Navigation Links
The skin aging regulator
Date:1/22/2013

These mechanisms, described in vivo in mice, engage molecule CD98hc, which is involved in epidermis renewal and could be an indicator of the skin's capacity for regeneration.

The results were published in the Journal of Experimental Medicine review.

The epidermis, the surface layer of the skin, is mainly composed of keratinocytes cells, which, in humans, are renewed continuously over a 21-day cycle. These cells are located on a membrane made up of components from the extracellular matrix that provides the junction with the dermis, the deep layer of the skin (see diagram). The epidermis is renewed by cell proliferation and differentiation that maintains the balance of adult tissues. This balance, known as "homeostasis", is essential for tissues to function correctly and any alterations to it are responsible for the physical changes associated with aging: sagging skin due to reduced skin cell proliferation, wound healing defects, loss of hair, etc.

The ATIP-Avenir team "Epidermal homeostasis and tumorigenesis" directed by Inserm researcher Chlo Fral, studied the numerous cellular factors involved in maintaining this balance. Particular attention was paid to CD98hc, a molecule known for its interaction with receptors that cause skin aging. With age, the activity of the transporter CD98hc and integrins (the receptors connected to the components in the extra cellular matrix) is disturbed. However, until now the mechanisms involved had never been identified.

Through their work, the researchers showed in vivo in mice that removing the gene CD98hc (coding gene for transporter CD98hc) disturbs skin balance and the healing process. By modifying cell proliferation and migration, removing this gene also causes a fault in the hair follicle cycle. The researchers have deciphered all the complex mechanisms associated with CD98hc, particularly integrin deregulation caused by this missing molecule in vivo. They confirm what was de
'/>"/>

Contact: Press Office
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. More effective method of imaging proteins
2. Food science poised to help address needs of aging population
3. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
4. Researcher awarded $1 million for stress-associated disease and aging research
5. Scientists uncover exciting lead into premature aging and heart disease
6. Scientists discover enzyme that could slow part of the aging process in astronauts -- and the elderly
7. Trial seeks improved lung-cancer screening by combining imaging and biomarkers
8. Radiologists study necessity of additional imaging recommendations in PET/CT oncologic reports
9. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
10. WSU researchers say genes and vascular risk modify effects of aging on brain and cognition
11. Managing biodiversity data from local government
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
The skin aging regulator
(Date:8/29/2014)... Researchers at UC Davis have made some surprising ... infection. Studying simian immunodeficiency virus (SIV), the team ... Paneth cells are early responders to viral invasion ... producing a cytokine called interleukin-1 beta (IL-1β). ... IL-1β causes breakdown of the gut epithelium that ...
(Date:8/29/2014)... the University of Texas Medical Branch at Galveston has gone ... can completely protect monkeys against a lethal dose of Ebola ... when the disease is severe. , Thomas Geisbert, professor of ... discussing advances in Ebola treatment research. The filoviruses known ... deadly of pathogens, with fatality rates of up to 90 ...
(Date:8/29/2014)... available in German . ... the natural nitrogen cycle on Earth and in biological ... thought to depend on nitrite as their source of ... Daims, a microbiologist at the University of Vienna, has ... an alternative source of energy. The oxidation of hydrogen ...
Breaking Biology News(10 mins):The early cost of HIV 2Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3
... nation,s Upper Midwest have changed greatly since the time ... coming. That,s according to research done by Lisa ... of Natural Resource Ecology and Management and her team ... entire ecosystem," said Schulte, whose research has recently been ...
... be lacking for perennial wheat to be grown on any ... Dr. Charlie Rush, Texas Agricultural Experiment Station plant pathologist., ... plant breeders, Rush is finding a groundswell of interest as ... on his perennial wheat study., Rush obtained his initial ...
... may occur, in part, because of a problem in an ... key chemical messenger in the brain, scientists have found in ... that the gene is turned on at increasingly high rates ... the brain involved in higher functions like thinking and decision-making ...
Cached Biology News:Upper Midwest forests are losing diversity, complexity, ISU study finds 2A wheat for all seasons -- and reasons 2A wheat for all seasons -- and reasons 3How schizophrenia develops: Major clues discovered 2
(Date:8/29/2014)... on electrons, but one of the most promising technologies ... based on light (photons) instead of electrons. First, it ... of single photons and control their direction. Researchers around ... achieve this control, but now scientists at the Niels ... of photons emitted one at a time and in ...
(Date:8/29/2014)... Pittsburgh, PA (PRWEB) August 29, 2014 ... Chairman, Hub MacDonald, and colleague Koichiro Matsuda, Horiba Scientific, ... JASIS on September 5, 2014. JASIS , Asia’s ... September 3-5, 2014, in Makuhari Messe, Japan. , ... New Tools for Bioanalysis from Single Molecules to Single ...
(Date:8/29/2014)... California (PRWEB) August 29, 2014 ... of Energy's 2014 Hydrogen Production R&D Award ... -- by splitting water using sunlight. , Shared ... (NREL) and the University of Nevada, Las Vegas ... work developing models of photoelectrochemical solar-hydrogen production and ...
(Date:8/29/2014)... August 29, 2014 Intrinsic Imaging, ... certified, GAMP® 5 compliant imaging core lab, announced ... Phase II clinical trial to assess a new ... this trial, Intrinsic Imaging will provide comprehensive imaging ... protocol and charter development, site qualification, site training ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2Livermore Team Awarded for Hydrogen Production Research 2Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2
... cells is limited by a lack of methods for studying ... different methods, a team of Uppsala researchers have now provided ... on several levels at the same time. Their article is ... also show that the method can be used to determine ...
... decorative, flower-like defects in the nanomaterial graphene could have ... and mechanical properties, according to researchers at the National ... In a new paper,* the team for the first ... occur naturally or be induced to occur in graphene, ...
... of the March 11 earthquake and rolling blackouts that ... award-winning undergraduate internship program NanoJapan is scrambling to run ... U.S. undergraduates travel to Japan for lab internships, NanoJapan ... send 25-30 students to Rice University laboratories for three ...
Cached Biology Technology:Combo method reveals cells' signal systems 2Defect in graphene may present bouquet of possibilities 2Reverse NanoJapan: Rice to host 25-30 Japanese students 2
Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C Terminus of the protein sequence according to NP_055196....
Polyclonal Antibody to SHPRH...
Rabbit polyclonal to TetR ( Abpromise for all tested applications). Antigen: Synthetic peptide: AQKLGVEQPTLYWHVKNKR, corresponding to amino acids 31 - 49 of TetR...
Biotin anti-mouse Ly-49C/F/I/H...
Biology Products: