Navigation Links
The secrets of a tadpole's tail and the implications for human healing
Date:1/13/2013

Scientists at The University of Manchester have made a surprising finding after studying how tadpoles re-grow their tails which could have big implications for research into human healing and regeneration.

It is generally appreciated that frogs and salamanders have remarkable regenerative capacities, in contrast to mammals, including humans. For example, if a tadpole loses its tail a new one will regenerate within a week. For several years Professor Enrique Amaya and his team at The Healing Foundation Centre in the Faculty of Life Sciences have been trying to better understand the regeneration process, in the hope of eventually using this information to find new therapies that will improve the ability of humans to heal and regenerate better.

In an earlier study, Professor Amaya's group identified which genes were activated during tail regeneration. Unexpectedly, that study showed that several genes that are involved in metabolism are activated, in particular those that are linked to the production of reactive oxygen species (ROS) - chemically reactive molecules containing oxygen. What was unusually about those findings is that ROS are commonly believed to be harmful to cells.

Professor Amaya and his group decided to follow up on this unexpected result and their new findings will be published in the next issue of Nature Cell Biology.

To examine ROS during tail regeneration, they measured the level of H2O2 (hydrogen peroxide, a common reactive oxygen species in cells) using a fluorescent molecule that changes light emission properties in the presence of H2O2. Using this advanced form of imaging, Professor Amaya and his group were able to show that a marked increase in H2O2 occurs following tail amputation and interestingly, they showed that the H2O2 levels remained elevated during the entire tail regeneration process, which lasts several days.

Talking about the research Professor Amaya says: "We were very surprised to find these high levels of ROS during tail regeneration. Traditionally, ROS have been thought to have a negative impact on cells. But in this case they seemed to be having a positive impact on tail re-growth."

To assess how vital the presence of ROS are in the regeneration process, Professor Amaya's team limited ROS production using two methods. The first was by using chemicals, including an antioxidant, and the second was by removing a gene responsible for ROS production. In both cases the regeneration process was inhibited and the tadpole tail did not grow back.

Professor Amaya says: "When we decreased ROS levels, tissue growth and regeneration failed to occur. Our research suggests that ROS are essential to initiate and sustain the regeneration response. We also found that ROS production is essential to activate Wnt signalling, which has been implicated in essentially every studied regeneration system, including those found in humans. It was also striking that our study showed that antioxidants had such a negative impact on tissue regrowth, as we are often told that antioxidants should be beneficial to health."

The publication of Professor Amaya's study comes just days after a paper from the Nobel Prize winner and co-discoverer of the structure of DNA, James Watson, who has suggested antioxidants could be harmful to people in the later stages of cancer.

Professor Amaya comments: "It's very interesting that two papers suggesting that antioxidants may not always be beneficial have been published recently. Our findings and those of others are leading to a reversal in our thinking about the relative beneficial versus harmful effects that oxidants and antioxidants may have on human health, and indeed that oxidants, such as ROS, may play some important beneficial roles in healing and regeneration."

The next step for the team at the Healing Foundation Centre will be to study ROS and their role in the healing and regenerative processes more closely. With a better understanding, Professor Amaya and his team hope to apply their findings to human health to identify whether manipulating ROS levels in the body could improve our ability to heal and regenerate tissues better. Thus these findings have very important implications in regenerative medicine.


'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Related biology news :

1. Secrets of gentle touch revealed
2. Biologists unlocking the secrets of plant defenses, 1 piece at a time
3. Pond skating insects reveal water-walking secrets
4. Biophysicists unravel secrets of genetic switch
5. Ancient genome reveals its secrets
6. New model gives hands-on help for learning the secrets of molecules
7. Decoding the secrets of balance
8. Hidden secrets in the worlds most northerly rainforests
9. Large, medically important class of proteins starts to yield its secrets
10. Rensselaer scientists unlock some key secrets of photosynthesis
11. Track Atlantic bluefin tuna to learn migration, habitat secrets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
(Date:3/29/2017)... CHICAGO , March 29, 2017  higi, the ... ecosystem in North America , today ... Partners and the acquisition of EveryMove. The new investment ... extensive set of tools to transform population health activities ... and lifestyle data. higi collects and secures ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... (PRWEB) , ... July 26, 2017 , ... ... management and analytics solutions, today announced that its Anzo Smart Data Lake® ... 2017 Software & Information Industry Association (SIIA) CODiE Awards. , Cambridge Semantics’ ...
(Date:7/26/2017)... Brea, Ca (PRWEB) , ... July 25, 2017 ... ... labels, specialty converted media and software solutions that enable short-run digital printing, is ... GHS Chemical Labels and its free GHS Wizard online software available at ...
(Date:7/26/2017)... ... July 25, 2017 , ... The ... that its regenerative stem cell therapy has been used on more than 13,000 ... for horses with potentially fatal injuries to tendons and ligaments. , In 2003 ...
(Date:7/26/2017)... ... July 25, 2017 , ... Provia Laboratories ... in the preparation and development of human cells and tissues for therapeutic use. ... Food and Drug Administration’s (FDA) Current Good Manufacturing Practices (cGMP) guidelines and provides ...
Breaking Biology Technology: