Navigation Links
The skin aging regulator
Date:1/22/2013

These mechanisms, described in vivo in mice, engage molecule CD98hc, which is involved in epidermis renewal and could be an indicator of the skin's capacity for regeneration.

The results were published in the Journal of Experimental Medicine review.

The epidermis, the surface layer of the skin, is mainly composed of keratinocytes cells, which, in humans, are renewed continuously over a 21-day cycle. These cells are located on a membrane made up of components from the extracellular matrix that provides the junction with the dermis, the deep layer of the skin (see diagram). The epidermis is renewed by cell proliferation and differentiation that maintains the balance of adult tissues. This balance, known as "homeostasis", is essential for tissues to function correctly and any alterations to it are responsible for the physical changes associated with aging: sagging skin due to reduced skin cell proliferation, wound healing defects, loss of hair, etc.

The ATIP-Avenir team "Epidermal homeostasis and tumorigenesis" directed by Inserm researcher Chlo Fral, studied the numerous cellular factors involved in maintaining this balance. Particular attention was paid to CD98hc, a molecule known for its interaction with receptors that cause skin aging. With age, the activity of the transporter CD98hc and integrins (the receptors connected to the components in the extra cellular matrix) is disturbed. However, until now the mechanisms involved had never been identified.

Through their work, the researchers showed in vivo in mice that removing the gene CD98hc (coding gene for transporter CD98hc) disturbs skin balance and the healing process. By modifying cell proliferation and migration, removing this gene also causes a fault in the hair follicle cycle. The researchers have deciphered all the complex mechanisms associated with CD98hc, particularly integrin deregulation caused by this missing molecule in vivo. They confirm what was described in vitro: the amino acid transporter CD98hc modules the integrin signal, which is essential for skin renewal. As such, CD98hc actively participates in skin renewal through the efficient and widespread recruitment of skin cells when needed (healing a wound, for example).

"CD98hc appears to be necessary for rapid and effective skin renewal. Its reduced expression, observed in vivo in elderly mice, confirms its role in maintaining tissues, the hair follicle cycle and healing, which are disturbed with age," states Chlo Fral. "The status of carrier CD98hc in vivo could be an indicator of the skin's capacity to renew itself" she concludes.


'/>"/>

Contact: Press Office
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert  

Related biology news :

1. More effective method of imaging proteins
2. Food science poised to help address needs of aging population
3. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
4. Researcher awarded $1 million for stress-associated disease and aging research
5. Scientists uncover exciting lead into premature aging and heart disease
6. Scientists discover enzyme that could slow part of the aging process in astronauts -- and the elderly
7. Trial seeks improved lung-cancer screening by combining imaging and biomarkers
8. Radiologists study necessity of additional imaging recommendations in PET/CT oncologic reports
9. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
10. WSU researchers say genes and vascular risk modify effects of aging on brain and cognition
11. Managing biodiversity data from local government
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The skin aging regulator
(Date:3/22/2017)... March 21, 2017   Neurotechnology , a ... technologies, today announced the release of the ... provides improved facial recognition using up to 10 ... single computer. The new version uses deep neural-network-based ... and it utilizes a Graphing Processing Unit (GPU) ...
(Date:3/22/2017)... LIVERMORE, Calif. , March 21, 2017 ... recognition analytics company serving law enforcement agencies, announced today ... Sheridan as director of public safety business development. ... of diversified law enforcement experience, including a focus on ... Vigilant. In his most recent position, Mr. Sheridan served ...
(Date:3/20/2017)... , March 20, 2017 PMD Healthcare ... personal spirometer and Wellness Management System (WMS), a remote, ... Founded in 2010, PMD Healthcare is a Medical Device, ... a mission dedicated to creating innovative solutions that empower ... With that intent focus, PMD developed the first ever ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... SANTA MONICA, Calif. , March 22, 2017 ... Council (MassMEDIC) are proud to announce their extended partnership ... Week will be headlined by the 21 st ... UBM,s BIOMEDevice Boston, taking place May 3-4, 2017. ... with Advanced Medical Technology Association (ADVAMED) President and ...
(Date:3/22/2017)... New York , March 22, 2017 ... is largely fragmented, states a research report by Transparency ... S.A., Pfizer Inc., Amgen Inc., and AbbVie Inc., accounted ... in 2015. The prominent players in this market are ... expand their product portfolio, which is likely to lead ...
(Date:3/22/2017)... , March 22, 2017   ... independent provider of product and service solutions ... that it has acquired EPL Archives, Inc., ... customers across the entire regulated product research, ... sample, document storage and ancillary services. EPL ...
(Date:3/22/2017)... ... ... Benchworks CEO Thad L. Bench Sr. will participate in the ... San Diego. The event is a gathering of executive leadership from companies in the ... Meyer will also participate in the forum. Participants will discuss the future of the ...
Breaking Biology Technology: