Navigation Links
The secrets of a tadpole's tail and the implications for human healing
Date:1/13/2013

Scientists at The University of Manchester have made a surprising finding after studying how tadpoles re-grow their tails which could have big implications for research into human healing and regeneration.

It is generally appreciated that frogs and salamanders have remarkable regenerative capacities, in contrast to mammals, including humans. For example, if a tadpole loses its tail a new one will regenerate within a week. For several years Professor Enrique Amaya and his team at The Healing Foundation Centre in the Faculty of Life Sciences have been trying to better understand the regeneration process, in the hope of eventually using this information to find new therapies that will improve the ability of humans to heal and regenerate better.

In an earlier study, Professor Amaya's group identified which genes were activated during tail regeneration. Unexpectedly, that study showed that several genes that are involved in metabolism are activated, in particular those that are linked to the production of reactive oxygen species (ROS) - chemically reactive molecules containing oxygen. What was unusually about those findings is that ROS are commonly believed to be harmful to cells.

Professor Amaya and his group decided to follow up on this unexpected result and their new findings will be published in the next issue of Nature Cell Biology.

To examine ROS during tail regeneration, they measured the level of H2O2 (hydrogen peroxide, a common reactive oxygen species in cells) using a fluorescent molecule that changes light emission properties in the presence of H2O2. Using this advanced form of imaging, Professor Amaya and his group were able to show that a marked increase in H2O2 occurs following tail amputation and interestingly, they showed that the H2O2 levels remained elevated during the entire tail regeneration process, which lasts several days.

Talking about the research Professor Amaya says: "We were very surpr
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Secrets of gentle touch revealed
2. Biologists unlocking the secrets of plant defenses, 1 piece at a time
3. Pond skating insects reveal water-walking secrets
4. Biophysicists unravel secrets of genetic switch
5. Ancient genome reveals its secrets
6. New model gives hands-on help for learning the secrets of molecules
7. Decoding the secrets of balance
8. Hidden secrets in the worlds most northerly rainforests
9. Large, medically important class of proteins starts to yield its secrets
10. Rensselaer scientists unlock some key secrets of photosynthesis
11. Track Atlantic bluefin tuna to learn migration, habitat secrets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/vq2k2f/bodyworn ... "Body-Worn Temperature Sensors Market - Global Industry Analysis, ... 2020" report to their offering. ... body-worn temperature sensors market. The global body-worn temperature ... of types, care setting, patient demographic, applications and ...
(Date:6/23/2015)... GARDENS, Fla. , June 23, 2015 ... identity management and authentication solutions, today announced enhanced ... strong, multi-factor authentication solution.  The enhancements build ... use of the DigitalPersona Altus platform and ... reader compatibility. In today,s environment ...
(Date:6/18/2015)... 18, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... the growing mobile commerce market announces that its Wocket® smart ... "Money on the Mark", scheduled to air on WABC Radio ... 20 th . The broadcast air- time ... to 8:00pm EST. NXT-ID, Inc.,s CEO Gino Pereira ...
Breaking Biology News(10 mins):Body-Worn Temperature Sensors Market - Global Industry Analysis 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3
... Scientists affiliated with the Natural Capital Project at Stanford University ... measure where and when people are using natural areas for ... and value that these areas provide to society. Tourism ... world economy, and it,s expected to grow to $10 billion ...
... many plants with wide ranges can vary geographically, depending on ... can also affect the genetic composition of natural plant populations, ... and Stockholm University are presenting the new study this week ... Sciences , PNAS . It is known that ...
... has evolved to produce individuals with two distinct appearancesan ... a form with a white stripe running down its ... its broader ecological community when the appearance of the ... The new findings, based on research carried out ...
Cached Biology News:Stanford scientists use Flickr photos to assess value of natural tourist attractions 2Grazers and pollinators shape plant evolution 2Poorly camouflaged insects can kick off a cascade of ecological impacts, new CU-Boulder study finds 2Poorly camouflaged insects can kick off a cascade of ecological impacts, new CU-Boulder study finds 3
(Date:7/1/2015)... 1, 2015   Neuraltus Pharmaceuticals, Inc. , a ... groundbreaking drugs to treat neurodegenerative diseases such as ... Robert G. Miller , M.D., Director of the Forbes ... Pacific Medical Center in San Francisco, has been awarded ... million to help fund a Phase 2 clinical ...
(Date:7/1/2015)... Ariz. , July 1, 2015 Isagenix ... it has earned three Gold, three Silver, and three ... Awards gala held in Chicago ... as the premier business awards program in the U.S. ... recognizes our company,s strength in developing leaders, cultivating talent, ...
(Date:7/1/2015)... 2015 InferMed , ... will augment ... clinical s olutions suite   Elsevier ... products and services, announced today the acquisition of  InferMed , ... technology company. InferMed,s Arezzo technology supports clinicians in ...
(Date:7/1/2015)... ... 01, 2015 , ... NEMA 4 (IP66) Medical Joysticks can ... Joysticks have an impermeable molecular barrier protection against bio-hazardous agents. Original Equipment ... increase healthcare worker safety and reduce financial costs. , CTI Electronics announces a ...
Breaking Biology Technology:Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2
... - Hutchinson Technology Inc. , a designer and ... goods, is nearing completion of a 70,000 square foot ... drives. , ,Following its completion next month, Hutchinson ... company engineers, and will tentatively have the first production ...
... of start-ups came through my office showing business plans that ... income and achieve some splendid valuation. We all know how ... a very few others - that presented a strong value ... on other companies for their businesses, more or less, did ...
... - One state initiative aimed at galvanizing ... having the desired effect. , ,Several emerging technology ... the attention of investors, after submitting winning business ... of ideas. , ,The Governor's Business Plan Contest, ...
Cached Biology Technology:Hutchinson plant expansion nears completion 2Searching for revenue streams 2Searching for revenue streams 3Winners of past business plan contests secure funding, credibility 2Winners of past business plan contests secure funding, credibility 3Winners of past business plan contests secure funding, credibility 4