Commercializing University Technology
3. Conference to discuss sensing technology developments and opportunities
4. Michael Graetzel wins the Millennium Technology Prize
5. Success with cisgenics in forestry offers new tools for biotechnology
6. Massive resources now directed at sustainable animal waste technology
7. Field Museum technology project wins prestigious award
8. Cutting-edge vaccine research to be showcased at AAPS National Biotechnology Conference
9. Biotherapeutic Innovations on Display at AAPS National Biotechnology Conference
10. Space technology revolutionizes archaeology, understanding of Maya
11. New LLNL detection technology identifies bacteria, viruses, other organisms within 24 hours
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 27, 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) today ... public offering of units of common stock and warrants ... proceeds of $20 million, prior to deducting underwriting discounts ... The shares and warrants are immediately separable and will ... in the offering consists of 2,000 shares of common ...
(Date:8/27/2014)... A big step in understanding the mysteries of the ... three analyses that provide the most detailed comparison yet ... and human function. , The research, appearing August ... how the information encoded in the three species, genomes ... are organized into chromosomes. , The results add billions ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... available in its catalogue: Law Enforcement ... http://www.reportlinker.com/p02316674/Law-Enforcement-Biometrics-Market-in-North-America-2014-2018.html About Biometrics ... individuals on the basis of their physical or ... of both physiological traits such as fingerprints, face ...
Breaking Biology News(10 mins):WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3Encyclopedia of how genomes function gets much bigger 2Encyclopedia of how genomes function gets much bigger 3Encyclopedia of how genomes function gets much bigger 4Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5
... research team led by Edward Yu of Iowa State University ... pumps that remove heavy metal toxins from bacteria, making them ... the Sept. 23 issue of the journal Nature . ... of physics and astronomy, of biochemistry, biophysics and molecular biology ...
... COLUMBUS, Ohio While birds living in urban areas face ... mean urban birds face more danger from nest robbers. ... 2004 to 2009 found that, as expected, rural areas that ... cats, and crows, also showed lower rates of nest survival. ...
... of plant and animal species generally increases from the North ... isn,t true for soil bacteria, according to a new study ... that the rules determining the patterns for plant and animal ... Grogan. The finding is important because one of the ...
Cached Biology News:Iowa State, Ames Lab researchers identify structure that allows bacteria to resist drugs 2More predators doesn't equal more danger for urban bird nest 2
(Date:8/27/2014)... mysteries is how plants survive impact by the ... rays, while using this energy for photosynthesis. The ... plant,s blades quickly dissipate the energy throughout the ... at DTU Physics have now managed to successfully ... bacteria contain light-absorbing proteins which play a role ...
(Date:8/27/2014)... , Aug. 27, 2014  A novel ... to help physicians better identify early-stage disease, when ... disability, according to a new study in The ... Diagnostics (NYSE: DGX ) and other ... 14-3-3eta protein outperformed conventional antibody-serum testing, including rheumatoid ...
(Date:8/27/2014)... , Aug. 27, 2014 Research and ... "Global Enzyme for Pulp & Paper Industry Report 2014" ... Global Enzyme for Pulp & Paper Industry Report 2014 ... state of the global enzyme for pulp & paper ... of the industry including definitions, classifications, applications and industry ...
(Date:8/27/2014)... FL (PRWEB) August 27, 2014 BIOEQUA, ... applied through the use of a handheld spray, has ... the United States. , The brand began with ... BIOEQUA researchers were surprised to learn that the application ... made extremely small and delivered directly to skin's basal ...
Breaking Biology Technology:DTU researchers film protein quake for the first time 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Global Enzyme for Pulp & Paper Industry Report 2014 2BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2
... life sciences nanotechnology company, has received a $1.6 million ... , ,The Small Business Innovation Research grant is for ... technology to enable faster screening of drugs for treatment ... liquid crystals to measure topography on a nanoscopic scale. ...
... Bruker AXS , a supplier of X-ray solutions for life ... announced on Tuesday the introduction of a new detector and ... systems were unveiled at the 2005 International Union of Crystallography ... imaging detector for macromolecular X-ray crystallography, was designed with zero ...
... investors and government representatives have suggested a series of ... stimulate investments in high-growth industries. , ,Their suggestions were ... more on that hearing, read: , Regulations still ... is a list of some of the key recommendations: ...
Cached Biology Technology:Suggestions offered to foster high-growth business investment 2
... Validation Service enables early selection of ... by providing quantitative data for sensitivity, ... each antibody. Furthermore quantitative antibody fingerprints ... activity of your antibodies., The full-service ...
... fluorescent microscopy-based imaging system that accurately counts ... calculates cell viability, in a single test. ... variability associated with the subjective interpretation of ... EasyCount ViaSure Kit, up to six tests ...
... new generation of microarrays to detect alternative ... to rapidly elucidate alternatively spliced events in ... drug discovery. The service combines ExonHits proprietary ... customized analysis with Agilents robust microarray platform. ...
... The new Adept CE 4100 ... provides superb flow precision, with software drive ... rates from 0.001-10mL/min are selectable in 0.001mL ... inserts, are inert and bio-compatible., Pumps may ...
Biology Products: