Navigation Links
The skin aging regulator
Date:1/22/2013

These mechanisms, described in vivo in mice, engage molecule CD98hc, which is involved in epidermis renewal and could be an indicator of the skin's capacity for regeneration.

The results were published in the Journal of Experimental Medicine review.

The epidermis, the surface layer of the skin, is mainly composed of keratinocytes cells, which, in humans, are renewed continuously over a 21-day cycle. These cells are located on a membrane made up of components from the extracellular matrix that provides the junction with the dermis, the deep layer of the skin (see diagram). The epidermis is renewed by cell proliferation and differentiation that maintains the balance of adult tissues. This balance, known as "homeostasis", is essential for tissues to function correctly and any alterations to it are responsible for the physical changes associated with aging: sagging skin due to reduced skin cell proliferation, wound healing defects, loss of hair, etc.

The ATIP-Avenir team "Epidermal homeostasis and tumorigenesis" directed by Inserm researcher Chlo Fral, studied the numerous cellular factors involved in maintaining this balance. Particular attention was paid to CD98hc, a molecule known for its interaction with receptors that cause skin aging. With age, the activity of the transporter CD98hc and integrins (the receptors connected to the components in the extra cellular matrix) is disturbed. However, until now the mechanisms involved had never been identified.

Through their work, the researchers showed in vivo in mice that removing the gene CD98hc (coding gene for transporter CD98hc) disturbs skin balance and the healing process. By modifying cell proliferation and migration, removing this gene also causes a fault in the hair follicle cycle. The researchers have deciphered all the complex mechanisms associated with CD98hc, particularly integrin deregulation caused by this missing molecule in vivo. They confirm what was de
'/>"/>

Contact: Press Office
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. More effective method of imaging proteins
2. Food science poised to help address needs of aging population
3. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
4. Researcher awarded $1 million for stress-associated disease and aging research
5. Scientists uncover exciting lead into premature aging and heart disease
6. Scientists discover enzyme that could slow part of the aging process in astronauts -- and the elderly
7. Trial seeks improved lung-cancer screening by combining imaging and biomarkers
8. Radiologists study necessity of additional imaging recommendations in PET/CT oncologic reports
9. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
10. WSU researchers say genes and vascular risk modify effects of aging on brain and cognition
11. Managing biodiversity data from local government
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The skin aging regulator
(Date:3/4/2015)... , Mar. 04, 2015 Research and ... the addition of the "Global Biometrics Market ... offering. The market for biometric authentication ... of around 14% till 2020 The ... be increasing security needs, government projects and constant ...
(Date:3/3/2015)... 3, 2015 Cryoport, Inc. (OTCBB: ... cryogenic logistics solutions for the life sciences ... cell lines, clinical research organizations, vaccine manufacturers, ... the expansion of its relationship with ... Hutch") Clinical Research Division with the inclusion ...
(Date:3/2/2015)... 2015 Synaptics Inc. (NASDAQ: ... solutions, today announced a new implementation of its ... rapid and secure transactions and reliable identification for ... a turnkey solution providing mouse and keyboard peripheral ... fingerprint ID solutions into their product offerings, bringing ...
Breaking Biology News(10 mins):Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3
... won the "Most Creative Visualization" award in the "commercial" ... achievement we are extremely proud of. iDEA is Illumina,s ... new and creative visualization and data analysis techniques. ... very first moment we heard about it. Genomatix is ...
... Kan. -- Preliminary research at Kansas State University may make ... scientists believe that cellulose, the most common organic compound on ... biofuels -- if a procedure to effectively break it down ... gives plants their rigidity. Kathrin Schrick, assistant professor in ...
... This press release is available in Spanish ... waters of the European Atlantic Ocean and, nevertheless, resists stock ... the mistakes made by humans. Ms Nerea Goikoetxea, a researcher ... the population dynamics of the northern European hake population, observing ...
Cached Biology News:Learning secrets of world's most common organic compound driving research for biofuels 2Hake population has withstood overfishing, thanks to the warming of the sea 2Hake population has withstood overfishing, thanks to the warming of the sea 3
(Date:3/4/2015)... INCLINE VILLAGE, Nev. , March 4, 2015 PDL ... that the adjusted conversion rate for the: , ... Notes), is 174.8506 shares of common stock per $1,000 principal ... The conversion rate for the note is adjusted ... be paid on March 12, 2015, to all stockholders who own ...
(Date:3/4/2015)... 4, 2015 In an article published and ... for Health Security review the clinical aspects of diseases ... as bioweapons. The article, "Clinical Management of Potential Bioterrorism-Related ... website of the New England Journal of Medicine ... Toner , and Tom Inglesby—review the clinical management of ...
(Date:3/4/2015)... BALTIMORE , March 4, 2015 The ... of its 2015 Fellows in the Emerging Leaders in ... fostering future leaders in the field of biosecurity, UPMC ... biosecurity from a wide array of backgrounds, including biological ... private sector. "With the vision and ...
(Date:3/4/2015)... March 4, 2015  Brooklyn residents now have a ... chronic pain and injuries. Nunzio Saulle , M.D., ... opening of his NJS Physical Medicine and Rehabilitation (PM&R) ... Thursday, March 5, 2015. Health Plus Management, LLC is ... located at 1178 Flatbush Avenue. This new PM&R practice ...
Breaking Biology Technology:PDL BioPharma Announces Conversion Rate Adjustment for Convertible Note 2Latest Clinical Information On Bioterrorism Threats 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3NJS Physical Medicine & Rehabilitation Opening on Flatbush Avenue, Brooklyn, NY 2
... Company to Make Key Marketing Claims, HARBIN, ... Inc. (the "Company") (OTC Bulletin Board: CKGT), a,vertically ... of cactus-based consumer products in China, announced today ... the Company,s Cactus,Cattle Feed. The studies, which included ...
... after an individual becomes infected with HIV the virus ... central nervous system [CNS]). Although this causes no immediate ... dementia and encephalitis (acute inflammation of the brain that ... HIV (SIV) also sometimes develop CNS damage and provide ...
... SAN FRANCISCO, Calif., June 3 Sunesis,Pharmaceuticals, Inc. ... of its,late-stage development leadership team with the appointment ... Vice President, Research and,Development and Mary G. Bolton, ... Judith A. Fox, Ph.D., has been promoted to ...
Cached Biology Technology:China Kangtai Cactus Biotech Announces Improved Milk Production in Cows From Company's Cactus Cattle Feed 2China Kangtai Cactus Biotech Announces Improved Milk Production in Cows From Company's Cactus Cattle Feed 3Sunesis Pharmaceuticals Expands Development Leadership Team to Focus on Late-Stage Development of Voreloxin (Formerly SNS-595) 2Sunesis Pharmaceuticals Expands Development Leadership Team to Focus on Late-Stage Development of Voreloxin (Formerly SNS-595) 3Sunesis Pharmaceuticals Expands Development Leadership Team to Focus on Late-Stage Development of Voreloxin (Formerly SNS-595) 4Sunesis Pharmaceuticals Expands Development Leadership Team to Focus on Late-Stage Development of Voreloxin (Formerly SNS-595) 5Sunesis Pharmaceuticals Expands Development Leadership Team to Focus on Late-Stage Development of Voreloxin (Formerly SNS-595) 6
One-step, microplate or cuvet, colorimetric, linear detection range 0.9 mg/dL to 200 mg/dL. Procedure: 2 min....
...
One-step, microplate or cuvet, colorimetric, detection range 0.1 mg/dL to 3 mg/dL. Procedure: 10 min....
Request Info...
Biology Products: