Navigation Links
The secrets of a tadpole's tail and the implications for human healing
Date:1/13/2013

Scientists at The University of Manchester have made a surprising finding after studying how tadpoles re-grow their tails which could have big implications for research into human healing and regeneration.

It is generally appreciated that frogs and salamanders have remarkable regenerative capacities, in contrast to mammals, including humans. For example, if a tadpole loses its tail a new one will regenerate within a week. For several years Professor Enrique Amaya and his team at The Healing Foundation Centre in the Faculty of Life Sciences have been trying to better understand the regeneration process, in the hope of eventually using this information to find new therapies that will improve the ability of humans to heal and regenerate better.

In an earlier study, Professor Amaya's group identified which genes were activated during tail regeneration. Unexpectedly, that study showed that several genes that are involved in metabolism are activated, in particular those that are linked to the production of reactive oxygen species (ROS) - chemically reactive molecules containing oxygen. What was unusually about those findings is that ROS are commonly believed to be harmful to cells.

Professor Amaya and his group decided to follow up on this unexpected result and their new findings will be published in the next issue of Nature Cell Biology.

To examine ROS during tail regeneration, they measured the level of H2O2 (hydrogen peroxide, a common reactive oxygen species in cells) using a fluorescent molecule that changes light emission properties in the presence of H2O2. Using this advanced form of imaging, Professor Amaya and his group were able to show that a marked increase in H2O2 occurs following tail amputation and interestingly, they showed that the H2O2 levels remained elevated during the entire tail regeneration process, which lasts several days.

Talking about the research Professor Amaya says: "We were very surpr
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Secrets of gentle touch revealed
2. Biologists unlocking the secrets of plant defenses, 1 piece at a time
3. Pond skating insects reveal water-walking secrets
4. Biophysicists unravel secrets of genetic switch
5. Ancient genome reveals its secrets
6. New model gives hands-on help for learning the secrets of molecules
7. Decoding the secrets of balance
8. Hidden secrets in the worlds most northerly rainforests
9. Large, medically important class of proteins starts to yield its secrets
10. Rensselaer scientists unlock some key secrets of photosynthesis
11. Track Atlantic bluefin tuna to learn migration, habitat secrets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... NEW YORK , July 8, 2015 ... today announced BD & Guidepoint Mentor, ... free access to Guidepoint,s expert network services. ... developing cutting-edge technologies to improve healthcare delivery and outcomes ... manager, each start-up entrepreneur will be able to directly ...
(Date:7/7/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... announces a revised version of one of its first 30 second ... CNBC in New York , Chicago ... San Francisco metro areas.    , , ... replace all the cards in your wallet and keep your identity ...
(Date:6/30/2015)... Pa. , June 30, 2015 ... the company as CEO to help further develop Genisphere,s ... wealth of partnering experience, having spent much of the ... including Therakine, Amgen, Baxter Bioscience, and Johnson & Johnson. ... focus on Technology and Biotech Corporate Finance. He graduated ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3
... German . , In order to track down pathogens ... to recognize myriad different foreign substances and react to them. ... Centre for Biological Signalling Studies BIOSS at the University of ... activated by numerous substances from our environment. The receptor molecules ...
... General Hospital researchers say they have determined how iron ... Alzheimer,s patients. The team, whose study results appear ... report that there is a very close link between ... enhanced production of the amyloid precursor protein, which in ...
... century-old museum specimens, researchers have found a place for the ... doves, identifying for the first time this unique bird,s closest ... which appears this month in Molecular Phylogenetics and Evolution ... to other North and South American pigeons, and not to ...
Cached Biology News:One lock, many keys 2New findings pull back curtain on relationship between iron and Alzheimer's disease 2Long-extinct passenger pigeon finds a place in the family tree 2Long-extinct passenger pigeon finds a place in the family tree 3
(Date:7/30/2015)... ... ... The 2015 Market Research Report on the Global Propanol Industry ... market with a focus on the Chinese situation. Major companies included in the propanol ... Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. , The report provides ...
(Date:7/30/2015)... 60,000 customers across the globe, ISN improves the efficiency and effectiveness of contractor management ... safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 ... Headquartered in Dallas, TX , ISN has additional offices in ...
(Date:7/30/2015)... NH (PRWEB) , ... July 30, 2015 , ... ... homogenizer for advanced fluid applications and designed for continuous operation up to 1500 ... and sterilization-in-place, ensuring safety, efficiency, and preventing toxic contamination. , The Pony™ NS2006L ...
(Date:7/29/2015)... / Japan (Q2 2015: +14% CER / 20% ... high-single-digit growth in China , as well as solid contributions ... Europe / Middle East / ... showed gains in Germany , Turkey ... CER / 49% of sales) grew 11%, excluding U.S. HPV sales, on demand ...
Breaking Biology Technology:Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10
... BioSurfaces, Inc., of Madison has been licensed to ... and labeling agents, GenTel announced on Tuesday. , ,GenTel ... reagents of Kreatech Biotechnology BV of Amsterdam, ... The kits are validated for use on GenTel's PATH ...
... -- A report is due this fall that will ... to proceed with an IT project that was put on ... it over a five-year period. The project was determined to ... management. , ,The Appointments, Payroll and Benefits Systems project (ABPS) ...
... Wis. - Alfalight, Inc., a manufacturer of ... worldwide, has received $7 million in expansion funding, ... package was led by GF Private Equity Group, ... major previous investors. Those include ARCH Venture Partners, ...
Cached Biology Technology:UW working to salvage multi-million HR software project 2UW working to salvage multi-million HR software project 3UW working to salvage multi-million HR software project 4UW working to salvage multi-million HR software project 5Alfalight receives $7 million in expansion funding 2
Request Info...
... ,5-Bromo-4-chloro-3-indoxyl-beta-D-galactopyranoside C 14 H 15 ... ,M.W.= 408.63 ,Assay: Greater than ... DMF) ,Biological Activity: Blue color with ... Agrees with theoretical values ,Thin Layer ...
Disposable tips with floating filter (US Patent 6,702,990) for PDM1.5 OneTouch Plus spotpicker, 10 racks of 96, DNAse and RNAse free...
prototype Nco I...
Biology Products: