Navigation Links
The skin aging regulator
Date:1/22/2013

These mechanisms, described in vivo in mice, engage molecule CD98hc, which is involved in epidermis renewal and could be an indicator of the skin's capacity for regeneration.

The results were published in the Journal of Experimental Medicine review.

The epidermis, the surface layer of the skin, is mainly composed of keratinocytes cells, which, in humans, are renewed continuously over a 21-day cycle. These cells are located on a membrane made up of components from the extracellular matrix that provides the junction with the dermis, the deep layer of the skin (see diagram). The epidermis is renewed by cell proliferation and differentiation that maintains the balance of adult tissues. This balance, known as "homeostasis", is essential for tissues to function correctly and any alterations to it are responsible for the physical changes associated with aging: sagging skin due to reduced skin cell proliferation, wound healing defects, loss of hair, etc.

The ATIP-Avenir team "Epidermal homeostasis and tumorigenesis" directed by Inserm researcher Chlo Fral, studied the numerous cellular factors involved in maintaining this balance. Particular attention was paid to CD98hc, a molecule known for its interaction with receptors that cause skin aging. With age, the activity of the transporter CD98hc and integrins (the receptors connected to the components in the extra cellular matrix) is disturbed. However, until now the mechanisms involved had never been identified.

Through their work, the researchers showed in vivo in mice that removing the gene CD98hc (coding gene for transporter CD98hc) disturbs skin balance and the healing process. By modifying cell proliferation and migration, removing this gene also causes a fault in the hair follicle cycle. The researchers have deciphered all the complex mechanisms associated with CD98hc, particularly integrin deregulation caused by this missing molecule in vivo. They confirm what was de
'/>"/>

Contact: Press Office
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. More effective method of imaging proteins
2. Food science poised to help address needs of aging population
3. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
4. Researcher awarded $1 million for stress-associated disease and aging research
5. Scientists uncover exciting lead into premature aging and heart disease
6. Scientists discover enzyme that could slow part of the aging process in astronauts -- and the elderly
7. Trial seeks improved lung-cancer screening by combining imaging and biomarkers
8. Radiologists study necessity of additional imaging recommendations in PET/CT oncologic reports
9. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
10. WSU researchers say genes and vascular risk modify effects of aging on brain and cognition
11. Managing biodiversity data from local government
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The skin aging regulator
(Date:11/5/2014)... -Individuals show great diversity in their ability to identify ... greatly differ in their perceptual evaluation of odors, with ... , Sex differences in olfactory detection may ... be connected to one,s perception of smell, which is ... olfactory superiority has been suggested to be cognitive or ...
(Date:11/4/2014)... (November 4, 2014) — Think about the way our ... do neighboring cells know that they are supposed to ... do these tissues find the correct place and alignment? ... these crucial questions. , In a new study, UM ... communicate with their surrounding neighbors, at the head-trunk region. ...
(Date:11/4/2014)...   Neurotechnology , a provider of high-precision ... version of its fingerprint matching algorithm has achieved ... evaluation organized by NIST. The MINEX test measures ... 378 fingerprint standard template format. MINEX compliance is ... the United States and ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2The inside story: How the brain and skull stay together 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
... WEST LAFAYETTE, Ind. - Honeybee populations have been in ... have identified one of the factors that cause bee ... dead in and around hives from several apiaries over ... insecticides, which are commonly used to coat corn and ...
... University of Illinois researchers have shown that by ... of metal nanoantennas, these nano-scale structures allow for ... particles. "Nanoantennas are extremely popular right ... optical fields in small areas," explained Kimani Toussaint, ...
... Calif. Scientists have long seen evidence of social behavior among ... the sea. Dolphins frolic together, lions live in packs, and ... the insects. And, right under our feet, it appears that ... the soil. Until recently, it was unknown how the worms ...
Cached Biology News:Researchers: Honeybee deaths linked to seed insecticide exposure 2Researchers: Honeybee deaths linked to seed insecticide exposure 3Optical nanoantennas enable efficient multipurpose particle manipulation 2Worm seeks worm: Caltech researchers find chemical cues driving aggregation in nematodes 2Worm seeks worm: Caltech researchers find chemical cues driving aggregation in nematodes 3
(Date:11/21/2014)... The California Healthcare Institute ... representing leading California academic institutions, biotechnology, medical device, ... today released a report revealing that California ... The trend shows a 4 percent increase between ... Industry Report indicates that, while biopharmaceutical and ...
(Date:11/21/2014)... (PRWEB) November 21, 2014 2014 ... Ferrocyanide Industry” is a professional and in-depth research ... Sodium ferrocyanide information, like its definition, classification, ... industry overview. This report covers the international market ... global (such as the US, Europe, Asia, China, ...
(Date:11/21/2014)... ON , Nov. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... and nine month periods ended September 30, 2014.  Biorem,s complete 2014 ... ( www.sedar.com ). Financial Summary:Three-months ended September ... except per share data) , 2014 , ... 2,282 , 5,281 , 6,715 ...
(Date:11/18/2014)... Diego, CA (PRWEB) November 17, 2014 Athena ... of Salk , Dr. Beverly Emerson, a professor in the ... of genes. Her most recent discovery points to an “off ... Dr. Emerson’s career and how her local research is making ... will present her findings and then join host Cheryl K. ...
Breaking Biology Technology:California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3
... ... Executive Officer of Merrimack Pharmaceuticals, will provide a company overview at the Jefferies 2010 ... ... announced that it will present at the Jefferies 2010 Global Life Sciences Conference in ...
... A team of Duke University chemists has perfected a simple ... conductors are small enough to be transparent, making them ideal ... displays. "Imagine a foldable iPad," said Benjamin Wiley, an ... findings online this week in Advanced Materials . ...
... CHAPEL HILL, N.C. , June 1 Companies invest hundreds of ... these new products to market.   , , ... on these vast investments, successful companies must maximize product uptake across all customer groups: ... win formulary access and improve product placement.   , ...
Cached Biology Technology:Merrimack Pharmaceuticals to Present at the Jefferies 2010 Global Life Sciences Conference 2Copper nanowires enable bendable displays and solar cells 2Maximize Market Research to Improve Formulary Access Within Managed Markets Sector 2Maximize Market Research to Improve Formulary Access Within Managed Markets Sector 3
...
... high-density serum biomarker chip to profile the ... antibody chip containing 120 human cancer serum ... biomarker discovery scientists to study panels of ... therapy and the likelihood of recurrence of ...
... Ventilates and removes chemical fumes, ... exhaust. Bonded charcoal filters remove ... ensure safe exhaust flow speed ... access opening. Includes air speed ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
Biology Products: